Abstract:
:Fifty adult men with mild to moderate hypertension were recruited to participate in a double-blind crossover study. Each subject received 14 days of drug treatment and 14 days of placebo treatment (random order). Half the subjects were assigned to a metoprolol (150 mg/day) vs placebo treatment regimen and half to an atenolol (100 mg/day) vs placebo regimen. Blood pressure levels as well as measures of simple (proofreading), intermediate (visual-motor task), and complex (management simulation) task performance were obtained at the end of the drug and placebo treatment periods. Metoprolol treatment generated better scores than did placebo or atenolol treatment for proofreading, visual-motor performance, and several measures of complex managerial competence. Atenolol treatment generally resulted in performance levels that did not differ from those observed with placebo. However, atenolol-treated subjects made more errors than did placebo-treated subjects in the visual-motor task and also showed some deterioration on one measure of complex managerial functioning.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Streufert S,DePadova A,McGlynn T,Pogash R,Piasecki Mdoi
10.1016/0002-8703(88)90106-8subject
Has Abstractpub_date
1988-07-01 00:00:00pages
311-5issue
1 Pt 2eissn
0002-8703issn
1097-6744pii
0002-8703(88)90106-8journal_volume
116pub_type
临床试验,杂志文章,随机对照试验abstract::Coronary arterial stenosis of varying severity and length were created in open-chest dogs. The reactive hyperemic responses (RHR) to 15 second occlusions were used to produce flow increases and judge the physiological significance of the narrowings. RHR are sensitive indices of functional impairment when resting flow ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(76)80010-5
更新日期:1976-12-01 00:00:00
abstract::The effectiveness of postextrasystolic potentiation (PESP) was assessed to detect residual function of the left ventricle in seven patients with idiopathic dilated cardiomyopathy (IDC). The postextrasystolic changes in the aortic pressure pulse, global left ventricular function, and quantitative regional left ventricu...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(87)90661-2
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Treatment strategies, either invasive or noninvasive, for patients with unstable coronary artery disease still vary. There are no published studies comparing the strategies for health-related quality of life. METHODS:A total of 2457 patients with unstable coronary artery disease were randomized. We prospect...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ahj.2003.11.026
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Reliable predictors have yet to be found for recurrent ischemia after thrombolysis for acute myocardial infarction (AMI), nor do we know whether early angiography can herald recurrent ischemia. This study sought to investigate the relationship between recurrent ischemia and cardiac procedures after thromboly...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2001.113226
更新日期:2001-04-01 00:00:00
abstract::The primary objective of this study was to apply a sophisticated coagulation monitoring system including estimation of the concentration of prothrombin fragment 1 + 2 (PTF 1 + 2) and the activity of prothrombin (coagulation factor II or FII) to cases of stent implantation and to compare the results with those of stand...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/0002-8703(95)90433-6
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:P2Y12 receptor antagonist therapy is recommended in addition to ASA for up to 1 year after acute coronary syndrome to reduce ischemic events. In contrast, the benefit of long-term dual antiplatelet therapy beyond 1 year remains unclear. Ticagrelor is a potent, reversibly binding P2Y12 receptor-antagonist tha...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/j.ahj.2013.12.020
更新日期:2014-04-01 00:00:00
abstract::Radiofrequency-powered, thermal balloon angioplasty is a new technique that enhances luminal dilatation with less dissection than conventional angioplasty. The purpose of this study was to assess the effect of radiofrequency heating of balloon fluid on the pressure-volume mechanics of in vitro balloon angioplasty and ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(94)90005-1
更新日期:1994-07-01 00:00:00
abstract::Acute myocardial infarction, particularly of the inferior wall, is frequently associated with bradycardia and hypotension. This study reports the occurrence of transient bradycardia hypotension (TBH) (Bezold-Jarisch reflex) following thrombolytic therapy with intravenous streptokinase. Of the 52 patients, 42 had succe...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(86)90508-9
更新日期:1986-09-01 00:00:00
abstract::Complex coronary morphologic abnormalities with thrombus and ulceration have been recognized in acute ischemic syndromes by angiography, angioscopy, and autopsy. However, in vivo histopathologic correlates of unstable ischemic syndromes have not been described. The purpose of this study was to characterize intracorona...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(94)90612-2
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Myocardial contractile reserve has been shown to provide important prognostic information in patients with heart failure. We hypothesized that myocardial contractile reserve would predict left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). METHODS:Thirty-one consecutive p...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.07.035
更新日期:2007-12-01 00:00:00
abstract::Coronary angiography of both right and left coronary arteries, using the Sones technique, was performed during the attack of total spastic obstruction in 11 patients with clinically documented history of variant angina. None of the patients had more than 70% stenosis of organic atherosclerosis in any coronary artery a...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(85)90635-0
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:There is increasing evidence that transplantation of autologous stem cells improves cardiac function after acute myocardial infarction (AMI). For propagation of peripheral blood stem cells (PBSCs), application of granulocyte-colony stimulating factor (G-CSF) has been shown to be feasible, effective, and safe...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/j.ahj.2006.03.012
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:We evaluated the influence of peak respiratory exchange ratio (pRER), as an index of effort adequacy, on peak VO2 prognostic reliability in patients with chronic heart failure (CHF) and reduced exercise capacity, whose peak VO2 may be underestimated because of poor patient motivation. METHODS:A cardiopulmon...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/S0002-8703(03)00100-5
更新日期:2003-06-01 00:00:00
