Duration of red cell storage before transfusion and in-hospital mortality.

Abstract:

BACKGROUND:Red cell transfusions are lifesaving in severely anemic or acutely bleeding patients but may be associated with an increased risk of cardiovascular events in critically ill patients. The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospital mortality. METHODS:We used multivariable Cox regression modeling with time-dependent stratification to assess the effect of age of transfused red blood cells on risk of in-hospital mortality in a registry of consecutive patients admitted to an acute care facility with a major diagnosis of cardiovascular disease. RESULTS:Four thousand nine hundred thirty-three consecutive patients with a major diagnosis of cardiovascular disease admitted to acute care facilities in Hamilton, Canada, received 21,435 units of red cells. The median number of units received was 3 (interquartile range 2-5), and the median age of transfused blood was 17 (interquartile range 13-22) days. After adjustment for demographics, clinical characteristics, and time-dependent covariates and stratification by the number of units transfused, the relative risk for death was 1.02 for every 1-day increase in maximum age of blood. The adjusted relative risk for death increased with each increasing quartile of maximum age of blood, with patients in the highest quartile having a relative risk for death of 1.48 (95% CI 1.07-2.05) compared with those in the lowest (reference) quartile. CONCLUSIONS:In hospitalized patients with a major diagnosis of cardiovascular disease, there is a modest independent association between increasing duration of storage of red cells and risk of in-hospital mortality that appears to be continuous and graded.

journal_name

Am Heart J

journal_title

American heart journal

authors

Eikelboom JW,Cook RJ,Liu Y,Heddle NM

doi

10.1016/j.ahj.2009.12.045

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

737-743.e1

issue

5

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(10)00161-4

journal_volume

159

pub_type

杂志文章
  • Adverse association between diabetic retinopathy and cardiac structure and function.

    abstract:BACKGROUND:Recent work has demonstrated a link between retinopathy, a marker of microvascular disease, and the development of heart failure, a finding particularly relevant in individuals with diabetes. Our objective was to assess the relationship between retinopathy and cardiac structure and function in a cohort of in...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2008.10.019

    authors: Aguilar D,Hallman DM,Piller LB,Klein BE,Klein R,Devereux RB,Arnett DK,Gonzalez VH,Hanis CL

    更新日期:2009-03-01 00:00:00

  • Echocardiographic characterization of left ventricular adaptation in a genetically determined heart failure rat model.

    abstract::This study uses echocardiography to characterize the pattern of left ventricular hypertrophy in a new hypertensive heart failure-prone rat strain designated SHHF/Mcc-cp (SHHF). M-mode echocardiograms of the left ventricle in nine 10- to 12-month old SHHF rats and nine age-matched spontaneously hypertensive rats (SHR) ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(95)90081-0

    authors: Haas GJ,McCune SA,Brown DM,Cody RJ

    更新日期:1995-10-01 00:00:00

  • Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure.

    abstract:BACKGROUND:A previous randomized controlled trial evaluating the use of spironolactone in heart failure patients reported a low risk of hyperkalemia (2%) and renal insufficiency (0%). Because treatments for heart failure have changed since the benefits of spironolactone were reported, the prevalence of these complicati...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2004.10.005

    authors: Tamirisa KP,Aaronson KD,Koelling TM

    更新日期:2004-12-01 00:00:00

  • The risk of stroke and death in patients with aortic and mitral valve endocarditis.

    abstract:BACKGROUND:Previous studies have generated inconsistent results when attempting to define predictors of stroke and death in patients with endocarditis. We sought to examine the relationship between vegetation 2-dimensional size and stroke in those with infective endocarditis (IE) and to identify differences between aor...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2001.115790

    authors: Cabell CH,Pond KK,Peterson GE,Durack DT,Corey GR,Anderson DJ,Ryan T,Lukes AS,Sexton DJ

    更新日期:2001-07-01 00:00:00

  • Changes in myocardial metabolism and transcardiac electrolytes during simulated ventricular tachycardia: effects of beta-adrenergic blockade.

    abstract::Myocardial ischemia, electrolyte changes, and fluctuations in autonomic tone may play an important role in the presentation of malignant ventricular arrhythmias. beta-Adrenoceptor blocking agents have been shown to decrease the incidence of ventricular fibrillation and sudden cardiac death in patients with coronary ar...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90015-9

    authors: Peuhkurinen KJ,Huikuri HV,Linnaluoto M,Takkunen JT

    更新日期:1994-07-01 00:00:00

  • Retrograde coronary blood flow during cardiopulmonary resuscitation in swine: intracoronary Doppler evaluation.

