Cigarette smoking status and outcome among patients with acute coronary syndromes without persistent ST-segment elevation: effect of inhibition of platelet glycoprotein IIb/IIIa with eptifibatide. The PURSUIT trial investigators.

Abstract:

BACKGROUND:Studies have shown that cigarette smokers constitute a substantial proportion of patients with acute coronary syndromes (ACS) and have platelet-rich coronary thrombi. We characterized the influence of smoking status on outcome of patients with ACS without persistent ST-segment elevation and tested the hypothesis that selective inhibition of the platelet glycoprotein IIb/IIIa receptor with eptifibatide would improve outcomes among cigarette smokers. METHODS:The study population included patients enrolled in the PURSUIT trial (Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy) with known smoking status presenting with ischemic chest pain

journal_name

Am Heart J

journal_title

American heart journal

authors

Hasdai D,Holmes DR Jr,Criger DA,Topol EJ,Califf RM,Wilcox RG,Paolasso E,Simoons M,Deckers J,Harrington RA

doi

10.1016/s0002-8703(00)90089-9

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

454-60

issue

3

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(00)90089-9

journal_volume

139

pub_type

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