当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Rational and design of the INtentional COronary revascularization versus conservative therapy in patients undergOing successful peripheRAl arTEry revascularization due to critical limb ischemia trial (INCORPORATE trial).

Rational and design of the INtentional COronary revascularization versus conservative therapy in patients undergOing successful peripheRAl arTEry revascularization due to critical limb ischemia trial (INCORPORATE trial).

Abstract：

:Critical limb ischemia is associated with excessively high risk for cardiovascular events, including myocardial infarction and death. Additionally, in this patient population non-invasive evaluation of coronary artery disease is limited due to (1) inability of exercise testing, (2) frequent occurrence of balanced ischemia and (3) frequent occurrence of diffuse coronary calcification. Intentional Coronary Revascularization Versus Conservative Therapy in Patients Undergoing Peripheral Artery Revascularization Due to Critical Limb Ischemia trial (INCORPORATE trial) is a multicentric international randomized open label clinical trial. Trial will recruit patients, who underwent successful peripheral artery revascularization due to critical limb ischemia and randomize 1:1 to conservative medical therapy versus an immediate invasive strategy to investigate and treat coronary artery disease. The objective is to evaluate whether intentional invasive strategy with ischemia targeted reasonably complete coronary revascularization is superior as compared to conventional primarily conservative approach in terms of spontaneous myocardial infarction and overall survival at 12 months follow-up. The trial is registered at clinicaltrials.gov (NCT03712644).

journal_name

Am Heart J

journal_title

American heart journal

authors

Toth G,Brodmann M,Barbato E,Mangiacapra F,Schneller L,Orias V,Gil R,Bil J,Bartus S,Ruzsa Z

doi

10.1016/j.ahj.2019.05.005

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

107-112

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(19)30124-3

journal_volume

214

pub_type

杂志文章

相关文献

AMERICAN HEART JOURNAL文献大全
  • Effectiveness of a thermal shape-memory patent ductus arteriosus occlusion coil.

    abstract：:A new shape-memory coil for transcatheter closure of the PDA was developed and evaluated in a dog PDA model. The coil is sensitive to temperature (composed of thermal shape-memory nickel-titanium). The coil was delivered to and implanted in the PDA model with a 5F catheter through the femoral artery. The PDA model was...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(96)90189-1

    authors： Liu C,Shiraishi H,Kikuchi Y,Yanagisawa M

    更新日期：1996-05-01 00:00:00

  • Incidence and predictors of late recurrence after beta-radiation therapy with a 188Re-MAG3-filled balloon for diffuse in-stent restenosis.

    abstract：BACKGROUND:The long-term fate of patent irradiated segments at 6 months after beta-radiation therapy has not been sufficiently evaluated. METHODS:Two-year follow-up angiography was performed in 52 patients with patent irradiated segments at 6 months after beta-radiation with a rhenium 188-mercaptoacetyltriglycine-fill...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.02.011

    authors： Lee SW,Park SW,Hong MK,Kim YH,Han KH,Kim J,Park JH,Oh SJ,Moon DH,Oh SJ,Lee CW,Kim JJ,Park SJ

    更新日期：2006-01-01 00:00:00

  • Effect of older age on diagnostic and prognostic performance of high-sensitivity troponin T in patients presenting to an emergency department.

    abstract：BACKGROUND:The effect of age on diagnostic and prognostic performance of high-sensitivity cardiac troponin T (hs-cTnT) has not been addressed adequately, so far. METHODS:High-sensitivity cardiac troponin T was measured serially in patients with acute symptoms presenting to our emergency department. We tested the diagn...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2012.08.003

    authors： Normann J,Mueller M,Biener M,Vafaie M,Katus HA,Giannitsis E

    更新日期：2012-11-01 00:00:00

  • Impact of target lesion calcification on coronary stent expansion after rotational atherectomy.

    abstract：BACKGROUND:Calcified lesions carry the risk of suboptimal stent expansion. The purpose of this study was to investigate the impact of target lesion calcification on intracoronary ultrasound (ICUS) guided stent expansion after rotational atherectomy. METHODS:Stent expansion was assessed by ICUS in 39 patients with the ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(99)70463-1

    authors： Henneke KH,Regar E,König A,Werner F,Klauss V,Metz J,Theisen K,Mudra H

    更新日期：1999-01-01 00:00:00

  • Atrial fibrillation: A major risk factor for cognitive decline.

    abstract：:Atrial fibrillation is a common disease of the elderly, conferring considerable morbidity and mortality related to cardiovascular effects and thromboembolic risks. Anticoagulation, antiarrhythmic medications, and rate control are the cornerstone of contemporary management, whereas ablation and evolving surgical techni...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2014.12.015

    authors： Hui DS,Morley JE,Mikolajczak PC,Lee R

    更新日期：2015-04-01 00:00:00

  • Insulin sensitivity in young women with vasovagal syncope.

