Abstract:
:The antihypertensive efficacy, safety, and lipid effects of doxazosin, a selective alpha 1-inhibitor, were assessed in a general practice setting. Three hundred twenty-six patients were entered into the study, which involved three phases: (1) a 2-week baseline period, (2) an 8-week period in which patients received 1 to 8 mg of doxazosin once daily, and (3) a 4-week maintenance period. After 12 weeks, 78.8% of efficacy-evaluable patients were considered therapy successes (sitting diastolic blood pressure either less than or equal to 90 mm Hg with greater than or equal to 5 mm Hg reduction from baseline or greater than or equal to 10 mm Hg reduction from baseline). The mean daily dose in patients considered a therapy success was 2.8 mg. By the final visit, sitting systolic/diastolic blood pressures of these patients were reduced by 16.4/13.5 mm Hg from a mean baseline of 170/106 mm Hg. The investigators' global assessment of efficacy of once-daily doxazosin therapy was excellent or good for 70% of patients. Of the 326 patients, 30.7% reported a total of 160 side effects; 78% of the side effects were mild or moderate in severity, and 24 patients (7.4%) discontinued treatment because of adverse experiences. The investigators' global assessment of toleration was excellent or good for 87% of patients. Doxazosin produced a significant decrease in total cholesterol (p = 0.02) and triglyceride (p less than 0.001) levels. From baseline to final visit there was also a highly significant reduction of 17% (p less than 0.001) in calculated risk score for coronary heart disease on the basis of the Framingham Heart Study risk equation.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Naber FBdoi
10.1016/0002-8703(91)90857-esubject
Has Abstractpub_date
1991-01-01 00:00:00pages
273-9issue
1 Pt 2eissn
0002-8703issn
1097-6744pii
0002-8703(91)90857-Ejournal_volume
121pub_type
临床试验,杂志文章abstract:BACKGROUND:Most analyses of complications after percutaneous coronary intervention have been limited to angiographic predictors of abrupt closure. We sought to determine the relation between baseline clinical and angiographic characteristics and clinical ischemic events and whether treatment with the platelet glycoprot...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/hj.1999.v137.92521
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Despite the known benefits of cardiac rehabilitation in patients with coronary artery disease, referral rates to rehabilitation programs remain low. We determined the incidence and determinants of cardiac rehabilitation referral rates for patients undergoing percutaneous coronary intervention (PCI). METHODS...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2010.11.016
更新日期:2011-03-01 00:00:00
abstract::Left ventricular (LV) adaptation to the hemodynamic load of pregnancy has been studied with load-sensitive ejection-phase indexes, but the results of these studies are conflicting. The aim of this study was to examine the effects of the hemodynamic load of pregnancy on the contractile state of the left ventricle by us...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(97)70247-3
更新日期:1997-01-01 00:00:00
abstract::African Americans have the highest overall coronary heart disease (CHD) mortality rate of any ethnic group in the United States. They also exhibit a greater prevalence of a number of individual CHD risk factors, especially hypertension and type 2 diabetes mellitus (a CHD risk equivalent) and greater clustering of risk...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/j.ahj.2003.12.011
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Transcatheter foramen ovale closure (TPC) has emerged as a potential treatment option for patients with cryptogenic strokes and persistent foramen ovale (PFO). However, previous randomized controlled trials could hardly demonstrate any benefit compared to medical treatment (Med-Tx). Recently new data have be...
journal_title:American heart journal
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ahj.2018.03.025
更新日期:2018-07-01 00:00:00
abstract::Terazosin is a new, long-acting, selective, postsynaptic alpha 1-adrenergic receptor antagonist with a chemical structure similar to that of prazosin. In this article the pharmacokinetics of terazosin are reviewed, and the incidence of adverse events in a dose-response study and a meta-analysis of 20 placebo-controlle...
