当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Comparison of the hemodynamic responses to molsidomine and isosorbide dinitrate in congestive heart failure.

Comparison of the hemodynamic responses to molsidomine and isosorbide dinitrate in congestive heart failure.

Abstract：

:To evaluate the mechanisms involved in nitrate tolerance, we randomized 23 patients with congestive heart failure resulting from coronary artery disease to an isosorbide dinitrate or a molsidomine infusion. The drugs were titrated to decrease pulmonary capillary wedge pressure by > or = 30% or > or = 10 mm Hg. Then isosorbide dinitrate, molsidomine, or placebo was infused in a double-blind randomized manner for 24 hours. In all patients, treatment with enalapril was begun > or = 48 hours before the beginning of the protocol and was continued throughout the study to avoid renin-angiotensin activation. The pulmonary capillary wedge pressure remained significantly decreased at 24 hours during molsidomine infusion only. No significant increase in catecholamines occurred. Because molsidomine differs from organic nitrates by its property of directly stimulating guanylate cyclase without depending on thiol group availability, these results suggest that impaired biotransformation of nitrates is involved in tolerance induced by high doses of isosorbide dinitrate in congestive heart failure.

journal_name

Am Heart J

journal_title

American heart journal

authors

Unger P,Vachiery JL,de Cannière D,Staroukine M,Berkenboom G

doi

10.1016/0002-8703(94)90632-7

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

557-63

issue

3

eissn

0002-8703

issn

1097-6744

pii

0002-8703(94)90632-7

journal_volume

128

pub_type

临床试验,杂志文章,随机对照试验

相关文献

AMERICAN HEART JOURNAL文献大全
  • Excess weight and life expectancy after acute myocardial infarction: The obesity paradox reexamined.

    abstract：BACKGROUND:An "obesity paradox" has been described in patients with acute myocardial infarction (AMI), whereby obese and overweight patients have a lower risk of short-term mortality after AMI than normal-weight patients. However, the long-term association of obesity with mortality after AMI remains unknown. METHODS:W...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2015.10.024

    authors： Bucholz EM,Beckman AL,Krumholz HA,Krumholz HM,Dr. Bucholz was affiliated with the Yale School of Medicine and Yale School of Public Health during the time that the work was conducted.

    更新日期：2016-02-01 00:00:00

  • Subclinical coronary atherosclerosis: racial profiling is necessary!

    abstract：OBJECTIVES:We aim to review the studies comparing coronary calcification across different ethnic groups. BACKGROUND:There is still uncertainty regarding ethnic differences in the prevalence, progression, and risk of coronary artery disease. Clues to possible racial differences in rates of coronary heart disease (CHD) ...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2006.08.008

    authors： Orakzai SH,Orakzai RH,Nasir K,Santos RD,Edmundowicz D,Budoff MJ,Blumenthal RS

    更新日期：2006-11-01 00:00:00

  • Multifaceted intervention to promote beta-blocker use in heart failure.

    abstract：BACKGROUND:Despite a survival benefit and guideline recommendation for beta-blockers in left ventricular systolic dysfunction, beta-blockers are underused in clinical practice. METHODS:Medical practices with > or = 15 patients with heart failure (HF) in the Duke Databank for Cardiovascular Disease (DDCD) were identifi...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2005.06.038

    authors： LaPointe NM,DeLong ER,Chen A,Hammill BG,Muhlbaier LH,Califf RM,Kramer JM

    更新日期：2006-05-01 00:00:00

  • Dobutamine and nitroprusside infusion in patients with severe congestive heart failure: hemodynamic improvement by discordant effects on mitral regurgitation, left atrial function, and ventricular function.

    abstract：OBJECTIVES:In patients with severe heart failure additional therapeutic support with intravenous inotropic or vasodilator drugs is frequently used in the attempt to obtain hemodynamic control. The nature and extent to which diastolic filling, atrial function, and mitral regurgitation are modified by these drugs have no...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(97)70030-9

    authors： Capomolla S,Pozzoli M,Opasich C,Febo O,Riccardi G,Salvucci F,Maestri R,Sisti M,Cobelli F,Tavazzi L

