Abstract：
BACKGROUND:We assessed left atrial function in normal subjects and in patients with hypertrophic cardiomyopathy (HCM) by using Doppler echocardiography at the supine position and after sudden standing. METHODS AND RESULTS:Twenty-seven patients with hypertrophic obstructive cardiomyopathy (HOCM), 17 patients with HCM, and 35 normal subjects were studied. From the transmitral Doppler flow velocities, peak early and late (E and A) waves, E/A ratio, and time velocity integrals (Ei and Ai) were calculated. Left atrial active contribution (LAAC) was assessed as the ratio Ei/(Ei + Ai). Furthermore, isovolumetric relaxation time (IVRT) was estimated by means of Doppler echocardiography. In the supine position, the E/A ratio was similar in the 3 groups. Conversely, LAAC was significantly higher in patients with HOCM (24.4 +/- 2.0) and in patients with HCM (23.3 +/- 3.3) compared with normal subjects (20.3 +/- 2.3, P <.001 and P <.05, respectively). After sudden standing, LAAC increased significantly in normal subjects by 11%, in patients with HOCM by 24%, and in patients with HCM by 13% (P <.001). Similarly, IVRT increased significantly in all study groups (P <. 001). By using stepwise forward multiple linear regression analysis, we found that LAAC was associated with age, IVRT, and body mass index in the supine position and with diastolic blood pressure and IVRT in the standing position. CONCLUSIONS:Left atrial contribution to left ventricular filling was increased after sudden changes of posture in normal subjects and in patients with HOCM or HCM.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Dernellis J,Tsiamis E,Stefanadis C,Pitsavos C,Toutouzas Pdoi
10.1016/s0002-8703(98)70153-xsubject
Has Abstractpub_date
1998-12-01 00:00:00pages
982-7issue
6eissn
0002-8703issn
1097-6744pii
S0002870398000131journal_volume
136pub_type
杂志文章abstract：:An extremely athletic 56-year-old male physician was found to have profound sinus bradycardia. His only symptom was markedly increased alertness while actively exercising. During pacemaker insertion he had an episode of prolonged sinus arrest terminated by a precordial thump. This case suggests that exercise can alter...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(80)90284-7
更新日期：1980-07-01 00:00:00
abstract：:Currently available antiplatelet agents are limited in the scope and magnitude of platelet inhibition. Orally active platelet glycoprotein IIb/IIIa antagonists are currently in clinical testing. These agents may extend platelet inhibition and clinical benefit from parenteral glycoprotein IIb/IIIa antagonists. The most...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1053/hj.1999.v138.99080
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:Several studies have shown that patency of the epicardial vessel does not guarantee optimal myocardial perfusion in patients undergoing primary angioplasty for ST-segment elevation myocardial infarction (STEMI). The aim of the current study was to identify clinical and angiographic correlates of unsuccessful...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2004.10.044
更新日期：2005-09-01 00:00:00
abstract：:Estimation of baroreflex sensitivity (BRS) is receiving increasing attention in clinical and experimental cardiology. Until recently, in most studies BRS has been assessed on the basis of invasive blood pressure measurement, which limits its use in large-scale studies and in clinical practice. The development of conti...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/0002-8703(95)90443-3
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:Compared with men, women have more evidence of myocardial ischemia with no obstructive coronary artery disease. Although low endogenous estrogen levels are associated with endothelial dysfunction, the role of low-dose hormone therapy has not been fully evaluated. We postulate that a 12-week duration of low-d...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ahj.2010.03.024
更新日期：2010-06-01 00:00:00
abstract：:Left ventricular (LV) adaptation to the hemodynamic load of pregnancy has been studied with load-sensitive ejection-phase indexes, but the results of these studies are conflicting. The aim of this study was to examine the effects of the hemodynamic load of pregnancy on the contractile state of the left ventricle by us...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(97)70247-3
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Automated implantable cardioverter-defibrillators (ICDs) have become standard therapy for patients at high risk for sudden cardiac death. Linked data allow examination of trends in use and long-term survival after ICD implantation in an adult population. METHODS:Linked state-wide person-based data on hospit...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2013.02.007
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Observational studies have shown apparently lower ischemic coronary disease risk in postmenopausal women receiving hormone replacement therapy (HRT). However, several recent studies have shown an increase in ischemic cardiac events when HRT is initiated in postmenopausal women with known coronary artery dise...
