A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular sal

abstract：:The purpose of this study was to delineate the clinical, ECG, and angiographic features of a large series of consecutive patients with angina at rest. Transient ST segment elevation during pain was observed in 219 patients (group I), while 220 patients showed ST segment depression during pain (group II). Group II pati...

journal_title：American heart journal

authors： de Servi S,Ghio S,Ferrario M,Ardissino D,Angoli L,Mussini A,Bramucci E,Salerno J,Viganò M,Montemartini C

更新日期：1986-01-01 00:00:00

abstract：:Three cases of apical left ventricular hypertrophy demonstrating a sequestered small left ventricular apical cavity with complete systolic and partial diastolic intraventricular obstruction are described. Doppler studies revealed that flow from the apical chamber is aborted during early systole with further emptying d...

journal_title：American heart journal

authors： Zoghbi WA,Haichin RN,Quinones MA

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:All patients who present to an emergency department (ED) are triaged. The ED triage score may determine when patients are seen by a physician. Half of patients with acute myocardial infarction (AMI) were given a low priority score in Ontario in 2000/2001. We assessed the appropriateness of ED triage and its ...

journal_title：American heart journal

authors： Atzema CL,Schull MJ,Austin PC,Tu JV

更新日期：2011-09-01 00:00:00

abstract：:The detection of premature ectopic beats coinciding with the T-wave of the antecedent beat is important for patient monitoring. In the method described here, the difficulties of direct measurement of QT time are avoided by evaluating the changes of QT time according to heart rate by use of a diode function generator. ...

journal_title：American heart journal

authors： Breithardt G,Loogen F,Schmiel FK,Seipel L

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:In recent reports, human toll-like receptor (TLR) 8 mediates the antiviral response by recognizing single-stranded RNA. The inflammatory response against enteroviral (EV) RNA replication may play an important role in dilated cardiomyopathy (DCM). The purpose of this study was to determine whether TLR8 was ex...

journal_title：American heart journal

authors： Satoh M,Akatsu T,Ishikawa Y,Minami Y,Takahashi Y,Nakamura M

更新日期：2007-09-01 00:00:00

abstract：:We studied the possibility that a mitral regurgitant Doppler signal area on a two-dimensional color Doppler echocardiogram can reflect changes in mitral regurgitant volume in 24 patients with several types of mitral regurgitation. In 20 patients, mitral regurgitant Doppler signal areas were clear enough to measure. In...

journal_title：American heart journal

authors： Otsuji Y,Tei C,Kisanuki A,Natsugoe K,Kawazoe Y

更新日期：1987-08-01 00:00:00

abstract：:Repetitive 10-hour ECG recordings of 289 patients obtained within a year after myocardial infarction were analyzed for the presence of ventricular runs, and their association with various types of ventricular ectopic activity (VEA), average rate of premature ventricular complexes (PVCs), and coupling interval of PVCs ...

journal_title：American heart journal

authors： Thanavaro S,Kleiger RE,Miller JP,Province MA,Friedman E,Oliver GC

更新日期：1983-09-01 00:00:00

abstract：:The neutral alkaloid, ryanodine, has several actions on cardiac muscle. To delineate better its mode of action, we studied ryanodine's effect upon contracting cat papillary muscles under changing loading conditions and stimulation frequencies. We also studied ryanodine's physiologic and metabolic effects upon isolated...

journal_title：American heart journal

authors： Blumlein SL,Sievers R,Wikman-Coffelt J,Parmley WW,Rouleau JL

更新日期：1985-08-01 00:00:00

abstract：:Giant cell arteritis is a disease of the elderly which is more common than previously recognized. It is important to be aware of this condition because treatment effectively relieves symptoms and prevents serious complications. The disease is suggested when an elderly patient complains of constitutional symptoms, head...

journal_title：American heart journal

authors： Huston KA,Hunder GG

更新日期：1980-07-01 00:00:00

abstract：:Several autoimmune diseases have been associated with increased frequencies of specific histocompatibility (HLA) antigens, particularly for the D (DR) locus, that may be linked to immune response genes. Rheumatic valvular heart disease (RHD) has been postulated to have autoimmune features, but HLA associations have no...

journal_title：American heart journal

authors： Anastasiou-Nana MI,Anderson JL,Carlquist JF,Nanas JN

更新日期：1986-11-01 00:00:00

abstract：:Mitochondria in skeletal and cardiac muscle have been found to be less stable in aging hamsters, in contrast to preparations from young animals. We have found previously that clofibrate (Atromid-S) will reverse this degeneration in the older hamsters. This study examined the exercise tolerance of aged hamsters, to see...

