On the mechanism of action of antiarrhythmic agents.

abstract：BACKGROUND:Today most patients with congenital heart disease survive childhood to be cared for by adult cardiologists. The number of physicians that should be trained to manage these lesions is unknown because we do not know the number of patients. METHODS:To answer this question, the expected numbers of infants with ...

journal_title：American heart journal

authors： Hoffman JI,Kaplan S,Liberthson RR

更新日期：2004-03-01 00:00:00

abstract：:Although the Doppler mitral flow velocity pattern changes in accordance with the degree of left ventricular diastolic dysfunction, it is "normalized" in the presence of heart failure. In this study the pulmonary venous flow velocity pattern was characterized in 43 hypertensive patients with and without heart failure t...

journal_title：American heart journal

authors： Masuyama T,Lee JM,Yamamoto K,Tanouchi J,Hori M,Kamada T

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Recent data indicate that cardiac antibodies play an active role in the pathogenesis of dilated cardiomyopathy (DCM) and may contribute to cardiac dysfunction in patients with DCM. The present study investigated the influence of immunoadsorption with subsequent immunoglobulin G substitution (IA/IgG) on cardi...

journal_title：American heart journal

authors： Herda LR,Trimpert C,Nauke U,Landsberger M,Hummel A,Beug D,Kieback A,Dörr M,Empen K,Knebel F,Ewert R,Angelow A,Hoffmann W,Felix SB,Staudt A

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:New percutaneous coronary intervention (PCI) device technologies are often rapidly adopted into clinical practice, yet few studies have examined the overall impact of these new technologies on patient outcomes in community practice. METHODS:In hopes of determining temporal trends in PCI outcomes, we used da...

journal_title：American heart journal

authors： Rao SV,Hess CN,Dai D,Green CL,Peterson ED,Douglas PS

更新日期：2013-08-01 00:00:00

abstract：:In a double blind, placebo-controlled study, the efficacy of propafenone, a new antiarrhythmic drug was compared to that of disopyramide. Sixteen patients with frequent and complex premature ventricular contractions (PVCs) were studied by serial 24-hour ambulatory monitoring, while they were receiving propafenone, 300...

journal_title：American heart journal

authors： Naccarella F,Bracchetti D,Palmieri M,Cantelli I,Bertaccini P,Ambrosioni E

更新日期：1985-04-01 00:00:00

abstract：:The conducting tissue of the heart was studied in 25 human cases of Chagas' myocarditis with a method which employs complete serial sections mounted on continuous transparent plastic tape. The pathological changes were correlated with electrocardiographic findings. The inflammation of the acute phase of Chagas' myocar...

journal_title：American heart journal

authors： Andrade ZA,Andrade SG,Oliveira GB,Alonso DR

更新日期：1978-03-01 00:00:00

abstract：:The calcium antagonist, manidipine, was developed on the basis of the hypothesis that antihypertensive drugs that act to improve renal hemodynamic alterations will be therapeutically beneficial in hypertensive patients. Manidipine shows long-lasting calcium channel-blocking action in vascular smooth muscle cells and a...

journal_title：American heart journal

authors： Nagaoka A

更新日期：1993-02-01 00:00:00

abstract：:Patent foramen ovale (PFO) and atrial septal aneurysm (ASA) have been identified as potential risk factors for stroke, but information about the risk of recurrent cerebral ischemia is scarce. The aim of this retrospective study was to assess the absolute risk of recurrent cerebrovascular events in 132 patients under 6...

journal_title：American heart journal

authors： Mas JL,Zuber M

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:In a previous study from a single center, radionuclide measures of collateral flow with technetium 99m sestamibi have been shown to be significantly associated with angiographic residual (antegrade and collateral) flow and independent predictors of final infarct size in acute myocardial infarction. This stud...

journal_title：American heart journal

authors： Chareonthaitawee P,Christian TF,O'Connor MK,Berger PB,Higano ST,O'Keefe JH,Spain MG,Grines CL,Gibbons RJ

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:The study aimed to compare the short-term costs and long-term cost-effectiveness of 2 antithrombotics, fondaparinux and enoxaparin, for non-ST-elevation acute coronary syndrome in the United States. METHODS:It was based on a large randomized trial of 20,078 patients Fifth Organization to Assess Strategies i...

journal_title：American heart journal

authors： Sculpher MJ,Lozano-Ortega G,Sambrook J,Palmer S,Ormanidhi O,Bakhai A,Flather M,Steg PG,Mehta SR,Weintraub W

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Protease-activated receptor 1 antagonism with vorapaxar represents a novel strategy for platelet inhibition. In TRACER, vorapaxar was compared with placebo plus standard of care among 12,944 patients with non-ST-segment elevation acute coronary syndromes. We anticipated that most patients would have received...

