当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Scintigraphic detection of early cardiac rejection by iodine 123-labeled monoclonal antibody directed against monomorphic determinant of major histocompatibility complex class II antigens.

Scintigraphic detection of early cardiac rejection by iodine 123-labeled monoclonal antibody directed against monomorphic determinant of major histocompatibility complex class II antigens.

Abstract：

:Although it has been shown that early cardiac rejection can be visualized by radioimmunoscintigraphy targeting major histocompatibility complex class II antigen, the use of antibodies that bind to a polymorphic determinant of class II antigen has certain disadvantages for clinical application. This investigation was designed to examine the feasibility of scintigraphic detection of cardiac allograft rejection by using a monoclonal antibody that reacts with a monomorphic determinant of rat IA antigens. Twenty PVG rats (RT1c) and five DA rats (RT1a) underwent heterotopic transplantation with DA hearts. Two of the 20 allografted rats were treated with FK506 (2 mg/kg/day). Seventeen rats were injected intravenously with 80 microCi of iodine 123-labeled monoclonal antibody reactive with a monomorphic determinant of rat major histocompatibility complex class II antigens (Ox6) 16 hours before scintigraphy, and images were compared with those obtained by injection of 123I-labeled monoclonal antibody against a polymorphic determinant of class II antigens (F17-23-6, anti-RT1a) (n = 8). Background activity was higher in rats injected with Ox6 than in rats injected with F17-23-6. Uptake of labeled Ox6 in the grafts reflected the severity of rejection as determined by histopathologic criteria. Rejecting allografts with lymphocyte infiltration but without myocyte necrosis could be identified by the scintigraphy with use of labeled Ox6.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Am Heart J

journal_title

American heart journal

authors

Isobe M,Southern JF,Yazaki Y

doi

10.1016/0002-8703(94)90050-7

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

1309-17

issue

5

eissn

0002-8703

issn

1097-6744

pii

0002-8703(94)90050-7

journal_volume

127

pub_type

杂志文章

相关文献

AMERICAN HEART JOURNAL文献大全
  • The incidence of cardiac events in Japanese men with atypical or nonanginal chest pain: a prospective study on the significance of exercise testing.

    abstract：:The incidence of cardiac events in Japanese men (mean age 54 +/- 10 years) with atypical or nonanginal chest pain was assessed prospectively. Three groups of patients, those with typical angina (TA; n = 134), those with atypical angina (AA; n = 192), and those with nonanginal chest pain (NA; n = 311) were studied with...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(92)90802-3

    authors： Sato I,Nishijima H,Matsumura N,Nishida M,Okita K,Yasuda H

    更新日期：1992-06-01 00:00:00

  • Clinical implications of exercise-induced chest pain: comparison of patients with and without pathologic Q waves in coronary artery disease.

    abstract：:We attempted to determine whether exercise-induced silent myocardial ischemia has different clinical implications in patients with and without pathologic Q waves. We studied 152 patients (121 men and 31 women) who had ischemic ST depression (greater than or equal to 0.05 mV) during exercise tests and greater than or e...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(90)90009-m

    authors： Ozawa T,Ikeda K,Yamaki M,Kubota I,Tsuiki K,Yasui S

    更新日期：1990-09-01 00:00:00

  • Validation of the accuracy of pretest and exercise test scores in women with a low prevalence of coronary disease: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) study.

    abstract：BACKGROUND:Recently revised American College of Cardiology/American Heart Association guidelines have suggested that exercise test scores be used in decisions concerning patients with suspected coronary artery disease (CAD). Pretest and exercise test scores derived for use in women without known CAD have not been teste...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ahj.2003.12.034

    authors： Morise AP,Olson MB,Merz CN,Mankad S,Rogers WJ,Pepine CJ,Reis SE,Sharaf BL,Sopko G,Smith K,Pohost GM,Shaw L

    更新日期：2004-06-01 00:00:00

  • Effect of lesion length on fractional flow reserve in intermediate coronary lesions.

