Abstract：
:The purpose of this study were to determine the specificity of the head-up tilt test in normal subjects when a graded isoproterenol infusion is used, and to evaluate the role of dynamic ventricular volume change during head-up tilt as a mechanism of syncope. We prospectively studied 12 normal volunteers, each of whom underwent an upright tilt test for 10 minutes at 80 degrees with and without an infusion of isoproterenol. A subgroup of five subjects had a third tilt test during administration of a combination of esmolol and isoproterenol. Blood pressure, heart rate, and left ventricular volumes and flow (obtained with Doppler echocardiography) were recorded in the following sequence: while supine, during upright tilt, while supine with isoproterenol, and during upright tilt with isoproterenol. During the initial head-up tilt, one subject had syncope. An additional eight subjects had presyncope or syncope during head-up tilt with isoproterenol. The remaining three subjects were asymptomatic. In subjects with syncope or near-syncope ("responders"), heart rate increased with isoproterenol but decreased markedly, to 76 +/- 5 beats/min, by the end of the protocol. Systolic blood pressure rose slightly above baseline during isoproterenol but fell from 118 +/- 4 to 85 +/- 5 mm Hg during head-up tilt with isoproterenol. The three asymptomatic subjects had only one significant change, an increase in heart rate with isoproterenol. In the five responders undergoing three tilt tests, left ventricular volume decreased significantly at end diastole (94 +/- 25 vs 58 +/- 22 ml) and end systole (34 +/- 13 vs 18 +/- 6 ml) when supine baseline is compared with initial upright tilt.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Am Heart Jjournal_title
American heart journalauthors
Nwosu EA,Rahko PS,Hanson P,Grogan EW Jrdoi
10.1016/0002-8703(94)90016-7subject
Has Abstractpub_date
1994-07-01 00:00:00pages
106-13issue
1eissn
0002-8703issn
1097-6744pii
0002-8703(94)90016-7journal_volume
128pub_type
杂志文章abstract：:This study attempted to define the role of endothelin (ET) in preconditioning. We previously showed that ET Is produced during myocardial ischemia and reperfusion. Because both preconditioning and ET act through protein kinase C, ET could play a role in preconditioning. Dogs were randomized to three groups subjected t...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(96)90394-4
更新日期：1996-07-01 00:00:00
abstract：:An acute thrombus at the proximal border of a high-grade atherosclerotic obstruction is the usual cause of myocardial infarction. Although intracoronary thrombolysis is potentially an exciting new therapy for reducing the extent of myocardial infarction by lysing coronary clot, a number of major difficulties limit its...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/0002-8703(82)90267-8
更新日期：1982-10-01 00:00:00
abstract：:This case report presents a young adult with asymmetric septal hypertrophy (ASH) and syncope. Infranodal complete heart block was demonstrated as his cause for syncope. Therapy consisted of implantation of a A-V sequential pacemaker. Cardiac output determinations and systolic time intervals demonstrated the beneficial...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(77)80177-4
更新日期：1977-01-01 00:00:00
abstract：BACKGROUND:In the United States, there continues to be debate about whether certain types of hospitals deliver improved patient outcomes. We sought to assess the association between hospital organizational characteristics and in-hospital outcomes for percutaneous coronary intervention (PCI). METHODS:Retrospective anal...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ahj.2011.10.010
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Comparing the dose-response of a new drug to that of a previously studied drug can aid in understanding their relative potencies. Two dose-finding studies addressed the effect of a new drug, rosuvastatin, on its ability to decrease low-density lipoprotein cholesterol (LDL-C) levels. One of these studies incl...