    abstract：BACKGROUND:Insulin, in addition to its known metabolic effects, has sympatho-excitatory and vasodilatory actions on muscular blood vessels. The goal of this study was to evaluate insulin sensitivity in young women with vasovagal syncope and positive tilt test results (HUT+) and to compare it with that in patients with ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/S0002-8703(02)94707-1

    authors： Ruiz GA,Calvar C,Hermes R,Rivadeneira D,Bengolea V,Chirife R,Tentori MC,Gelpi RJ

    更新日期：2003-05-01 00:00:00

  • Ten-year experience with mitral valve replacement in the elderly.

    abstract：:Limited data are available on mitral valve replacement in the elderly patient. Therefore we report our 10-year experience including predictors of perioperative mortality and subsequent long-term cardiac mortality in elderly patients with mitral valve replacement compared to younger patients. Of the 126 consecutive pat...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(92)90934-n

    authors： Nair CK,Biddle WP,Kaneshige A,Cook C,Ryschon K,Sketch MH Sr

    更新日期：1992-07-01 00:00:00

  • Diastolic wall motion abnormality after myocardial infarction: relation to neurohormonal activation and prognostic implications.

    abstract：BACKGROUND:Systolic wall motion abnormality (WMA) after acute myocardial infarction (AMI) is a major determinant of outcome; the presence and importance of diastolic WMA after AMI are unknown. We therefore sought to detect diastolic WMA using color kinesis and to assess its relation to neurohormonal activation and its ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.11.024

    authors： Husic M,Nørager B,Egstrup K,Lang RM,Møller JE

    更新日期：2005-10-01 00:00:00

  • Ventricular arrhythmias in dilated cardiomyopathy: efficacy of amiodarone.

    abstract：:Sixty-five patients with dilated cardiomyopathy were studied by means of 24-hour ECG monitoring. Ventricular arrhythmias were present in 62 (95.4%), of whom 52 (80%) showed a complex form (multiform ventricular extrasystoles, pairs, and ventricular tachycardia). Forty-one patients, presenting with complex ventricular ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90711-3

    authors： Neri R,Mestroni L,Salvi A,Pandullo C,Camerini F

    更新日期：1987-03-01 00:00:00

  • Mode of stimulation versus response: validation of a protocol for induction of ventricular tachycardia.

    abstract：:Electrophysiologic studies were prospectively performed in 91 consecutive patients referred for evaluation of sustained ventricular tachycardia or sudden cardiac death. Fifty-two patients had a history of sustained ventricular tachycardia and 39 patients had a history of sudden cardiac death. The identical stimulation...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90088-2

    authors： Oseran DS,Gang ES,Hamer AW,Zaher CA,Rosenthal ME,Mandel WJ,Peter T

    更新日期：1985-09-01 00:00:00

  • Effects of losartan and captopril on left ventricular systolic and diastolic function after acute myocardial infarction: results of the Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan (OPTIMAAL) echocardiographic substudy.

    abstract：BACKGROUND:Angiotensin-converting enzyme inhibitors have been shown to attenuate adverse remodeling after acute myocardial infarction (AMI), and the same has been suggested for angiotensin II type 1 receptor antagonists in animal models. Therefore the aim of the study was to compare the effects of losartan and captopri...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ahj.2003.10.031

    authors： Møller JE,Dahlström U,Gøtzsche O,Lahiri A,Skagen K,Andersen GS,Egstrup K,OPTIMAAL Study Group.

    更新日期：2004-03-01 00:00:00

  • Precordial ST-segment mapping 3. Stability of maps in the early phase of acute myocardial infarction.

    abstract：:To evaluate the stability of precordial ST-segment mapping techniques in assessing ischemic myocardial injury, we studied 28 patients with acute anterior myocardial infarction using a 49-lead electrocardiographic system (1 mV. = 10 mm.). The sum of ST elevations in millimeters was taken as an index of ischemic injury,...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(77)80011-2

    authors： Madias JE,Hood WB Jr

    更新日期：1977-05-01 00:00:00

  • High-risk myocardial infarction in the young: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial.

    abstract：BACKGROUND:Advanced age is a well-established prognostic risk factor after acute myocardial infarction (AMI), yet approximately 10% of MIs occur in patients <45 years. We examined characteristics, cardiovascular outcomes, and the influence of risk factors on outcomes in young survivors of AMI. METHODS:Fourteen thousan...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2007.11.016

    authors： Anderson RE,Pfeffer MA,Thune JJ,McMurray JJ,Califf RM,Velazquez E,White HD,Rouleau JL,Skali H,Maggioni A,Solomon SD