    abstract：BACKGROUND:Fractional flow reserve (FFR) has become a gold standard in physiological assessment of coronary artery stenosis. An FFR < 0.75 is considered as a reliable physiological parameter indicating functionally significant lesion. Lesion length (LL) may affect the translesional hemodynamics. However, the effect of ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.09.007

    authors： Brosh D,Higano ST,Lennon RJ,Holmes DR Jr,Lerman A

    更新日期：2005-08-01 00:00:00

  • Flosequinan: a vasodilator with positive inotropic activity.

    abstract：:Flosequinan is an oral arterial and venous vasodilator that is currently under investigation for the treatment of congestive heart failure. The effects of flosequinan on ventricular performance and myocardial contractility were studied in 10 patients with severe congestive heart failure during right and left cardiac c...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(91)90723-u

    authors： Corin WJ,Monrad ES,Strom JA,Giustino S,Sonnenblick ES,LeJemtel T

    更新日期：1991-02-01 00:00:00

  • Sex differences in health behavior change after premature acute coronary syndrome.

    abstract：BACKGROUND:Limited information is available on the health behavior profile of patients with premature acute coronary syndrome (ACS). The purpose of this study is to desribe the health bahvior of young patients with ACS at the baseline and 1 year post-ACS and examine sex differences. METHODS:GENESIS-PRAXY is a prospect...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2015.04.016

    authors： Leung Yinko SS,Maheswaran J,Pelletier R,Bacon SL,Daskalopoulou SS,Khan NA,Eisenberg MJ,Karp I,Lavoie KL,Behlouli H,Pilote L,GENESIS-PRAXY investigators.

    更新日期：2015-08-01 00:00:00

  • The role of niacin in raising high-density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol Rationale and study design. The Atherothro

    abstract：BACKGROUND:The aim of this study was to test the hypothesis that patients with atherosclerotic cardiovascular (CV) disease optimally treated on a statin but with residual atherogenic dyslipidemia (low high-density lipoprotein cholesterol [HDL-C] and high triglycerides) will benefit from addition of niacin with fewer CV...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2010.11.017

    authors： AIM-HIGH Investigators.

    更新日期：2011-03-01 00:00:00

  • How does warfarin affect the activated coagulation time?

    abstract：BACKGROUND:The activated coagulation time (ACT) is a rapid measurement of a patient's level of heparin anticoagulation during cardiac catheterization. Patients receiving warfarin therapy occasionally are seen at the catheterization laboratory for emergent procedures. The effects of warfarin on ACT activity have not bee...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(98)70223-6

    authors： Chang RJ,Doherty TM,Goldberg SL

    更新日期：1998-09-01 00:00:00

  • Gender differences among patients with acute coronary syndromes undergoing percutaneous coronary intervention in the American College of Cardiology-National Cardiovascular Data Registry (ACC-NCDR).

    abstract：BACKGROUND:Although prior studies have demonstrated disparities in the management and outcomes of women with acute coronary syndrome (ACS), there are limited large-scale contemporary data on gender differences in post-intervention outcomes in this population. METHODS:We analyzed patients according to 2 ACS categories,...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.08.012

    authors： Akhter N,Milford-Beland S,Roe MT,Piana RN,Kao J,Shroff A

    更新日期：2009-01-01 00:00:00

  • Epidemiology of angina pectoris: role of natural language processing of the medical record.

    abstract：BACKGROUND:The diagnosis of angina is challenging because it relies on symptom descriptions. Natural language processing (NLP) of the electronic medical record (EMR) can provide access to such information contained in free text that may not be fully captured by conventional diagnostic coding. OBJECTIVE:To test the hyp...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2006.12.022

    authors： Pakhomov SS,Hemingway H,Weston SA,Jacobsen SJ,Rodeheffer R,Roger VL

    更新日期：2007-04-01 00:00:00

  • Comparison of the right and left ventricle as a systemic ventricle during exercise in patients with congenital heart disease.