journal_title:American heart journal
pub_type: 杂志文章,meta分析
doi:10.1016/0002-8703(91)90809-v
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:To evaluate the impact of adjunctive high-dose glucose-insulin-potassium (GIK) on ST-segment elevation resolution in patients with ST-segment elevation myocardial infarction (MI). METHODS:As part of a randomized controlled trial of GIK versus no GIK in patients treated with primary percutaneous coronary int...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2005.03.023
更新日期:2005-06-01 00:00:00
abstract::To evaluate the therapeutic efficacy of oral angiotensin-converting inhibition (ACE) with captopril in chronic normotensive congestive heart failure (CHF), acute and cardiocirculatory actions were determined by cardiac catheterization and forearm plethysmography, and ambulatory effects were assessed by echocardiograph...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(81)90379-3
更新日期:1981-01-01 00:00:00
abstract::The acute effects of diltiazem on coronary reactive hyperemia were studied in 12 patients with flow-limiting coronary stenosis. Reactive hyperemia was elicited by injection of 8 ml contrast medium into the left coronary artery, while coronary sinus blood flow and left ventricular and aortic pressures were continuously...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(86)90353-4
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Health care utilization patterns and associated costs of congenital heart disease (CHD) in young adulthood are not well understood. METHODS:California State Inpatient Databases 2005 to 2009 were used to conduct a retrospective study on inpatient admissions of CHD patients 10 to 29 years old (n = 7,419) and ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2014.08.006
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The optimal antibiotic treatment length for infective endocarditis (IE) is uncertain. International guidelines recommend treatment duration of up to 6 weeks for patients with left-sided IE but are primarily based on historical data and expert opinion. Efficacies of modern therapies, fast recovery seen in man...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2020.05.012
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation remains a frequent complication after heart surgery. The optimal strategy to treat the condition has not been established. Several retrospective studies have suggested that a primary rate-control strategy may be equivalent to a strategy that restores sinus rhythm. METHODS:Fifty patients ...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1067/mhj.2000.111104
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Although the prognostic power of heart rate variability (HRV) at rest has been demonstrated, the prognostic potential of exercise-induced HRV has not been investigated. We aimed to evaluate the prognostic power of exercise-induced HRV during and after standard exercise testing. METHODS:Time- and frequency-d...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2006.11.001
更新日期:2007-02-01 00:00:00
abstract::In a demographic study, the black Ohio residents were characterized by those born in Ohio and those born in other regions of the United States, and comparisons were made of rates for all deaths (1960-1967) for coronary heart disease (420), endocarditis and myocardial degeneration (421-422), hypertensive cardiovascular...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(75)90329-4
更新日期:1975-09-01 00:00:00
abstract::A new integrated method for quantitating temporal and spatial systolic wall motion heterogeneity was developed and applied in 15 normal subjects and 26 patients with previous myocardial infarction (MI). After frame by frame digitizing, right anterior oblique left cineventriculograms (LV) were analyzed with 90 spaced r...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(86)90465-5
更新日期:1986-10-01 00:00:00
abstract::We studied the prevalence and clinical significance of transient U wave inversion in 43 patients with variant angina. Twenty-four patients (group A) had ST segment elevation in the anterolateral and 19 patients (group B) had this finding in the inferoposterior leads of the ECG during spontaneous angina. In none of the...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(84)90452-6
更新日期:1984-10-01 00:00:00
abstract::sulfoconjugated dopamine constitutes the major portion of circulating or excreted dopamine, but its physiologic significance is still unknown. To test whether conjugated dopamine serves as a source of free dopamine in response to acute stress, plasma concentrations of free and conjugated dopamine were measured during ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(94)90671-8
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Surgical ventricular restoration (SVR) is an operation that demonstrates promise to improve outcomes for patients with left ventricular dysfunction. Current use and operative outcomes of SVR have come from centers of expertise, and operative risks of SVR in community practice are unknown. We sought to charac...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2006.01.016
