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Ten-year clinical follow-up after sirolimus-eluting stent implantation.

Abstract：

BACKGROUND:Little is known on the "very" long-term incidence of major adverse cardiac events (MACE), target-lesion revascularization (TLR), target-vessel revascularization and stent thrombosis after sirolimus-eluting stent (SES) implantation. We present the first study to provide a 10-year clinical follow-up in an unselected patient population who underwent SES implantation. METHODS AND RESULTS:We ran a systematic 10-year clinical follow-up in a series of 200 consecutive patients treated with unrestricted SES implantation between April 2002 and April 2003 in two Swiss hospitals. Outcomes and follow-up were obtained in all 200 patients. The cumulative 10-year MACE rate was 47% with all-cause death of 20%, cardiac death of 9%, myocardial infarction of 7%, TLR and target-vessel revascularization of 8% and 11% respectively. Academic Research Consortium-defined "definite and probable" stent thrombosis-rate was 2.5%. TLR risk was maximal between 3 to 6 years. New lesion revascularization increased throughout the study period. CONCLUSION:Incidence of TLR was maximal 3 to 6 years after SES implantation and decreased thereafter. MACE and non-TLR revascularization rates steadily increased during the complete follow-up underlining the progression of coronary artery disease.

journal_name

Am Heart J

journal_title

American heart journal

authors

Palhais N,Arroyo D,Lehmann S,Togni M,Kaufmann U,Puricel SG,Stauffer JC,Goy JJ,Cook S

doi

10.1016/j.ahj.2013.12.013

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

893-9

issue

6

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(14)00006-4

journal_volume

167

pub_type

杂志文章

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