当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events.

Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events.

Abstract：

BACKGROUND:The prodrug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding enzymes for clopidogrel activation are polymorphic, leading to reduced or increased function, depending on the respective genotype. Reduced-function alleles have been associated with an increase in cardiovascular events. METHODS:We tested the association of the presence of the ABCB1 (C/T) T-allele, CYP2C19*2 (G/A) A-allele, or CYP2C19*17 (C/T) T-allele with the primary end point of the need of clinically-driven target lesion revascularization (TLR) and the secondary end points of major adverse cardiovascular events (MACE; including death, myocardial infarction [MI], and TLR) at 1 year in a high-risk population of 928 patients with acute MI. RESULTS:Carriers of the CYP2C19*17 T-allele, with increased clopidogrel activation, had a 37% relative reduction in the TLR incidence, the primary end point (14.0% vs 22.3%, P = .002), and a 22% relative reduction of the secondary end point MACE (22.0% vs 28.1%, P = .04) compared with noncarriers, respectively. The association of the T-allele with TLR remained significant in the multivariate analysis (P = .001). The ABCB1 (C/T) and the CYP2C19*2 (G/A) polymorphisms were not associated with the incidence of TLR or MACE. CONCLUSIONS:Based on the genetic analysis in a high-risk population of acute MI patients with interventional treatment and continuous clopidogrel therapy, our study found a protective effect for carriers of an increased-function CYP2C19*17 T-allele with significantly lower rates of TLR and MACE. T-allele carriers with acute MI and increased clopidogrel activation had significantly reduced clinical event rates.

journal_name

Am Heart J

journal_title

American heart journal

authors

Tiroch KA,Sibbing D,Koch W,Roosen-Runge T,Mehilli J,Schömig A,Kastrati A

doi

10.1016/j.ahj.2010.06.039

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

506-12

issue

3

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(10)00555-7

journal_volume

160

pub_type

杂志文章

相关文献

AMERICAN HEART JOURNAL文献大全
  • Effect of intravenous metoprolol before hospital admission on chest pain in suspected acute myocardial infarction.

    abstract：BACKGROUND:The aim of this study was to describe the effect of intravenous metoprolol on the intensity of chest pain before hospital admission in patients with suspected acute myocardial infarction AMI). METHODS AND RESULTS:Two hundred sixty-two patients with acute chest pain and suspected AMI were randomly assigned b...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-8703(99)70405-9

    authors： Gardtman M,Dellborg M,Brunnhage C,Lindkvist J,Waagstein L,Herlitz J

    更新日期：1999-05-01 00:00:00

  • Use of aspirin for prevention of cardiovascular disease--1981-82 to 1985-86: the Minnesota Heart Survey.

    abstract：:The efficacy of aspirin to prevent ischemic cardiovascular disease has received considerable attention recently. To determine the prevalence of aspirin use for cardiovascular disease prevention, the Minnesota Heart Survey examined population-based samples of Twin Cities' adults in 1981 to 82 and 1985 to 86. Over the 4...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90344-4

    authors： Folsom AR,Iso H,Sprafka JM,Edlavitch SA,Luepker RV

    更新日期：1988-09-01 00:00:00

  • Worldwide evaluation of a defibrillation lead with a small geometric electrode surface for high-impedance pacing.

    abstract：BACKGROUND:Pacing leads with a small electrode surface for high-impedance stimulation have been shown to prolong pacemaker longevity, but no sufficient data is available on the safety and feasibility of a defibrillation lead with this novel design. METHODS:We evaluated the clinical performance of a tined, steroid-elut...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/S0002-8703(03)00411-3

    authors： Vollmann D,Ahern T,Gerritse B,Canby RC,Zenker D,Binner L,Kimber SK,Unterberg C,Worldwide Medtronic Model 6944 Investigators.