journal_title：American heart journal
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ahj.2004.10.028
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Gastrointestinal bleeding (GIB) after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and coronary artery disease (CAD) is associated with high morbidity and mortality. METHODS:The NIS database from 1998 to 2006 was used to identify 1,216,759 PCIs performed for ACS and CAD. We sou...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2011.09.009
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Drug-eluting stents (DES) have largely replaced bare-metal stents (BMS) for percutaneous coronary intervention (PCI). It is uncertain, however, whether introduction of DES had a significant impact on the comparative effectiveness of PCI versus coronary artery bypass graft surgery (CABG) for death and myocard...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2014.10.004
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Transcatheter aortic valve replacement (TAVR) is an effective therapeutic option for patients with severe aortic stenosis at high risk for surgery. Identification of causes of death after TAVR may help improve patient selection and outcome. METHODS:We enrolled 874 consecutive patients who underwent TAVR at ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2014.07.023
更新日期：2014-11-01 00:00:00
abstract：:Although it has been shown that early cardiac rejection can be visualized by radioimmunoscintigraphy targeting major histocompatibility complex class II antigen, the use of antibodies that bind to a polymorphic determinant of class II antigen has certain disadvantages for clinical application. This investigation was d...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(94)90050-7
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:Although monitoring the clinical status of patients with heart failure rests at the core of clinical medicine, the ability of different techniques to reflect clinical change has not been evaluated. This study sought to describe changes in various measures of disease status associated with gradations of clini...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ahj.2004.12.010
更新日期：2005-10-01 00:00:00
abstract：:To evaluate the antiischemic effects of intravenous milrinone, 20 patients with angiographically proved coronary artery disease and stable angina were studied at rest and during exercise under control conditions and after an intravenous loading injection of milrinone (50 micrograms/kg/10 min) followed by an infusion w...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/0002-8703(91)90835-6
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:Myocardial contractile reserve has been shown to provide important prognostic information in patients with heart failure. We hypothesized that myocardial contractile reserve would predict left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). METHODS:Thirty-one consecutive p...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2007.07.035
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Reliable predictors have yet to be found for recurrent ischemia after thrombolysis for acute myocardial infarction (AMI), nor do we know whether early angiography can herald recurrent ischemia. This study sought to investigate the relationship between recurrent ischemia and cardiac procedures after thromboly...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1067/mhj.2001.113226
更新日期：2001-04-01 00:00:00
abstract：:Eight patients with multifocal atrial tachycardia received 7 to 12 gm of magnesium sulfate intravenously over a 5-hour period. Potassium supplements were given initially or added later. Initial arterial blood gases showed mean pH 7.48 +/- 0.03, PcO2 39.7 torr, PO2 72 torr, HCO-3 29.8 +/- 4.5 mEq/L, and base excess 6.8...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(85)90458-2
更新日期：1985-10-01 00:00:00
abstract：:After injecting 125I- or 131I-labeled lipoproteins, plasma was subjected to discontinuous density gradient centrifugation, which separates low-density lipoproteins (LDL) into three subfractions. Analysis of changes in apolipoprotein B-specific activity with time showed that light LDL is normally the product of interme...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(87)90623-5
更新日期：1987-02-01 00:00:00
abstract：BACKGROUND:High-intensity interval training has been shown to be superior to moderate continuous exercise training in improving exercise capacity and endothelial function in patients with coronary artery disease. The objective of this study was to evaluate this training model on in-stent restenosis following percutaneo...
