当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > The acute effects of flecainide in the swine heart failing from incessant supraventricular tachycardia.

The acute effects of flecainide in the swine heart failing from incessant supraventricular tachycardia.

Abstract：

:The acute hemodynamic and electrophysiologic effects of flecainide in tachycardia-induced ventricular dysfunction were investigated using an animal model. Seven swine were initially (CON) evaluated by echocardiography and then by right heart catheterization and provocative electrical ventricular stimulation both before and after treatment with intravenous flecainide. Rapid atrial pacing at 210 to 240 beats/min (SVT) was then employed for 2 to 4 weeks until echocardiographic evidence of left ventricular dysfunction developed. Immediately upon termination of pacing, the above studies were repeated both before and after treatment with flecainide. Significant (p less than 0.0001) pacing-related hemodynamic effects on the cardiac output (CON:3.0 L/min versus SVT:1.6 L/min), right ventricular ejection fraction (CON:55% versus SVT:17%), and pulmonary wedge pressure (CON:8 mm Hg versus SVT:22 mm Hg) were observed. Pacing-related electrophysiologic effects included increases in the PR interval (CON:94 msec versus SVT:119 msec, p less than 0.001) and QTc interval (CON:418 msec versus SVT:450 msec, p = 0.016). With serum flecainide concentrations in the human therapeutic range, no significant effect on hemodynamic or electrophysiologic parameters in either the normal or failing heart were detected. Nonsustained ventricular tachycardia induced prior to pacing in one animal and after pacing in another animal was seen before but not following use of flecainide. No acute proarrhythmic effects were observed. In summary, intravenous flecainide had no significant acute adverse hemodynamic, electrophysiologic, or proarrhythmic effects in an animal model of tachycardia-induced ventricular dysfunction.

journal_name

Am Heart J

journal_title

American heart journal

authors

Trippel DL,Harold ME,Spinale FG,Buckles DS,Gillette PC

doi

10.1016/0002-8703(91)90018-d

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

1721-6

issue

6 Pt 1

eissn

0002-8703

issn

1097-6744

pii

0002-8703(91)90018-D

journal_volume

121

pub_type

杂志文章

相关文献

AMERICAN HEART JOURNAL文献大全
  • Does current treatment of cardiogenic shock complicating the acute coronary syndromes comply with guidelines?

    abstract：BACKGROUND:The purpose of our study was to evaluate the implementation of guidelines for the treatment of cardiogenic shock (CS) complicating the acute coronary syndromes (ACS). METHODS AND RESULTS:Of the 10 136 patients in the Euro-Heart-Survey-ACS with complete data, CS occurred in 549 (5.4%), of whom 28.6% had CS u...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.06.004

    authors： Iakobishvili Z,Behar S,Boyko V,Battler A,Hasdai D

    更新日期：2005-01-01 00:00:00

  • Coffee consumption and mortality after acute myocardial infarction: the Stockholm Heart Epidemiology Program.

    abstract：BACKGROUND:Cohort studies have suggested little effect of coffee consumption on risk of acute myocardial infarction. The effect of coffee consumption on prognosis after myocardial infarction is uncertain. METHODS:In a population-based inception cohort study, we followed 1,369 patients hospitalized with a confirmed fir...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.11.009

    authors： Mukamal KJ,Hallqvist J,Hammar N,Ljung R,Gémes K,Ahlbom A,Ahnve S,Janszky I

    更新日期：2009-03-01 00:00:00

  • Doppler measurement of left atrial depressurization and mitral valve area in patients with suspected mitral stenosis: validation of a new method.

    abstract：:Atrial depressurization time measurement by Doppler ultrasound can be used to quantify stenotic mitral valve area. In this report, we present the results of a blinded trial comparing the standard Doppler method for "pressure half-time" (A) and another Doppler method we devised (B) for measurement of atrial depressuriz...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(87)90045-7

    authors： Pearlman JD,Gibson RS

    更新日期：1987-04-01 00:00:00

  • Troponin T is a better predictor than creatine kinase-MB of long-term mortality after coronary artery bypass graft surgery.

