Abstract:
:To determine whether cholinergic mechanisms contribute to blood pressure responses during arterial baroreflex inhibition and stimulation, we assessed the effects of atropine on pressor and depressor responses during and after release of the Valsalva maneuver, upon administration of intravenous phenylephrine and nitroglycerin, and during neck suction in 12 healthy people. Atropinization augmented the depressor response during the Valsalva maneuver (269%), the pressor response after release of the maneuver (544%), the pressor response to phenylephrine (109%), and the depressor response to nitroglycerin (76%), whereas the depressor response to externally applied neck suction was attenuated or abolished in all subjects. Cardiac output as indicated by impedance cardiography was unchanged during carotid baroreceptor stimulation. The results are best explained by inhibition by atropine of compensatory cholinergic heart rate, vasodilator, and negative inotropic responses.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Goldstein DS,Keiser HRdoi
10.1016/0002-8703(84)90837-8subject
Has Abstractpub_date
1984-05-01 00:00:00pages
974-9issue
5 Pt 1eissn
0002-8703issn
1097-6744pii
0002-8703(84)90837-8journal_volume
107pub_type
杂志文章abstract::Noninvasive risk assessment in survivors of AMI can effectively subdivide patients into groups with differing risk profiles after hospital discharge, but some patients at risk for late death or recurrent AMI may be incorrectly identified; data from cardiac catheterization and angiography provide complementary and gene...
journal_title:American heart journal
pub_type: 社论
doi:10.1016/0002-8703(91)90747-6
更新日期:1991-02-01 00:00:00
abstract::Sixty-nine patients receiving atrioventricular sequential (DVI) pacemakers are compared to 67 patients receiving ventricular demand (VVI) pacemakers for control of the symptoms of sinus node dysfunction. The populations were similar with comparable preparing incidences of each assayed symptom and number of symptoms pe...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(82)90162-4
更新日期:1982-12-01 00:00:00
abstract::Thirty-four patients with acute myocardial infarction (mean age 55 years) who received intracoronary streptokinase for coronary thrombosis were followed for a mean of 9.4 months (longest 25 months) following the procedure of percutaneous transluminal coronary recanalization (PTCR). Twelve patients had undergone corona...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(82)90265-4
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND:Systemic markers of inflammation increase after percutaneous coronary intervention (PCI). The rise in inflammatory markers after PCI is frequently attributed to the inflammatory stimulus associated with coronary artery injury during balloon inflation and coronary stent implantation. The aim of this study was...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/S0002-8703(03)00407-1
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Intracranial hemorrhage is an uncommon but very dangerous complication in patients receiving thrombolytic therapy for acute myocardial infarction. Neurosurgical evacuation is often an available treatment option. However, the association between neurosurgical evacuation and clinical outcomes in these patients...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0002-8703(99)70152-3
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:In the setting of ST-segment elevation myocardial infarction, timely restoration of normal blood flow is associated with improved myocardial salvage and survival. Despite improvements in door-to-needle and door-to-balloon times, there remains an unmet need with respect to improved symptom-to-door times. A pr...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.ahj.2014.05.010
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Firm evidence exists for reduction in mortality and morbidity by lipid-lowering therapy in patients with coronary artery disease (CAD), yet a significant proportion remain untreated. This prospective study determined the effectiveness of a planned strategy of management using a cardiac rehabilitation nurse i...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1067/mhj.2001.118739
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Although there is evidence linking smoking and heart failure (HF), the association between lifetime smoking exposure and HF in older adults and the strength of this association among current and past smokers is not well known. METHODS:We examined the association between smoking status, pack-years of exposur...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2012.05.013
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Inflammation might promote the development of atherosclerosis, and high levels of C-reactive protein (CRP) and fibrinogen are associated with an increased risk of acute coronary events. OBJECTIVE:We assessed the levels of CRP and other risk factors in patients with angiographically documented coronary arter...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1053/hj.1999.v137.92052
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:In the treatment of coronary artery disease, a "pro-healing" approach for prevention of in-stent restenosis and late stent thrombosis is intuitively favored over the use of cytotoxic or cytostatic drugs released from a drug-eluting stent (DES). Promoting accelerated endothelial coverage of the stent surface,...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2009.07.022
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Myocardial contractile reserve has been shown to provide important prognostic information in patients with heart failure. We hypothesized that myocardial contractile reserve would predict left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). METHODS:Thirty-one consecutive p...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.07.035
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:In the era of coronary stenting with high-pressure expansion, stent thrombosis remains a major life-threatening risk. Because of its superior imaging mode, intracoronary ultrasound could provide insight into potential risk factors for stent thrombosis. PATIENTS AND METHODS:In 215 patients with stent implant...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(98)70097-3
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:The Fontan operation results in a circulation that is dependent on low pulmonary vascular resistance to maintain an adequate cardiac output. Medical therapies that lower pulmonary vascular resistance may augment cardiac output and improve long-term outcomes. OBJECTIVES:This phase I/II clinical trial conduct...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2017.02.030