    abstract：BACKGROUND:Few studies have investigated the clinical advantages of surgical correction with the morphologic left ventricle (MLV) instead of the morphologic right ventricle as a systemic ventricle (SV) in patients with congenital heart disease. METHODS:Twenty-four healthy control subjects (group A1), 6 patients with i...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(99)70381-9

    authors： Ohuchi H,Hiraumi Y,Tasato H,Kuwahara A,Chado H,Toyohara K,Arakaki Y,Yagihara T,Kamiya T

    更新日期：1999-06-01 00:00:00

  • Beneficial effects of the alpha-adrenergic antagonist nicergoline during acute myocardial ischemia and reperfusion in the dog.

    abstract：:Recent experimental and clinical data have stimulated interest in the use of alpha-adrenergic antagonists in acute myocardial infarction. We evaluated nicergoline, a new relatively selective alpha 1-antagonist which uniquely lowers heart rate. Open-chest dogs, randomized to control (n = 25) or intravenously treated gr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(83)90646-4

    authors： Bolli R,Brandon TA,Fisher DJ,Fernandez GC,Miller RR

    更新日期：1983-11-01 00:00:00

  • High-dose, brief intravenous streptokinase early in acute myocardial infarction.

    abstract：:An acute thrombus at the proximal border of a high-grade atherosclerotic obstruction is the usual cause of myocardial infarction. Although intracoronary thrombolysis is potentially an exciting new therapy for reducing the extent of myocardial infarction by lysing coronary clot, a number of major difficulties limit its...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(82)90267-8

    authors： Spann JF,Sherry S,Carabello BA,Mann RH,McCann WD,Gault JH,Gentzler RD,Rosenberg KM,Maurer AH,Denenberg BS,Warner HF,Rubin RN,Malmud LS,Comerota A

    更新日期：1982-10-01 00:00:00

  • Immediate blood pressure effects of the renin inhibitor enalkiren and the angiotensin-converting enzyme inhibitor enalaprilat.

    abstract：:The antihypertensive effects of the renin inhibitor enalkiren were compared with those of the angiotensin-converting enzyme inhibitor enalaprilat in 17 hypertensive patients (14 white, 3 black; mean age 57 years), whose renin systems had been stimulated by diuretic pretreatment. Patients were studied on 3 separate in-...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(91)90477-y

    authors： Neutel JM,Luther RR,Boger RS,Weber MA

    更新日期：1991-10-01 00:00:00

  • Response of the left ventricle in idiopathic dilated cardiomyopathy to postextrasystolic potentiation.

    abstract：:The effectiveness of postextrasystolic potentiation (PESP) was assessed to detect residual function of the left ventricle in seven patients with idiopathic dilated cardiomyopathy (IDC). The postextrasystolic changes in the aortic pressure pulse, global left ventricular function, and quantitative regional left ventricu...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90661-2

    authors： Yamazoe M

    更新日期：1987-06-01 00:00:00

  • Simultaneous invasive and noninvasive evaluations of baroreflex sensitivity with bolus phenylephrine technique.

    abstract：:Estimation of baroreflex sensitivity (BRS) is receiving increasing attention in clinical and experimental cardiology. Until recently, in most studies BRS has been assessed on the basis of invasive blood pressure measurement, which limits its use in large-scale studies and in clinical practice. The development of conti...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(95)90443-3

    authors： Hartikainen JE,Tahvanainen KU,Mäntysaari MJ,Tikkanen PE,Länsimies EA,Airaksinen KE

    更新日期：1995-08-01 00:00:00

  • Fondaparinux versus Enoxaparin in non-ST-elevation acute coronary syndromes: short-term cost and long-term cost-effectiveness using data from the Fifth Organization to Assess Strategies in Acute Ischemic Syndromes Investigators (OASIS-5) trial.

