Effects of prostacyclin on systemic and coronary hemodynamics in the dog.

Abstract:

:The hemodynamic effects of intravenous and intracoronary prostacyclin (PGI2) were evaluated in anesthetized, open-chest instrumented dogs. Coronary artery and aortic blood flows, aortic and left ventricular (LV) diastolic pressure, and heart rate were measured continuously. With intravenous PGI2 both left anterior descending (LAD) and circumflex (LCX) coronary artery blood flows remained unchanged; both arterial and LV diastolic pressures declined; coronary resistance declined progressively with increasing PGI2; peak reactive hyperemic flow following 10-second coronary artery occlusion declined progressively with increased PGI2; heart rate responses were variable at low doses but increased at high dose; and aortic blood flow increased consistently. With intracoronary PGI2 both LAD and LCX coronary blood flows increased promptly in dose-related manner. In dogs with critical coronary artery narrowing (loss of reactive hyperemia) created by an external plastic occluder, intravenous prostacyclin (0.5 microgram/kg/min) did not alter flow in narrowed coronary artery, but increased flow in the non-narrowed coronary artery (p less than 0.02) as both systemic arterial and LV diastolic pressure declined. These results show that PGI2 has potent direct coronary and systemic vasodilator actions.

journal_name

Am Heart J

journal_title

American heart journal

authors

Mehta J,Nichols WW,Mehta P,Pepine C,Conti CR

doi

10.1016/0002-8703(81)90033-8

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

835-40

issue

5

eissn

0002-8703

issn

1097-6744

pii

0002-8703(81)90033-8

journal_volume

102

pub_type

杂志文章
  • Microwave ablation of canine atrial tachycardia induced by aconitine.

    abstract::We tested the efficacy of microwave-frequency energy for ablating atrial tachycardia in eight open-chest dogs. Five other dogs served as controls. Atrial tachycardia was induced by direct application of aconitine crystals to the epicardial atrial surface or by injection of aconitine solution (0.15 mg/ml) into the righ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(95)90126-4

    authors: Rho TH,Ito M,Pride HP,Waller B,Zipes DP

    更新日期:1995-05-01 00:00:00

  • Combined use of high-sensitivity cardiac troponin T and N-terminal pro-B type natriuretic peptide improves measurements of performance over established mortality risk factors in chronic heart failure.

    abstract:BACKGROUND:Heart failure still maintains a high mortality. Biomarkers reflecting different pathophysiological pathways are under evaluation to better stratify the mortality risk. The objective was to assess high-sensitivity cardiac troponin T (hs-cTnT) in combination with N-terminal pro-B type natriuretic peptide (NT-p...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2012.03.004

    authors: de Antonio M,Lupon J,Galan A,Vila J,Urrutia A,Bayes-Genis A

    更新日期:2012-05-01 00:00:00

  • Hierarchy of risk based on history and location of prior myocardial infarction in the thrombolytic era. GUSTO-I Investigators.

    abstract:BACKGROUND:Among patients receiving thrombolytic therapy for myocardial infarction, the outcome for those with a history of infarction is dramatically worse than for those with their first event. Methods And Results We performed a post hoc analysis of patients with a history of myocardial infarction enrolled in the Glo...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/mhj.2000.106166

    authors: Brieger DB,Mak KH,Miller DP,Califf RM,Topol EJ

    更新日期:2000-07-01 00:00:00

  • Concerns about the implantable cardioverter defibrillator: a determinant of anxiety and depressive symptoms independent of experienced shocks.

    abstract:BACKGROUND:Patients with an implantable cardioverter defibrillator (ICD) are at increased risk of anxiety disorders. In turn, anxiety has been identified as a precipitant of ventricular arrhythmias. Anxiety may in part be attributed to concerns about the ICD firing, but the relationship between ICD concerns, psychologi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2004.06.031

    authors: Pedersen SS,van Domburg RT,Theuns DA,Jordaens L,Erdman RA

    更新日期:2005-04-01 00:00:00

  • Heart failure disease management in an indigent population.

    abstract:BACKGROUND:Multidisciplinary disease management programs (MDMP) have demonstrated reduced hospitalizations in motivated pretransplant heart failure populations, but little is known about their effectiveness in largely indigent patients who are not transplant candidates. METHODS AND RESULTS:We studied 35 patients with ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2001.111956

    authors: O'Connell AM,Crawford MH,Abrams J

    更新日期:2001-02-01 00:00:00

  • Hemodynamic evaluation of the Ionescu-Shiley pericardial xenograft in the mitral position.

