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Dalteparin in combination with abciximab during percutaneous coronary intervention.

Abstract：

BACKGROUND:Despite proved efficacy for either dalteparin or platelet glycoprotein IIb/IIIa blockade in improving clinical outcomes of patients with non-ST-segment elevation acute coronary syndromes, algorithms guiding concomitant therapy with these agents have not been devised. The purpose of this study was to assess anticoagulant effect and clinical safety for several dose regimens of dalteparin administered in combination with abciximab during percutaneous coronary intervention (PCI). METHODS AND RESULTS:Patients undergoing PCI with standard dose abciximab received dalteparin as follows: 120 IU/kg subcutaneously (SQ) to a maximum of 10,000 U if < or =8 hours before PCI (n = 3); for PCI 8-12 hours after the SQ dose, an additional 40 IU/kg intravenously (IV) was administered (n = 1); for PCI >12 hours after SQ dalteparin or with no prior dalteparin therapy, random allocation to 40 (n = 27) or 60 (n = 28) IU/kg IV during PCI was performed. Those patients who received 60 IU/kg of dalteparin IV had a lower incidence of procedural thrombosis (0% vs 11.1%, P <.01), more consistent antithrombotic effect (anti-factor Xa activity) and a similar incidence of major bleeding (3.7% vs 2.6%) compared with patients who received 40 IU/kg of intravenous dalteparin. CONCLUSIONS:Dalteparin 60 IU/kg IV appears to be safe and effective when administered in conjunction with abciximab for percutaneous coronary intervention.

journal_name

Am Heart J

journal_title

American heart journal

authors

Kereiakes DJ,Kleiman NS,Fry E,Mwawasi G,Lengerich R,Maresh K,Burkert ML,Aquilina JW,DeLoof M,Broderick TM,Shimshak TM

doi

10.1067/mhj.2001.113217

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

348-52

issue

3

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(01)47222-X

journal_volume

141

pub_type

临床试验,杂志文章,随机对照试验

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