abstract::This study was performed to assess the relation between the regional work and oxidative metabolism in hypertrophic cardiomyopathy (HCM). By using carbon 11 acetate as a tracer of myocardial blood flow (%A(0)) and oxygen consumption (k value), 12 patients with HCM with asymmetric septal hypertrophy and 10 normal subjec...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(97)70143-1
更新日期:1997-05-01 00:00:00
abstract::In a demographic study, the black Ohio residents were characterized by those born in Ohio and those born in other regions of the United States, and comparisons were made of rates for all deaths (1960-1967) for coronary heart disease (420), endocarditis and myocardial degeneration (421-422), hypertensive cardiovascular...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(75)90329-4
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:The purpose of the current study was to determine whether survival after revascularization (coronary artery bypass grafting or percutaneous transluminal coronary angioplasty) is influenced by the extent of electrocardiographic (ECG) evidence of previous myocardial infarction (MI) in patients with ischemic ca...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2002.119996
更新日期:2002-01-01 00:00:00
abstract::Potential antiarrhythmic effects of calcium (slow-channel)-blocking drugs ca be indirect or direct. The indirect effect would affect ischemia-induced arrhythmias by improving myocardial perfusion or decreasing myocardial oxygen consumption. The direct effect would affect the electrical activity of the sinoatrial (SA) ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(82)90476-8
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:Experimental evidence shows that activation of the autonomic nervous system influences ventricular repolarization and, therefore, the QT interval on the ECG. To test the hypothesis that the QT interval is abnormal in autonomic dysfunction, we examined ECGs in patients with severe primary autonomic failure an...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(98)70014-6
更新日期:1998-10-01 00:00:00
abstract::Valve area and cardiac output were determined with magnetic resonance (MR) velocity mapping in 12 patients with aortic stenosis. Heart catheterization, Doppler echocardiography, and indicator dilution were performed for comparison. Left ventricle could be catheterized in only nine patients; in these cases, MR measured...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(93)90669-z
更新日期:1993-11-01 00:00:00
abstract::Sixteen patients with mild or moderate essential hypertension received 1 to 8 mg/day of doxazosin (mean daily dose, 2.7 mg). Blood pressure reduction (supine and standing) was highly significant (p less than 0.001), and no significant changes in heart rate were observed. A significant reduction (p less than 0.01) in l...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/0002-8703(91)90871-e
更新日期:1991-01-01 00:00:00
abstract::In prior studies, we have shown that the antikaliuretic drugs, triamterene and amiloride, through a direct cardiac effect reduce the loss of cardiac potassium induced by the administration of digitalis. Since loss of myocardial potassium is thought to underlie digitalis arrhythmias, this study was performed to determi...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(75)90257-4
更新日期:1975-07-01 00:00:00
abstract:BACKGROUND:Peculiar asynergy, which consists of hypokinesis or akinesis from the mid portion to the apical area and hyperkinesis of the basal area on contrast left ventriculogram, is rare. Because the end-systolic left ventriculogram looks like a "tako-tsubo," which was used for trapping octopuses in Japan, we proposed...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2002.120403
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Endothelial injury plays a critical role in coronary artery disease (CAD), but the assessment of this injury has been problematical. Recently, it has been shown in vitro that endothelial cells (ECs) release endothelial microparticles (EMPs) on activation or apoptosis and that an assay of EMPs can provide use...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/S0002-8703(03)00103-0
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Drug-eluting stents have been shown to reduce restenosis in many types of lesions. The purpose of this article is to assess the efficacy of sirolimus- and paclitaxel-eluting stents in patients with bifurcation lesions. METHODS:Between June 2003 and October 2004, 205 patients were enrolled in a prospective r...
journal_title:American heart journal
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ahj.2006.10.017
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Preoperative use of angiotensin-blocking drug therapy (ABDT) with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and its link to occurrence of postoperative atrial fibrillation (POAF), a common marker of poor outcomes after cardiac surgery, remain controversial. METHODS:From 19...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2010.05.033
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Cardiac resynchronization therapy (CRT) improves outcomes, functional capacity and quality of life in patients with heart failure. Despite two decades of experience with CRT, the rate of non-response remains approximately 30%. CRT efficacy is impacted by pacing location, which is anatomically limited in conv...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2019.04.002
更新日期:2019-11-01 00:00:00
abstract::Currently available internal cardiac defibrillators use a uniphasic, truncated exponential waveform morphology of about 6 msec in duration at an energy level of 23 to 33 joules. To determine if improved defibrillation could be achieved with a different waveform morphology, we implanted 4.5 cm2 titanium patches to the ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(89)90187-7
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:The 6-minute walk test is a submaximal exercise test that is widely used as an outcomes measure in clinical trials and cardiopulmonary rehabilitation. An initial learning effect with repeated administration is well documented, but it is unknown whether this learning effect persists with time. METHODS:This s...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/S0002-8703(03)00119-4
更新日期:2003-07-01 00:00:00
abstract::The aortocaval fistula is a classic model of pure cardiac volume overload in rats. This model is characterized by dilation of the ventricular cavities and eccentric cardiac hypertrophy. There are also changes in peripheral arterial flow: high flow in the proximal part of the aorta, upstream of the shunt, and low flow ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(93)90929-4
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Acute myocardial infarction (AMI) is a leading cause of mortality in Asia. However, quantitative risk scores to predict mortality after AMI were developed without the participation of Asian countries. METHODS:We evaluated the performance of the Global Registry of Acute Coronary Events (GRACE) in-hospital mo...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2011.05.016
更新日期:2011-08-01 00:00:00