    abstract：BACKGROUND:Elevations of creatine kinase-MB (CK-MB) and cardiac troponin T (cTnT) have an uncertain long-term prognostic value after coronary artery bypass graft (CABG) surgery. We aimed to test the hypothesis that CK-MB and cTnT are predictors of long-term survival after CABG and to assess which of these 2 biomarkers ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2012.05.027

    authors： Søraas CL,Friis C,Engebretsen KV,Sandvik L,Kjeldsen SE,Tønnessen T

    更新日期：2012-11-01 00:00:00

  • Combined use of high-sensitivity cardiac troponin T and N-terminal pro-B type natriuretic peptide improves measurements of performance over established mortality risk factors in chronic heart failure.

    abstract：BACKGROUND:Heart failure still maintains a high mortality. Biomarkers reflecting different pathophysiological pathways are under evaluation to better stratify the mortality risk. The objective was to assess high-sensitivity cardiac troponin T (hs-cTnT) in combination with N-terminal pro-B type natriuretic peptide (NT-p...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2012.03.004

    authors： de Antonio M,Lupon J,Galan A,Vila J,Urrutia A,Bayes-Genis A

    更新日期：2012-05-01 00:00:00

  • Aging and pain perception in ischemic heart disease.

    abstract：:Age is a recognized risk factor for coronary artery disease, but the relationship between age and silent ischemia is not well understood. We analyzed the data from 35 rest/stress radionuclide ventriculography examinations in patients with documented ischemic coronary artery disease who had experienced 1 mm ST segment ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(90)90156-r

    authors： Miller PF,Sheps DS,Bragdon EE,Herbst MC,Dalton JL,Hinderliter AL,Koch GG,Maixner W,Ekelund LG

    更新日期：1990-07-01 00:00:00

  • Effects of exercise training on left ventricular volumes and function in patients with nonischemic cardiomyopathy: application of magnetic resonance myocardial tagging.

    abstract：BACKGROUND:Exercise training is now an accepted component of the therapeutic regimen in patients with heart failure and underlying ischemia, but few data are available on the effects of training in patients with nonischemic dilated cardiomyopathy. METHODS:Twenty-four patients (mean age 55 +/- 9 years, mean ejection fr...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1067/mhj.2002.124401

    authors： Myers J,Wagner D,Schertler T,Beer M,Luchinger R,Klein M,Rickli H,Muller P,Mayer K,Schwitter J,Dubach P

    更新日期：2002-10-01 00:00:00

  • Abnormal mitral valve motion associated with ventricular septal defect following acute myocardial infarction.

    abstract：:It is often difficult to make the clinical distinction between acute mitral regurgitation caused by papillary muscle dysfunction or rupture and ventricular septal defect complicating an acute myocardial infarction. A case of a patient with rapidly progressive congestive heart failure and a loud murmur is presented. Ec...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(79)90291-6

    authors： Rosenthal R,Kleid JJ,Cohen MV

    更新日期：1979-11-01 00:00:00

  • Transitional adherence and persistence in the use of aldosterone antagonist therapy in patients with heart failure.

    abstract：BACKGROUND:Aldosterone antagonist therapy is recommended for selected patients with heart failure and reduced ejection fraction. Adherence to therapy in the transition from hospital to home is not well understood. METHODS:We identified patients with heart failure and reduced ejection fraction who were ≥65 years old, e...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2013.03.007

    authors： Curtis LH,Mi X,Qualls LG,Check DK,Hammill BG,Hammill SC,Heidenreich PA,Masoudi FA,Setoguchi S,Hernandez AF,Fonarow GC

    更新日期：2013-06-01 00:00:00

  • Truncus arteriosus communis. Clinical, angiocardiographic, and pathologic findings in 100 patients.