    更新日期：1997-12-01 00:00:00

  • The incidence of cardiac events in Japanese men with atypical or nonanginal chest pain: a prospective study on the significance of exercise testing.

    abstract：:The incidence of cardiac events in Japanese men (mean age 54 +/- 10 years) with atypical or nonanginal chest pain was assessed prospectively. Three groups of patients, those with typical angina (TA; n = 134), those with atypical angina (AA; n = 192), and those with nonanginal chest pain (NA; n = 311) were studied with...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(92)90802-3

    authors： Sato I,Nishijima H,Matsumura N,Nishida M,Okita K,Yasuda H

    更新日期：1992-06-01 00:00:00

  • Sudden death and silent myocardial ischemia.

    abstract：:Recent research indicates that silent myocardial ischemia may play a role in sudden cardiac death. To what extent treatment can reduce occurrence of silent ischemia remains to be assessed. Three classes of silent ischemia patients are identified: type 1--totally asymptomatic; type 2--post myocardial infarction; and ty...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(89)90673-x

    authors： Sheps DS,Heiss G

    更新日期：1989-01-01 00:00:00

  • Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: data from

    abstract：BACKGROUND:Although inflammation is a core element of atherogenesis and plasma levels of fibrinogen (FGB), homocysteine, and intercellular adhesion molecule-1 (ICAM-1) differ by race/ethnicity, little is known about the role of genetic polymorphisms in the FGB, methylenetetrahydrofolate reductase (MTHFR), and ICAM-1 ge...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.12.012

    authors： Albert MA,Pare G,Morris A,Rose L,Buring J,Ridker PM,Zee RY

    更新日期：2009-04-01 00:00:00

  • Atrial fibrillation: A major risk factor for cognitive decline.

    abstract：:Atrial fibrillation is a common disease of the elderly, conferring considerable morbidity and mortality related to cardiovascular effects and thromboembolic risks. Anticoagulation, antiarrhythmic medications, and rate control are the cornerstone of contemporary management, whereas ablation and evolving surgical techni...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2014.12.015

    authors： Hui DS,Morley JE,Mikolajczak PC,Lee R

    更新日期：2015-04-01 00:00:00

  • Reduction of hospital mortality rate of acute myocardial infarction with glucose-insulin-potassium infusion.

    abstract：:Free fatty acids (FFA), the predominant myocardial energy substrate, are present in increased quantities immediately following acute myocardial infarction (AMI) and may cause deleterious alterations in cardiac rhythm, oxygen consumption, and mechanical performance. In an attempt to suppress FFA and simultaneously incr...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0002-8703(76)80043-9

    authors： Rogers WJ,Stanley AW Jr,Breinig JB,Prather JW,McDaniel HG,Moraski RE,Mantle JA,Russell RO Jr,Rackley CE

    更新日期：1976-10-01 00:00:00

  • What have we learned from in vitro intravascular ultrasound?

    abstract：:In vitro studies have established that intravascular ultrasound is a reliable technique for accurate assessment of vascular anatomic structure and disease conditions before and after intervention. In addition, quantitative data from intravascular ultrasound studies correspond well with histologic findings, which serve...

    journal_title：American heart journal

    pub_type： 社论,评审

    doi：10.1016/s0002-8703(96)90263-x

    authors： Gussenhoven EJ,van der Lugt A,van der Steen AF,Ligtvoet KM

    更新日期：1996-09-01 00:00:00

  • Systolic excursion of the mitral annulus to assess septal function in paradoxic septal motion.