journal_title：American heart journal
pub_type： 杂志文章,meta分析,评审
doi：10.1016/S0002-8703(03)00106-6
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:The prevalence of acute myocardial infarction (AMI) has increased due to the recent definitions, but the magnitude of this effect using contemporary highly sensitive troponin assays is unclear. The objective of this study is to compare the diagnosis of AMI using a contemporary troponin I (cTnI) biomarker and...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2005.09.022
更新日期：2006-07-01 00:00:00
abstract：:The prognostic significance of functional status has not been previously studied in the setting of acute myocardial infarction. We assessed the Karnofsky Performance Status (KPS) score, a simple functional status scale that is commonly used to categorize physical ability, in 849 patients with acute myocardial infarcti...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/0002-8703(91)90141-4
更新日期：1991-05-01 00:00:00
abstract：BACKGROUND:Little is known about the management of elderly patients with congestive heart failure (CHF) although they represent the majority of the CHF population. Therefore, the TIME-CHF study was set up (1) to evaluate the medical management of very old patients (> or = 75 years) with CHF compared with younger patien...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ahj.2005.10.022
更新日期：2006-05-01 00:00:00
abstract：:Positive deviance studies combining qualitative and quantitative designs-a mixed-methods approach-can discover strategies to produce exemplary performance. We present the SAMI study, a national positive deviance study to discover hospital strategies associated with lower 30-day hospital risk-standardized mortality rat...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2011.09.004
更新日期：2011-12-01 00:00:00
abstract：:Current antitachycardia systems are incapable of adequately distinguishing stable from unstable tachycardias. Previously, integration of a pressure sensor or an impedance sensor, together with electrogram analysis, has been investigated as an improved method of identifying unstable arrhythmias. A mixed venous oxygen s...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(91)90519-n
更新日期：1991-09-01 00:00:00
abstract：:A new radiopaque, highly flexible balloon-expandable tantalum stent was tested. Thirty-six of 40 stents were successfully deployed percutaneously in the coronary arteries of 31 dogs. The dogs were given aspirin before, intravenous heparin during, and aspirin alone after the procedure. One dog died at 24 hours because ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(92)90992-5
更新日期：1992-10-01 00:00:00
abstract：:Several autoimmune diseases have been associated with increased frequencies of specific histocompatibility (HLA) antigens, particularly for the D (DR) locus, that may be linked to immune response genes. Rheumatic valvular heart disease (RHD) has been postulated to have autoimmune features, but HLA associations have no...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(86)90311-x
更新日期：1986-11-01 00:00:00
abstract：:Results of recent studies have suggested that routine cardiac catheterization may be unnecessary after reperfusion therapy for acute myocardial infarction. Therefore to better define the short-term prognostic value of early coronary angiography, and specifically the prognostic significance of multivessel coronary arte...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0002-8703(91)90661-z
更新日期：1991-04-01 00:00:00
abstract：OBJECTIVES:The study aimed to analyze the use of intensive lipid-lowering therapy (I-LLT) at discharge in a broad population of patients hospitalized with acute coronary syndrome (ACS). BACKGROUND:Early and intensive statin therapy in ACS has been shown to reduce cardiovascular morbidity and mortality. Utilization and...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ahj.2010.12.014
更新日期：2011-02-01 00:00:00
abstract：:It is often difficult to make the clinical distinction between acute mitral regurgitation caused by papillary muscle dysfunction or rupture and ventricular septal defect complicating an acute myocardial infarction. A case of a patient with rapidly progressive congestive heart failure and a loud murmur is presented. Ec...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/0002-8703(79)90291-6
更新日期：1979-11-01 00:00:00
abstract：:A new shape-memory coil for transcatheter closure of the PDA was developed and evaluated in a dog PDA model. The coil is sensitive to temperature (composed of thermal shape-memory nickel-titanium). The coil was delivered to and implanted in the PDA model with a 5F catheter through the femoral artery. The PDA model was...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(96)90189-1
更新日期：1996-05-01 00:00:00
abstract：:The resonant frequencies of five commonly used fluid-filled catheters connected to a solidstate microdisplacement pressure gauge were 18 to 33 per cent higher than those obtained with a conventional manometer. Four catheters had a flat amplitude response to 26 Hz. or more at the 20 per cent amplitude distortion level...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(75)90508-6
更新日期：1975-05-01 00:00:00