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is a major risk factor for stroke and systemic embolism. Trials comparing warfarin with non-vitamin K oral anticoagulants (NOACs) have demonstrated that, when compared with warfarin, the NOACs are at least as effective in preventing stroke, although detailed analyses characterizing s...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2015.06.020
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Glycoprotein (GP) IIb/IIIa antagonists have become a mainstay for the treatment of acute coronary syndromes. Yet, they have rarely been evaluated under relevant pathophysiologic conditions, for example, high shear rates in the presence of physiologic calcium concentrations. We compared the efficacy of eptifi...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ahj.2003.11.003
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:The latest cholesterol guidelines have shifted focus from achieving low-density lipoprotein cholesterol (LDL-C) targets toward statin use and intensity guided by atherosclerotic cardiovascular disease (ASCVD) risk. METHODS:Statin use and intensity were evaluated in 5,905 statin-eligible primary or secondary...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2017.08.005
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The inverse relation between alcohol intake and clinical coronary artery disease (CAD) is well established, although the mechanisms remain speculative. We studied the relation between alcohol intake and subclinical CAD to assess the possible role of alcohol in atherogenesis. METHODS:We conducted a prospecti...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2004.05.023
更新日期:2004-11-01 00:00:00
abstract::The effects of amiodarone on delayed afterdepolarization (DAD) and triggered automaticity induced by low potassium (0.5 mEq/L) were evaluated on isolated rabbit right ventricular muscles, by means of standard microelectrode techniques. Triggered automaticity was induced in 6 of 10 muscles in the control group, in four...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(87)90267-5
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:Nitroglycerin is known to augment vessel wall squeezing at the site with coronary-myocardial bridging (CMB). This study was designed to define the mechanism of nitroglycerin-induced augmentation of CMB in clinical settings. METHODS:We analyzed nitroglycerin reactivity at the site with CMB in 39 patients. Ma...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(99)70123-7
更新日期:1999-08-01 00:00:00
abstract::In older patients (70 ± 7 years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6 months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exercise oxygen consumption (14.9 ± 0.2 mL kg-1 min-1 versus 14.4 ...
journal_title:American heart journal
pub_type: 信件
doi:10.1016/j.ahj.2018.03.019
更新日期:2018-07-01 00:00:00
abstract::Calcium channel blockers and central alpha-agonists are among the classes of antihypertensive drugs that yield the most favorable overall effects on risk factors for hypertension-related end-organ damage. An open-label prospective trial in 42 patients with a mean baseline blood pressure of 144/102 mm Hg sought to asse...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/0002-8703(93)90707-g
更新日期:1993-10-01 00:00:00
abstract::We report the angiographic studies of 53 consecutive patients with angiographic coronary artery disease (CAD) and recurrent sustained ventricular tachycardia occurring at least 6 weeks remote from an acute myocardial infarction. Triple-vessel disease was present in 25 patients (47%), double-vessel disease in 19 patien...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(83)90392-7
更新日期:1983-06-01 00:00:00
abstract::The expected implant lifetime of pacemaker generators has been extended with the introduction of lithium power sources. Consequently, the pacing lead may become the component that determines the total implant lifetime of the pacemaker. This fact emphasizes the necessity for accurate assessment of the integrity of a ch...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(84)90269-2
更新日期:1984-06-01 00:00:00
abstract::Standard evaluation of children with sinus node (SN) dysfunction cannot distinguish abnormal autonomic tone from intrinsic SN disease. This distinction has potentially important therapeutic and prognostic implications. Intrinsic heart rate (IHR)--the peak heart rate (HR) measured during pharmacologic combined autonomi...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(05)80331-x
更新日期:1990-04-01 00:00:00
abstract::After dipyridamole, canine studies have demonstrated a slower rate of myocardial thallium-201 clearance from zones distal to a coronary artery stenosis compared to normal zones. To determine if criteria based on canine myocardial thallium-201 clearance rates could be applied clinically, 40 patients with and 26 patient...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(84)90088-7
更新日期:1984-03-01 00:00:00
abstract::"Stunned" myocardium prevents the assessment of myocardial salvage after streptokinase. In order to unmask "stunning," we sought to evaluate left ventricular inotropic contractile reserve of patients after streptokinase. Radionuclide ventriculograms were obtained in 75 consecutive patients 2 weeks after myocardial inf...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(86)90628-9
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:The diagnosis of angina is challenging because it relies on symptom descriptions. Natural language processing (NLP) of the electronic medical record (EMR) can provide access to such information contained in free text that may not be fully captured by conventional diagnostic coding. OBJECTIVE:To test the hyp...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2006.12.022
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Current guidelines recommend anticoagulation therapy during primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI). However, whether anticoagulation should be continued after pPCI has not been well investigated. METHODS/DESIGN:The RIGHT trial is a prospectiv...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2020.06.005
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Long-term treatment with beta-blockers reduces mortality after acute myocardial infarction (AMI). Whether beta-blockers exert a class effect is unknown. METHODS:We analyzed mortality after AMI in Canadian patients 65 years or older who were discharged from hospital with a diagnosis of AMI from April 1996 to...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2006.11.008
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Coronary calcium detected noninvasively is an attractive way to diagnose atherosclerosis before the development of symptoms. This study examines the prognostic value of coronary calcium in asymptomatic subjects with usual cardiovascular risk. METHODS AND RESULTS:In 425 asymptomatic subjects, 229 men (aged 4...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2003.169
更新日期:2003-03-01 00:00:00