当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Obesity and survival in patients with heart failure and preserved systolic function: a U-shaped relationship.

Obesity and survival in patients with heart failure and preserved systolic function: a U-shaped relationship.

Abstract：

BACKGROUND:Studies document better survival in heart failure patients with decreased left ventricular ejection fraction (EF) and higher body mass index (BMI; kg/m(2)) compared to those with a lower BMI. However, it is unknown if this "obesity paradox" applies to heart failure patients with preserved EF or if it extends to the very obese (BMI >35). METHODS:We determined all-cause mortality for 1,236 consecutive patients with a prior diagnosis of heart failure and a preserved EF (> or =50%). RESULTS:Obesity (BMI>30) was noted in 542 patients (44%). The mean age was 71 +/- 12 years, but this varied depending on BMI. One-year all-cause mortality decreased with increasing BMI, except at BMI >45 where mortality began to increase (55% if BMI <20, 38% if BMI 20-25, 26% if BMI 26-30, 25% if BMI 31-35, 17% if BMI 36-40, 18% if BMI 41-45, and 25% if BMI>45, P < .001). After adjustment for patient age, history, medications, and laboratory and echocardiographic parameters, the hazard ratios for total mortality (relative to BMI 26-30) were 1.68 (95% CI, 1.04-2.69) for BMI <20, 1.25 (95% CI, 0.92-1.68) for BMI 20 to 25, 0.99 (95% CI, 0.71-1.36) for BMI 31-35, 0.58 (95% CI, 0.35-0.97) for BMI 36 to 40, 0.79 (95% CI, 0.44-1.4) for BMI 41 to 45, and 1.38 (95% CI 0.74-2.6) for BMI >45 (P < .0001). CONCLUSIONS:Low BMI is associated with increased mortality in patients with heart failure and preserved systolic function. However, with a BMI of >45, mortality increased, raising the possibility of a U-shaped relationship between BMI and survival.

journal_name

Am Heart J

journal_title

American heart journal

authors

Kapoor JR,Heidenreich PA

doi

10.1016/j.ahj.2009.10.026

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

75-80

issue

1

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(09)00824-2

journal_volume

159

pub_type

杂志文章

相关文献

AMERICAN HEART JOURNAL文献大全
  • Two-dimensional echocardiographic study of right ventricular outflow and great artery anatomy in pulmonary atresia with ventricular septal defects and in truncus arteriosus.

    abstract：:In this study, we reviewed M-mode and two-dimensional (2DE) echocardiographic observations in 13 patients with pulmonary atresia with ventricular septal defect and in six patients with truncus arteriosus in order to attempt to identify echocardiographic features distinguishing these two abnormalities in which no anato...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(83)90528-8

    authors： Vargas Barron J,Sahn DJ,Attie F,Valdes-Cruz LM,Grenadier E,Allen HD,Oliveira Lima C,Goldberg SJ

    更新日期：1983-02-01 00:00:00

  • An integrated approach to diagnosis and therapeutic management of patients with systolic heart failure in the Copenhagen metropolitan area.

    abstract：BACKGROUND:Studies on the effect of heart failure clinics have been encouraging and convincing with respect to reduced hospitalizations, improved quality of life, and reduced cost. However, previous results have been derived from patient populations either recently discharged and with specific exclusion criteria or fro...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2002.123841

    authors： Galatius S,Gustafsson F,Nielsen PH,Atar D,Hildebrandt PR

    更新日期：2002-08-01 00:00:00

  • The effect of enhanced depression care on adherence to risk-reducing behaviors after acute coronary syndromes: findings from the COPES trial.

    abstract：BACKGROUND:The presence of depression after an acute coronary syndrome (ACS) is associated with worse prognosis and lower adherence to risk-reducing behaviors. We reported earlier that an enhanced depression care intervention reduces depression symptoms and major adverse cardiac events. This study evaluates the impact ...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2012.07.024

    authors： Kronish IM,Rieckmann N,Burg MM,Edmondson D,Schwartz JE,Davidson KW

    更新日期：2012-10-01 00:00:00

  • Long-term outcome after heart transplantation for peripartum cardiomyopathy.