    更新日期：2008-04-01 00:00:00

  • The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure.

    abstract：BACKGROUND:Exercise training is recommended for chronic heart failure (HF) patients to improve functional status and reduce risk of adverse outcomes. Elevated plasma levels of amino-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), and cardiac troponin T (cTnT) are associ...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2013.10.018

    authors： Ahmad T,Fiuzat M,Mark DB,Neely B,Neely M,Kraus WE,Kitzman DW,Whellan DJ,Donahue M,Zannad F,Piña IL,Adams K,O'Connor CM,Felker GM

    更新日期：2014-02-01 00:00:00

  • Vorapaxar in patients with peripheral artery disease and acute coronary syndrome: insights from Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER).

    abstract：BACKGROUND:In the TRACER trial, vorapaxar, a protease-activated receptor-1 antagonist, plus standard care in non-ST-segment elevation acute coronary syndrome (NSTE ACS) patients did not significantly reduce the primary composite end point but reduced a key secondary end point and significantly increased bleeding. Histo...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2014.06.017

    authors： Jones WS,Tricoci P,Huang Z,Moliterno DJ,Harrington RA,Sinnaeve PR,Strony J,Van de Werf F,White HD,Held C,Armstrong PW,Aylward PE,Chen E,Patel MR,Mahaffey KW

    更新日期：2014-10-01 00:00:00

  • Calcium channel blockers that prolong the QT interval.

    abstract：:The development of a group of calcium channel blockers that prolong the QT interval has raised interest in their possible proarrhythmic potential. In animal experiments lidoflazine has no observed arrhythmogenic potential and no antiarrhythmic potential in a model sensitive to the antiarrhythmic properties of both con...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90628-3

    authors： Somberg JC

    更新日期：1985-02-01 00:00:00

  • Clinical and pathologic findings of aortic dissection at autopsy: Review of 336 cases over nearly 6 decades.

    abstract：BACKGROUND:We aimed to characterize the clinical and pathologic findings of aortic dissection (AD) over a nearly 60-year period. METHODS:The Jesse E. Edwards Registry of Cardiovascular Disease database was queried for cardiac specimens from autopsies with AD as a diagnosis and compared 2 cohorts: early (1956-1992) and...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2018.11.006

    authors： Huynh N,Thordsen S,Thomas T,Mackey-Bojack SM,Duncanson ER,Nwuado D,Garberich RF,Harris KM

    更新日期：2019-03-01 00:00:00

  • Kidney function and anemia as risk factors for coronary heart disease and mortality: the Atherosclerosis Risk in Communities (ARIC) Study.

    abstract：BACKGROUND:Kidney failure causes anemia and is associated with a very high risk of coronary heart disease (CHD). Mildly to moderately decreased kidney function is far more common and also is associated with an elevated prevalence of anemia and CHD risk. Recent data suggest an even higher risk of CHD when both condition...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.03.055

    authors： Astor BC,Coresh J,Heiss G,Pettitt D,Sarnak MJ

    更新日期：2006-02-01 00:00:00

  • Stratifying the patient at risk from coronary disease: new insights from the Framingham Heart Study.

    abstract：:Although cardiovascular disease remains the leading cause of death in the United States, cardiovascular disease mortality has decreased steadily during the past 2 decades. This trend is largely attributable to improved detection and management of cardiovascular risk factors, in which the Framingham Heart Study has pla...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(05)80050-x

    authors： Levy D,Wilson PW,Anderson KM,Castelli WP

    更新日期：1990-03-01 00:00:00

  • Comparison of propafenone and disopyramide for treatment of chronic ventricular arrhythmias: placebo-controlled, double-blind, randomized crossover study.

    abstract：:In a double blind, placebo-controlled study, the efficacy of propafenone, a new antiarrhythmic drug was compared to that of disopyramide. Sixteen patients with frequent and complex premature ventricular contractions (PVCs) were studied by serial 24-hour ambulatory monitoring, while they were receiving propafenone, 300...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(85)90647-7

    authors： Naccarella F,Bracchetti D,Palmieri M,Cantelli I,Bertaccini P,Ambrosioni E

    更新日期：1985-04-01 00:00:00

  • Renin-angiotensin system: genes to bedside.

    abstract：:Atherosclerosis and its vascular sequela are responsible for considerable morbidity and mortality rates. Several risk factors have been implicated in the pathogenesis of atherosclerosis, and the search for other risk factors continues on the medical horizon. Renin-angiotensin system (RAS), a multienzyme, multilocale a...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/s0002-8703(97)70089-9

    authors： Malik FS,Lavie CJ,Mehra MR,Milani RV,Re RN

    更新日期：1997-09-01 00:00:00

  • High- and low-dose superoxide dismutase plus catalase does not reduce myocardial infarct size in a subhuman primate model.