journal_title：American heart journal

authors： Tricoci P,Lokhnygina Y,Huang Z,Van de Werf F,Cornel JH,Chen E,Wallentin L,Held C,Aylward PE,Moliterno DJ,Jennings LK,White HD,Armstrong PW,Harrington RA,Strony J,Mahaffey KW

更新日期：2014-12-01 00:00:00

abstract：:The antihypertensive efficacy, safety, and lipid effects of doxazosin, a selective alpha 1-inhibitor, were assessed in a general practice setting. Three hundred twenty-six patients were entered into the study, which involved three phases: (1) a 2-week baseline period, (2) an 8-week period in which patients received 1 ...

journal_title：American heart journal

authors： Naber FB

更新日期：1991-01-01 00:00:00

abstract：:To evaluate whether the identification of the different types of relations between premature ventricular contractions (PVCs) and the preceding sinus cycle length is capable of predicting the effect of beta-blockers on the PVCs themselves, 55 patients (43 men, 12 women, mean age 52.6 +/- 15.6 years) with different card...

journal_title：American heart journal

authors： Pitzalis MV,Mastropasqua F,Massari F,Totaro P,Di Maggio M,Rizzon P

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Chocolate consumption has been inconsistently associated with risk of atrial fibrillation (AF). We investigated the association between chocolate consumption and risk of AF in Swedish adults from two cohort studies and conducted a meta-analysis to summarize available evidence from cohort studies on this topi...

journal_title：American heart journal

authors： Larsson SC,Drca N,Jensen-Urstad M,Wolk A

更新日期：2018-01-01 00:00:00

abstract：:Chronic exposure to fine particulate matter (PM2.5) is accepted as a causal risk factor for coronary heart disease (CHD). However, most of the evidence for this hypothesis is based upon cohort studies in whites, comprised of either only males or females who live in urban areas. It is possible that many estimates of th...

journal_title：American heart journal

authors： Loop MS,McClure LA,Levitan EB,Al-Hamdan MZ,Crosson WL,Safford MM

更新日期：2018-03-01 00:00:00

abstract：:Recently, the theory that hyperinflammation is the body's primary response to potent stimulus has been challenged. Indeed, a deregulation of the immune system could be the cause of multiple organ failure. So far, clinicians have focused on the last steps of the inflammatory cascade. However, little attention has been ...

journal_title：American heart journal

authors： Bodi V,Sanchis J,Nunez J,Mainar L,Minana G,Benet I,Solano C,Chorro FJ,Llacer A

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:In adults with an atrial septal defect (ASD) transcatheter closure leads to an improvement of peak oxygen uptake (VO2), but the kinetics of recovery of VO2 after maximal exercise in this patient population and the impact of transcatheter ASD closure have never been investigated. METHODS:Twenty consecutive p...

journal_title：American heart journal

authors： Giardini A,Donti A,Specchia S,Coutsoumbas G,Formigari R,Prandstraller D,Bronzetti G,Bonvicini M,Picchio FM

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:The optimal antibiotic treatment length for infective endocarditis (IE) is uncertain. International guidelines recommend treatment duration of up to 6 weeks for patients with left-sided IE but are primarily based on historical data and expert opinion. Efficacies of modern therapies, fast recovery seen in man...

journal_title：American heart journal

authors： Østergaard L,Pries-Heje MM,Hasselbalch RB,Rasmussen M,Åkesson P,Horvath R,Povlsen J,Gill S,Bruun NE,Müllertz K,Tuxen CD,Ihlemann N,Helweg-Larsen J,Moser C,Fosbøl EL,Bundgaard H,Iversen K

更新日期：2020-09-01 00:00:00

abstract：:The efficacy and safety of sotalol therapy for ventricular arrhythmias was evaluated in 133 patients with drug-refractory ventricular arrhythmias. All patients had baseline electrophysiologic studies before and after oral sotalol therapy. Sixty-six patients were discharged home, treated with sotalol (52 patients witho...

journal_title：American heart journal

authors： Lee RJ,Wong M,Siu A,Namekawa-Wong M,Epstein LM,Fitzpatrick AP,Grogin HR,Scheinman MM,Lesh MD

更新日期：1996-11-01 00:00:00

abstract：:Hemodynamic and echocardiographic data from 33 consecutive patients undergoing cardiac transplantation were correlated with endomyocardial biopsy results to determine whether reversible restrictive hemodynamics accompany histologic evidence of transplant rejection. During the study period 251 biopsy specimens were obt...