    abstract：:To elucidate the long-term outcome and frequency of complications after heart transplantation for peripartum cardiomyopathy (PPCM), we compared the courses of eight consecutive patients undergoing transplantation for PPCM with those of nine female age-matched control subjects undergoing transplantation for idiopathic ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(94)90051-5

    authors： Rickenbacher PR,Rizeq MN,Hunt SA,Billingham ME,Fowler MB

    更新日期：1994-05-01 00:00:00

  • Alterations in heart rate variability in patients undergoing dobutamine stress echocardiography, including patients with neurocardiogenic hypotension.

    abstract：:Frequency-domain analysis of heart rate variability (HRV) appears to distinguish sympathetic and parasympathetic modulation of heart rate. The effects of acute reflex, as opposed to tonically augmented, cardiac vagal tone on HRV are not clearly defined. Power spectral components of HRV were measured in 36 patients und...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(95)90143-4

    authors： Hogue CW Jr,Dávila-Román VG,Stein PK,Feinberg M,Lappas DG,Pérez JE

    更新日期：1995-12-01 00:00:00

  • Sex differences in health behavior change after premature acute coronary syndrome.

    abstract：BACKGROUND:Limited information is available on the health behavior profile of patients with premature acute coronary syndrome (ACS). The purpose of this study is to desribe the health bahvior of young patients with ACS at the baseline and 1 year post-ACS and examine sex differences. METHODS:GENESIS-PRAXY is a prospect...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2015.04.016

    authors： Leung Yinko SS,Maheswaran J,Pelletier R,Bacon SL,Daskalopoulou SS,Khan NA,Eisenberg MJ,Karp I,Lavoie KL,Behlouli H,Pilote L,GENESIS-PRAXY investigators.

    更新日期：2015-08-01 00:00:00

  • What have we learned from in vitro intravascular ultrasound?

    abstract：:In vitro studies have established that intravascular ultrasound is a reliable technique for accurate assessment of vascular anatomic structure and disease conditions before and after intervention. In addition, quantitative data from intravascular ultrasound studies correspond well with histologic findings, which serve...

    journal_title：American heart journal

    pub_type： 社论,评审

    doi：10.1016/s0002-8703(96)90263-x

    authors： Gussenhoven EJ,van der Lugt A,van der Steen AF,Ligtvoet KM

    更新日期：1996-09-01 00:00:00

  • Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy.

    abstract：BACKGROUND:The left atrium is afterload sensitive, responding to immediate changes in left ventricular (LV) diastolic pressure, and left atrial volumetric remodeling has been reported in conditions associated with abnormal diastolic function. We examined the relationship between left atrial volumetric remodeling and ob...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.07.017

    authors： Sachdev V,Shizukuda Y,Brenneman CL,Birdsall CW,Waclawiw MA,Arai AE,Mohiddin SA,Tripodi D,Fananapazir L,Plehn JF

    更新日期：2005-04-01 00:00:00

  • Coronary restenosis: evaluation of a restenosis injury index in a swine model.

    abstract：:To investigate the mechanisms of restenosis and detect useful interventions to prevent it, reliable quantitative measurements must be evaluated. Coronary arteries of domestic and minipigs (n = 18) were mechanically injured by balloon overstretching and killed at different intervals (2 to 25 weeks) after quantitative a...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(93)90531-d

    authors： Bonan R,Paiement P,Scortichini D,Cloutier MJ,Leung TK

    更新日期：1993-12-01 00:00:00

  • Effect of raloxifene on aortic elasticity in healthy postmenopausal women.

    abstract：BACKGROUND:The effect of raloxifene on aortic elasticity in healthy postmenopausal women is unknown. The purpose of the present study was to examine the effect of raloxifene on aortic elasticity and cardiovascular structure and function in healthy postmenopausal women. METHODS:A randomized, crossover, double-blind, pl...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2005.02.020

    authors： Tritos NA,Goepfert L,Kissinger KV,Katsimaglis G,Manning WJ,Danias PG

    更新日期：2005-12-01 00:00:00

  • In women with symptoms of cardiac ischemia, nonobstructive coronary arteries, and microvascular dysfunction, angiotensin-converting enzyme inhibition is associated with improved microvascular function: A double-blind randomized study from the National Hea

    abstract：BACKGROUND:We investigated the role of the renin-angiotensin system in women with signs and symptoms of ischemia without obstructive coronary artery disease (CAD). Although microvascular dysfunction has been suggested to explain this syndrome and recently was found to predict adverse outcomes, the mechanisms and treatm...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2011.07.011

    authors： Pauly DF,Johnson BD,Anderson RD,Handberg EM,Smith KM,Cooper-DeHoff RM,Sopko G,Sharaf BM,Kelsey SF,Merz CN,Pepine CJ