    abstract：:Salient clinical, hemodynamic, angiocardiographic, and pathologic findings are presented in 100 patients with truncus arteriosus communis, 79 of whom were studied at autopsy. In this study of typical truncus, all had a ventricular septal defect (type A). Truncus with a partially formed aorticopulmonary septum (type A1...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(76)80400-0

    authors： Calder L,Van Praagh R,Van Praagh S,Sears WP,Corwin R,Levy A,Keith JD,Paul MH

    更新日期：1976-07-01 00:00:00

  • Myocardial infarct size reduction by the synergistic effect of hyperbaric oxygen and recombinant tissue plasminogen activator.

    abstract：:Fasting mongrel dogs underwent hyperbaric oxygen treatment (HBOT), recombinant tissue plasminogen activator (rt-PA) treatment, and simultaneous HBOT and rt-PA treatment following prior experimental left anterior descending coronary artery occlusion for 2 hours. Thrombosis in and around a copper coil was recorded angio...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(90)90194-3

    authors： Thomas MP,Brown LA,Sponseller DR,Williamson SE,Diaz JA,Guyton DP

    更新日期：1990-10-01 00:00:00

  • Elevated vascular endothelial growth factor levels are associated with aortopulmonary collateral vessels in patients before and after the Fontan procedure.

    abstract：BACKGROUND:Aortopulmonary collaterals (APCs) are frequently observed before and after the Fontan procedure. However, the mechanism of the development of APCs is unknown. We hypothesized that one or several antiangiogenic and/or angiogenic growth factors might play a role in the development of APCs. METHODS:Eighty-five...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2007.03.009

    authors： Mori Y,Shoji M,Nakanishi T,Fujii T,Nakazawa M

    更新日期：2007-06-01 00:00:00

  • Long-term results of electrophysiologically guided sotalol therapy for life-threatening ventricular arrhythmias.

    abstract：:The efficacy and safety of sotalol therapy for ventricular arrhythmias was evaluated in 133 patients with drug-refractory ventricular arrhythmias. All patients had baseline electrophysiologic studies before and after oral sotalol therapy. Sixty-six patients were discharged home, treated with sotalol (52 patients witho...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(96)90008-3

    authors： Lee RJ,Wong M,Siu A,Namekawa-Wong M,Epstein LM,Fitzpatrick AP,Grogin HR,Scheinman MM,Lesh MD

    更新日期：1996-11-01 00:00:00

  • Heart failure disease management in an indigent population.

    abstract：BACKGROUND:Multidisciplinary disease management programs (MDMP) have demonstrated reduced hospitalizations in motivated pretransplant heart failure populations, but little is known about their effectiveness in largely indigent patients who are not transplant candidates. METHODS AND RESULTS:We studied 35 patients with ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2001.111956

    authors： O'Connell AM,Crawford MH,Abrams J

    更新日期：2001-02-01 00:00:00

  • Cigarette smoking and coronary heart disease in blacks: comparison to whites in a prospective study.

    abstract：:The American Cancer Society's prospective study of 1 million Americans was analyzed to determine whether coronary heart disease (CHD) mortality rates by cigarette smoking in blacks differed from those in whites. More than 22,000 blacks were followed up for nearly 200,000 person-years in the 12-year study, 1960-1972. A...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(84)90675-6

    authors： Garfinkel L

    更新日期：1984-09-01 00:00:00

  • Diagnostic value of 12-lead electrocardiogram during dobutamine echocardiographic studies.

    abstract：BACKGROUND:The diagnostic value of 12-lead electrocardiography during dobutamine stress echocardiography (DSE) is not well documented. METHODS AND RESULTS:We reviewed the records of 116 patients referred for DSE and coronary angiography, 52 of whom were excluded because of abnormal ST segment or inadequate DSE. Of the...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(98)70163-2

    authors： Shaheen J,Luria D,Klutstein MW,Rosenmann D,Tzivoni D

    更新日期：1998-12-01 00:00:00

  • Validation of pressure-volume data obtained in patients by initial transit radionuclide angiocardiography.