    更新日期：2003-12-01 00:00:00

  • Supported angioplasty with synchronized retroperfusion in high-risk patients with left main trunk or near left main trunk obstruction.

    abstract：:To test the feasibility of synchronized retroperfusion (SRP) as a support device of percutaneous transluminal coronary angioplasty (PTCA) for high-risk patients, 10 patients with left main trunk or near left main trunk obstruction underwent PTCA with SRP. An 8.5F retroperfusion catheter was inserted from the antecubit...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(93)90004-s

    authors： Nanto S,Nishida K,Hirayama A,Mishima M,Komamura K,Masai M,Sakakibara T,Kodama K

    更新日期：1993-02-01 00:00:00

  • Existence of PAF receptors in human platelets and human lung tissue but not in the human myocardium.

    abstract：:The aim of this study was to investigate whether platelet-activating factor (PAF), PAF receptors, and PAF receptor-mediated effects in the human myocardium play a role in cardiac depression during anaphylaxis or septic shock. The effects of PAF, the biologically inactive derivative lyso-PAF, and the specific PAF antag...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(92)90593-k

    authors： Schwinger RH,Böhm M,La Rosée K,Erdmann E

    更新日期：1992-08-01 00:00:00

  • Rationale and design of a randomized controlled trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with asymptomatic left ventricular dysfunction with previous symptoms or mild heart failure--the REsynchronization reV

    abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) improves symptoms, reduces heart failure (HF)-related hospitalizations, and reverses left ventricular remodeling in some patients with moderate to severe HF and ventricular dyssynchrony defined by a prolonged QRS duration. The effects of CRT on HF outcomes in patients ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.03.002

    authors： Linde C,Gold M,Abraham WT,Daubert JC,REVERSE Study Group.

    更新日期：2006-02-01 00:00:00

  • Coronary vascular reactivity is abnormal in patients with Chagas' heart disease.

    abstract：:Symptoms of myocardial ischemia, such as chest pain (sometimes with anginal features), acute myocardial infarction, and segmental wall motion abnormalities (including left ventricular apical aneurysm), frequently occur in patients with Chagas' heart disease. Because these clinical findings occur in the presence of nor...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(95)90122-1

    authors： Torres FW,Acquatella H,Condado JA,Dinsmore R,Palacios IF

    更新日期：1995-05-01 00:00:00

  • Origin of the basal systolic murmurs in mitral stenosis. A study with intracardiac phonocardiography.

    abstract：:In order to study the origin of the basal systolic murmurs in mitral stenosis, left and right heart catheterization was performed in 18 patients with mitral stenosis using intracardiac phonocardiography. Our data revealed that the basal systolic murmurs originated in the aorta, the pulmonary artery, and the outflow tr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(78)90163-1

    authors： Kambe T,Suzuki S,Kato T,Hibi N,Fukui Y,Arakawa T,Nishimura K,Miwa A,Sakamoto N

    更新日期：1978-10-01 00:00:00

  • Obesity and survival in patients with heart failure and preserved systolic function: a U-shaped relationship.

    abstract：BACKGROUND:Studies document better survival in heart failure patients with decreased left ventricular ejection fraction (EF) and higher body mass index (BMI; kg/m(2)) compared to those with a lower BMI. However, it is unknown if this "obesity paradox" applies to heart failure patients with preserved EF or if it extends...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2009.10.026

    authors： Kapoor JR,Heidenreich PA

    更新日期：2010-01-01 00:00:00

  • Incidence, presentation, diagnosis, and management of malfunctioning implantable cardioverter-defibrillator rate-sensing leads.

    abstract：:Recognition of tachyarrhythmia by an implantable cardioverter-defibrillator (ICD) requires an intact rate-sensing lead. We retrospectively examined 266 consecutive patients requiring an ICD to characterize the incidence, clinical presentation, diagnosis, and management of a defective rate-sensing lead. To identify cli...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(94)90585-1

    authors： Daoud EG,Kirsh MM,Bolling SF,Strickberger SA,Morady F,Kou WH

    更新日期：1994-11-01 00:00:00

  • Relation between diastolic left ventricular function and myocardial blood volume during adenosine-induced coronary hyperemia.

