当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Transdermal clonidine as an adjunct to nifedipine-GITS therapy in patients with mild-to-moderate hypertension.

Transdermal clonidine as an adjunct to nifedipine-GITS therapy in patients with mild-to-moderate hypertension.

Abstract：

:Calcium channel blockers and central alpha-agonists are among the classes of antihypertensive drugs that yield the most favorable overall effects on risk factors for hypertension-related end-organ damage. An open-label prospective trial in 42 patients with a mean baseline blood pressure of 144/102 mm Hg sought to assess the usefulness of adjunctive treatment with transdermal clonidine (0.1 to 0.3 mg/day) in patients responding inadequately to nifedipine--gastrointestinal therapeutic system (GITS) (30 to 60 mg/day) monotherapy. Thirty-nine patients who failed to reach the goal of a seated mean diastolic blood pressure of < 90 mm Hg when treated only with once-a-day nifedipine-GITS entered a transdermal clonidine (once a week) titration phase followed by an 8-week maintenance course of the two drugs combined. The 35 patients completing this last phase responded with a mean seated diastolic blood pressure of 127/87 mm Hg. Only six patients required the highest dose of clonidine for control. A 97% compliance rate with the transdermal medication contrasted with a compliance rate of only 73% for the oral nifedipine. Two of three patients who had contact dermatitis after wearing a transdermal clonidine patch withdrew from the trial prematurely; other minor side effects required no interruption of therapy. The nifedipine-clonidine combination not only achieved blood pressure control in these patients but may prove advantageous in combining the protective effects of the two agents against complications of the hypertensive syndrome.

journal_name

Am Heart J

journal_title

American heart journal

authors

Houston MC,Hays L

doi

10.1016/0002-8703(93)90707-g

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

918-23

issue

4

eissn

0002-8703

issn

1097-6744

pii

0002-8703(93)90707-G

journal_volume

126

pub_type

临床试验,杂志文章

相关文献

AMERICAN HEART JOURNAL文献大全
  • Pulmonary function in hypertensive patients treated with pindolol: a report of two studies.

    abstract：:Pulmonary function was measured serially in two separate randomized trials of pindolol in the treatment of essential hypertension. Patients with overt obstructive airways disease were excluded. In study 1, 131 hypertensive patients were randomized to placebo (31) and 15 mg (33), 30 mg (33), and 60 mg (34) of pindolol....

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(82)90135-1

    authors： Hamilton BP,Hamilton J,Kirkendall WM

    更新日期：1982-08-01 00:00:00

  • Complications and long-term outcome after percutaneous coronary angioplasty in chronic hemodialysis patients.

    abstract：:The objective of this investigation was to assess the acute and long-term outcome after coronary angioplasty in patients undergoing chronic hemodialysis. Previous studies have suggested a high incidence of restenosis after coronary angioplasty performed in patients with renal failure. Medical discharge abstracts for 8...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(94)90476-6

    authors： Ahmed WH,Shubrooks SJ,Gibson CM,Baim DS,Bittl JA

    更新日期：1994-08-01 00:00:00

  • The periprocedural management of novel oral anticoagulants in patients with nonvalvular atrial fibrillation: rationale and a summary of the available evidence from phase 3 clinical trials.

    abstract：:The novel oral anticoagulants (NOACs) have rapidly emerged as an alternative therapy to warfarin. Several recent phase 3 randomized control trials have demonstrated the efficacy and safety of the NOACs in the treatment for patients with nonvalvular atrial fibrillation. As the NOACs are incorporated in clinical practic...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2014.12.008

    authors： Krishnamoorthy A,Sherwood MW,Lopes RD,Becker RC

    更新日期：2015-03-01 00:00:00

  • Association of left ventricular dilatation and hypertrophy with chronotropic incompetence in the Framingham Heart Study.