    abstract::Hemodynamic studies were performed in 27 patients at a mean interval of 40.3 (range 24 to 59) months following mitral valve replacement with pericardial xenografts. Six patients had sequential studies, one before operation and two separate investigations at mean intervals of 11.2 and 42.8 months following valve replac...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(78)90301-0

    authors: Tandon AP,Smith DR,Ionescu MI

    更新日期:1978-05-01 00:00:00

  • Diltiazem attenuates the inotropic and peripheral vascular effects of cardiac glycosides.

    abstract::The influence of diltiazem on the hemodynamic effects of ouabain in 10 preinstrumented awake dogs was studied. Mean aortic pressure increased from 102 to 119 mm Hg with ouabain (p less than 0.05), an effect that was attenuated by pretreatment with diltiazem. The increase in systemic vascular resistance of 30% with oua...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(89)90587-5

    authors: Watford WH,Walsh RA,O'Rourke RA

    更新日期:1989-10-01 00:00:00

  • Relationship between initial white blood cell counts, stage of acute myocardial infarction evolution at presentation, and incidence of Thrombolysis In Myocardial Infarction-3 flow after streptokinase.

    abstract:BACKGROUND:The initial white cell counts in patients with acute myocardial infarction (AMI) may reflect the stage of AMI evolution, and may also be related to the efficacy of thrombolytic agents in recanalizing occluded epicardial arteries. METHODS:In 312 patients with a first AMI, we divided the initial white cell co...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1067/mhj.2003.64

    authors: Wong CK,French JK,Gao W,White HD

    更新日期:2003-01-01 00:00:00

  • T wave abnormalities in top-ranking athletes: effects of isoproterenol, atropine, and physical exercise.

    abstract::Eight cases of top-ranking athletes with "repolarization disorders" are reported. All subjects were asymptomatic and were otherwise suited for excellent cardiovascular performances. Seven athletes did not show any evidence of heart disease. Seven had MVP (mitral valve prolapse). Umprompted variability of ECG tracings ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(80)90117-9

    authors: Zeppilli P,Pirrami MM,Sassara M,Fenici R

    更新日期:1980-08-01 00:00:00

  • Usefulness of anticoagulant therapy in the prevention of embolic complications of atrial fibrillation.

    abstract::The medical records of 254 patients with atrial fibrillation were reviewed to determine the incidence of embolic events in relation to type of cardiovascular disease, duration of atrial fibrillation, and use of anticoagulants. During a total follow-up of 833 patient-years in atrial fibrillation, there were 32 instance...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90318-2

    authors: Roy D,Marchand E,Gagné P,Chabot M,Cartier R

    更新日期:1986-11-01 00:00:00

  • Design and rationale of the TRI-stent adjudication study (TRIAS) program.

    abstract:BACKGROUND:In the treatment of coronary artery disease, a "pro-healing" approach for prevention of in-stent restenosis and late stent thrombosis is intuitively favored over the use of cytotoxic or cytostatic drugs released from a drug-eluting stent (DES). Promoting accelerated endothelial coverage of the stent surface,...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2009.07.022

    authors: Klomp M,Beijk MA,Verouden NJ,Tijssen JG,de Winter RJ,TRIAS Investigators.

    更新日期:2009-10-01 00:00:00

  • Significance of new Q waves after bypass grafting: correlations between graft patency, ventriculogram, and surgical venting technique.

    abstract::New postoperative electrocardiographic Q waves have been described in eight of 40 per cent of patients undergoing bypass grafting for coronary artery disease. Various theories have been proposed to explain these new Q waves. Correlations of new Q waves to vein bypass occlusion, prolonged pump time or aortic cross-clam...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(78)90233-8

    authors: Aintablian A,Hamby RI,Hoffman I,Weisz D,Voleti C,Wisoff BG

    更新日期:1978-04-01 00:00:00

  • Newer antiarrhythmic drugs in children.

    abstract::Our experience with the use of five new antiarrhythmic drugs for treating life-threatening arrhythmias in children will be briefly reviewed. Prevention of recurrent episodes of atrial flutter with digoxin and local anesthetic antiarrhythmic drugs often is only moderately successful, benefiting 65% of patients. Amiodar...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90027-5

    authors: Moak JP,Smith RT,Garson A Jr

    更新日期:1987-01-01 00:00:00

  • Impedance measurement of absolute blood flow using an angioplasty catheter: a validation study.

    abstract::An angioplasty catheter was developed to allow measurement of absolute coronary blood flow during interventional procedures. This method uses electrical impedance changes induced by a 0.5 ml bolus of 5% dextrose solution and indicator-dilution principles. The indicator is injected through a port located just proximal ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90184-j

    authors: Martin LW,Johnson RA,Scott H,Robinson S,Beauman G,Englehardt M,Vogel RA

    更新日期:1991-03-01 00:00:00

  • High-risk myocardial infarction in the young: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial.