    abstract：BACKGROUND:The study aimed to compare the short-term costs and long-term cost-effectiveness of 2 antithrombotics, fondaparinux and enoxaparin, for non-ST-elevation acute coronary syndrome in the United States. METHODS:It was based on a large randomized trial of 20,078 patients Fifth Organization to Assess Strategies i...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2009.02.017

    authors： Sculpher MJ,Lozano-Ortega G,Sambrook J,Palmer S,Ormanidhi O,Bakhai A,Flather M,Steg PG,Mehta SR,Weintraub W

    更新日期：2009-05-01 00:00:00

  • Range gated echo-Doppler velocity and turbulence mapping in patients with valvular aortic stenosis.

    abstract：:Flow beyond a stenotic aortic valve (AS) is dynamically complex. Numerous hydraulic studies have demonstrated that at least four well-known major flow areas occur distal to a stenotic valve. These include a jet, an area alongside the jet (the parajet), an area of flow disturbance, and an area in which disturbed flow a...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(82)90400-8

    authors： Goldberg SJ,Kececioglu-Draelos Z,Sahn DJ,Valdes-Cruz LM,Allen HD

    更新日期：1982-05-01 00:00:00

  • Noninvasive quantification of mitral regurgitation in dilated cardiomyopathy: correlation of two Doppler echocardiographic methods.

    abstract：:The presence and severity of functional mitral regurgitation were quantified by Doppler echocardiography in 17 patients with dilated cardiomyopathy and no evidence of primary valvular disease. Mitral regurgitant fraction was greater than 20% in 11 of the 17 patients, and exceeded 40% in four patients. Total stroke vol...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90334-1

    authors： Keren G,Katz S,Strom J,Sonnenblick EH,LeJemtel TH

    更新日期：1988-09-01 00:00:00

  • Atrial fibrillation: A major risk factor for cognitive decline.

    abstract：:Atrial fibrillation is a common disease of the elderly, conferring considerable morbidity and mortality related to cardiovascular effects and thromboembolic risks. Anticoagulation, antiarrhythmic medications, and rate control are the cornerstone of contemporary management, whereas ablation and evolving surgical techni...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2014.12.015

    authors： Hui DS,Morley JE,Mikolajczak PC,Lee R

    更新日期：2015-04-01 00:00:00

  • Glomerular filtration rate and association to stroke, major bleeding, and death in patients with mechanical heart valve prosthesis.

    abstract：AIMS:The impact of estimated glomerular filtration rate (eGFR) on adverse events in patients with mechanical heart valves (MHVs) is unknown. We analyzed the independent association of eGFR and thromboembolism (TE), major bleeding, and mortality in patients with MHV in an observational cohort study. METHODS AND RESULTS...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2015.06.016

    authors： Labaf A,Grzymala-Lubanski B,Själander A,Svensson PJ,Stagmo M

    更新日期：2015-09-01 00:00:00

  • Excess weight and life expectancy after acute myocardial infarction: The obesity paradox reexamined.

    abstract：BACKGROUND:An "obesity paradox" has been described in patients with acute myocardial infarction (AMI), whereby obese and overweight patients have a lower risk of short-term mortality after AMI than normal-weight patients. However, the long-term association of obesity with mortality after AMI remains unknown. METHODS:W...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2015.10.024

    authors： Bucholz EM,Beckman AL,Krumholz HA,Krumholz HM,Dr. Bucholz was affiliated with the Yale School of Medicine and Yale School of Public Health during the time that the work was conducted.

    更新日期：2016-02-01 00:00:00

  • Kinetics of LDL subfractions.

    abstract：:After injecting 125I- or 131I-labeled lipoproteins, plasma was subjected to discontinuous density gradient centrifugation, which separates low-density lipoproteins (LDL) into three subfractions. Analysis of changes in apolipoprotein B-specific activity with time showed that light LDL is normally the product of interme...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90623-5

    authors： Thompson GR,Teng B,Sniderman AD

    更新日期：1987-02-01 00:00:00

  • Decreased peripheral blood flow in the pathogenesis of the metabolic syndrome comprising hypertension, hyperlipidemia, and hyperinsulinemia.

    abstract：:Major cardiovascular risk factors, such as hypertension, hyperlipidemia, and diabetes, often cluster in the same individuals. It has been claimed that obesity, hyperinsulinemia, insulin resistance, and a deranged intracellular handling of ions have pathogenetic importance in the development of this metabolic syndrome....