abstract：:The pharmacokinetic properties and hemodynamic effect of molsidomine and its pharmacologically active metabolite SIN-1 were investigated in 13 healthy volunteers following single oral doses. Hemodynamic changes were measured by finger plethysmography (peripheral arterial resistance), impedance plethysmography (venous ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(85)90671-4
更新日期：1985-03-01 00:00:00
abstract：BACKGROUND:Pregnancy is increasingly common in women with congenital heart disease (CHD), but little is known about long-term cardiovascular outcome after pregnancy in these patients. We studied the incidence of cardiovascular events 1-year postpartum and compared cardiac function prepregnancy and 1-year postpartum in ...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ahj.2014.11.010
更新日期：2015-02-01 00:00:00
abstract：:High degree AV block occurred in 144 of 843 patients consecutively admitted because of acute inferior myocardial infarction and was associated with more extensive myocardial damage and a higher mortality rate, as compared to those without AV block. Patients with power failure at the time of appearance of high degree A...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(80)90308-7
更新日期：1980-01-01 00:00:00
abstract：:Meta-analyses of major outcome trials have demonstrated that the benefits of antihypertensive treatment for reduction of the incidence of stroke are entirely consistent with the benefits predicted from epidemiologic data; however, there remains a shortfall in the expected reduction of the incidence of coronary heart d...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：
更新日期：1996-07-01 00:00:00
abstract：:Transthoracic echocardiography has played a useful role in the screening of cardiac transplant donors. However, transthoracic echocardiograms may be suboptimal in many patients on ventilators. The role of transesophageal echocardiography in cardiac donor screening is unknown. Therefore we compared the potential benefi...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(93)90758-2
更新日期：1993-06-01 00:00:00
abstract：:High levels of endogenous plasma catecholamines in patients with severe congestive heart failure induce a down-regulation of the myocardial beta-adrenoreceptors and thus cause adrenoreceptor agonists, such as dobutamine, to be less effective in the treatment of these patients. Phosphodiesterase III inhibitors work ind...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/0002-8703(91)90834-5
更新日期：1991-06-01 00:00:00
abstract：:Atherosclerotic coronary artery disease is a serious clinical problem. Clinicians dealing with patients can make a diagnosis of coronary disease in several ways. Unfortunately all too often the diagnosis is made via sudden death or acute myocardial infarction. At other times the diagnosis is made by evaluation of pati...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/0002-8703(92)91039-4
更新日期：1992-05-01 00:00:00
abstract：:The results of percutaneous transseptal balloon mitral valvuloplasty (PTBMV) in 30 Chinese patients with rheumatic mitral stenosis are reported. PTBMV with the Inoue balloon catheter was successfully performed in 27 patients without any significant complications. The mean left atrial pressure decreased from 20.15 +/- ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(88)90061-0
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND:Controversy remains regarding whether gender differences exist in clinical management after exercise treadmill testing (ETT). METHODS:We studied 7,506 patients (49.8% women) without documented coronary heart disease referred for ETT from July 2001 to June 2004 in a community-based setting. We assessed the r...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2008.03.022
更新日期：2008-08-01 00:00:00
abstract：:To determine how early myocardial infarction can be detected, serial creatine kinase MB concentrations were sampled in 313 patients during triage of acute (less than 12 hours) chest pain. Serum was sampled on hospital arrival (baseline) and hourly for 3 hours (total of four samples). Creatine kinase MB concentrations ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(92)90646-d
更新日期：1992-02-01 00:00:00
abstract：:The effects and possible mechanisms of actions of indomethacin on systemic and coronary hemodynamics were studied in 17 patients with coronary artery disease. Group I patients (12) were given either indomethacin or placebo in the absence of prior cyclooxygenase inhibition and group II (five) were given indomethacin af...
journal_title：American heart journal
pub_type： 临床试验,杂志文章
doi：10.1016/0002-8703(85)90149-8
更新日期：1985-08-01 00:00:00
abstract：:The purpose of this study was to determine whether myocardium salvaged by reperfusion following coronary occlusion could respond to inotropic stimulation by dopamine. Mongrel dogs underwent a 2-hour occlusion of the proximal left anterior descending coronary artery, followed by reperfusion for 5 or 28 hours. Dopamine ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(84)90126-1
更新日期：1984-01-01 00:00:00
abstract：:We investigated the incidence and mechanism of pulmonary artery hypertension (PAH) in a consecutive series of patients with aortic stenosis who were undergoing diagnostic cardiac catheterization. Forty-five patients with severe aortic stenosis were divided into two groups: group 1 comprised 13 patients (29%) with PAH ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(93)90067-j
更新日期：1993-01-01 00:00:00
