Long-term lorcainide therapy in patients with ventricular tachycardia.

Abstract:

:One hundred patients inducible at electrophysiologic studies underwent serial drug testing with procainamide, lidocaine, and lorcainide to determine comparative efficacy. Acute intravenous administration was followed by repeat programmed electrical stimulation (PES) studies on separate days for each antiarrhythmic drug. Lorcainide prevented ventricular tachycardia (VT) induction in 69% of the 100 patients studied, procainamide was effective in 50% of the 75 patients studied, and lidocaine prevented VT induction in 30% of 53 patients. Following PES and serial drug testing, 46 patients were started on lorcainide, nine patients on procainamide, and 45 patients were started on other antiarrhythmic drug regimens. Seventy percent of the patients have remained on lorcainide therapy, while 47% have continued on other drug therapies started over a 20.5 +/- 3.2-month mean follow-up period. Despite sleep-wake disturbances and a need for sedation at night, lorcainide therapy was tolerated well in this population and remained an effective antiarrhythmic with prolonged administration.

journal_name

Am Heart J

journal_title

American heart journal

authors

Somberg J,Butler B,Flowers D,Keefe D,Torres V,Miura D

doi

10.1016/0002-8703(85)90412-0

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

33-40

issue

1

eissn

0002-8703

issn

1097-6744

pii

0002-8703(85)90412-0

journal_volume

109

pub_type

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