    abstract：:To determine whether mitral valve annulus displacement (MVAD) can be used to assess septal contractility in patients with paradoxical septal motion, we assessed four atrioventricular regions (septum, lateral wall, anterior wall, and inferior wall) by MVAD in 80 consecutive patients. The patients were divided into five...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(96)90062-9

    authors： Silva JA,Khuri B,Barbee W,Fontenot D,Cheirif J

    更新日期：1996-01-01 00:00:00

  • Screening of MYH7, MYBPC3, and TNNT2 genes in Brazilian patients with hypertrophic cardiomyopathy.

    abstract：BACKGROUND:Hypertrophic cardiomyopathy (HC) is the most prevalent genetic cardiac disease caused by a mutation in sarcomeres, Z-disks, or calcium-handling genes and is characterized by unexplained left ventricular hypertrophy. The aim of this study was to determine the genetic profile of Brazilian patients with HC and ...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2013.07.029

    authors： Marsiglia JD,Credidio FL,de Oliveira TG,Reis RF,Antunes Mde O,de Araujo AQ,Pedrosa RP,Barbosa-Ferreira JM,Mady C,Krieger JE,Arteaga-Fernandez E,Pereira Ada C

    更新日期：2013-10-01 00:00:00

  • Lipid management in contemporary community practice: Results from the Provider Assessment of Lipid Management (PALM) Registry.

    abstract：BACKGROUND:The latest cholesterol guidelines have shifted focus from achieving low-density lipoprotein cholesterol (LDL-C) targets toward statin use and intensity guided by atherosclerotic cardiovascular disease (ASCVD) risk. METHODS:Statin use and intensity were evaluated in 5,905 statin-eligible primary or secondary...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2017.08.005

    authors： Navar AM,Wang TY,Li S,Robinson JG,Goldberg AC,Virani S,Roger VL,Wilson PWF,Elassal J,Lee LV,Peterson ED

    更新日期：2017-11-01 00:00:00

  • Effect of exercise training on heart rate variability in healthy older adults.

    abstract：OBJECTIVE:To determine the effect of exercise training on cardiac autonomic modulation in normal older adults by using analysis of heart rate variability. SUBJECTS:The exercise group consisted of 7 men and 9 women aged 66 +/- 4 years. The comparison group consisted of 7 men and 9 women also aged 66 +/- 4 years. METHO...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(99)70162-6

    authors： Stein PK,Ehsani AA,Domitrovich PP,Kleiger RE,Rottman JN

    更新日期：1999-09-01 00:00:00

  • Implications of the links between hypertension and myocardial infarction for choice of drug therapy in patients with hypertension.

    abstract：:Meta-analyses of major outcome trials have demonstrated that the benefits of antihypertensive treatment for reduction of the incidence of stroke are entirely consistent with the benefits predicted from epidemiologic data; however, there remains a shortfall in the expected reduction of the incidence of coronary heart d...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：

    authors： Meredith PA

    更新日期：1996-07-01 00:00:00

  • Long-term outcome of unsuccessful percutaneous transluminal coronary angioplasty.

    abstract：:We analyzed the long-term outcome of 198 patients after unsuccessful percutaneous transluminal coronary angioplasty. Forty-nine percent underwent emergency coronary artery bypass grafting surgery, 17% had elective bypass surgery, and 34% were treated medically. The in-hospital mortality rate was 4%, and myocardial inf...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(05)80313-8

    authors： Tuzcu M,Simpfendorfer C,Dorosti K,Franco I,Golding L,Hollman J,Whitlow P

    更新日期：1990-04-01 00:00:00

  • Coronary artery bypass surgery in patients with acute coronary syndromes is difficult to predict.

    abstract：BACKGROUND:Although the use of clopidogrel in patients "unlikely" to require coronary artery bypass grafting (CABG) is recommended in current guidelines of acute coronary syndrome (ACS) management, an important minority of patients require CABG. We assessed the ability to predict need for CABG from demographics known a...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2007.12.002

    authors： Chew DP,Mahaffey KW,White HD,Huang Z,Hoekstra JW,Ferguson JJ,Califf RM,Aylward PE

