Abstract:
BACKGROUND:Many young investigators are interested in cardiovascular (CV) outcomes research; however, the current training experience of early investigators across the United States is uncertain. METHODS:From April to November 2014, we surveyed mentees and mentors of early-stage CV outcomes investigators across the United States. We contacted successful grantees of government agencies, members of professional organizations, and trainees in CV outcomes training programs. RESULTS:A total of 185 (of 662) mentees and 76 (of 541) mentors completed the survey. Mentees were equally split by sex; most had completed training >3 years before completing the survey and were clinicians. Mentors were more likely women, mostly ≥20 years posttraining, and at an associate/full professor rank. Mentors reported devoting more time currently to clinical work than when they were early in their career and mentoring 2-4 people simultaneously. More than 80% of mentees started training to become academicians and completed training with the same goal. More than 70% of mentees desired at least 50% research time in future jobs. More than 80% of mentors believed that future investigators would need more than 50% time dedicated to research. Most mentees (80%) were satisfied with their relationship with their mentor and reported having had opportunities to develop independently. Mentors more frequently than mentees reported that funding cutbacks had negatively affected mentees' ability to succeed (84% vs 58%). Across funding mechanisms, mentees were more optimistic than mentors about securing funding. Both mentees and mentors reported greatest preparedness for job/career satisfaction (79% for both) and publications (84% vs 92%) and least preparedness for future financial stability (48% vs 46%) and work-life balance (47% vs 42%). CONCLUSIONS:Survey findings may stimulate future discourse and research on how best to attract, train, and retain young investigators in CV outcomes research. Insights may help improve existing training programs and inform the design of new ones.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Khazanie P,Al-Khatib SM,Wang TY,Crowley MJ,Kressin NR,Krumholz HM,Kiefe CI,Wells BL,O'Brien SM,Peterson ED,Sanders GDdoi
10.1016/j.ahj.2017.07.022subject
Has Abstractpub_date
2018-02-01 00:00:00pages
170-177eissn
0002-8703issn
1097-6744pii
S0002-8703(17)30281-8journal_volume
196pub_type
杂志文章abstract::CHD remains the leading cause of death in most developed countries; therefore, elucidation of risk factors and associated mechanisms for atherosclerosis and development of CHD has been a high priority. Data from the Framingham Heart Study and other large-scale epidemiologic studies have identified major risk factors a...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/s0002-8703(96)90096-4
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Standard gray-scale imaging (GSI), three-dimensional (3D) echocardiography has been shown to be superior to two-dimensional echocardiography in measuring left ventricular volume. However, the often relatively poor quality of transthoracic gray-scale data can limit the potential application of this technique....
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(98)70061-4
更新日期:1998-06-01 00:00:00
abstract::One hundred patients inducible at electrophysiologic studies underwent serial drug testing with procainamide, lidocaine, and lorcainide to determine comparative efficacy. Acute intravenous administration was followed by repeat programmed electrical stimulation (PES) studies on separate days for each antiarrhythmic dru...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-8703(85)90412-0
更新日期:1985-01-01 00:00:00
abstract::Left ventricular aneurysm has been associated with increased mortality rates. The Cardiac Arrhythmia Suppression Trial (CAST) database was used prospectively to assess (1) the prognostic significance of left ventricular (LV) aneurysm after myocardial infarction on mortality rates and (2) the relation of LV aneurysm to...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0002-8703(94)90549-5
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:The impact of race and sex on clinical outcomes after percutaneous coronary interventions remains incompletely understood. Specific data on patient demographics, lesion characteristics, and outcomes of black versus white patients are poorly described. To further evaluate these issues, we analyzed the New App...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2000.106645
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Controversy remains regarding whether gender differences exist in clinical management after exercise treadmill testing (ETT). METHODS:We studied 7,506 patients (49.8% women) without documented coronary heart disease referred for ETT from July 2001 to June 2004 in a community-based setting. We assessed the r...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2008.03.022