    abstract：:In order to validate the measurement of pressure-volume loops and stroke work in humans, simultaneous digital subtraction ventriculography (DSA) and first-pass radionuclide angiocardiography (RNA) coupled with high-fidelity micromanometer left ventricular pressure measurements were undertaken in 34 patients, mean age ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(89)90234-2

    authors： Harpole DH,Skelton TN,Davidson CJ,Jones RH,Bashore TM

    更新日期：1989-11-01 00:00:00

  • Excess weight and life expectancy after acute myocardial infarction: The obesity paradox reexamined.

    abstract：BACKGROUND:An "obesity paradox" has been described in patients with acute myocardial infarction (AMI), whereby obese and overweight patients have a lower risk of short-term mortality after AMI than normal-weight patients. However, the long-term association of obesity with mortality after AMI remains unknown. METHODS:W...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2015.10.024

    authors： Bucholz EM,Beckman AL,Krumholz HA,Krumholz HM,Dr. Bucholz was affiliated with the Yale School of Medicine and Yale School of Public Health during the time that the work was conducted.

    更新日期：2016-02-01 00:00:00

  • Rationale and design of the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC).

    abstract：BACKGROUND:Although the management of thoracic aortic aneurysms (TAAs) has improved significantly, patients presenting with aortic dissections, rupture, or other acute complications of TAAs continue to have high rates of morbidity and mortality. Accumulating data have indicated that many TAAs are due to underlying gene...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2008.10.005

    authors： Eagle KA,GenTAC Consortium.

    更新日期：2009-02-01 00:00:00

  • Ten-year clinical follow-up after sirolimus-eluting stent implantation.

    abstract：BACKGROUND:Little is known on the "very" long-term incidence of major adverse cardiac events (MACE), target-lesion revascularization (TLR), target-vessel revascularization and stent thrombosis after sirolimus-eluting stent (SES) implantation. We present the first study to provide a 10-year clinical follow-up in an unse...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2013.12.013

    authors： Palhais N,Arroyo D,Lehmann S,Togni M,Kaufmann U,Puricel SG,Stauffer JC,Goy JJ,Cook S

    更新日期：2014-06-01 00:00:00

  • Insulin sensitivity in young women with vasovagal syncope.

    abstract：BACKGROUND:Insulin, in addition to its known metabolic effects, has sympatho-excitatory and vasodilatory actions on muscular blood vessels. The goal of this study was to evaluate insulin sensitivity in young women with vasovagal syncope and positive tilt test results (HUT+) and to compare it with that in patients with ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/S0002-8703(02)94707-1

    authors： Ruiz GA,Calvar C,Hermes R,Rivadeneira D,Bengolea V,Chirife R,Tentori MC,Gelpi RJ

    更新日期：2003-05-01 00:00:00

  • Association of left ventricular dilatation and hypertrophy with chronotropic incompetence in the Framingham Heart Study.

    abstract：BACKGROUND:Chronotropic incompetence and left ventricular (LV) dilatation have both been shown to be markers of an adverse cardiovascular prognosis. Chronotropic incompetence has been described in patients with symptomatic LV dilatation and dysfunction, but the effect of asymptomatic LV dilatation and hypertrophy on ex...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(99)70415-1

    authors： Lauer MS,Larson MG,Evans JC,Levy D

    更新日期：1999-05-01 00:00:00

  • Effect of rosuvastatin on C-reactive protein and progression of aortic stenosis.

    abstract：BACKGROUND:Elevated C-reactive protein (CRP) is a common finding in patients with aortic stenosis (AS) and may be associated with rapid AS progression and worse outcome. The purpose of the study was to examine the role of high-sensitivity CRP and its interaction with rosuvastatin on the progression of AS. METHODS:We m...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2011.03.016

    authors： Chan KL,Dumesnil JG,Tam J,Ni A,Teo K

    更新日期：2011-06-01 00:00:00

  • Effect of intravenous metoprolol before hospital admission on chest pain in suspected acute myocardial infarction.

