Effects of physiologic load of pregnancy on left ventricular contractility and remodeling.

Abstract:

:Left ventricular (LV) adaptation to the hemodynamic load of pregnancy has been studied with load-sensitive ejection-phase indexes, but the results of these studies are conflicting. The aim of this study was to examine the effects of the hemodynamic load of pregnancy on the contractile state of the left ventricle by using load-adjusted indexes of contractility. Thirty-four healthy women were prospectively studied by serial echo and Doppler examinations at six periods during pregnancy and after delivery. LV volume increased 10.5%, paralleling the change in stroke volume. End-systolic stress, an index of myocardial afterload, decreased 28.8% because of a decrease in end-systolic pressure and an increase in LV thickness/diameter ratio. Despite the increase in preload and the decrease in afterload, ejection phase indexes did not change during or after pregnancy. Although remaining within the normal range, the afterload-adjusted velocity of circumferential fiber shortening, an index of contractility that is relatively insensitive to preload, transiently decreased by 1.75 SDs during gestation, returning to non-pregnant values 2 to 4 weeks postpartum. Thus the increase in hemodynamic load that characterizes normal pregnancy is associated with preservation of global pump function. The transient decrease in contractile state may represent an adaptation phase of the contractile elements of the myocardium to the rapid changes in loading conditions observed during the first trimester of pregnancy.

journal_name

Am Heart J

journal_title

American heart journal

authors

Geva T,Mauer MB,Striker L,Kirshon B,Pivarnik JM

doi

10.1016/s0002-8703(97)70247-3

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

53-9

issue

1

eissn

0002-8703

issn

1097-6744

pii

S0002870397000069

journal_volume

133

pub_type

杂志文章
  • The evolving pattern of digoxin intoxication: observations at a large urban hospital from 1980 to 1988.

    abstract::Digoxin intoxication has been reported to be a common adverse drug reaction with an in-hospital incidence of 6% to 23% and an associated mortality rate as high as 41%. A retrospective review was conducted to assess the accuracy of diagnosis, the morbidity and mortality of digoxin intoxication, and its incidence in hos...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(90)90135-k

    authors: Mahdyoon H,Battilana G,Rosman H,Goldstein S,Gheorghiade M

    更新日期:1990-11-01 00:00:00

  • The post-pulmonary infarction syndrome.

    abstract::Following pulmonary infarction, three patients developed the classical signs and symptoms of the Dressler syndrome associated with persistent left pleural effusion. Each responded dramatically to corticosteroid therapy. While the pathogenesis of this "Post-Pulmonary Infarction syndrome," like the Dressler syndrome, is...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(79)90477-0

    authors: Sklaroff HJ

    更新日期:1979-12-01 00:00:00

  • The feasibility and accuracy of evaluating lipid management performance metrics using an electronic health record.

    abstract:BACKGROUND:Over the past decade, electronic health records (EHRs) have emerged as a potential tool to assess quality of care; however, the feasibility and accuracy of EHRs to assess adherence to lipid management performance measures have not been evaluated. METHODS:We created a retrospective cohort of 3779 patients wi...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2013.07.024

    authors: Danford CP,Navar-Boggan AM,Stafford J,McCarver C,Peterson ED,Wang TY

    更新日期:2013-10-01 00:00:00

  • Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women.

    abstract:BACKGROUND:Elevated resting heart rate (RHR) is known to be associated with reduced survival but inconsistencies remain, including lack of significance in most studies of healthy women, lack of independence from systolic blood pressure (SBP) in some, and the suggestion that RHR is merely functioning as a marker of phys...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2009.12.029

    authors: Cooney MT,Vartiainen E,Laatikainen T,Juolevi A,Dudina A,Graham IM

    更新日期:2010-04-01 00:00:00

  • Racial differences in long-term survival among patients with coronary artery disease.

    abstract:BACKGROUND:Cardiovascular disease is the leading cause of death among blacks and whites in the United States. Despite this, there are insufficient data on the long-term prognosis of black patients with coronary artery disease (CAD) as well as the major clinical related determinants of outcome. METHODS:We studied 22,61...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2010.06.014

    authors: Thomas KL,Honeycutt E,Shaw LK,Peterson ED

    更新日期:2010-10-01 00:00:00

  • Causes and timing of death during long-term follow-up after transcatheter aortic valve replacement.

    abstract:BACKGROUND:Transcatheter aortic valve replacement (TAVR) is an effective therapeutic option for patients with severe aortic stenosis at high risk for surgery. Identification of causes of death after TAVR may help improve patient selection and outcome. METHODS:We enrolled 874 consecutive patients who underwent TAVR at ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2014.07.023

    authors: Saia F,Latib A,Ciuca C,Gasparetto V,Napodano M,Sticchi A,Anderlucci L,Marrozzini C,Naganuma T,Alfieri O,Facchin M,Hoxha B,Moretti C,Marzocchi A,Colombo A,Tarantini G

