Effects of prostacyclin on systemic and coronary hemodynamics in the dog.

Abstract:

:The hemodynamic effects of intravenous and intracoronary prostacyclin (PGI2) were evaluated in anesthetized, open-chest instrumented dogs. Coronary artery and aortic blood flows, aortic and left ventricular (LV) diastolic pressure, and heart rate were measured continuously. With intravenous PGI2 both left anterior descending (LAD) and circumflex (LCX) coronary artery blood flows remained unchanged; both arterial and LV diastolic pressures declined; coronary resistance declined progressively with increasing PGI2; peak reactive hyperemic flow following 10-second coronary artery occlusion declined progressively with increased PGI2; heart rate responses were variable at low doses but increased at high dose; and aortic blood flow increased consistently. With intracoronary PGI2 both LAD and LCX coronary blood flows increased promptly in dose-related manner. In dogs with critical coronary artery narrowing (loss of reactive hyperemia) created by an external plastic occluder, intravenous prostacyclin (0.5 microgram/kg/min) did not alter flow in narrowed coronary artery, but increased flow in the non-narrowed coronary artery (p less than 0.02) as both systemic arterial and LV diastolic pressure declined. These results show that PGI2 has potent direct coronary and systemic vasodilator actions.

journal_name

Am Heart J

journal_title

American heart journal

authors

Mehta J,Nichols WW,Mehta P,Pepine C,Conti CR

doi

10.1016/0002-8703(81)90033-8

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

835-40

issue

5

eissn

0002-8703

issn

1097-6744

pii

0002-8703(81)90033-8

journal_volume

102

pub_type

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