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Long-term results of electrophysiologically guided sotalol therapy for life-threatening ventricular arrhythmias.

Abstract：

:The efficacy and safety of sotalol therapy for ventricular arrhythmias was evaluated in 133 patients with drug-refractory ventricular arrhythmias. All patients had baseline electrophysiologic studies before and after oral sotalol therapy. Sixty-six patients were discharged home, treated with sotalol (52 patients without inducible ventricular tachycardia or fibrillation and 14 patients with hemodynamically stable inducible ventricular tachycardia). The mean follow-up period was 41 +/- 27 months for the 14 patients with hemodynamically stable ventricular tachycardia. Sotalol was effective in 8 of these 14 patients. Recurrent nonlethal ventricular tachycardia occurred in 3 patients; 2 patients had sudden death; and 1 patient had adverse side effects. The 52 patients without inducible ventricular tachycardia were followed up for a mean period of 36 +/- 30 months. Thirty-five of 52 patients were successfully treated. Two patients had recurrent ventricular tachycardia; both of these episodes of ventricular tachycardia occurred within the first year. Four patients had sudden cardiac death; three of these deaths occurred within the first month, and the last episode of sudden death occurred after 8 years of sotalol therapy. The actuarial incidence of sotalol efficacy was 76% at 1 year, 72% at 2 years, 64% at 4 years, and 52% at 5 years. Approximately 46% of patients receiving long-term sotalol treatment reported side effects. Side effects severe enough to warrant withdrawal of sotalol occurred in 7 (11%) patients. The results of our study suggest that sotalol is effective for selected patients with drug refractory ventricular arrhythmias. Although the incidence of side effects are high, patients appear to tolerate long-term sotalol therapy well.

journal_name

Am Heart J

journal_title

American heart journal

authors

Lee RJ,Wong M,Siu A,Namekawa-Wong M,Epstein LM,Fitzpatrick AP,Grogin HR,Scheinman MM,Lesh MD

doi

10.1016/s0002-8703(96)90008-3

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

973-8

issue

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(96)90008-3

journal_volume

132

pub_type

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Long-term results of electrophysiologically guided sotalol therapy for life-threatening ventricular arrhythmias.