    abstract:BACKGROUND:Advanced age is a well-established prognostic risk factor after acute myocardial infarction (AMI), yet approximately 10% of MIs occur in patients <45 years. We examined characteristics, cardiovascular outcomes, and the influence of risk factors on outcomes in young survivors of AMI. METHODS:Fourteen thousan...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2007.11.016

    authors: Anderson RE,Pfeffer MA,Thune JJ,McMurray JJ,Califf RM,Velazquez E,White HD,Rouleau JL,Skali H,Maggioni A,Solomon SD

    更新日期:2008-04-01 00:00:00

  • Limited value of exercise testing in the detection of silent restenosis after successful coronary angioplasty.

    abstract::We studied the diagnostic value of exercise electrocardiographic (ECG) testing in 191 patients who were completely asymptomatic 6 months after a successful percutaneous transluminal coronary angioplasty procedure. With > 70%- and > 50%-diameter stenosis at follow-up as restenosis criteria, the sensitivities of exercis...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-8703(95)90267-8

    authors: Desmet W,De Scheerder I,Piessens J

    更新日期:1995-03-01 00:00:00

  • Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention.

    abstract:BACKGROUND:In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce t...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2016.07.001

    authors: deFilippi CR,de Lemos JA,Newman AB,Guralnik JM,Christenson RH,Pahor M,Church T,Espeland M,Krithevsky SB,Stafford R,Seliger SL,LIFE Study Group.

    更新日期:2016-09-01 00:00:00

  • Mode of stimulation versus response: validation of a protocol for induction of ventricular tachycardia.

    abstract::Electrophysiologic studies were prospectively performed in 91 consecutive patients referred for evaluation of sustained ventricular tachycardia or sudden cardiac death. Fifty-two patients had a history of sustained ventricular tachycardia and 39 patients had a history of sudden cardiac death. The identical stimulation...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(85)90088-2

    authors: Oseran DS,Gang ES,Hamer AW,Zaher CA,Rosenthal ME,Mandel WJ,Peter T

    更新日期:1985-09-01 00:00:00

  • The post-pulmonary infarction syndrome.

    abstract::Following pulmonary infarction, three patients developed the classical signs and symptoms of the Dressler syndrome associated with persistent left pleural effusion. Each responded dramatically to corticosteroid therapy. While the pathogenesis of this "Post-Pulmonary Infarction syndrome," like the Dressler syndrome, is...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(79)90477-0

    authors: Sklaroff HJ

    更新日期:1979-12-01 00:00:00

  • Acute coronary occlusion occurring after successful percutaneous transluminal coronary angioplasty: temporal relationship to discontinuation of anticoagulation.

    abstract::The incidence and prognosis of acute coronary reocclusion occurring after patients had left the catheterization laboratory following a successful percutaneous transluminal coronary angioplasty (PTCA) procedure and the temporal relation of this event to the discontinuation of systemic heparin administration were analyz...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(88)90326-2

    authors: Gabliani G,Deligonul U,Kern MJ,Vandormael M

    更新日期:1988-09-01 00:00:00

  • Ultraslow thrombolytic therapy: A novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: The Ultra-slow PROMETEE trial.

    abstract:BACKGROUND:Low-dose (25mg), slow infusion (6hours) of tissue-type plasminogen activator (t-PA) with repetition as needed has been shown to provide effective and safer thrombolysis in patients with prosthetic valve thrombosis (PVT). Further prolonging the infusion time may be rational with regard to reducing complicatio...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ahj.2015.04.025

    authors: Özkan M,Gündüz S,Gürsoy OM,Karakoyun S,Astarcıoğlu MA,Kalçık M,Aykan AÇ,Çakal B,Bayram Z,Oğuz AE,Ertürk E,Yesin M,Gökdeniz T,Duran NE,Yıldız M,Esen AM

    更新日期:2015-08-01 00:00:00

  • A randomized trial of prophylactic antiarrhythmic agents (amiodarone and sotalol) in patients with atrial fibrillation for whom direct current cardioversion is planned.

    abstract:UNLABELLED:Antiarrhythmic agents enhance maintenance of sinus rhythm (SR) after direct current cardioversion (DCC) for atrial fibrillation but there are few comparative trials. BACKGROUND:The aims of the study were (1) to establish whether patients successfully cardioverted to SR are more likely to stay in SR over 6 m...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2005.09.009

    authors: Vijayalakshmi K,Whittaker VJ,Sutton A,Campbell P,Wright RA,Hall JA,Harcombe AA,Linker NJ,Stewart MJ,Davies A,de Belder MA

    更新日期:2006-04-01 00:00:00

  • HLA-DR typing and lymphocyte subset evaluation in rheumatic heart disease: a search for immune response factors.