    abstract：:Adenosine infusion is accompanied by increases in coronary blood flow and myocardial blood volume. Myocardial blood volume may produce changes in diastolic left ventricular (LV) performance by increasing myocardial turgor. Diastolic dysfunction may also be the result of myocardial ischemia. The relation between change...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(95)90318-6

    authors： Ren JF,Pancholy SB,Kegel JG,Lighty GW Jr,Heo J,Iskandrian AS

    更新日期：1995-04-01 00:00:00

  • Arrhythmia inducibility and ventricular vulnerability in a chronic feline infarction model.

    abstract：:Ventricular tachyarrhythmias are the cause of sudden cardiac death in ischemic heart disease. Reliable animal models are necessary to study techniques for identifying individuals at risk and to develop effective modes of therapy. The purpose of the present study was to evaluate the inducibility of ventricular tachyarr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90191-7

    authors： Wetstein L,Mark R,Kelliher GJ,Friehling T,O'Connor KM,Kowey PR

    更新日期：1985-11-01 00:00:00

  • Comparison of heart rate and blood pressure response to amyl nitrite, isoproterenol, and standing before and during acute beta-adrenergic blockade with intravenous propranolol.

    abstract：:Heart rate responses to three different procedures (amyl nitrite inhalation, standing up, and isoproterenol infusion), were studied before and during acute adrenergic beta blockade with intravenous propranolol in three normal and six hypertensive subjects. Propranolol decreased, but did not completely abolish, the hea...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(78)90125-4

    authors： Niarchos AP,Tahmooressi P,Tarazi RC

    更新日期：1978-07-01 00:00:00

  • A neural link to explain the "muscle hypothesis" of exercise intolerance in chronic heart failure.

    abstract：BACKGROUND:In chronic heart failure the cause of exercise limitation is still unclear: ergoreceptors, muscle afferents sensitive to exercise metabolites, are proposed as a neural link between muscular abnormalities and the limited exercise responses in this syndrome. METHODS:In 92 stable patients with heart failure (3...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(99)70361-3

    authors： Piepoli M,Ponikowski P,Clark AL,Banasiak W,Capucci A,Coats AJ

    更新日期：1999-06-01 00:00:00

  • Selection of thrombolytic therapy for individual patients: development of a clinical model. GUSTO-I Investigators.

    abstract：:We developed a logistic regression model with data from the GUSTO-I trial to predict mortality rate differences in individual patients who received accelerated tissue plasminogen activator (TPA) versus streptokinase treatment for acute myocardial infarction. A nomogram was developed from a reduced version of this mode...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-8703(97)70164-9

    authors： Califf RM,Woodlief LH,Harrell FE Jr,Lee KL,White HD,Guerci A,Barbash GI,Simes RJ,Weaver WD,Simoons ML,Topol EJ

    更新日期：1997-06-01 00:00:00

  • Magnum/Magnarail versus conventional systems for recanalization of chronic total coronary occlusions: a randomized comparison.

    abstract：:The Magnum/Magnarail system consists of "over-the-wire" balloon catheters and a 0.021 inch (0.53 mm) guide wire with a 1 mm olive-shaped tip. To compare it to conventional systems, 100 consecutive unselected patients with chronic total coronary occlusions were randomly assigned to one of two groups. If the balloon cou...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(92)91020-2

    authors： Pande AK,Meier B,Urban P,de la Serna F,Villavicencio R,Dorsaz PA,Favre J

    更新日期：1992-05-01 00:00:00

  • Prospective evaluation of shoulder-related problems in patients with pectoral cardioverter-defibrillator implantation.

    abstract：BACKGROUND:The pectoral approach to implantation of cardioverter defibrillators (ICDs) has become a standard in defibrillator therapy because of reduced generator size, weight, and volume. But the size of these devices is still comparable to the size of the early conventional antibradycardia pacemakers that were associ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(98)70270-4

    authors： Korte T,Jung W,Schlippert U,Wolpert C,Esmailzadeh B,Fimmers R,Schmitt O,Lüderitz B

    更新日期：1998-04-01 00:00:00

  • Association between angiotensin I-converting enzyme gene insertion/deletion polymorphism and mitral valve prolapse syndrome.