    更新日期：2011-10-01 00:00:00

  • Temporal trends in gastrointestinal bleeding associated with percutaneous coronary intervention: analysis of the 1998-2006 Nationwide Inpatient Sample (NIS) database.

    abstract：BACKGROUND:Gastrointestinal bleeding (GIB) after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and coronary artery disease (CAD) is associated with high morbidity and mortality. METHODS:The NIS database from 1998 to 2006 was used to identify 1,216,759 PCIs performed for ACS and CAD. We sou...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2011.09.009

    authors： Shivaraju A,Patel V,Fonarow GC,Xie H,Shroff AR,Vidovich MI

    更新日期：2011-12-01 00:00:00

  • Angiotensin inhibition in renovascular disease: a population-based cohort study.

    abstract：BACKGROUND:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers effectively reduce blood pressure in patients with renovascular disease (RVD); yet, randomized cardiovascular prevention trials of these drugs typically exclude individuals with this condition. PATIENTS AND METHODS:We studied the ass...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.05.013

    authors： Hackam DG,Duong-Hua ML,Mamdani M,Li P,Tobe SW,Spence JD,Garg AX

    更新日期：2008-09-01 00:00:00

  • Rational and design of a randomized, double-blind, multicenter trial to evaluate the safety and tolerability of furosemide withdrawal in stable chronic outpatients with heart failure: The ReBIC-1 trial.

    abstract：AIMS:Furosemide is commonly prescribed for symptom relief in heart failure (HF) patients. Although few data support the continuous use of loop diuretics in apparently euvolemic HF patients with mild symptoms, there is concern about safety of diuretic withdrawal in these patients. The ReBIC-1 trial was designed to evalu...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2017.08.012

    authors： da Rosa PR,Rohde LE,Doebber M,Ribeiro ALP,Prado DP,Bertoldi EG,Figueiredo Neto JA,Kohler I,Beck-da-Silva L,Danzmann LC,Moura LZ,Rover M,Simões MV,Sant'Anna RT,Biolo A

    更新日期：2017-12-01 00:00:00

  • Left atrial thrombus resolution in atrial fibrillation or flutter: Results of a prospective study with rivaroxaban (X-TRA) and a retrospective observational registry providing baseline data (CLOT-AF).

    abstract：BACKGROUND:Data on left atrial/left atrial appendage (LA/LAA) thrombus resolution after non-vitamin K antagonist (VKA) oral anticoagulant treatment are scarce. The primary objective of X-TRA was to explore the use of rivaroxaban for the resolution of LA/LAA thrombi in patients with nonvalvular atrial fibrillation (AF) ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2016.05.007

    authors： Lip GY,Hammerstingl C,Marin F,Cappato R,Meng IL,Kirsch B,van Eickels M,Cohen A,X-TRA study and CLOT-AF registry investigators.

    更新日期：2016-08-01 00:00:00

  • Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS)--study design.

    abstract：BACKGROUND AND OBJECTIVE:Embolization of atherothrombotic material is common during percutaneous coronary intervention (PCI) in acute myocardial infarction (MI). This may lead to distal vessel occlusion resulting in impaired myocardial perfusion, which is associated with larger infarct size and increased mortality. Adj...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2005.11.010

    authors： Svilaas T,van der Horst IC,Zijlstra F

    更新日期：2006-03-01 00:00:00

  • Biplane transesophageal echo-Doppler studies of atrial septal defects: quantitative evaluation and monitoring for transcatheter closure.