    abstract：BACKGROUND:Chronotropic incompetence and left ventricular (LV) dilatation have both been shown to be markers of an adverse cardiovascular prognosis. Chronotropic incompetence has been described in patients with symptomatic LV dilatation and dysfunction, but the effect of asymptomatic LV dilatation and hypertrophy on ex...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(99)70415-1

    authors： Lauer MS,Larson MG,Evans JC,Levy D

    更新日期：1999-05-01 00:00:00

  • Changes in transmitral and pulmonary venous flow velocity patterns after cardioversion of atrial fibrillation.

    abstract：:To examine the recovery time of left atrial mechanical function after electrical cardioversion of atrial fibrillation, we recorded transmitral flow, pulmonary venous flow velocities, and interatrial septal motion during atrial systole within 24 hours (16 +/- 5 hours) and 10 days after cardioversion in 25 patients with...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(96)90353-1

    authors： Iuchi A,Oki T,Fukuda N,Tabata T,Manabe K,Kageji Y,Sasaki M,Hama M,Yamada H,Ito S

    更新日期：1996-02-01 00:00:00

  • Isosorbide dinitrate and exercise performance in patients with congestive heart failure.

    abstract：:Nitrates are widely used for the management of congestive heart failure (CHF), as well as angina pectoris. In both situations, nitrates significantly increase exercise capacity. The mechanism of this beneficial effect is unclear, especially in CHF. Isosorbide dinitrate reduces pulmonary capillary wedge pressure (PCWP)...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(85)90494-6

    authors： Franciosa JA

    更新日期：1985-07-01 00:00:00

  • Correlation between the signal-averaged electrocardiogram and electrophysiologic study findings in patients with coronary artery disease and sustained ventricular tachycardia.

    abstract：:Ventricular late potentials at the end of the surface QRS, detected on the signal-averaged electrocardiogram (SAECG) have been shown to be markers for spontaneous and/or inducible ventricular tachycardia (VT) in patients with coronary artery disease (CAD). We examined the correlations between electrophysiologic study ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90884-8

    authors： Borbola J,Ezri MD,Denes P

    更新日期：1988-04-01 00:00:00

  • Blood pressure control and hormone replacement therapy in postmenopausal women at risk for coronary heart disease.

    abstract：BACKGROUND:Coronary heart disease (CHD) in women is strongly associated with estrogen deprivation. For example, risk for CHD increases dramatically after menopause. However, the role of hormone replacement therapy (HRT) in CHD prevention currently is unresolved. To better understand CHD in women, the precise mechanisms...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2002.121262

    authors： McCubbin JA,Helfer SG,Switzer FS 3rd,Price TM

    更新日期：2002-04-01 00:00:00

  • Trends in health care resource use and expenditures in patients with newly diagnosed paroxysmal supraventricular tachycardia in the United States.

    abstract：BACKGROUND:Few data are available on the temporal patterns of health resource utilization (HRU) and expenditures around paroxysmal supraventricular tachycardia (PSVT) diagnosis. This study assessed the longitudinal trends in HRU and expenditures in the 3 years preceding and subsequent to PSVT diagnosis. METHODS:Adult ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2020.12.012

    authors： Chew DS,Sacks NC,Emden MR,Preib MT,Cyr PL,Wood D,Pokorney SD

    更新日期：2021-01-15 00:00:00

  • Risk stratification in survivors of acute myocardial infarction: routine cardiac catheterization and angiography is a reasonable approach in most patients.

    abstract：:Noninvasive risk assessment in survivors of AMI can effectively subdivide patients into groups with differing risk profiles after hospital discharge, but some patients at risk for late death or recurrent AMI may be incorrectly identified; data from cardiac catheterization and angiography provide complementary and gene...

    journal_title：American heart journal

    pub_type： 社论

    doi：10.1016/0002-8703(91)90747-6

    authors： Kulick DL,Rahimtoola SH

    更新日期：1991-02-01 00:00:00

  • Comparison of 3- versus 6-minute infusions of adenosine in thallium-201 myocardial perfusion imaging.