    更新日期：2008-05-01 00:00:00

  • Oxygen uptake efficiency slope, a new submaximal parameter in evaluating exercise capacity in chronic heart failure patients.

    abstract：BACKGROUND:The oxygen uptake efficiency slope (OUES) is a new submaximal parameter which objectively predicts the maximal exercise capacity in children and healthy subjects. However, the usefulness of OUES in adult patients with and without advanced heart failure remains undetermined. The present study investigates the...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.07.004

    authors： Van Laethem C,Bartunek J,Goethals M,Nellens P,Andries E,Vanderheyden M

    更新日期：2005-01-01 00:00:00

  • Hemodynamic effects of molsidomine in patients with heart failure following acute myocardial infarction.

    abstract：:The short-term hemodynamic effects of molsidomine (4 mg sublingually) were evaluated in 13 patients with congestive heart failure following acute myocardial infarction. Right heart catheterization was performed by means of a Swan-Ganz thermodilution catheter. Hemodynamic measurements were made 30, 60, 120, and 180 min...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：

    authors： Cantelli I,Lolli C,Brunelli A,Bracchetti D

    更新日期：1985-03-01 00:00:00

  • Does current treatment of cardiogenic shock complicating the acute coronary syndromes comply with guidelines?

    abstract：BACKGROUND:The purpose of our study was to evaluate the implementation of guidelines for the treatment of cardiogenic shock (CS) complicating the acute coronary syndromes (ACS). METHODS AND RESULTS:Of the 10 136 patients in the Euro-Heart-Survey-ACS with complete data, CS occurred in 549 (5.4%), of whom 28.6% had CS u...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.06.004

    authors： Iakobishvili Z,Behar S,Boyko V,Battler A,Hasdai D

    更新日期：2005-01-01 00:00:00

  • Electrophysiologic and antiarrhythmic actions of nadolol: acute ischemia in the presence of previous myocardial infarction.

    abstract：:The actions of the beta-adrenergic receptor antagonist, d,l-nadolol, were examined in anesthetized dogs subjected to circumflex coronary artery ligation in the presence of previous anterior myocardial infarction. With circumflex ligation, control dogs (N = 18) developed premature ventricular beats and ventricular tach...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90444-9

    authors： Patterson E,Lucchesi BR

    更新日期：1988-11-01 00:00:00

  • Effects of indomethacin on systemic and coronary hemodynamics in patients with coronary artery disease.

    abstract：:The effects and possible mechanisms of actions of indomethacin on systemic and coronary hemodynamics were studied in 17 patients with coronary artery disease. Group I patients (12) were given either indomethacin or placebo in the absence of prior cyclooxygenase inhibition and group II (five) were given indomethacin af...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(85)90149-8

    authors： Forman MB,Uderman H,Jackson EK,Roy L,Bostick D,Robertson D,Robertson RM

    更新日期：1985-08-01 00:00:00

  • Cardiovascular malformations in the fetal alcohol syndrome.

    abstract：:Cardiovascular anomalies are a frequently reported feature of the fetal alcohol syndrome, but only rarely have such children been catheterized. This article fully described the cardiac anomaly in two infants with this syndrome. The malformations found in both cases include a ventricular septal defect, and the rather u...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(79)90290-4

    authors： Steeg CN,Woolf P

    更新日期：1979-11-01 00:00:00

  • Comparison of clinical features of non-Q wave and Q wave myocardial infarction.

    abstract：:The clinical spectrum and outcome of 119 patients with acute non-Q wave myocardial infarction (NQMI) were studied, in comparison with those of 354 patients with acute Q wave myocardial infarction (QMI). The patients with NQMI had a significantly higher incidence of preinfarction angina (73% vs 63%), previous myocardia...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(86)90056-6

    authors： Ogawa H,Hiramori K,Haze K,Saito M,Sumiyoshi T,Fukami K,Goto Y,Ikeda M

    更新日期：1986-03-01 00:00:00

  • Characteristics and outcomes of cardiomyopathy in children with Duchenne or Becker muscular dystrophy: a comparative study from the Pediatric Cardiomyopathy Registry.

