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Angiographic methods to assess human coronary angiogenesis.

Abstract：

:It is unclear how agents designed to promote angiogenesis in the human heart affect the arteriographic appearance of the collateral circulation. Possible changes in collateral vessels include new collateral vessels arising from epicardial arteries, new branches emanating from existing collateral vessels, wider or longer collateral vessels, and higher dye transit rates that result in improved recipient vessel filling. Given the multiple mechanisms by which these new agents may improve myocardial perfusion, a rigorous, systematic, and comprehensive analysis of coronary arteriograms is required to discern the true mechanism of benefit. The method of analysis must account for potential changes in collateral blood flow, number, branching pattern, and length as well as changes in recipient vessel filling. The ability to detect differences between intricate networks of vessels in an angiographic study is dependent on maintaining consistency in cinefilming as well as the core laboratory methods between time points. In this report, we describe the methodology our angiographic core laboratory has found to be most effective to evaluate these very complex angiograms and attempt to capture all the possible modalities of angiogenesis.

journal_name

Am Heart J

journal_title

American heart journal

authors

Gibson CM,Ryan K,Sparano A,Moynihan JL,Rizzo M,Kelley M,Marble SJ,Laham R,Simons M,McClusky TR,Dodge JT Jr

doi

10.1016/s0002-8703(99)70473-4

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

169-79

issue

1

eissn

0002-8703

issn

1097-6744

pii

S0002870399005426

journal_volume

137

pub_type

杂志文章,评审

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