journal_title：American heart journal

authors： Guntheroth WG,Inamdar AR,Person R,Mackler B

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Because coronary artery disease (CAD) is a prevalent comorbidity in patients with low ejection function (EF), a number of patients with heart failure undergo diagnostic cardiac catheterization. The objective of this study was to develop a model to assist clinicians in determining the likelihood of CAD before...

journal_title：American heart journal

authors： Whellan DJ,Tuttle RH,Velazquez EJ,Shaw LK,Jollis JG,Ellis W,O'Connor CM,Califf RM,Borges-Neto S

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:The purpose of this study is to assess incidence and risk factors for severe renal dysfunction in patients requiring oral anticoagulation to help guide initial drug choice and provide a rational basis for interval monitoring of renal function for patients prescribed non-vitamin K oral anticoagulants. METHOD...

journal_title：American heart journal

authors： Fanola CL,Mooney D,Cowan AJ,Ko D,Sisson EK,Henault LE,Tripodis Y,Hylek EM

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Less than half of patients with cardiometabolic disease consistently take prescribed medications. While health insurers and some delivery organizations use claims to measure adherence, most clinicians do not have access during routine interactions. Self-reported scales exist, but their practical utility is o...

journal_title：American heart journal

authors： Lauffenburger JC,Fontanet CP,Isaac T,Gopalakrishnan C,Sequist TD,Gagne JJ,Jackevicius CA,Fischer MA,Solomon DH,Choudhry NK

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The favorable effects of lowering low-density lipoprotein (LDL)-cholesterol on reducing clinical events in patients with coronary disease have been well established. The mechanisms responsible for this benefit, however, have not been fully understood. This study examined the impact of lipid-lowering therapy ...

journal_title：American heart journal

authors： Cohen JD,Drury JH,Ostdiek J,Finn J,Babu BR,Flaker G,Belew K,Donohue T,Labovitz A

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:The Fontan operation results in a circulation that is dependent on low pulmonary vascular resistance to maintain an adequate cardiac output. Medical therapies that lower pulmonary vascular resistance may augment cardiac output and improve long-term outcomes. OBJECTIVES:This phase I/II clinical trial conduct...

journal_title：American heart journal

authors： Goldberg DJ,Zak V,Goldstein BH,Chen S,Hamstra MS,Radojewski EA,Maunsell E,Mital S,Menon SC,Schumacher KR,Payne RM,Stylianou M,Kaltman JR,deVries TM,Yeager JL,Paridon SM,Pediatric Heart Network Investigators.

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:The effect of age on diagnostic and prognostic performance of high-sensitivity cardiac troponin T (hs-cTnT) has not been addressed adequately, so far. METHODS:High-sensitivity cardiac troponin T was measured serially in patients with acute symptoms presenting to our emergency department. We tested the diagn...

journal_title：American heart journal

authors： Normann J,Mueller M,Biener M,Vafaie M,Katus HA,Giannitsis E

更新日期：2012-11-01 00:00:00

abstract：:Characteristics of color-coded Doppler imaging combined with two-dimensional and M-mode echocardiography in six patients with systolic-diastolic murmurs are reported. PDA, congenital absence of pulmonary valve leaflets, ventricular septal defect and aortic regurgitation, two ruptured aneurysms of sinus of Valsalva, an...

journal_title：American heart journal

authors： Vargas-Barron J,Attie F,Skronme D,Sanchez-Ugarte T,Keirns C,Santana-Gonzalez A

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Recent data indicate that cardiac antibodies play an active role in the pathogenesis of dilated cardiomyopathy (DCM) and may contribute to cardiac dysfunction in patients with DCM. The present study investigated the influence of immunoadsorption with subsequent immunoglobulin G substitution (IA/IgG) on cardi...

journal_title：American heart journal

authors： Herda LR,Trimpert C,Nauke U,Landsberger M,Hummel A,Beug D,Kieback A,Dörr M,Empen K,Knebel F,Ewert R,Angelow A,Hoffmann W,Felix SB,Staudt A

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Heart rate recovery (HRR) is a marker of vagal tone that is associated with survival, but little is known about the effects of exercise training on HRR in patients with heart failure (HF). METHODS:Twenty-four patients with HF were randomized to a 2-month residential rehabilitation program or to usual care. ...