    abstract：:Adenosine thallium stress testing has a demonstrated utility in the detection of coronary artery disease. The optimal dose for diagnostic efficacy with minimal side effects has not been critically evaluated. A randomized 3- and 6-minute infusion of adenosine (140 micrograms/kg/min) was performed in 11 subjects. Subjec...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-8703(07)80015-9

    authors： Villegas BJ,Hendel RC,Dahlberg ST,McSherry BA,Leppo JA

    更新日期：1993-07-01 00:00:00

  • Myocardial contractile reserve predicts improvement in left ventricular function after cardiac resynchronization therapy.

    abstract：BACKGROUND:Myocardial contractile reserve has been shown to provide important prognostic information in patients with heart failure. We hypothesized that myocardial contractile reserve would predict left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). METHODS:Thirty-one consecutive p...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2007.07.035

    authors： Ypenburg C,Sieders A,Bleeker GB,Holman ER,van der Wall EE,Schalij MJ,Bax JJ

    更新日期：2007-12-01 00:00:00

  • Weight change after myocardial infarction--the Enhancing Recovery in Coronary Heart Disease patients (ENRICHD) experience.

    abstract：BACKGROUND:The relationship of changes in weight to outcomes in patients after myocardial infarction (MI) is controversial. METHODS:From the ENRICHD trial data, we assessed weight change, and the associations of baseline weight and change at follow-up with outcomes and interactions between psychosocial factors. RESUL...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2007.10.026

    authors： Lopez-Jimenez F,Wu CO,Tian X,O'Connor C,Rich MW,Burg MM,Sheps D,Raczynski J,Somers VK,Jaffe AS

    更新日期：2008-03-01 00:00:00

  • Correlates of resting and maximal exercise systolic blood pressure after repair of coarctation of the aorta: a multivariable analysis.

    abstract：:Repair of coarctation of the aorta may not prevent the subsequent development of elevated systemic blood pressure at rest or with exercise. The correlates of late postoperative resting systolic blood pressure and maximal exercise systolic blood pressure levels were investigated in a retrospective study of 42 patients ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90277-8

    authors： Daniels SR,James FW,Loggie JM,Kaplan S

    更新日期：1987-02-01 00:00:00

  • Comparison of transradial and femoral approaches for percutaneous coronary interventions: a systematic review and hierarchical Bayesian meta-analysis.

    abstract：BACKGROUND:Despite lower risks of access site-related complications with transradial approach (TRA), its clinical benefit for percutaneous coronary intervention (PCI) is uncertain. We conducted a systematic review and meta-analysis of clinical studies comparing TRA and transfemoral approach (TFA) for PCI. METHODS:Rand...

    journal_title：American heart journal

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ahj.2012.01.015

    authors： Bertrand OF,Bélisle P,Joyal D,Costerousse O,Rao SV,Jolly SS,Meerkin D,Joseph L

    更新日期：2012-04-01 00:00:00

  • Left ventricular outflow obstruction resulting from insertion of mitral prostheses leaving the native leaflets intact: adverse clinical outcome in seven patients.

    abstract：:Left ventricular (LV) outflow obstruction may result from retaining the anterior mitral leaflet when a mitral prosthesis is inserted in the mitral anulus. We retrospectively reviewed the echocardiograms (two-dimensional Doppler and Doppler color flow imaging, or transesophageal with color flow imaging) obtained in sev...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(91)91005-8

    authors： Waggoner AD,Pérez JE,Barzilai B,Rosenbloom M,Eaton MH,Cox JL

    更新日期：1991-08-01 00:00:00

  • The role of niacin in raising high-density lipoprotein cholesterol to reduce cardiovascular events in patients with atherosclerotic cardiovascular disease and optimally treated low-density lipoprotein cholesterol Rationale and study design. The Atherothro

    abstract：BACKGROUND:The aim of this study was to test the hypothesis that patients with atherosclerotic cardiovascular (CV) disease optimally treated on a statin but with residual atherogenic dyslipidemia (low high-density lipoprotein cholesterol [HDL-C] and high triglycerides) will benefit from addition of niacin with fewer CV...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2010.11.017

    authors： AIM-HIGH Investigators.