    abstract::Cardiopulmonary resuscitation-generated coronary perfusion pressure and intracoronary flow velocity was studied with high-fidelity pressure transducers and an intracoronary Doppler catheter in 11 swine undergoing closed-chest manual cardiopulmonary resuscitation. Retrograde coronary blood flow in the mid left anterior...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90622-x

    authors: Kern KB,Hilwig R,Ewy GA

    更新日期:1994-09-01 00:00:00

  • Variant angina pectoris: a clinical and coronary arteriographic spectrum.

    abstract::The clinical course and coronary arteriographic findings in eight patients with Prinzmetal's variant angina pectoris are reviewed and contrasted to previously reported cases. In six patients with S-T-elevation inferiorly, three had normal coronary arteriograms, one had complete right coronary artery occlusion, one ha...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(75)90501-3

    authors: Donsky MS,Harris MD,Curry GC,Blomqvist CG,Willerson JT,Mullins CB

    更新日期:1975-05-01 00:00:00

  • Ischemic ST segment depression in leads V2-V3 as the presenting electrocardiographic feature of posterolateral wall myocardial infarction.

    abstract::In this study of 14 patients hospitalized with a first event of myocardial infarction, maximal ST segment depression in precordial leads V2 and V3 was the sole ECG finding during chest pain in the first 24 hours of evolving posterolateral infarction, based upon further two-dimensional echocardiographic examination and...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90916-1

    authors: Sclarovsky S,Topaz O,Rechavia E,Strasberg B,Agmon J

    更新日期:1987-05-01 00:00:00

  • A new method of scoring coronary angiograms to reflect extent of coronary atherosclerosis and improve correlation with major risk factors.

    abstract::We developed a new angiographic score of the extent of coronary disease (extent score), which we compared with conventional stenosis and vessel scores that emphasize the severity of stenosis. Scores were determined in 132 patients (29 women, 103 men with a mean age of 55 +/- 10 years) who underwent elective coronary a...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(05)80173-5

    authors: Sullivan DR,Marwick TH,Freedman SB

    更新日期:1990-06-01 00:00:00

  • Restenosis revisited: insights provided by quantitative coronary angiography.

    abstract::In this editorial, the problem of restenosis after coronary balloon angioplasty and other transluminal interventions is reviewed from the perspective of quantitative coronary angiography. The review is largely based on the experience of the Thoraxcentre in the application of quantitative angiography to the study of re...

    journal_title:American heart journal

    pub_type: 社论

    doi:10.1016/0002-8703(93)90689-7

    authors: Serruys PW,Foley DP,Kirkeeide RL,King SB 3rd

    更新日期:1993-11-01 00:00:00

  • The impact of the AMPD1 gene polymorphism on exercise capacity, other prognostic parameters, and survival in patients with stable congestive heart failure: a study in 686 consecutive patients.

    abstract:BACKGROUND:Previous studies have demonstrated that the adenosine monophosphate deaminase 1 (AMPD1) C34T polymorphism may be associated with survival in cardiac populations with a protective effect of the T allele. However, these studies included limited number of patients with few cardiovascular events. METHODS:We pro...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2006.04.003

    authors: de Groote P,Lamblin N,Helbecque N,Mouquet F,Hermant X,Amouyel P,Dallongeville J,Bauters C

    更新日期:2006-10-01 00:00:00

  • Transesophageal echocardiographic evaluation of cor triatriatum in children.

    abstract::Four children with cor triatriatum underwent intraoperative transesophageal echocardiography. Two patients had cor triatriatum alone and two had associated complex congenital heart disease. Transesophageal echocardiography provided optimal imaging of these defects and provided unique information that facilitated surgi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(95)90277-5

    authors: Shuler CO,Fyfe DA,Sade R,Crawford FA

    更新日期:1995-03-01 00:00:00

  • Early detection of doxorubicin cardiotoxicity: interest of Doppler echocardiographic analysis of left ventricular filling dynamics.

    abstract::Doxorubicin (Adriamycin) is an effective anticancer agent but its therapeutic value is limited by its myocardial cardiotoxicity. To improve early detection of doxorubicin cardiotoxicity, studies were performed in patients with long-term doxorubicin treatment using pulsed Doppler echocardiography to assess the changes ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(89)90077-x

    authors: Marchandise B,Schroeder E,Bosly A,Doyen C,Weynants P,Kremer R,Pouleur H

    更新日期:1989-07-01 00:00:00

  • Diet and incident venous thromboembolism: the Iowa Women's Health Study.

    abstract:BACKGROUND:Little is known about the role of diet in the development of venous thromboembolism (VTE). We explored the prospective relation of dietary patterns, food groups, and nutrients to incident VTE in older women. METHODS:In 1986, Iowa women aged 55 to 69 years completed a mailed survey, including a 127-item food...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2009.04.003

    authors: Lutsey PL,Steffen LM,Virnig BA,Folsom AR

    更新日期:2009-06-01 00:00:00

  • Within-patient comparison of effects of different dosages of enalapril on functional capacity and neurohormone levels in patients with chronic heart failure.