    abstract：:Forty-four patients with atrial septal defects, aged 7 months to 18 years (median 8.9), underwent biplane transesophageal (TEE) and transthoracic (TTE) echocardiography. The size of the defect and the shunt flow volume were measured by TEE and compared with the actual size at surgery (N = 14) or the shunt volume measu...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(93)91008-3

    authors： Ishii M,Kato H,Inoue O,Takagi J,Maeno Y,Sugimura T,Miyake T,Kumate M,Kosuga K,Ohishi K

    更新日期：1993-05-01 00:00:00

  • Clinical implications of exercise-induced chest pain: comparison of patients with and without pathologic Q waves in coronary artery disease.

    abstract：:We attempted to determine whether exercise-induced silent myocardial ischemia has different clinical implications in patients with and without pathologic Q waves. We studied 152 patients (121 men and 31 women) who had ischemic ST depression (greater than or equal to 0.05 mV) during exercise tests and greater than or e...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(90)90009-m

    authors： Ozawa T,Ikeda K,Yamaki M,Kubota I,Tsuiki K,Yasui S

    更新日期：1990-09-01 00:00:00

  • Diet and incident venous thromboembolism: the Iowa Women's Health Study.

    abstract：BACKGROUND:Little is known about the role of diet in the development of venous thromboembolism (VTE). We explored the prospective relation of dietary patterns, food groups, and nutrients to incident VTE in older women. METHODS:In 1986, Iowa women aged 55 to 69 years completed a mailed survey, including a 127-item food...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2009.04.003

    authors： Lutsey PL,Steffen LM,Virnig BA,Folsom AR

    更新日期：2009-06-01 00:00:00

  • A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular sal

    abstract：OBJECTIVES:The objective of the study was to test the hypothesis that intracellular calcium modulation by 5-methyl-2-[piperazin-1-yl] benzene sulfonic acid monohydrate (MCC-135 [Caldaret]; Mitsubishi Pharma Corporation, Osaka, Japan) would preserve left ventricular function and reduce infarct size in patients undergoin...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2007.08.020

    authors： Jang IK,Weissman NJ,Picard MH,Zile MR,Pettigrew V,Shen S,Tatsuno J,Hibberd MG,Tzivoni D,Wackers FJ,EVOLVE Investigators.

    更新日期：2008-01-01 00:00:00

  • Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol.

    abstract：BACKGROUND:In patients with chronic heart failure, the use of carvedilol therapy induces clinical and hemodynamic improvement. However, although the benefits of this beta-blocker have been established in patients with chronic heart failure, the mechanisms underlying them and the changes in left ventricular systolic fun...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0002-8703(00)90036-x

    authors： Capomolla S,Febo O,Gnemmi M,Riccardi G,Opasich C,Caporotondi A,Mortara A,Pinna GD,Cobelli F

    更新日期：2000-04-01 00:00:00

  • Systolic anterior motion of the mitral chordae tendineae: prevalence and clinical and Doppler-echocardiographic features.

    abstract：:The objective of this investigation was to determine the prevalence and clinical associations of systolic anterior motion (SAM) of the mitral chordae (chordal SAM) in patients without evidence of hypertrophic cardiomyopathy. Although SAM of the mitral valve is thought to be a specific marker of hypertrophic obstructiv...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(96)90282-3

    authors： Pearson AC,Pasierski TJ,Orsinelli DA,Gray P,Huschart K

    更新日期：1996-04-01 00:00:00

  • Response of the left ventricle in idiopathic dilated cardiomyopathy to postextrasystolic potentiation.

    abstract：:The effectiveness of postextrasystolic potentiation (PESP) was assessed to detect residual function of the left ventricle in seven patients with idiopathic dilated cardiomyopathy (IDC). The postextrasystolic changes in the aortic pressure pulse, global left ventricular function, and quantitative regional left ventricu...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90661-2

    authors： Yamazoe M

    更新日期：1987-06-01 00:00:00

  • Mode of stimulation versus response: validation of a protocol for induction of ventricular tachycardia.