    abstract：BACKGROUND:The aim of this study was to describe the effect of intravenous metoprolol on the intensity of chest pain before hospital admission in patients with suspected acute myocardial infarction AMI). METHODS AND RESULTS:Two hundred sixty-two patients with acute chest pain and suspected AMI were randomly assigned b...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-8703(99)70405-9

    authors： Gardtman M,Dellborg M,Brunnhage C,Lindkvist J,Waagstein L,Herlitz J

    更新日期：1999-05-01 00:00:00

  • Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) study.

    abstract：OBJECTIVES:To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans. BACKGROUND:African-Americans reportedly have a lower risk of AF than whites despite their higher exposure to AF risk factors. However, precise estimates of AF incidence in Af...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2009.05.010

    authors： Alonso A,Agarwal SK,Soliman EZ,Ambrose M,Chamberlain AM,Prineas RJ,Folsom AR

    更新日期：2009-07-01 00:00:00

  • Pulmonary artery hypertension in severe aortic stenosis: incidence and mechanism.

    abstract：:We investigated the incidence and mechanism of pulmonary artery hypertension (PAH) in a consecutive series of patients with aortic stenosis who were undergoing diagnostic cardiac catheterization. Forty-five patients with severe aortic stenosis were divided into two groups: group 1 comprised 13 patients (29%) with PAH ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(93)90067-j

    authors： Silver K,Aurigemma G,Krendel S,Barry N,Ockene I,Alpert J

    更新日期：1993-01-01 00:00:00

  • Tachyarrhythmias associated with programmable automatic atrial antitachycardia pacemakers.

    abstract：:A multiprogrammable automatic antitachycardia pacemaker (Cybertach-60), connected to a tined "J" wire electrode, was positioned in the right atrial appendage in three patients with recurrent supraventricular tachycardia (SVT). Mechanisms of SVT included atrioventricular (AV) nodal reentry (two patients) and reciprocat...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(83)90648-8

    authors： Lerman BB,Waxman HL,Buxton AE,Sweeney M,Josephson ME

    更新日期：1983-11-01 00:00:00

  • Cost effectiveness of a gene expression score and myocardial perfusion imaging for diagnosis of coronary artery disease.

    abstract：BACKGROUND:Over 3 million patients annually present with symptoms suggestive of obstructive coronary artery disease (oCAD) in the United States (US), but a cardiac etiology is found in as few as 10% of cases. Usual care may include advanced cardiac testing with myocardial perfusion imaging (MPI), with attendant radiati...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2014.02.005

    authors： Phelps CE,O'Sullivan AK,Ladapo JA,Weinstein MC,Leahy K,Douglas PS

    更新日期：2014-05-01 00:00:00

  • Mitral valve prolapse in anxiety neurosis (panic disorder).

    abstract：:Our purpose was to determine the incidence of mitral valve prolapse in patients with anxiety neurosis or panic disorder, with symptoms including recurrent anxiety attacks, dyspnea, palpitations, chest pain, dizziness, and paresthesias. Twenty-one patients and 20 age- and sex-matched normal controls were studied. Objec...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(80)90142-8

    authors： Venkatesh A,Pauls DL,Crowe R,Noyes R Jr,Van Valkenburg C,Martins JB,Kerber RE

    更新日期：1980-09-01 00:00:00

  • Vorapaxar in patients with peripheral artery disease and acute coronary syndrome: insights from Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER).

    abstract：BACKGROUND:In the TRACER trial, vorapaxar, a protease-activated receptor-1 antagonist, plus standard care in non-ST-segment elevation acute coronary syndrome (NSTE ACS) patients did not significantly reduce the primary composite end point but reduced a key secondary end point and significantly increased bleeding. Histo...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2014.06.017

    authors： Jones WS,Tricoci P,Huang Z,Moliterno DJ,Harrington RA,Sinnaeve PR,Strony J,Van de Werf F,White HD,Held C,Armstrong PW,Aylward PE,Chen E,Patel MR,Mahaffey KW

    更新日期：2014-10-01 00:00:00