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Uncontrolled immune response in acute myocardial infarction: unraveling the thread.

Abstract：

:Recently, the theory that hyperinflammation is the body's primary response to potent stimulus has been challenged. Indeed, a deregulation of the immune system could be the cause of multiple organ failure. So far, clinicians have focused on the last steps of the inflammatory cascade. However, little attention has been paid to lymphocytes, which play an important role as strategists of the inflammatory response. Experimental evidence suggests a crucial role of T lymphocytes in the pathophysiology of atherosclerosis and acute myocardial infarction (AMI). In summary, from the bottom of an imaginary inverted pyramid, a few regulatory T-cells control the upper parts represented by the wide spectrum of the inflammatory cascade. In AMI, a loss of regulation of the inflammatory system occurs in patients with a decreased activity of regulatory T-cells. As a consequence, aggressive T-cells boost and anti-inflammatory T-cells drop. A pleiotropic proinflammatory imbalance with damaging effects in terms of left ventricular performance and patient outcome is the result of this uncontrolled immune response. It is needed to unravel the thread of the inflammatory cells to better understand the pathophysiology as well as to open innovative therapeutic options in AMI.

journal_name

Am Heart J

journal_title

American heart journal

authors

Bodi V,Sanchis J,Nunez J,Mainar L,Minana G,Benet I,Solano C,Chorro FJ,Llacer A

doi

10.1016/j.ahj.2008.07.008

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

1065-73

issue

6

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(08)00619-4

journal_volume

156

pub_type

杂志文章,评审

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