    更新日期:2014-11-01 00:00:00

  • Coronary artery bypass surgery in patients with acute coronary syndromes is difficult to predict.

    abstract:BACKGROUND:Although the use of clopidogrel in patients "unlikely" to require coronary artery bypass grafting (CABG) is recommended in current guidelines of acute coronary syndrome (ACS) management, an important minority of patients require CABG. We assessed the ability to predict need for CABG from demographics known a...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2007.12.002

    authors: Chew DP,Mahaffey KW,White HD,Huang Z,Hoekstra JW,Ferguson JJ,Califf RM,Aylward PE

    更新日期:2008-05-01 00:00:00

  • Intravascular ultrasound versus angiography for measurement of luminal diameters in normal and diseased coronary arteries.

    abstract::Quantitation of coronary luminal diameter with a 20 MHz mechanically rotating intravascular ultrasound (IVUS) catheter was compared with orthogonal-view cineangiography by use of a semiautomated edge-detection algorithm in 48 patients undergoing coronary angioplasty. Quantitative comparison of 196 matched segments was...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90110-4

    authors: De Scheerder I,De Man F,Herregods MC,Wilczek K,Barrios L,Raymenants E,Desmet W,De Geest H,Piessens J

    更新日期:1994-02-01 00:00:00

  • Phase image analysis of anomalous ventricular activation in pediatric patients with preexcitation syndromes or ventricular tachycardia.

    abstract::This prospective study evaluated the accuracy of phase analysis of scintigraphic imaging in defining the site of earliest ventricular activation in pediatric patients with electrophysiologic disorders. Twenty patients (10.8 +/- 5.5 years) with preexcitation (n = 16) or ventricular tachycardia (VT) (n = 4) were indepen...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(93)90015-2

    authors: Silka MJ,Chelsky R,Kron J,Wilson RA

    更新日期:1993-02-01 00:00:00

  • Left atrial thrombus resolution in atrial fibrillation or flutter: Results of a prospective study with rivaroxaban (X-TRA) and a retrospective observational registry providing baseline data (CLOT-AF).

    abstract:BACKGROUND:Data on left atrial/left atrial appendage (LA/LAA) thrombus resolution after non-vitamin K antagonist (VKA) oral anticoagulant treatment are scarce. The primary objective of X-TRA was to explore the use of rivaroxaban for the resolution of LA/LAA thrombi in patients with nonvalvular atrial fibrillation (AF) ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2016.05.007

    authors: Lip GY,Hammerstingl C,Marin F,Cappato R,Meng IL,Kirsch B,van Eickels M,Cohen A,X-TRA study and CLOT-AF registry investigators.

    更新日期:2016-08-01 00:00:00

  • Effect of verapamil on conduction delay produced by myocardial ischemia and reperfusion.

    abstract::Changes in conduction times induced by ischemia (delta CT) have been shown to be quantitatively related to genesis of spontaneous ischemic ventricular fibrillation (VF). We studied conduction delay encountered by premature impulses in epicardium and endocardium in both anterograde and retrograde directions during isch...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(81)90308-2

    authors: Hamamoto H,Peter T,Fujimoto T,Mandel WJ

    更新日期:1981-09-01 00:00:00

  • Magnesium and potassium therapy in multifocal atrial tachycardia.

    abstract::Eight patients with multifocal atrial tachycardia received 7 to 12 gm of magnesium sulfate intravenously over a 5-hour period. Potassium supplements were given initially or added later. Initial arterial blood gases showed mean pH 7.48 +/- 0.03, PcO2 39.7 torr, PO2 72 torr, HCO-3 29.8 +/- 4.5 mEq/L, and base excess 6.8...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(85)90458-2

    authors: Iseri LT,Fairshter RD,Hardemann JL,Brodsky MA

    更新日期:1985-10-01 00:00:00

  • Smoking status at the time of acute myocardial infarction and subsequent prognosis.

    abstract::A population of 2955 patients admitted to the hospital with acute myocardial infarction (AMI) was followed for 1 year after AMI or until death. Smokers as compared to nonsmokers were over 10 years younger (p less than 0.001) and had a lower prevalence of hypertension (p less than 0.01), congestive heart failure (p les...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(85)90071-7

    authors: Kelly TL,Gilpin E,Ahnve S,Henning H,Ross J Jr

    更新日期:1985-09-01 00:00:00

  • Hepatocyte growth factor as a potential predictor of the presence of atherosclerotic aorto-iliac artery disease.