    abstract:BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors are established as first-line therapy in chronic heart failure (CHF). However, conflicting results exist regarding the dose-effect relation of ACE inhibitors. METHODS:We investigated 45 patients (age 55 +/- 10 years) with stable CHF who presented with a mainten...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0002-8703(99)70179-1

    authors: Brunner-La Rocca HP,Weilenmann D,Kiowski W,Maly FE,Candinas R,Follath F

    更新日期:1999-10-01 00:00:00

  • Sudden death and silent myocardial ischemia.

    abstract::Recent research indicates that silent myocardial ischemia may play a role in sudden cardiac death. To what extent treatment can reduce occurrence of silent ischemia remains to be assessed. Three classes of silent ischemia patients are identified: type 1--totally asymptomatic; type 2--post myocardial infarction; and ty...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(89)90673-x

    authors: Sheps DS,Heiss G

    更新日期:1989-01-01 00:00:00

  • Predictors of response to cardiac resynchronization therapy (PROSPECT)--study design.

    abstract:BACKGROUND:Cardiac resynchronization therapy (CRT) is currently indicated in patients with moderate to severe heart failure, a wide QRS complex and significant left ventricular dysfunction despite optimal medical therapy. Adoption of these criteria for CRT results in a favorable response in only two thirds of candidate...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2004.12.013

    authors: Yu CM,Abraham WT,Bax J,Chung E,Fedewa M,Ghio S,Leclercq C,León AR,Merlino J,Nihoyannopoulos P,Notabartolo D,Sun JP,Tavazzi L,PROSPECT Investigators.

    更新日期:2005-04-01 00:00:00

  • Angiographic follow-up after successful percutaneous coronary angioplasty for chronic total coronary occlusion: experience in 110 consecutive patients.

    abstract::Percutaneous transluminal coronary angioplasty (PTCA) was performed in 110 consecutive patients (111 vessels) with chronically occluded coronary arteries and was successful in 69 patients (69 vessels). Successful initial PTCA was related to the extent of coronary artery disease, the morphology of the proximal surface ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90503-7

    authors: Ishizaka N,Issiki T,Saeki F,Ishizaka Y,Ikari Y,Abe J,Soumitsu Y,Hashimoto H,Masaki K,Yamaguchi T

    更新日期:1994-01-01 00:00:00

  • Angiotensin II receptor antagonists: a new approach to blockade of the renin-angiotensin system.

    abstract::A-II exerts its activity on various target tissues by binding to its receptors. The discovery of local RASs and A-II receptors within various tissues has generated interest in the clinical usefulness of RAS inhibition by directly blocking the action of A-II at the receptor level. Different A-II receptor subtypes have ...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(94)90061-2

    authors: Kang PM,Landau AJ,Eberhardt RT,Frishman WH

    更新日期:1994-05-01 00:00:00

  • Brachytherapy and bivalirudin evaluation study.

    abstract:BACKGROUND:Bivalirudin is shown to be a competent substitute for heparin in percutaneous coronary intervention (PCI). The safety and efficacy of bivalirudin in patients undergoing PCI and vascular brachytherapy (VBT) are not known. This study aimed to assess the safety and efficacy of bivalirudin as a single antithromb...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2004.11.013

    authors: Kuchulakanti P,Wolfram R,Torguson R,Rha SW,Cheneau E,Pinnow EE,Canos D,Satler LF,Pichard AD,Kent KM,Waksman R

    更新日期:2005-10-01 00:00:00

  • Resting thallium-201 myocardial perfusion patterns in patients with severe left ventricular dysfunction: differences between patients with primary cardiomyopathy, chronic coronary artery disease, or acute myocardial infarction.

    abstract::This study examined the value of resting thallium-201 imaging in differentiating patients with primary cardiomyopathy from those with ischemic cardiomyopathy. There were 15 patients with primary cardiomyopathy (group I); 20 with chronic CAD (group II); and 25 with acute Q wave myocardial infarction (group III). All pa...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90113-4

    authors: Iskandrian AS,Hakki AH,Kane S

    更新日期:1986-04-01 00:00:00

  • Results of a phase I/II multi-center investigation of udenafil in adolescents after fontan palliation.

    abstract:BACKGROUND:The Fontan operation results in a circulation that is dependent on low pulmonary vascular resistance to maintain an adequate cardiac output. Medical therapies that lower pulmonary vascular resistance may augment cardiac output and improve long-term outcomes. OBJECTIVES:This phase I/II clinical trial conduct...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2017.02.030

    authors: Goldberg DJ,Zak V,Goldstein BH,Chen S,Hamstra MS,Radojewski EA,Maunsell E,Mital S,Menon SC,Schumacher KR,Payne RM,Stylianou M,Kaltman JR,deVries TM,Yeager JL,Paridon SM,Pediatric Heart Network Investigators.