journal_title：American heart journal

authors： Myers J,Hadley D,Oswald U,Bruner K,Kottman W,Hsu L,Dubach P

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Plasma levels of brain natriuretic peptide (BNP) are increased in patients with left heart failure. In patients with severe pulmonary embolism (PE), primary right ventricular (RV) dysfunction is frequent. Little is known about BNP secretion in acute RV failure. METHODS:We prospectively studied 50 consecutiv...

journal_title：American heart journal

authors： Krüger S,Graf J,Merx MW,Koch KC,Kunz D,Hanrath P,Janssens U

更新日期：2004-01-01 00:00:00

abstract：:Mitral valve prolapse (MVP) is a common cardiac valve abnormality that affects women more frequently than men. We have previously shown that mild dehydration induces echocardiographic signs of MVP in approximately 50% of healthy asthenic women with previously normal cardiac findings. The present study was designed to ...

journal_title：American heart journal

authors： Aufderheide S,Lax D,Goldberg SJ

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) improves outcomes, functional capacity and quality of life in patients with heart failure. Despite two decades of experience with CRT, the rate of non-response remains approximately 30%. CRT efficacy is impacted by pacing location, which is anatomically limited in conv...

journal_title：American heart journal

authors： Singh JP,Abraham WT,Auricchio A,Delnoy PP,Gold M,Reddy VY,Sanders P,Lindenfeld J,Rinaldi CA

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:To examine sex differences in pain and associated symptoms in patients with exercise-related ischemia, as well as the independence of these findings from other clinical factors. METHODS:Prospective study of 482 women and 425 men (mean age 58 years) undergoing exercise stress testing with myocardial perfusio...

journal_title：American heart journal

authors： D'Antono B,Dupuis G,Fortin C,Arsenault A,Burelle D

更新日期：2006-04-01 00:00:00

abstract：:Digoxin pharmacokinetics were studied in 16 obese (mean +/- SD weight, 100.2 +/- 36.8 kg) and 13 control (64.6 +/- 10.5 kg) subjects. All subjects had normal renal function and no other coexisting disease. After administration of 0.75 mg digoxin by intravenous infusion, multiple plasma samples obtained over the 96 hou...

journal_title：American heart journal

authors： Abernethy DR,Greenblatt DJ,Smith TW

更新日期：1981-10-01 00:00:00

abstract：:Cardiac arrhythmias arise from disturbances in the functioning of the specific ion channels that normally control excitation or from the functional expression of previously latent channels. Antiarrhythmic agents act by blocking the membrane sodium, potassium, and calcium channels, but no agent has exclusive action on ...

journal_title：American heart journal

authors： Grant AO Jr

更新日期：1992-04-01 00:00:00

abstract：:Mechanisms responsible for the well-documented "protection" against myocardial ischemia and infarction in young women and subsequent loss of protection after menopause remain speculative. One possibility is that gender-related variables (such as endogenous hormone levels or regular loss of stored iron) alter the susce...

journal_title：American heart journal

authors： Przyklenk K,Ovize M,Bauer B,Kloner RA

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Procedural volume has been shown to be associated with outcome in cardiac catheterization and intervention in adults. The impact of center-level factors (such as volume) and their interaction with subject- and procedure-level factors on outcome after cardiac catheterization in children is not well described....

journal_title：American heart journal

authors： O'Byrne ML,Glatz AC,Shinohara RT,Jayaram N,Gillespie MJ,Dori Y,Rome JJ,Kawut S

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Noninvasive methods are needed for the identification of women at highest risk for coronary artery disease (CAD) who might benefit most from aggressive preventive therapy. Identification of brachial artery atherosclerosis, which correlates with coronary artery atherosclerosis, may be useful to estimate or st...

journal_title：American heart journal

authors： Holubkov R,Karas RH,Pepine CJ,Rickens CR,Reichek N,Rogers WJ,Sharaf BL,Sopko G,Merz CN,Kelsey SF,McGorray SP,Reis SE

更新日期：2002-05-01 00:00:00

abstract：:This study uses echocardiography to characterize the pattern of left ventricular hypertrophy in a new hypertensive heart failure-prone rat strain designated SHHF/Mcc-cp (SHHF). M-mode echocardiograms of the left ventricle in nine 10- to 12-month old SHHF rats and nine age-matched spontaneously hypertensive rats (SHR) ...

journal_title：American heart journal

authors： Haas GJ,McCune SA,Brown DM,Cody RJ

更新日期：1995-10-01 00:00:00