    abstract:BACKGROUND:Hepatocyte growth factor (HGF), a member of the endothelial-specific growth factors with the greatest mitogenic activity, may play a role in the protection and/or repair of vascular endothelial cells injured by atherosclerosis. As a result, plasma HGF concentration may increase in response to endothelial cel...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2002.120151

    authors: Tateishi J,Waku S,Masutani M,Ohyanagi M,Iwasaki T

    更新日期:2002-02-01 00:00:00

  • Rationale and design of the RIGHT trial: A multicenter, randomized, double-blind, placebo-controlled trial of anticoagulation prolongation versus no anticoagulation after primary percutaneous coronary intervention for ST-segment elevation myocardial infar

    abstract:BACKGROUND:Current guidelines recommend anticoagulation therapy during primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI). However, whether anticoagulation should be continued after pPCI has not been well investigated. METHODS/DESIGN:The RIGHT trial is a prospectiv...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2020.06.005

    authors: Yan Y,Wang X,Guo J,Li Y,Ai H,Gong W,Que B,Zhen L,Lu J,Ma C,Montalescot G,Nie S

    更新日期:2020-09-01 00:00:00

  • Survival for 20 years or longer after transmural acute myocardial infarction: analysis of eight well-documented necropsy patients.

    abstract::Clinical and necropsy findings are described in eight patients who lived 20 to 31 years (mean 24 years) after healing of a transmural acute myocardial infarct. Two had left ventricular aneurysms and one had both right and left ventricular infarcts. Survival for 2 decades or more after healing of a transmural acute myo...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(81)80006-3

    authors: McManus BM,Roberts WC

    更新日期:1981-08-01 00:00:00

  • Right-sided valvular endocarditis: etiology, diagnosis, and an approach to therapy.

    abstract::Right- and left-sided endocarditis are two distinct entities, both clinically and experimentally. As such, they require different clinical approaches. The accurate diagnosis of right-sided endocarditis rests largely on a high index of suspicion which is often raised in the case of an intravenous drug abuser with fever...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90564-8

    authors: Robbins MJ,Soeiro R,Frishman WH,Strom JA

    更新日期:1986-01-01 00:00:00

  • Diastolic wall motion abnormality after myocardial infarction: relation to neurohormonal activation and prognostic implications.

    abstract:BACKGROUND:Systolic wall motion abnormality (WMA) after acute myocardial infarction (AMI) is a major determinant of outcome; the presence and importance of diastolic WMA after AMI are unknown. We therefore sought to detect diastolic WMA using color kinesis and to assess its relation to neurohormonal activation and its ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2004.11.024

    authors: Husic M,Nørager B,Egstrup K,Lang RM,Møller JE

    更新日期:2005-10-01 00:00:00

  • Three-dimensional echocardiographic evaluation of left ventricular volume: comparison of Doppler myocardial imaging and standard gray-scale imaging with cineventriculography--an in vitro and in vivo study.

    abstract:BACKGROUND:Standard gray-scale imaging (GSI), three-dimensional (3D) echocardiography has been shown to be superior to two-dimensional echocardiography in measuring left ventricular volume. However, the often relatively poor quality of transthoracic gray-scale data can limit the potential application of this technique....

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(98)70061-4

    authors: Lange A,Palka P,Nowicki A,Olszewski R,Anderson T,Adamus J,Sutherland GR,Fox KA

    更新日期:1998-06-01 00:00:00

  • Differences in mortality in acute coronary syndrome symptom clusters.

    abstract:BACKGROUND:The timely and accurate identification of symptoms of acute coronary syndrome (ACS) is a challenge for patients and clinicians. It is unknown whether response times and clinical outcomes differ with specific symptoms. We sought to identify which ACS symptoms are related-symptom clusters-and to determine if s...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2010.01.003

    authors: Riegel B,Hanlon AL,McKinley S,Moser DK,Meischke H,Doering LV,Davidson P,Pelter MM,Dracup K

    更新日期:2010-03-01 00:00:00

  • How to use ACE-inhibitors, beta-blockers, and newer therapies in AMI.

    abstract::Besides reperfusion treatment, which is the most powerful approach to the underlying pathophysiological cause of myocardial infarction, adjunctive therapies should be considered to reduce clinical symptoms, and improve left ventricular function and mortality rates. Randomized clinical trials and overviews of adjunctiv...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/s0002-8703(99)70341-8

    authors: Maggioni AP,Latini R

    更新日期:1999-08-01 00:00:00

  • Findings of coronary angioscopy in angiographically normal coronary segments of patients with coronary artery disease.

    abstract::Compared with pathologic studies coronary angiography is a relatively insensitive technique to detect early atherosclerosis. Coronary angioscopy is a new technique providing direct information on luminal vessel surface. To determine whether coronary angioscopy may detect the presence of atherosclerotic disease on angi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(95)90198-1

    authors: Alfonso F,Goicolea J,Hernandez R,Segovia J,Silva JC,Perez-Vizcayno MJ,Rollan MJ,Bañuelos C,Macaya C

