Abstract：
BACKGROUND:Elevated C-reactive protein (CRP) is a common finding in patients with aortic stenosis (AS) and may be associated with rapid AS progression and worse outcome. The purpose of the study was to examine the role of high-sensitivity CRP and its interaction with rosuvastatin on the progression of AS. METHODS:We measured CRP at baseline, 1 year, and end of follow-up in 260 patients with a median follow-up of 3.5 years. Analyses were performed based on baseline CRP tertiles and baseline CRP >3 and ≤3 mg/L. RESULTS:After adjustment for baseline characteristics, higher CRP levels were associated with age, female gender, body mass index, and lower high-density lipoprotein cholesterol levels but not with AS severity. Treatment with rosuvastatin led to a persistent decrease in CRP at 1 year and end of follow-up. Progression of AS was detected in patients in all 3 CRP tertiles, and rosuvastatin treatment had no impact on progression in all 3 tertiles. Similar findings were observed using CRP >3 mg/L as the cutpoint. Multiple linear regression showed that baseline AS velocity (P < .001), but not CRP, was the only predictor of progression of AS; age (P = .05) and baseline AS velocity (P < .001), but not CRP and rosuvastatin treatment, were predictors of outcome events. CONCLUSION:C-reactive protein does not predict severity, progression, and prognosis in patients with mild to moderate AS. Treatment with rosuvastatin reduces CRP levels but has no effect on the progression and clinical events of AS.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Chan KL,Dumesnil JG,Tam J,Ni A,Teo Kdoi
10.1016/j.ahj.2011.03.016subject
Has Abstractpub_date
2011-06-01 00:00:00pages
1133-9issue
6eissn
0002-8703issn
1097-6744pii
S0002-8703(11)00197-9journal_volume
161pub_type
杂志文章,随机对照试验abstract：:This study compares the effectiveness of teaching the calculation of frontal plane QRS axis with the use of the classical versus the orderly electrocardiographic limb lead display. Eighty-three students from two environments were randomized into two groups and were taught to determine frontal plane axis with one of th...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-8703(97)70020-6
更新日期：1997-12-01 00:00:00
abstract：:The potential use of ancrod, a purified isolate from the venom of the Malaysian pit viper, Agkistrodon rhodostoma, in decreasing the frequency of cyclic flow variations in severely stenosed canine coronary arteries and causing thrombolysis of an acute coronary thrombus induced by a copper coil was evaluated. Open-ches...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(87)90050-0
更新日期：1987-04-01 00:00:00
abstract：:Traditionally, assessment of therapy has been judged by the ability of treatment to alleviate symptoms with tolerable side effects or toxicity. In recent years, it has become obvious that more subtle and patient-oriented approaches are urgently needed to evaluate progression of cardiovascular disease and to monitor th...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(87)90963-x
更新日期：1987-07-01 00:00:00
abstract：:Studies were conducted in 15 patients with coronary artery disease to determine if the type of pacing used to induce an extrasystole had a bearing on subsequent postextrasystolic potentiation (PESP) and if the fact that these were evaluated in jeopardized or nonjeopardized portions of the ventricle altered the ability...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0002-8703(86)90149-3
更新日期：1986-02-01 00:00:00
abstract：:Bacterial shock due to Gram-negative bacilli is best managed by prompt control of the infection with appropriate antibiotics and surgical drainage or excision. Corticosteroids for purposes of controlling systemic reactions to bacteria and their toxins constitute adjunctive therapy. Volume repletion and respiratory sup...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(77)80352-9
更新日期：1977-07-01 00:00:00
abstract：BACKGROUND:Physical activity and symptom questionnaires have been used as surrogates for exercise testing to estimate a patient's functional capacity and to individualize an exercise testing protocol in accordance with exercise testing guidelines. To validate these approaches, they must be compared with measured oxygen...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1067/mhj.2001.118740
更新日期：2001-12-01 00:00:00
abstract：:Hypertensive cardiovascular risk may be related primarily to vascular overload, the sum of three vascular abnormalities: increased arteriolar resistance, increased large-artery stiffness, and the effect of increased early pulse-wave reflection. A method for quantifying vascular overload as an index can be derived from...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(94)90278-x
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:We compared efficacy and safety of short- (3 or 6 months) versus long-term (≥12 months) dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation, according to the presence of chronic kidney disease (CKD). METHODS:Patient-level pooled analysis was performed with 7242 patients (87.2% with ...
