Abstract:
:Left ventricular (LV) adaptation to the hemodynamic load of pregnancy has been studied with load-sensitive ejection-phase indexes, but the results of these studies are conflicting. The aim of this study was to examine the effects of the hemodynamic load of pregnancy on the contractile state of the left ventricle by using load-adjusted indexes of contractility. Thirty-four healthy women were prospectively studied by serial echo and Doppler examinations at six periods during pregnancy and after delivery. LV volume increased 10.5%, paralleling the change in stroke volume. End-systolic stress, an index of myocardial afterload, decreased 28.8% because of a decrease in end-systolic pressure and an increase in LV thickness/diameter ratio. Despite the increase in preload and the decrease in afterload, ejection phase indexes did not change during or after pregnancy. Although remaining within the normal range, the afterload-adjusted velocity of circumferential fiber shortening, an index of contractility that is relatively insensitive to preload, transiently decreased by 1.75 SDs during gestation, returning to non-pregnant values 2 to 4 weeks postpartum. Thus the increase in hemodynamic load that characterizes normal pregnancy is associated with preservation of global pump function. The transient decrease in contractile state may represent an adaptation phase of the contractile elements of the myocardium to the rapid changes in loading conditions observed during the first trimester of pregnancy.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Geva T,Mauer MB,Striker L,Kirshon B,Pivarnik JMdoi
10.1016/s0002-8703(97)70247-3subject
Has Abstractpub_date
1997-01-01 00:00:00pages
53-9issue
1eissn
0002-8703issn
1097-6744pii
S0002870397000069journal_volume
133pub_type
杂志文章abstract::Digoxin intoxication has been reported to be a common adverse drug reaction with an in-hospital incidence of 6% to 23% and an associated mortality rate as high as 41%. A retrospective review was conducted to assess the accuracy of diagnosis, the morbidity and mortality of digoxin intoxication, and its incidence in hos...
journal_title:American heart journal
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更新日期:1990-11-01 00:00:00
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pub_type: 杂志文章
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doi:10.1016/j.ahj.2004.11.024
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2002-09-01 00:00:00
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更新日期:1993-06-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
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更新日期:2008-01-01 00:00:00
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journal_title:American heart journal
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更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-08-01 00:00:00
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journal_title:American heart journal
pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
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journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-07-01 00:00:00