journal_title：American heart journal

authors： Wilensky RL,Bourdillon PD,O'Donnell JA,Sharp SM,Armstrong WF,Fineberg NS,Himes V,Waller BF

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Left atrial appendage flow velocity (LAAFV) is a predictor of thromboembolism in atrial fibrillation (AF) patients, as well as CHA2DS2-VASc score. However, little is known about LAAFV in sinus rhythm (SR) after catheter ablation. The aim of this study was to determine clinical predictors of low LAAFV in pati...

journal_title：American heart journal

authors： Kusa S,Komatsu Y,Taniguchi H,Uchiyama T,Takagi T,Nakamura H,Miyazaki S,Hachiya H,Iesaka Y

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Contemporary use of dual antiplatelet therapy and consistency with guideline recommendations in acute coronary syndrome patients undergoing percutaneous coronary intervention (PCI) have not been well characterized. METHODS:The COAPT was a prospective, observational, multicenter, longitudinal study of patien...

journal_title：American heart journal

authors： Déry JP,Mehta SR,Fisher HN,Zhang X,Zhu YE,Welsh RC,Lavi S,Cieza T,Henderson MA,Lutchmedial S,Siega AJ,Cheema AN,Wong BY,Kokis A,Dehghani P,Goodman SG,Canadian Observational AntiPlatelet sTudy (COAPT) Investigators.

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Glycoprotein (GP) IIb/IIIa inhibitors can improve outcomes in patients with non-ST-segment elevation acute coronary syndromes but raise the risk of bleeding, particularly if dosed in excess. The impact of GP IIb/IIIa dosing feedback on safety and major bleeding is unknown. METHODS:Glycoprotein IIb/IIIa dosi...

journal_title：American heart journal

authors： Mudrick DW,Chen AY,Roe MT,Newby LK,Gibler WB,Ohman EM,Peterson ED,Alexander KP

更新日期：2010-12-01 00:00:00

abstract：:The present experiments were conducted on isolated dog hearts to demonstrate that conduction disturbances can be induced in the bundle branches by transection of about 50 per cent of the cross-sectional area of the His bundle on the right or left side. The His bundle, the posterior and anterior divisions of left bundl...

journal_title：American heart journal

authors： Fabregas RA,Tse WW,Han J

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:It has been reported that mineralocorticoid receptor antagonist improves the prognosis of chronic heart failure (CHF). Recently, hemoglobin A₁(c) (HbA₁(c)) levels have been reported to be an independent risk factor for mortality in CHF, suggesting the important role of insulin resistance in CHF. We compared ...

journal_title：American heart journal

authors： Yamaji M,Tsutamoto T,Kawahara C,Nishiyama K,Yamamoto T,Fujii M,Horie M

更新日期：2010-11-01 00:00:00

abstract：:Therapeutics involves the careful balance between treatment disadvantages and advantages--the so-called risk-benefit ratio. Even after 20 years beta-blockers must be selected carefully to suit the patient's needs. This review examines several problems associated with beta-blockade. Generally, beta1-cardioselectivity i...

journal_title：American heart journal

authors： Reid JL

更新日期：1988-11-01 00:00:00

abstract：:Exercise stress testing is a well-established method for the diagnostic, prognostic, and functional assessment of patients with known or suspected CAD. A variety of alternative tests have been described in patients unable to perform leg exercise. Atrial pacing and dipyridamole imaging have been evaluated most extensiv...

journal_title：American heart journal

authors： Stratmann HG,Kennedy HL

更新日期：1989-06-01 00:00:00

abstract：:There are many similarities between the clinical features of viral heart disease and of rheumatic carditis, as defined in the revised Jones criteria for the diagnosis of rheumatic fever. Because of this, it is likely that viral heart disease has been, and still is, diagnosed as rheumatic. This situation can be avoided...

journal_title：American heart journal

authors： Ward C

更新日期：1976-05-01 00:00:00

abstract：:Following pulmonary infarction, three patients developed the classical signs and symptoms of the Dressler syndrome associated with persistent left pleural effusion. Each responded dramatically to corticosteroid therapy. While the pathogenesis of this "Post-Pulmonary Infarction syndrome," like the Dressler syndrome, is...

journal_title：American heart journal

authors： Sklaroff HJ

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to describe the effect of intravenous metoprolol on the intensity of chest pain before hospital admission in patients with suspected acute myocardial infarction AMI). METHODS AND RESULTS:Two hundred sixty-two patients with acute chest pain and suspected AMI were randomly assigned b...

journal_title：American heart journal

authors： Gardtman M,Dellborg M,Brunnhage C,Lindkvist J,Waagstein L,Herlitz J

更新日期：1999-05-01 00:00:00