journal_title：American heart journal
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ahj.2009.08.021
更新日期：2009-11-01 00:00:00
abstract：:In a double blind, placebo-controlled study, the efficacy of propafenone, a new antiarrhythmic drug was compared to that of disopyramide. Sixteen patients with frequent and complex premature ventricular contractions (PVCs) were studied by serial 24-hour ambulatory monitoring, while they were receiving propafenone, 300...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-8703(85)90647-7
更新日期：1985-04-01 00:00:00
abstract：:To evaluate the mechanisms involved in nitrate tolerance, we randomized 23 patients with congestive heart failure resulting from coronary artery disease to an isosorbide dinitrate or a molsidomine infusion. The drugs were titrated to decrease pulmonary capillary wedge pressure by > or = 30% or > or = 10 mm Hg. Then is...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-8703(94)90632-7
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND:A previous randomized controlled trial evaluating the use of spironolactone in heart failure patients reported a low risk of hyperkalemia (2%) and renal insufficiency (0%). Because treatments for heart failure have changed since the benefits of spironolactone were reported, the prevalence of these complicati...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2004.10.005
更新日期：2004-12-01 00:00:00
abstract：:The hemodynamic, electrocardiographic, and metabolic responses of dogs with acute myocardial ischemia to intravenous administration of fructose-1,6-diphosphate (FDP) were assessed. Analysis of the results (compared to dextrose control) revealed evidence of major improvement of LVEDP and cardiac output, significant dec...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(80)90228-8
更新日期：1980-11-01 00:00:00
abstract：:Coronary arterial stenosis of varying severity and length were created in open-chest dogs. The reactive hyperemic responses (RHR) to 15 second occlusions were used to produce flow increases and judge the physiological significance of the narrowings. RHR are sensitive indices of functional impairment when resting flow ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(76)80010-5
更新日期：1976-12-01 00:00:00
abstract：BACKGROUND:The diagnostic value of 12-lead electrocardiography during dobutamine stress echocardiography (DSE) is not well documented. METHODS AND RESULTS:We reviewed the records of 116 patients referred for DSE and coronary angiography, 52 of whom were excluded because of abnormal ST segment or inadequate DSE. Of the...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(98)70163-2
更新日期：1998-12-01 00:00:00
abstract：:Intracoronary streptokinase (SK) was administered to 11 patients with evolving acute transmural myocardial infarction 5.5 +/- 0.4 hours from the onset of symptoms. Ten patients (91%) had total coronary occlusion, and one had subocclusion of the vessel corresponding to the ECG site of infarction. Intracoronary nitrogly...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(81)90646-3
更新日期：1981-12-01 00:00:00
abstract：BACKGROUND:Understanding pulmonary vein (PV) anatomy is important for the planning and execution of PV isolation for the treatment of atrial fibrillation, screening for PV stenosis after the procedure, and investigating the pathophysiology of atrial fibrillation. We hypothesized that significant changes in PV size occu...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2006.05.018
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:Patients with diabetes have an increased incidence and severity of ischemic heart disease, which leads to an increased requirement for coronary revascularization. Comparative information regarding mode of revascularization--coronary artery bypass graft surgery surgery (CABG) or percutaneous coronary interven...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2004.07.001
更新日期：2005-01-01 00:00:00
abstract：:In a study of GTN absorption during exercise and high ambient temperature, 12 healthy volunteers carried 10 mg glyceryl trinitrate (GTN, nitroglycerin) transdermal patches for 6 hours during each of 3 days. During a control day the mean plasma GTN concentration ranged from 1.0 nmol/L (SD +/- 0.8 nmol/L) to 1.5 nmol/L ...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-8703(86)90518-1
更新日期：1986-09-01 00:00:00
abstract：:Incidence of myonecrosis in patients undergoing rotational atherectomy was evaluated by preprocedural statin use. The incidence of any myonecrosis (24.1% vs 52.3%, P < .001) or significant myonecrosis (7.5% vs 21.8%, P < .001) was significantly lower among patients pretreated with statins. This difference remained sig...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2006.02.026
更新日期：2006-05-01 00:00:00
