当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Randomized trial comparing the efficacy between different types of paclitaxel-eluting stents: the comparison of efficacy between COroflex PLEASe ANd Taxus stent (ECO-PLEASANT) randomized controlled trial.

Randomized trial comparing the efficacy between different types of paclitaxel-eluting stents: the comparison of efficacy between COroflex PLEASe ANd Taxus stent (ECO-PLEASANT) randomized controlled trial.

Abstract：

AIMS:Paclitaxel-eluting stents (PESs) have been shown to inhibit neointimal hyperplasia after percutaneous coronary intervention. Coroflex Please (B Braun, Melsungen, Germany) is a newly developed PES. We compared the clinical and angiographic efficacy of Coroflex Please with Taxus Liberte (Boston Scientific, Natick, MA) in a real-world practice. METHODS AND RESULTS:We performed a prospective, open-label, randomized, controlled study that enrolled 945 patients undergoing percutaneous coronary interventions in 18 centers in Korea. The primary end point was clinically driven target vessel revascularization at 9 months. The baseline characteristics were mostly similar and comparable between 2 groups. At 9 months, the incidence of clinically driven target vessel revascularization was 14.6% for Coroflex and 6.4% for Taxus, which was significantly different (hazard ratio 2.43, 95% CI 1.50-3.94, noninferiority P value = 1.000). This is well corroborated by the difference of in-stent late loss between 2 stents (0.71 ± 0.64 mm vs 0.52 ± 0.50 mm, P < .001) by 9-month follow-up angiography (n = 415 vs 215). Among secondary clinical end points, stent thrombosis (definite and probable) for 1 year was 2.2% in Coroflex and 1.3% in Taxus (P = .317). Also, myocardial infarction for 9 months was higher in Coroflex group than that in Taxus (4.9% vs 1.6%, P = .012), which was partly contributed by the higher incidence of periprocedural myocardial infarction in Coroflex arm (2.2% vs 0.3%, P = .028). CONCLUSIONS:Coroflex Please was inferior to Taxus Liberte with regard to clinical and angiographic efficacy.

journal_name

Am Heart J

journal_title

American heart journal

authors

Seo JB,Kang SH,Hur SH,Park KW,Youn TJ,Park JS,Yang HM,Lee HY,Kang HJ,Koo BK,Bae JH,Kim SW,Moon KW,Choi JW,Lee SG,Chung WY,Kim SJ,Kim DI,Kim BO,Hyon MS,Park KS,Cha TJ,Yoo CW,Jeon HK,Kim HS

doi

10.1016/j.ahj.2013.02.009

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

733-43

issue

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(13)00131-2

journal_volume

165

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

在线工具

Randomized trial comparing the efficacy between different types of paclitaxel-eluting stents: the comparison of efficacy between COroflex PLEASe ANd Taxus stent (ECO-PLEASANT) randomized controlled trial.