    abstract：BACKGROUND:Some studies have reported that patients with mitral valve prolapse syndrome (MVPS) also have a disorder in the autonomic or neuroendocrine function, which can cause a host of related symptoms. A potential role of the renin-angiotensin system in the pathogenesis of MVPS has been addressed. However, the role ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2003.26

    authors： Chou HT,Chen YT,Shi YR,Tsai FJ

    更新日期：2003-01-01 00:00:00

  • Impact of valve prosthesis-patient mismatch estimated by echocardiographic-determined effective orifice area on long-term outcome after aortic valve replacement.

    abstract：BACKGROUND:The impact of valve prosthesis-patient mismatch on long-term outcome after aortic valve replacement estimated by various variables such as projected indexed effective orifice area and internal geometric orifice area obtained from in vivo or in vitro published data is still controversial. METHODS:The effecti...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2007.12.037

    authors： Florath I,Albert A,Rosendahl U,Ennker IC,Ennker J

    更新日期：2008-06-01 00:00:00

  • Multivessel vs culprit-only percutaneous coronary intervention among patients 65 years or older with acute myocardial infarction.

    abstract：BACKGROUND:Older adults presenting with acute myocardial infarction (MI) often have multivessel coronary artery disease amenable to percutaneous coronary intervention (PCI), yet the risks of multivessel intervention may outweigh potential benefits in these patients. We sought to determine if nonculprit intervention dur...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2015.10.017

    authors： Wang TY,McCoy LA,Bhatt DL,Rao SV,Roe MT,Resnic FS,Cavender MA,Messenger JC,Peterson ED

    更新日期：2016-02-01 00:00:00

  • Clinical and electrophysiologic effects of calcium channel blockers in patients receiving ibutilide.

    abstract：BACKGROUND:Ibutilide is indicated for the acute termination of atrial fibrillation and atrial flutter. Recent work concludes that ibutilide activates a late inward sodium current that is blocked by nifedipine. Because calcium channel blockers are commonly used in patients with atrial fibrillation, it is important to ex...

    journal_title：American heart journal

    pub_type： 杂志文章,meta分析

    doi：10.1067/mhj.2002.120156

    authors： Wood MA,Gilligan DM,Brown-Mahoney C,Nematzadeh F,Stambler BS,Ellenbogen KA

    更新日期：2002-01-01 00:00:00

  • Ultraslow thrombolytic therapy: A novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: The Ultra-slow PROMETEE trial.

    abstract：BACKGROUND:Low-dose (25mg), slow infusion (6hours) of tissue-type plasminogen activator (t-PA) with repetition as needed has been shown to provide effective and safer thrombolysis in patients with prosthetic valve thrombosis (PVT). Further prolonging the infusion time may be rational with regard to reducing complicatio...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ahj.2015.04.025

    authors： Özkan M,Gündüz S,Gürsoy OM,Karakoyun S,Astarcıoğlu MA,Kalçık M,Aykan AÇ,Çakal B,Bayram Z,Oğuz AE,Ertürk E,Yesin M,Gökdeniz T,Duran NE,Yıldız M,Esen AM

    更新日期：2015-08-01 00:00:00

  • Multifaceted intervention to promote beta-blocker use in heart failure.

    abstract：BACKGROUND:Despite a survival benefit and guideline recommendation for beta-blockers in left ventricular systolic dysfunction, beta-blockers are underused in clinical practice. METHODS:Medical practices with > or = 15 patients with heart failure (HF) in the Duke Databank for Cardiovascular Disease (DDCD) were identifi...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2005.06.038

    authors： LaPointe NM,DeLong ER,Chen A,Hammill BG,Muhlbaier LH,Califf RM,Kramer JM

    更新日期：2006-05-01 00:00:00

  • Identification of the ischemic etiology of heart failure by cardiovascular magnetic resonance imaging: diagnostic accuracy of late gadolinium enhancement.