    更新日期：2011-03-01 00:00:00

  • Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications.

    abstract：:Fingolimod, a sphingosine-1-phosphate receptor (S1PR) modulator, was the first oral disease-modifying therapy approved for relapsing forms of multiple sclerosis; it reduces autoreactive lymphocytes' egress from lymphoid tissues by down-regulating S1PRs. Sphingosine-1-phosphate signaling is implicated in a range of phy...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2014.06.028

    authors： Camm J,Hla T,Bakshi R,Brinkmann V

    更新日期：2014-11-01 00:00:00

  • Noninvasive prediction of residual blood flow within the risk area during acute myocardial infarction: a multicenter validation study of patients undergoing direct coronary angioplasty.

    abstract：BACKGROUND:In a previous study from a single center, radionuclide measures of collateral flow with technetium 99m sestamibi have been shown to be significantly associated with angiographic residual (antegrade and collateral) flow and independent predictors of final infarct size in acute myocardial infarction. This stud...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0002-8703(97)70046-2

    authors： Chareonthaitawee P,Christian TF,O'Connor MK,Berger PB,Higano ST,O'Keefe JH,Spain MG,Grines CL,Gibbons RJ

    更新日期：1997-10-01 00:00:00

  • Abrupt vessel closure: changing importance, management, and consequences.

    abstract：:Percutaneous coronary interventions have been performed for 20 years. Despite the success and progress of these interventions, abrupt vessel closure has been a dramatic adverse event of coronary interventions. Closure has frequently led to the major complications of death, myocardial infarction, and emergency coronary...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/s0002-8703(97)70069-3

    authors： Bergelson BA,Fishman RF,Tommaso CL

    更新日期：1997-09-01 00:00:00

  • Home monitoring with IT-supported specialist management versus home monitoring alone in patients with heart failure: Design and baseline results of the SUPPORT-HF 2 randomized trial.

    abstract：OBJECTIVES:SUPPORT-HF 2 tests the hypothesis that home monitoring with information technology-supported specialist management is more effective in optimizing medical therapy than is home monitoring alone for patients with heart failure. METHODS AND RESULTS:The study was designed as a 2-armed partially blinded parallel...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2018.09.007

    authors： SUPPORT-HF 2 Investigators and Committees. Electronic address: kazem.rahimi@georgeinstitute.ox.ac.uk.

    更新日期：2019-02-01 00:00:00

  • Apixaban compared with parenteral heparin and/or vitamin K antagonist in patients with nonvalvular atrial fibrillation undergoing cardioversion: Rationale and design of the EMANATE trial.

    abstract：BACKGROUND:Stroke prevention in anticoagulation-naïve patients with atrial fibrillation undergoing cardioversion has not been systematically studied. OBJECTIVE:To determine outcomes in anticoagulation-naïve patients (defined as those receiving an anticoagulant for <48 hours during the index episode of atrial fibrillat...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2016.06.008

    authors： Ezekowitz MD,Pollack CV,Sanders P,Halperin JL,Spahr J,Cater N,Petkun W,Breazna A,Kirchhof P,Oldgren J

    更新日期：2016-09-01 00:00:00

  • The triglyceride-high-density lipoprotein axis: an important target of therapy?

    abstract：:Coronary heart disease is the single largest cause of morbidity and mortality in the United States. The link between elevated low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) has been clearly established. However, triglycerides (TG) are increasingly believed to be independently assoc...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/j.ahj.2004.03.037

    authors： Szapary PO,Rader DJ

    更新日期：2004-08-01 00:00:00

  • Relationships among clinic, home, and ambulatory blood pressures with small vessel disease of the brain and functional status in older people with hypertension.