    更新日期:1995-11-01 00:00:00

  • Effect of risk stratification on cost-effectiveness of the implantable cardioverter defibrillator.

    abstract:BACKGROUND:Implantable cardioverter defibrillators (ICDs) effectively prevent sudden cardiac death, but selection of appropriate patients for implantation is complex. We evaluated whether risk stratification based on risk of sudden cardiac death alone was sufficient to predict the effectiveness and cost-effectiveness o...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2002.125501

    authors: Owens DK,Sanders GD,Heidenreich PA,McDonald KM,Hlatky MA

    更新日期:2002-09-01 00:00:00

  • Exercise-induced alterations of signal-averaged electrocardiograms in marathon runners.

    abstract::Late potentials have been shown to predict malignant ventricular arrhythmias and sudden cardiac death. To determine whether prolonged, strenuous activity is associated with the development of ventricular late potentials, signal-averaged electrocardiography was performed on 30 marathon runners before, immediately after...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(89)90010-0

    authors: Smith GS,Vacek JL,Wilson DB,Hawkins JW,Boyer TA

    更新日期:1989-12-01 00:00:00

  • The role of transesophageal echocardiography in cardiac donor screening.

    abstract::Transthoracic echocardiography has played a useful role in the screening of cardiac transplant donors. However, transthoracic echocardiograms may be suboptimal in many patients on ventilators. The role of transesophageal echocardiography in cardiac donor screening is unknown. Therefore we compared the potential benefi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(93)90758-2

    authors: Stoddard MF,Longaker RA

    更新日期:1993-06-01 00:00:00

  • Interactions of wine drinking with omega-3 fatty acids in patients with coronary heart disease: a fish-like effect of moderate wine drinking.

    abstract:BACKGROUND:Moderate alcohol drinking and marine omega-3 fatty acids (omega3) have both been associated with low mortality from coronary heart disease (CHD). However, there is little data evaluating the interactions of wine ethanol drinking with omega3 in CHD patients. METHODS:The relationships between wine drinking an...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2007.08.009

    authors: de Lorgeril M,Salen P,Martin JL,Boucher F,de Leiris J

    更新日期:2008-01-01 00:00:00

  • CardioSEAL/STARflex versus Amplatzer devices for percutaneous closure of small to moderate (up to 18 mm) atrial septal defects.

    abstract:BACKGROUND:The Amplatzer septal occluder (ASO) allows the percutaneous closure of small to very large atrial septal defects (ASDs). The CardioSEAL/STARflex (CS/SF) can be used only for closure of small to moderate ASDs (stretch size up to 18 mm). These 2 devices are widely used in clinical practice. Therefore, a compar...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2004.03.013

    authors: Butera G,Carminati M,Chessa M,Delogu A,Drago M,Piazza L,Giamberti A,Frigiola A

    更新日期:2004-09-01 00:00:00

  • Usefulness of magnetic resonance imaging for evaluating great-vessel anatomy after arterial switch operation for D-transposition of the great arteries.

    abstract::Magnetic resonance imaging (MRI) produces high-resolution images of great-vessel anatomy in pediatric patients. In this study seven patients, aged 6 to 27 months were evaluated by using gated MRI and two-dimensional echocardiography 4 to 26 months after arterial switch operation for D-transposition of the great arteri...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90486-3

    authors: Hardy CE,Helton GJ,Kondo C,Higgins SS,Young NJ,Higgins CB

    更新日期:1994-08-01 00:00:00

  • Safety, feasibility, and prognostic implications of pharmacologic stress echocardiography in 1482 patients evaluated in an ambulatory setting.

    abstract:BACKGROUND:The outpatient prognostic assessment of coronary artery disease (CAD) by exercise electrocardiography has limitations, including the feasibility of the test and its low positive predictive value in several clinical conditions. In the current study we investigated the safety, feasibility, and prognostic value...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2001.113997

    authors: Cortigiani L,Picano E,Coletta C,Chiarella F,Mathias W,Gandolfo N,De Alcantara M,Mazzoni V,Gensini GF,Landi P,Echo Persantine International Cooperative (EPIC) Study Group.,Echo Dobutamine International Cooperative (EDIC) Study Group

    更新日期:2001-04-01 00:00:00

  • Invasive treatment in unstable coronary artery disease promotes health-related quality of life: results from the FRISC II trial.

    abstract:BACKGROUND:Treatment strategies, either invasive or noninvasive, for patients with unstable coronary artery disease still vary. There are no published studies comparing the strategies for health-related quality of life. METHODS:A total of 2457 patients with unstable coronary artery disease were randomized. We prospect...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.ahj.2003.11.026

    authors: Janzon M,Levin LA,Swahn E

    更新日期:2004-07-01 00:00:00