    abstract：:Electrophysiologic studies were prospectively performed in 91 consecutive patients referred for evaluation of sustained ventricular tachycardia or sudden cardiac death. Fifty-two patients had a history of sustained ventricular tachycardia and 39 patients had a history of sudden cardiac death. The identical stimulation...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90088-2

    authors： Oseran DS,Gang ES,Hamer AW,Zaher CA,Rosenthal ME,Mandel WJ,Peter T

    更新日期：1985-09-01 00:00:00

  • Predictors of improvement in left ventricular function after percutaneous revascularization of occluded coronary arteries: a report from the Total Occlusion Study of Canada (TOSCA).

    abstract：BACKGROUND:The Total Occlusion Study of Canada (TOSCA) is a multicenter, randomized trial evaluating the effect of stenting with > =1 heparin-coated stent on long-term patency after percutaneous coronary intervention by balloon angioplasty of occluded coronary arteries. The purpose of the current study was to compare t...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1067/mhj.2001.116960

    authors： Dzavik V,Carere RG,Mancini GB,Cohen EA,Catellier D,Anderson TE,Barbeau G,Lazzam C,Title LM,Berger PB,Labinaz M,Teo KK,Buller CE,Total Occlusion Study of Canada Investigators.

    更新日期：2001-08-01 00:00:00

  • Survival of DDD pacing mode after atrioventricular junction ablation and pacing for refractory atrial fibrillation.

    abstract：BACKGROUND:Patients with recurrent forms of atrial fibrillation may receive dual-chamber pacemakers after atrioventricular junction ablation for refractory symptoms. These patients are at risk for chronic atrial fibrillation, which would negate the benefits of dual-chamber pacing. The purpose of this study was to exami...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0002-8703(99)70223-1

    authors： Wood MA,Curtis AB,Takle-Newhouse TA,Ellenbogen KA

    更新日期：1999-04-01 00:00:00

  • Daily variability of electrically induced reciprocating tachycardia in patients with atrioventricular accessory pathways.

    abstract：:Sequential bedside electrophysiologic testing was performed over 22 hours at intervals of 1 to 2 hours in 13 patients with left-sided Kent bundles to assess possible daily variations in the capacity to electrically induce reciprocating tachycardia. In all patients the tachycardia involved the accessory pathway in retr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(87)90499-6

    authors： Cinca J,Moya A,Bardají A,Figueras J,Rius J

    更新日期：1987-08-01 00:00:00

  • Noninvasive determination of endothelium-mediated vasodilation as a screening test for coronary artery disease: pilot study to assess the predictive value in comparison with angina pectoris, exercise electrocardiography, and myocardial perfusion imaging.

    abstract：BACKGROUND:Peripheral endothelial dysfunction (ED) quantified by the determination of flow-mediated dilation (FMD%) of the brachial artery with the use of high-resolution ultrasound is an early marker of atherosclerosis. Although a positive correlation with coronary artery disease (CAD) has been reported, the unanswere...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(99)70189-4

    authors： Schroeder S,Enderle MD,Ossen R,Meisner C,Baumbach A,Pfohl M,Herdeg C,Oberhoff M,Haering HU,Karsch KR

    更新日期：1999-10-01 00:00:00

  • Extent of ischemic stimulus and plasma beta-endorphin levels in silent myocardial ischemia.

    abstract：BACKGROUND:Beta-endorphin has been reported to play a role in the mechanism of silent myocardial ischemia. OBJECTIVES:Plasma beta-endorphin levels during coronary angioplasty-induced silent and symptomatic myocardial ischemia were compared with those during exercise-induced silent ischemia. METHODS AND RESULTS:The st...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(98)70039-0

    authors： Hikita H,Etsuda H,Takase B,Satomura K,Kurita A,Nakamura H

    更新日期：1998-05-01 00:00:00

  • Recurrent cerebrovascular events in patients with patent foramen ovale, atrial septal aneurysm, or both and cryptogenic stroke or transient ischemic attack. French Study Group on Patent Foramen Ovale and Atrial Septal Aneurysm.

    abstract：:Patent foramen ovale (PFO) and atrial septal aneurysm (ASA) have been identified as potential risk factors for stroke, but information about the risk of recurrent cerebral ischemia is scarce. The aim of this retrospective study was to assess the absolute risk of recurrent cerebrovascular events in 132 patients under 6...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(95)90212-0

    authors： Mas JL,Zuber M

    更新日期：1995-11-01 00:00:00