    abstract：:Oxygen free radical scavengers have been found to decrease infarct size in dogs subjected to myocardial ischemia-reperfusion injury. A baboon open-chest model was used to determine if superoxide dismutase (SOD), an oxygen free radical scavenger, together with catalase would be equally effective in subhuman primates (b...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(93)90697-8

    authors： Watanabe BI,Premaratne S,Limm W,Mugiishi MM,McNamara JJ

    更新日期：1993-10-01 00:00:00

  • The diagnostic utility of contrast echocardiography in patients with refractory hypoxemia.

    abstract：:Three illustrative cases of refractory hypoxemia in adults are presented. In two cases contrast echocardiography was invaluable in establishing the diagnosis of a true anatomic right to left shunt, as well as in localizing the shunt to an intracardiac or extracardiac site. In the third case true anatomic right to left...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(93)90126-t

    authors： Gin KG,Fenwick JC,Pollick C,Thompson CR

    更新日期：1993-04-01 00:00:00

  • The natural history of benign and potentially malignant ventricular arrhythmias with special reference to nonsustained ventricular tachycardia.

    abstract：:Ambulatory ECG recordings are routinely used to identify patients at increased risk of sudden cardiac death and to monitor changes in ventricular arrhythmias during antiarrhythmic drug therapy. The arrhythmia frequency established during the initial baseline has previously been reported to change during a second place...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(88)90139-1

    authors： Pratt CM,Francis M,Mahler S,Aogaichi K,Keus P,Young JB

    更新日期：1988-10-01 00:00:00

  • Abnormal mitral valve motion associated with ventricular septal defect following acute myocardial infarction.

    abstract：:It is often difficult to make the clinical distinction between acute mitral regurgitation caused by papillary muscle dysfunction or rupture and ventricular septal defect complicating an acute myocardial infarction. A case of a patient with rapidly progressive congestive heart failure and a loud murmur is presented. Ec...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(79)90291-6

    authors： Rosenthal R,Kleid JJ,Cohen MV

    更新日期：1979-11-01 00:00:00

  • Percutaneous angioscopic evaluation of luminal changes induced by excimer laser angioplasty.

    abstract：:Angioscopy has been shown to provide more detailed information on lesion morphology before and after interventional procedures than angiography. Therefore to evaluate the effects of laser angioplasty, angioscopy was performed in five patients with peripheral or coronary vascular disease who underwent excimer laser ang...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(92)90058-4

    authors： Nakamura F,Kvasnicka J,Uchida Y,Geschwind HJ

    更新日期：1992-12-01 00:00:00

  • Evaluation of coronary artery disease in the patient unable to exercise: alternatives to exercise stress testing.

    abstract：:Exercise stress testing is a well-established method for the diagnostic, prognostic, and functional assessment of patients with known or suspected CAD. A variety of alternative tests have been described in patients unable to perform leg exercise. Atrial pacing and dipyridamole imaging have been evaluated most extensiv...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(89)90417-1

    authors： Stratmann HG,Kennedy HL

    更新日期：1989-06-01 00:00:00

  • Human epicardial adipose tissue: a review.

    abstract：:We discuss the anatomy, physiology, and pathophysiology of epicardial adipose tissue and its relationship to coronary atherosclerosis. Epicardial fat stores triglyceride to supply free fatty acids for myocardial energy production and produces adipokines. It shares a common embryological origin with mesenteric and omen...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2007.03.019

    authors： Sacks HS,Fain JN

    更新日期：2007-06-01 00:00:00

  • Comparative hemodynamic effects of digoxin vs nitroprusside in conscious dogs with aortocaval fistula-induced chronic left ventricular volume overload and normal systolic performance.

    abstract：:We compared the effects of IV digoxin (0.04 mg/kg) and nitroprusside (NP) (1.2 and 1.8 microgram/kg/min) on left ventricular (LV) performance in six preinstrumented conscious dogs with 3 and 6 hours after digoxin administration (serum level, 3.5 +/- 0.6 ng/ml), there were no changes in heart rate, LV systolic (LVSP) a...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(82)90335-0

    authors： O'Rourke RA,Badke FR,Forst D

    更新日期：1982-04-01 00:00:00

  • Relation of left atrial V-wave/left ventricular systolic pressure ratio to mitral regurgitant volume.

    abstract：:Evaluation of mitral regurgitation is difficult whether invasive or noninvasive methods are used. The determination of the regurgitant volume itself cannot be done in clinical practice with reasonable accuracy. In six sheep with chronic mitral regurgitation, left ventricular and left atrial pressures were recorded wit...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(95)90009-8

    authors： Teien D,Jones M,Shiota T,Yamada I,Sahn DJ

    更新日期：1995-02-01 00:00:00