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Arterial compliance adds to conventional risk factors for prediction of angiographic coronary artery disease.

Abstract：

BACKGROUND:Arterial compliance is related to left ventricular hypertrophy and risk for cardiovascular disease events; however, its association with coronary artery stenosis remains uncertain. We sought to assess the relation between lower extremity arterial compliance and presence of angiographically defined coronary artery disease. METHODS:Lower extremity arterial compliance was measured with the use of a noninvasive air plethysmography technique in 376 subjects undergoing routine diagnostic coronary angiography. RESULTS:Measures of calf arterial compliance were significantly associated with the presence of one or more stenoses > or =50% compared with no stenoses, even after adjustment for age, sex, smoking, diabetes, hypertension, hypercholesterolemia, and obesity (P =.03). Measures of thigh arterial compliance were also lower in subjects with disease, although this association did not reach statistical significance (P =.07). Receiver operator curves illustrate the incremental predictive ability of calf arterial compliance over and above age, sex, and conventional risk factors. CONCLUSIONS:Lower extremity arterial compliance is associated with presence of significant coronary stenoses in a cardiac catheterization laboratory referral population. This observation lends support for additional efforts to determine the utility of vascular stiffness measures in both clinical and pre-clinical populations to guide treatment and prevention efforts.

journal_name

Am Heart J

journal_title

American heart journal

authors

Herrington DM,Kesler K,Reiber Jh,Davis W,Brown WV,Helms R,Mallon SM,Raines J

doi

10.1016/S0002-8703(03)00254-0

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

662-7

issue

4

eissn

0002-8703

issn

1097-6744

pii

S0002870303002540

journal_volume

146

pub_type

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