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:The prevalence of renal disease in cardiac intensive care units (CICUs) is increasing, but little is known about the utilization, concurrent therapies, and outcomes of patients requiring acute renal replacement therapy (RRT) in this specialized environment. METHODS:In the Critical Care Cardiology Trials Net...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2020.01.005
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Carvedilol therapy during congestive heart failure demonstrated a good efficacy in mortality rate reduction and in improvement of left ventricular (LV) systolic performance. However, currently there is not any finding about the drug's effect on diastolic filling. The aim of this study was to evaluate the eff...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0002-8703(03)00525-8
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The ODYSSEY COMBO I study (http://clinicaltrials.gov/show/NCT01644175) evaluated efficacy and safety of alirocumab as add-on therapy to stable maximally tolerated daily statin with or without other lipid-lowering therapy in high cardiovascular risk patients with suboptimally controlled hypercholesterolemia. ...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2015.03.004
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:National registries are advocated as instrumental to the solution of rarity-related problems for patients with hypertrophic cardiomyopathy (HCM), including limited access to advanced treatment options. Thus, an Italian Registry for HCM was created to assess the clinical profile and the level of care nationwi...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2005.01.005
更新日期:2005-11-01 00:00:00
abstract::Nitrates are widely used for the management of congestive heart failure (CHF), as well as angina pectoris. In both situations, nitrates significantly increase exercise capacity. The mechanism of this beneficial effect is unclear, especially in CHF. Isosorbide dinitrate reduces pulmonary capillary wedge pressure (PCWP)...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/0002-8703(85)90494-6
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:Gastrointestinal bleeding (GIB) after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and coronary artery disease (CAD) is associated with high morbidity and mortality. METHODS:The NIS database from 1998 to 2006 was used to identify 1,216,759 PCIs performed for ACS and CAD. We sou...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2011.09.009
更新日期:2011-12-01 00:00:00
abstract::A longitudinal study was performed in nine nonhydropic and nine hydropic fetuses with supraventricular tachycardia (SVT). First, because of a lack of reference methods in utero, the validity of spatial (length and area) and temporal parameters for semiquantitative grading of atrioventricular (AV) valve regurgitation b...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(93)90997-n
更新日期:1993-05-01 00:00:00
abstract::Out of 160 prospectively followed patients with aortic regurgitation, the clinical courses of 53 patients with pure, severe, and chronic aortic regurgitation and without coronary artery disease who were selected for surgery on the basis of predefined criteria is discussed. Surgical criteria were either unequivocal sym...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(90)90023-q
更新日期:1990-09-01 00:00:00
abstract::Patent foramen ovale (PFO) and atrial septal aneurysm (ASA) have been identified as potential risk factors for stroke, but information about the risk of recurrent cerebral ischemia is scarce. The aim of this retrospective study was to assess the absolute risk of recurrent cerebrovascular events in 132 patients under 6...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(95)90212-0
更新日期:1995-11-01 00:00:00
abstract::Left ventricular (LV) filling was examined by Doppler and M-mode echocardiography in 24 patients with LV hypertrophy (five with aortic stenosis, six with hypertrophic cardiomyopathy, and 13 with LV hypertrophy secondary to systemic hypertension) and in 18 normal subjects. Patients with LV hypertrophy had significantly...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(87)90657-0
更新日期:1987-06-01 00:00:00
abstract::Pulmonary function was measured serially in two separate randomized trials of pindolol in the treatment of essential hypertension. Patients with overt obstructive airways disease were excluded. In study 1, 131 hypertensive patients were randomized to placebo (31) and 15 mg (33), 30 mg (33), and 60 mg (34) of pindolol....