journal_title：American heart journal
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ahj.2017.11.013
更新日期：2018-03-01 00:00:00
abstract：:The effects of nadolol (N) and propranolol (P) were studied in atrial and ventricular tachyarrhythmias. Interpretation of the results should take into account the dependence of the arrhythmia on the sympathetic tone, and the drug effect on the sinus node frequency. The day/night ratio of the sinus rate is too sensitiv...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(84)90589-1
更新日期：1984-10-01 00:00:00
abstract：:Because of its unique ability to demonstrate the metabolic consequences of myocardial ischemia, positron emission tomography (PET) is extremely valuable in assessing myocardial viability. PET imaging can identify the myocardial segments that are likely to improve after revascularization and may be more sensitive and s...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/0002-8703(91)90803-p
更新日期：1991-07-01 00:00:00
abstract：:A new radiopaque, highly flexible balloon-expandable tantalum stent was tested. Thirty-six of 40 stents were successfully deployed percutaneously in the coronary arteries of 31 dogs. The dogs were given aspirin before, intravenous heparin during, and aspirin alone after the procedure. One dog died at 24 hours because ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(92)90992-5
更新日期：1992-10-01 00:00:00
abstract：BACKGROUND:Although outcomes data on transcatheter aortic valve replacement (TAVR) and transcatheter mitral valve repair (Mitraclip) are available via the Transcatheter Valve Therapy (TVT) registry, dissemination of TVT data is often delayed. The Food and Drug Administration's Manufacturer and User Facility Device Expe...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2017.10.013
更新日期：2018-04-01 00:00:00
abstract：:In this overview we studied evidence for the occurrence of silent myocardial ischemia, its pathophysiologic mechanisms, and the circadian distribution of ischemic episodes. The correlation between many hemodynamic parameters and their potential as drug targets was assessed. ECG evidence of myocardial ischemia (ST segm...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/0002-8703(89)90830-2
更新日期：1989-11-01 00:00:00
abstract：:The rate and form of creatine kinase-MB (CK-MB) enzyme release following reflow to ischemic myocardium has not been specifically examined in man. In this investigation, we examined the combined CK-MB time-activity curves during acute transmural myocardial infarction (AMI) in a group of patients receiving conventional ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(83)90084-4
更新日期：1983-10-01 00:00:00
abstract：:Inducible ventricular tachycardia frequently persists despite solitary class I antiarrhythmic drug therapy. To determine the effect of metoprolol as adjuvant therapy, 19 patients with clinical ventricular tachycardia with baseline inducible sustained monomorphic ventricular tachycardia and persistently inducible ventr...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(92)90270-6
更新日期：1992-09-01 00:00:00
abstract：:Subclinical myocardial involvement frequently occurs in patients with systemic lupus erythematosus (SLE). In this study, left ventricular diastolic function was assessed in 58 patients (54 female and 4 male; mean age 32 +/- 11 years) and in 40 sex-matched and age-matched healthy control subjects (37 female and 3 male;...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(90)90163-r
更新日期：1990-07-01 00:00:00
abstract：:A review of the clinical course of chronic heart failure demonstrates that current outcomes remain highly unsatisfactory both in mortality and perhaps more important in morbidity. The extraordinary satisfactory functional responses seen in patients who undergo cardiac transplantation clearly identify the primary cause...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/0002-8703(90)90056-4
更新日期：1990-12-01 00:00:00
abstract：:Patients with syndrome X have been found to have an abnormal coronary blood flow reserve. The physical performance during exercise, however, has been incompletely investigated. Cardiopulmonary exercise testing (CPX) is a reliable noninvasive method to provide indexes of lung, heart, circulation, and muscle functions. ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(93)90162-3
更新日期：1993-03-01 00:00:00
abstract：:Contrast bidimensional echocardiographic (2DE) studies were performed in eight patients with d-transposition of the great vessels in the postoperative period of the Senning technique. Contrast was injected into a peripheral vein of all patients, and into the arterial atrium in five in the postoperative period. The 2DE...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(84)90552-0