    abstract：BACKGROUND:A large proportion of patients with heart failure (HF) have a large and poorly contracting left ventricle. The noninvasive recognition of the ischemic etiology of such patients is difficult, and for this purpose, usually patients undergo coronary angiography. It has been shown that cardiovascular magnetic re...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.03.068

    authors： Casolo G,Minneci S,Manta R,Sulla A,Del Meglio J,Rega L,Gensini G

    更新日期：2006-01-01 00:00:00

  • Cardiopulmonary exercise testing in syndrome X.

    abstract：:Patients with syndrome X have been found to have an abnormal coronary blood flow reserve. The physical performance during exercise, however, has been incompletely investigated. Cardiopulmonary exercise testing (CPX) is a reliable noninvasive method to provide indexes of lung, heart, circulation, and muscle functions. ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(93)90162-3

    authors： Montorsi P,Agostoni PG,Annoni L,Vincenzi P,Guazzi MD

    更新日期：1993-03-01 00:00:00

  • Magnesium and potassium therapy in multifocal atrial tachycardia.

    abstract：:Eight patients with multifocal atrial tachycardia received 7 to 12 gm of magnesium sulfate intravenously over a 5-hour period. Potassium supplements were given initially or added later. Initial arterial blood gases showed mean pH 7.48 +/- 0.03, PcO2 39.7 torr, PO2 72 torr, HCO-3 29.8 +/- 4.5 mEq/L, and base excess 6.8...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90458-2

    authors： Iseri LT,Fairshter RD,Hardemann JL,Brodsky MA

    更新日期：1985-10-01 00:00:00

  • Risk markers of incident atrial fibrillation in patients with coronary heart disease.

    abstract：BACKGROUND:In patients with coronary heart disease (CHD), atrial fibrillation (AF) is associated with increased morbidity and mortality. We investigated the associations between clinical risk factors and biomarkers with incident AF in patients with CHD. METHODS AND RESULTS:Around 13,153 patients with optimally treated...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2020.12.016

    authors： Tomasdottir M MD,Held C MD, PhD,Hadziosmanovic N,Westerbergh J,Lindbäck J,Aylward PE,Budaj A,Cannon CP,Engdahl J,Granger CB,Koenig W,Manolis AJ,Oldgren J,Stewart RAH,Svennberg E,Vinereanu D,White HD,Siegbahn A,Wallent

    更新日期：2021-01-02 00:00:00

  • Kidney function and anemia as risk factors for coronary heart disease and mortality: the Atherosclerosis Risk in Communities (ARIC) Study.

    abstract：BACKGROUND:Kidney failure causes anemia and is associated with a very high risk of coronary heart disease (CHD). Mildly to moderately decreased kidney function is far more common and also is associated with an elevated prevalence of anemia and CHD risk. Recent data suggest an even higher risk of CHD when both condition...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.03.055

    authors： Astor BC,Coresh J,Heiss G,Pettitt D,Sarnak MJ

    更新日期：2006-02-01 00:00:00

  • Beta-blocking therapy in atrial and ventricular tachyarrhythmias: experience with nadolol.

    abstract：:The effects of nadolol (N) and propranolol (P) were studied in atrial and ventricular tachyarrhythmias. Interpretation of the results should take into account the dependence of the arrhythmia on the sympathetic tone, and the drug effect on the sinus node frequency. The day/night ratio of the sinus rate is too sensitiv...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(84)90589-1

    authors： Coumel P,Escoubet B,Attuel P

    更新日期：1984-10-01 00:00:00

  • Prognostic implications of complicated ventricular arrhythmias early after hospital discharge in acute myocardial infarction: a serial ambulatory electrocardiography study.

    abstract：:To assess the prevalence and prognostic implications of complicated ventricular ectopic depolarizations (VEDs) after hospital discharge in patients with acute myocardial infarction (AMI), we obtained serial 24-hour Holter recordings in 85 patients during the first 6 weeks after AMI. Recordings were obtained during two...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(84)90745-2

    authors： Olson HG,Lyons KP,Troop P,Butman SM,Piters KM

    更新日期：1984-11-01 00:00:00