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-8703(82)90135-1
更新日期:1982-08-01 00:00:00
abstract::Despite gratifying immediate results, significant recoarctation at follow-up has been observed after balloon angioplasty of native aortic coarctation. Risk factors for such recurrences have been identified in one of our previous studies. In this study we examined the value of these risk factors in the prediction of re...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(95)90245-7
更新日期:1995-07-01 00:00:00
abstract::Polymorphic ventricular arrhythmias (PVAs) initiated by programmed electrical stimulation may be a nonspecific response or evidence of ventricular electrical instability. To determine if PVAs initiated in patients with spontaneous sustained ventricular tachycardia or fibrillation differ from those which are clearly a ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(86)90008-6
更新日期:1986-06-01 00:00:00
abstract::Ambulatory ECG recordings were obtained from 313 consecutive, totally symptom-free male subjects on whom cardiac catheterization was subsequently performed for occupational reasons. These recordings were examined for ventricular ectopy and the results were studied in relation to the findings on selective coronary angi...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(89)90405-5
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:We investigated the role of the renin-angiotensin system in women with signs and symptoms of ischemia without obstructive coronary artery disease (CAD). Although microvascular dysfunction has been suggested to explain this syndrome and recently was found to predict adverse outcomes, the mechanisms and treatm...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2011.07.011
更新日期:2011-10-01 00:00:00
abstract::A multiprogrammable automatic antitachycardia pacemaker (Cybertach-60), connected to a tined "J" wire electrode, was positioned in the right atrial appendage in three patients with recurrent supraventricular tachycardia (SVT). Mechanisms of SVT included atrioventricular (AV) nodal reentry (two patients) and reciprocat...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(83)90648-8
更新日期:1983-11-01 00:00:00
abstract::Motion of the posterior aortic root on echocardiography is related to left atrial volume changes. Early diastolic posterior motion of the aortic root reflects both LA emptying and filling and has been measured as the atrial emptying index. To study late diastolic motion of the aortic root, we measured the slope of pos...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(80)90654-7
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND:Few data are available on the temporal patterns of health resource utilization (HRU) and expenditures around paroxysmal supraventricular tachycardia (PSVT) diagnosis. This study assessed the longitudinal trends in HRU and expenditures in the 3 years preceding and subsequent to PSVT diagnosis. METHODS:Adult ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2020.12.012
更新日期:2021-01-15 00:00:00
abstract::Pressor response to norepinephrine, cardiopulmonary blood volume, and hemodynamic parameters were studied in 41 borderline hypertensive patients in comparison with 42 permanent essential hypertensive patients and 28 normal subjects. Borderline hypertensive subjects had high cardiac index (p less than 0.0001), normal t...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(75)90155-6
更新日期:1975-04-01 00:00:00
abstract::Antiplatelet therapy is the current criterion standard for the treatment of patients undergoing percutaneous coronary intervention and patients who have acute coronary syndromes. Clopidogrel in combination with aspirin is the current standard of care for reducing cardiovascular events in these patients. However, patie...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/j.ahj.2008.06.003
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:African-American ancestry, hypokalemia, and QT interval prolongation on the electrocardiogram are all risk factors for sudden cardiac death (SCD), but their interactions remain to be characterized. SCN5A-1103Y is a common missense variant, of African ancestry, of the cardiac sodium channel gene. SCN5A-1103Y ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2013.10.009
更新日期:2014-01-01 00:00:00
abstract::It has been shown that brief episodes of myocardial ischemia can render the heart more resistant to a prolonged subsequent ischemic episode. This phenomenon, called "preconditioning," has been described in human beings during coronary angioplasty with the use of clinical, electrocardiographic (ECG), or metabolic param...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(97)70200-x
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:The relationship of changes in weight to outcomes in patients after myocardial infarction (MI) is controversial. METHODS:From the ENRICHD trial data, we assessed weight change, and the associations of baseline weight and change at follow-up with outcomes and interactions between psychosocial factors. RESUL...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2007.10.026
更新日期:2008-03-01 00:00:00
abstract::The effects of intravenous adenosine and adenosine triphosphate (ATP) were studied in a double-blind randomized study during 68 episodes of supraventricular tachycardia in 39 patients. Adenosine restored sinus rhythm in 20 patients (25 of 27 episodes) and produced atrioventricular block to reveal atrial arrhythmias in...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0002-8703(05)80022-5
更新日期:1990-02-01 00:00:00