更新日期：1984-07-01 00:00:00
abstract：:The calcium antagonist, manidipine, was developed on the basis of the hypothesis that antihypertensive drugs that act to improve renal hemodynamic alterations will be therapeutically beneficial in hypertensive patients. Manidipine shows long-lasting calcium channel-blocking action in vascular smooth muscle cells and a...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/0002-8703(93)90203-l
更新日期：1993-02-01 00:00:00
abstract：:Hemodynamic and echocardiographic data from 33 consecutive patients undergoing cardiac transplantation were correlated with endomyocardial biopsy results to determine whether reversible restrictive hemodynamics accompany histologic evidence of transplant rejection. During the study period 251 biopsy specimens were obt...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(91)90475-w
更新日期：1991-10-01 00:00:00
abstract：BACKGROUND:Balloon inflation during coronary angioplasty results in shear stress-induced vessel wall injury with development of restenosis. This randomized trial compared the impact of two different balloon inflation strategies (slow versus fast) on restenosis after coronary angioplasty. METHODS:Two hundred seven pati...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-8703(98)70290-x
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:The treatment of cocaine-related acute coronary syndromes presents unique challenges. Although percutaneous coronary intervention in cocaine abusers appears to be safe in the short term, longer-term outcomes have not been reported. We postulated that cocaine use would be associated with increased risk for st...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2007.04.004
更新日期：2007-07-01 00:00:00
abstract：:Anesthetized dogs were cooled to a core body temperature of 26 degree C. or maintained at a body temperature of 37 degree C. during periods of 5 and 10 hours of LAD coronary artery occlusion. Subsequent macroscopic dehydrogenase enzyme mapping showed that ischemic injury was 25 per cent less after 5 hours of coronary ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(78)90010-8
更新日期：1978-12-01 00:00:00
abstract：:Patients with diabetes were compared with nondiabetic control subjects, with respect to the prevalence of silent myocardial ischemia, by means of treadmill exercise testing and coronary angiography. Results of treadmill exercise testing showed ischemic ST depression in 41 of the 132 diabetic patients (mean age 61 +/- ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(92)90745-h
更新日期：1992-01-01 00:00:00
abstract：:Right- and left-sided endocarditis are two distinct entities, both clinically and experimentally. As such, they require different clinical approaches. The accurate diagnosis of right-sided endocarditis rests largely on a high index of suspicion which is often raised in the case of an intravenous drug abuser with fever...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(86)90564-8
更新日期：1986-01-01 00:00:00
abstract：:Plasma cholesterol levels were measured in 15,892 participants of a cholesterol screening in Hartford, Connecticut. The screenees were typically health conscious as evidenced by the low prevalence of current cigarette smoking (12%). However, more than 25% of the men and 35% of the women over the age of 50 years had ch...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(89)90741-2
更新日期：1989-03-01 00:00:00
abstract：:The isovolumic relaxation time (IVRT) is an important noninvasive index of left ventricular diastolic function. Despite its widespread use, however, the IVRT has not been related analytically to invasive parameters of ventricular function. Establishing such a relationship would make the IVRT more useful by itself and ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(92)90416-s
更新日期：1992-11-01 00:00:00
abstract：:We performed a chronologic investigation of left (LV) and right (RV) ventricular myosin ATPase activity and hemodynamics in newborn lambs. We found an elevation in myosin ATPase activity for the LV, which was achieved by 6 to 8 weeks of age and which correlated directly with increasing ventricular stroke work. Myosin ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(82)90396-9
更新日期：1982-05-01 00:00:00
abstract：:In chronic heart failure (CHF) the contributing role of increased sympathetic activity and hemodynamic dysfunction in the genesis of ventricular arrhythmias has not been well established. To assess the relation between severe ventricular arrhythmias, hemodynamic impairment, and autonomic nervous system derangement, 14...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(97)80011-7
更新日期：1997-11-01 00:00:00
