Abstract:
BACKGROUND:The relationship of changes in weight to outcomes in patients after myocardial infarction (MI) is controversial. METHODS:From the ENRICHD trial data, we assessed weight change, and the associations of baseline weight and change at follow-up with outcomes and interactions between psychosocial factors. RESULTS:At baseline, 73.6% of patients (n = 1706) were overweight or obese; 134 patients had body mass index of > or = 40. Underweight patients were more likely to die or have nonfatal recurrent MI. After controlling for covariates, overweight and obese patients had similar outcomes to normal-weight patients. Eighteen percent of patients gained > 5%, 27% lost > 5%, and 55% had < or = 5% change in weight. Compared with weight loss of < or = 5%, the risk of death (adjusted hazard ratio 1.74, P = .01) and cardiovascular death (hazard ratio 1.79, P = .04) increased with weight loss of > 5%. After propensity matching, weight loss of > 5% remained as a significant risk factor for death and cardiovascular death. There was no interaction between weight change and depression and/or social support at baseline or follow-up. Weight change was not associated with recurrent MI or cardiovascular hospitalizations. CONCLUSIONS:A large proportion of patients lose or gain > 5% of body weight after an MI. The association between obesity and lower mortality is modulated by comorbidities. Weight loss after MI is associated with worse outcomes and is not related to depression or social support.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Lopez-Jimenez F,Wu CO,Tian X,O'Connor C,Rich MW,Burg MM,Sheps D,Raczynski J,Somers VK,Jaffe ASdoi
10.1016/j.ahj.2007.10.026subject
Has Abstractpub_date
2008-03-01 00:00:00pages
478-84issue
3eissn
0002-8703issn
1097-6744pii
S0002-8703(07)00859-9journal_volume
155pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Current practice related to the management of atrial fibrillation (AF) complicating coronary artery bypass grafting (CABG) is uncertain. METHODS:We examined management of post-CABG AF in the PREVENT-IV trial, and we explored patterns of use of postoperative rhythm versus rate control and anticoagulation for...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
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更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:Racial differences in cardiovascular mortality among women remain largely unexplained. Preliminary data suggest that African American and Caucasian differences in endothelial function may parallel differential cardiovascular disease (CVD) risk in women. To further study differences in endothelial function bet...
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2003-06-01 00:00:00
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更新日期:1985-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-09-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-05-01 00:00:00