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(93)90446-g

    authors： Lind L,Lithell H

    更新日期：1993-05-01 00:00:00

  • The effects of periodontal therapy on vascular endothelial function: a pilot trial.

    abstract：BACKGROUND:Chronic periodontal infection is associated with an increased risk of coronary heart disease. Although the mechanism responsible for the relationship between periodontal disease and cardiovascular events is not fully understood, it is hypothesized that the chronic inflammatory burden of periodontal disease m...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.10.002

    authors： Elter JR,Hinderliter AL,Offenbacher S,Beck JD,Caughey M,Brodala N,Madianos PN

    更新日期：2006-01-01 00:00:00

  • Arterial compliance adds to conventional risk factors for prediction of angiographic coronary artery disease.

    abstract：BACKGROUND:Arterial compliance is related to left ventricular hypertrophy and risk for cardiovascular disease events; however, its association with coronary artery stenosis remains uncertain. We sought to assess the relation between lower extremity arterial compliance and presence of angiographically defined coronary a...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/S0002-8703(03)00254-0

    authors： Herrington DM,Kesler K,Reiber Jh,Davis W,Brown WV,Helms R,Mallon SM,Raines J

    更新日期：2003-10-01 00:00:00

  • Apixaban compared with parenteral heparin and/or vitamin K antagonist in patients with nonvalvular atrial fibrillation undergoing cardioversion: Rationale and design of the EMANATE trial.

    abstract：BACKGROUND:Stroke prevention in anticoagulation-naïve patients with atrial fibrillation undergoing cardioversion has not been systematically studied. OBJECTIVE:To determine outcomes in anticoagulation-naïve patients (defined as those receiving an anticoagulant for <48 hours during the index episode of atrial fibrillat...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2016.06.008

    authors： Ezekowitz MD,Pollack CV,Sanders P,Halperin JL,Spahr J,Cater N,Petkun W,Breazna A,Kirchhof P,Oldgren J

    更新日期：2016-09-01 00:00:00

  • Thirty-year trends (1975-2005) in the magnitude and hospital death rates associated with complete heart block in patients with acute myocardial infarction: a population-based perspective.

    abstract：BACKGROUND:The contemporary magnitude and prognostic implications of complete heart block (CHB) in patients with acute myocardial infarction (AMI) are unknown. As part of a community-based study of patients hospitalized with AMI in the Worcester, MA, metropolitan area, changes over time in the incidence rates of CHB co...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.03.011

    authors： Nguyen HL,Lessard D,Spencer FA,Yarzebski J,Zevallos JC,Gore JM,Goldberg RJ

    更新日期：2008-08-01 00:00:00

  • Temporal trends in percutaneous coronary intervention outcomes among older patients in the United States.

    abstract：BACKGROUND:New percutaneous coronary intervention (PCI) device technologies are often rapidly adopted into clinical practice, yet few studies have examined the overall impact of these new technologies on patient outcomes in community practice. METHODS:In hopes of determining temporal trends in PCI outcomes, we used da...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2013.05.006

    authors： Rao SV,Hess CN,Dai D,Green CL,Peterson ED,Douglas PS

    更新日期：2013-08-01 00:00:00

  • Effects of chronic congestive heart failure on 24-hour blood pressure and heart rate patterns: a hemodynamic approach.

    abstract：:For 29 patients with congestive heart failure (CHF), 24-hour noninvasive ambulatory blood pressure (ABP) and heart rate (HR) measurement profiles were described, using the periodogram method, and were compared with the same findings in 22 matched controls. Right-sided heart catheterization was performed in all patient...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(92)90710-d

    authors： van de Borne P,Abramowicz M,Degre S,Degaute JP

    更新日期：1992-04-01 00:00:00