    abstract：BACKGROUND:Subcortical small vessel disease, represented as white matter hyperintensity (WMH) on magnetic resonance images (MRI) is associated with functional decline in older people with hypertension. We evaluated the relationships of clinic and out-of-office blood pressures (BP) with WMH and functional status in olde...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ahj.2018.08.002

    authors： White WB,Jalil F,Wakefield DB,Kaplan RF,Bohannon RW,Hall CB,Moscufo N,Fellows D,Guttmann CRG,Wolfson L

    更新日期：2018-11-01 00:00:00

  • The incidence of cardiac events in Japanese men with atypical or nonanginal chest pain: a prospective study on the significance of exercise testing.

    abstract：:The incidence of cardiac events in Japanese men (mean age 54 +/- 10 years) with atypical or nonanginal chest pain was assessed prospectively. Three groups of patients, those with typical angina (TA; n = 134), those with atypical angina (AA; n = 192), and those with nonanginal chest pain (NA; n = 311) were studied with...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(92)90802-3

    authors： Sato I,Nishijima H,Matsumura N,Nishida M,Okita K,Yasuda H

    更新日期：1992-06-01 00:00:00

  • Acute and chronic effects of amiodarone on delayed afterdepolarization and triggered automaticity in rabbit ventricular myocardium.

    abstract：:The effects of amiodarone on delayed afterdepolarization (DAD) and triggered automaticity induced by low potassium (0.5 mEq/L) were evaluated on isolated rabbit right ventricular muscles, by means of standard microelectrode techniques. Triggered automaticity was induced in 6 of 10 muscles in the control group, in four...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90267-5

    authors： Ohta M,Karagueuzian HS,Mandel WJ,Peter T

    更新日期：1987-02-01 00:00:00

  • Magnesium and potassium therapy in multifocal atrial tachycardia.

    abstract：:Eight patients with multifocal atrial tachycardia received 7 to 12 gm of magnesium sulfate intravenously over a 5-hour period. Potassium supplements were given initially or added later. Initial arterial blood gases showed mean pH 7.48 +/- 0.03, PcO2 39.7 torr, PO2 72 torr, HCO-3 29.8 +/- 4.5 mEq/L, and base excess 6.8...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90458-2

    authors： Iseri LT,Fairshter RD,Hardemann JL,Brodsky MA

    更新日期：1985-10-01 00:00:00

  • Selection criteria for placement of left ventricular assist devices.

    abstract：:The 2,000 heart donors available annually continue to be inadequate for the 50,000 patients with end-stage congestive heart failure who require heart transplantation to survive. This discrepancy has led to the successful use of long-term implantable LVADs as a bridge to transplantation and has raised the issue of perm...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(95)90056-x

    authors： Oz MC,Rose EA,Levin HR

    更新日期：1995-01-01 00:00:00

  • EMERGEncy versus delayed coronary angiogram in survivors of out-of-hospital cardiac arrest with no obvious non-cardiac cause of arrest: Design of the EMERGE trial.

    abstract：BACKGROUND:In adults, the most common cause of out-of-hospital cardiac arrests (OHCA) is acute coronary artery occlusion. If an immediate coronary angiogram (CAG) is recommended for survivors presenting a ST segment elevation on the electrocardiogram (ECG) performed after resuscitation, there is still a debate regardin...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2020.01.006

    authors： Hauw-Berlemont C,Lamhaut L,Diehl JL,Andreotti C,Varenne O,Leroux P,Lascarrou JB,Guerin P,Loeb T,Roupie E,Daubin C,Beygui F,Vilfaillot A,Glippa S,Djadi-Prat J,Chatellier G,Cariou A,Spaulding C,EMERGE investigators.

    更新日期：2020-04-01 00:00:00

  • Cardiologists' discussions about sexuality with patients with chronic coronary artery disease.

    abstract：BACKGROUND:Sexuality is an important factor influencing quality of life that may be altered for patients with coronary disease. Little is known about the extent to which patients want their cardiologists to counsel them about sexuality. PURPOSE:Our study evaluated the extent to which patients with known coronary disea...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2002.124053

    authors： Bedell SE,Duperval M,Goldberg R

    更新日期：2002-08-01 00:00:00