    更新日期:2017-06-01 00:00:00

  • Comparative analysis of physiologic responses to three different maximal graded exercise test protocols in healthy women.

    abstract::The purpose of this study was to compare the three most commonly used maximal graded exercise test (GXT) protocols in healthy women. Submaximal and maximal metabolic and hemodynamic responses were determined from two treadmill protocols, Bruce and Balke, and a bicycle protocol, in 49 women. Maximum oxygen uptake (VO2 ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(82)90275-7

    authors: Pollock ML,Foster C,Schmidt D,Hellman C,Linnerud AC,Ward A

    更新日期:1982-03-01 00:00:00

  • Obesity and survival in patients with heart failure and preserved systolic function: a U-shaped relationship.

    abstract:BACKGROUND:Studies document better survival in heart failure patients with decreased left ventricular ejection fraction (EF) and higher body mass index (BMI; kg/m(2)) compared to those with a lower BMI. However, it is unknown if this "obesity paradox" applies to heart failure patients with preserved EF or if it extends...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2009.10.026

    authors: Kapoor JR,Heidenreich PA

    更新日期:2010-01-01 00:00:00

  • Identification of the ischemic etiology of heart failure by cardiovascular magnetic resonance imaging: diagnostic accuracy of late gadolinium enhancement.

    abstract:BACKGROUND:A large proportion of patients with heart failure (HF) have a large and poorly contracting left ventricle. The noninvasive recognition of the ischemic etiology of such patients is difficult, and for this purpose, usually patients undergo coronary angiography. It has been shown that cardiovascular magnetic re...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2005.03.068

    authors: Casolo G,Minneci S,Manta R,Sulla A,Del Meglio J,Rega L,Gensini G

    更新日期:2006-01-01 00:00:00

  • Training cardiovascular outcomes researchers: A survey of mentees and mentors to identify critical training gaps and needs.

    abstract:BACKGROUND:Many young investigators are interested in cardiovascular (CV) outcomes research; however, the current training experience of early investigators across the United States is uncertain. METHODS:From April to November 2014, we surveyed mentees and mentors of early-stage CV outcomes investigators across the Un...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2017.07.022

    authors: Khazanie P,Al-Khatib SM,Wang TY,Crowley MJ,Kressin NR,Krumholz HM,Kiefe CI,Wells BL,O'Brien SM,Peterson ED,Sanders GD

    更新日期:2018-02-01 00:00:00

  • Gender differences in cardiovascular mortality by C-reactive protein level in the United States: evidence from the National Health and Nutrition Examination Survey III.

    abstract:BACKGROUND:The association between C-reactive protein (CRP) and cardiovascular (CV) mortality by gender has not been previously described using a data set that is representative of the US population. METHODS:We used Cox proportional hazards models to explore gender differences in CRP-associated mortality via the Natio...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2013.03.017

    authors: Doran B,Zhu W,Muennig P

    更新日期:2013-07-01 00:00:00

  • Nicorandil improves cardiac function and clinical outcome in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: role of inhibitory effect on reactive oxygen species formation.

    abstract:BACKGROUND:Early reperfusion therapy improves the clinical outcomes of patients with acute myocardial infarction (AMI), but benefits are limited by reperfusion injury in some patients. We examined the effect of nicorandil, a hybrid of K(ATP) channel opener and nicotinamide nitrate, on reactive oxygen species (ROS) form...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.ahj.2004.05.014

    authors: Ono H,Osanai T,Ishizaka H,Hanada H,Kamada T,Onodera H,Fujita N,Sasaki S,Matsunaga T,Okumura K

    更新日期:2004-10-01 00:00:00

  • Magnum/Magnarail versus conventional systems for recanalization of chronic total coronary occlusions: a randomized comparison.

    abstract::The Magnum/Magnarail system consists of "over-the-wire" balloon catheters and a 0.021 inch (0.53 mm) guide wire with a 1 mm olive-shaped tip. To compare it to conventional systems, 100 consecutive unselected patients with chronic total coronary occlusions were randomly assigned to one of two groups. If the balloon cou...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-8703(92)91020-2

    authors: Pande AK,Meier B,Urban P,de la Serna F,Villavicencio R,Dorsaz PA,Favre J

    更新日期:1992-05-01 00:00:00

  • Metabolic risk factors for coronary heart disease in women: perspective from the Framingham Study.

    abstract::In over 30 years of surveillance of 2873 women, 574 developed initial clinical manifestations of CHD. A number of antecedent metabolic risk factors proved atherogenic, including blood lipids, glucose tolerance, uric acid, and menopause. Serum total cholesterol predicts as strongly in women as in men. The predictive po...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90511-4

    authors: Kannel WB

    更新日期:1987-08-01 00:00:00