    abstract：OBJECTIVE:The aim of this study was to determine in pediatric Duchenne (DMD) and Becker muscular dystrophy (BMD) or other dilated cardiomyopathies (ODCM) whether outcomes differ by diagnosis. BACKGROUND:Children with dilated cardiomyopathy are treated as a single undifferentiated group. METHODS:This cohort study of 1...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.01.018

    authors： Connuck DM,Sleeper LA,Colan SD,Cox GF,Towbin JA,Lowe AM,Wilkinson JD,Orav EJ,Cuniberti L,Salbert BA,Lipshultz SE,Pediatric Cardiomyopathy Registry Study Group.

    更新日期：2008-06-01 00:00:00

  • Significance of magnesium in congestive heart failure.

    abstract：:Electrolyte balance has been regarded as a factor important to cardiovascular stability, particularly in congestive heart failure. Among the common electrolytes, the significance of magnesium has been debated because of difficulty in accurate measurement and other associated factors, including other electrolyte abnorm...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/s0002-8703(96)90253-7

    authors： Douban S,Brodsky MA,Whang DD,Whang R

    更新日期：1996-09-01 00:00:00

  • Implantable cardioverter defibrillator: use in patients with no symptoms and at high risk.

    abstract：:Twenty-seven patients with asymptomatic, nonsustained ventricular tachycardia whose evaluation suggested they were at high risk for sustained ventricular arrhythmias were treated with implantable cardioverter defibrillators. The option of conventional therapy (including the option of no therapy) was presented to each ...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0002-8703(96)90051-4

    authors： Levine JH,Waller T,Hoch D,Greenberg S,Goldberger J,Kadish A

    更新日期：1996-01-01 00:00:00

  • Gender differences among patients with acute coronary syndromes undergoing percutaneous coronary intervention in the American College of Cardiology-National Cardiovascular Data Registry (ACC-NCDR).

    abstract：BACKGROUND:Although prior studies have demonstrated disparities in the management and outcomes of women with acute coronary syndrome (ACS), there are limited large-scale contemporary data on gender differences in post-intervention outcomes in this population. METHODS:We analyzed patients according to 2 ACS categories,...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.08.012

    authors： Akhter N,Milford-Beland S,Roe MT,Piana RN,Kao J,Shroff A

    更新日期：2009-01-01 00:00:00

  • Novel predictor of prognosis from exercise stress testing: heart rate variability response to the exercise treadmill test.

    abstract：BACKGROUND:Although the prognostic power of heart rate variability (HRV) at rest has been demonstrated, the prognostic potential of exercise-induced HRV has not been investigated. We aimed to evaluate the prognostic power of exercise-induced HRV during and after standard exercise testing. METHODS:Time- and frequency-d...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2006.11.001

    authors： Dewey FE,Freeman JV,Engel G,Oviedo R,Abrol N,Ahmed N,Myers J,Froelicher VF

    更新日期：2007-02-01 00:00:00

  • The Coronary Artery Revascularisation in Diabetes (CARDia) trial: background, aims, and design.

    abstract：BACKGROUND:Patients with diabetes have an increased incidence and severity of ischemic heart disease, which leads to an increased requirement for coronary revascularization. Comparative information regarding mode of revascularization--coronary artery bypass graft surgery surgery (CABG) or percutaneous coronary interven...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.07.001

    authors： Kapur A,Malik IS,Bagger JP,Anderson JR,Kooner JS,Thomas M,Punjabi P,Mayet J,Millane T,Goedicke J,Jamrozik K,de Belder MA,Hall RJ,Beatt KJ

    更新日期：2005-01-01 00:00:00