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Protease inhibitors (PIs) may be associated with accelerated atherosclerosis in individuals infected with human immunodeficiency virus (HIV). We assessed the effects of HIV PIs on subclinical atherosclerosis. METHODS:The lipid profiles, C-reactive protein (CRP) levels, coronary artery calcification (CAC) sc...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2002.125009
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Galectin-3, a β-galactoside binding lectin involved in important regulatory roles in adhesion, inflammation, immunity, and fibrosis, may be relevant to atrial fibrillation (AF) etiology. METHODS:We included 8,436 participants free of AF at baseline (1996-1998) and with measures of plasma galectin-3 from the...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2017.07.001
更新日期:2017-10-01 00:00:00
abstract::Results of recent studies have suggested that routine cardiac catheterization may be unnecessary after reperfusion therapy for acute myocardial infarction. Therefore to better define the short-term prognostic value of early coronary angiography, and specifically the prognostic significance of multivessel coronary arte...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/0002-8703(91)90661-z
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Acute myocardial infarction (AMI) is a leading cause of mortality in Asia. However, quantitative risk scores to predict mortality after AMI were developed without the participation of Asian countries. METHODS:We evaluated the performance of the Global Registry of Acute Coronary Events (GRACE) in-hospital mo...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2011.05.016
更新日期:2011-08-01 00:00:00
abstract::The purpose of this study were to determine the specificity of the head-up tilt test in normal subjects when a graded isoproterenol infusion is used, and to evaluate the role of dynamic ventricular volume change during head-up tilt as a mechanism of syncope. We prospectively studied 12 normal volunteers, each of whom ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(94)90016-7
更新日期:1994-07-01 00:00:00
abstract::Thallium-201 redistribution pattern after exercise was related to rest and exercise left ventricular regional and global function, measured by radionuclide ventriculography, in 61 patients, 50 with coronary artery disease (CAD). Sixteen patients had exclusively transient thallium defects, suggesting ischemia: in this ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(81)90608-6
更新日期:1981-06-01 00:00:00
abstract::Calcium channel blockers and central alpha-agonists are among the classes of antihypertensive drugs that yield the most favorable overall effects on risk factors for hypertension-related end-organ damage. An open-label prospective trial in 42 patients with a mean baseline blood pressure of 144/102 mm Hg sought to asse...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/0002-8703(93)90707-g
更新日期:1993-10-01 00:00:00
abstract::To understand the process of atherosclerosis, the homeostatic and protective functions of the endothelium must be considered. The endothelium serves as the interface between blood flow and the vascular tissues. It normally regulates vascular tone and structure through the release of vasoactive substances and maintenan...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/0002-8703(94)90251-8
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Case fatality rates after acute myocardial infarction (MI) have decreased markedly over the last 3 decades. Some subgroups may have benefited more than others, but this hypothesis has not been evaluated in a large nationally representative cohort. Accordingly, we sought to assess long-term temporal trends in...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2008.04.009
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Quality improvement programs have shown increased use of beta-blockers post-myocardial infarction (MI), but there are no data on whether appropriate doses are administered. METHODS:In a prospective registry that enrolled consecutive patients with MI, we evaluated beta-blocker dosing at discharge after MI an...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2010.06.023
更新日期:2010-09-01 00:00:00
abstract::The aim of this study was to examine the effect of ventricular fibrillation and a subsequent defibrillation shock on ventricular excitability and refractoriness in human beings. We studied 16 consecutive patients with implantable cardioverter-defibrillators undergoing follow-up studies. The pre- and post-shock pacing ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(96)90086-1
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:The effect of age on diagnostic and prognostic performance of high-sensitivity cardiac troponin T (hs-cTnT) has not been addressed adequately, so far. METHODS:High-sensitivity cardiac troponin T was measured serially in patients with acute symptoms presenting to our emergency department. We tested the diagn...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2012.08.003
更新日期:2012-11-01 00:00:00