    abstract::Several autoimmune diseases have been associated with increased frequencies of specific histocompatibility (HLA) antigens, particularly for the D (DR) locus, that may be linked to immune response genes. Rheumatic valvular heart disease (RHD) has been postulated to have autoimmune features, but HLA associations have no...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90311-x

    authors: Anastasiou-Nana MI,Anderson JL,Carlquist JF,Nanas JN

    更新日期:1986-11-01 00:00:00

  • The relationship between gender and clinical management after exercise stress testing.

    abstract:BACKGROUND:Controversy remains regarding whether gender differences exist in clinical management after exercise treadmill testing (ETT). METHODS:We studied 7,506 patients (49.8% women) without documented coronary heart disease referred for ETT from July 2001 to June 2004 in a community-based setting. We assessed the r...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2008.03.022

    authors: Daugherty SL,Peterson PN,Magid DJ,Ho PM,Bondy J,Hokanson JE,Ross CA,Rumsfeld JS,Masoudi FA

    更新日期:2008-08-01 00:00:00

  • Antiplatelet and antithrombotic treatment after primary percutaneous coronary intervention: balancing safety and efficacy.

    abstract::Antiplatelet therapy has been shown to significantly reduce the risk of serious vascular events in high-risk patients, including those with a prior acute ischemic event. The long-term use of antiplatelet agents is a key component of secondary prevention measures following acute coronary syndromes, including ST-segment...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2010.10.014

    authors: Valgimigli M,Minarelli M

    更新日期:2010-12-01 00:00:00

  • Prevention of nitroglycerin tolerance with diuretics.

    abstract::Tolerance to prolonged nitroglycerin (NTG) may be due to drug-induced intravascular expansion. To test the hypothesis that concomitant diuretics may reduce volume expansions and thus prevent NTG tolerance, we studied 23 healthy volunteers randomized to hydrochlorthiazide or placebo before and during 74-hour continuous...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-8703(95)90361-5

    authors: Mohanty N,Wasserman AG,Walker P,Katz RJ

    更新日期:1995-09-01 00:00:00

  • Everolimus-eluting stent versus bare metal stent in proximal left anterior descending ST-elevation myocardial infarction: insights from the EXAMINATION trial.

    abstract:BACKGROUND:ST-elevation myocardial infarctions (STEMI) caused by proximal left-anterior descending (LAD) lesions have more myocardium at risk and worse outcomes than those located in other segments. The aim is to compare outcomes of patients with STEMI and proximal-LAD lesions treated with bare-metal stents (BMS) versu...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2013.04.012

    authors: Gomez-Lara J,Brugaletta S,Gomez-Hospital JA,Ferreiro JL,Roura G,Romaguera R,Martin-Yuste V,Masotti M,Iñiguez A,Serra A,Hernandez-Antolin R,Mainar V,Valgimigli M,Tespili M,den Heijer P,Bethencourt A,Vazquez N,Serruys P,

    更新日期:2013-07-01 00:00:00

  • Cardiac transplantation for the cardiologist not trained in transplantation.

    abstract::This review focuses on selected aspects of the treatment of patients being evaluated for and undergoing cardiac transplantation. Cardiac transplantation is a potential therapeutic option for a variety of irreversible cardiac disorders when the symptomatic status and anticipated survival after transplantation exceeds t...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(95)90288-0

    authors: Taylor AJ,Bergin JD

    更新日期:1995-03-01 00:00:00

  • Incidence and characteristics of stroke during 90-day follow-up in patients stabilized after an acute coronary syndrome.

    abstract:BACKGROUND:Stroke is a rare but serious event that complicates the course of patients with acute coronary syndromes (ACS). The type, outcome, and risk factors of stroke occurring in stabilized patients with ACS have not been previously reported. METHODS:We evaluated stroke incidence, subtypes, and outcomes, in additio...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2004.01.028

    authors: Kassem-Moussa H,Mahaffey KW,Graffagnino C,Tasissa G,Sila CA,Simes RJ,White HD,Califf RM,Bhapkar MV,Newby LK,SYMPHONY and 2nd SYMPHONY Investigators.

    更新日期:2004-09-01 00:00:00

  • Intrinsic heart rate in children and young adults: an index of sinus node function isolated from autonomic control.

    abstract::Standard evaluation of children with sinus node (SN) dysfunction cannot distinguish abnormal autonomic tone from intrinsic SN disease. This distinction has potentially important therapeutic and prognostic implications. Intrinsic heart rate (IHR)--the peak heart rate (HR) measured during pharmacologic combined autonomi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(05)80331-x

    authors: Marcus B,Gillette PC,Garson A Jr

    更新日期:1990-04-01 00:00:00