Abstract:
BACKGROUND:There are limited data regarding the clinical correlates and prognostic significance of echocardiographically defined mitral regurgitation (MR) early after acute myocardial infarction (MI). The current study addressed these issues. METHODS:Seven hundred thirty-seven patients with acute MI who underwent transthoracic echocardiography with assessment of MR during their index admission were identified. Patients were followed up a median of 19 months later. The study end point was all-cause mortality. RESULTS:The prevalence of MR increased with age. It was more common in women, in patients with non-ST-elevation MI, and in those with a history of diabetes, hypertension, prior MI, or previous revascularization. Patients with MR had worse left ventricular (LV) systolic function, more LV dilatation, and more clinical evidence of LV failure. Patients with moderate or severe MR had worse survival than those with no or mild MR (hazard ratio 2.3, 95% CI 1.6-3.2, P < .0001). Even mild MR predicted a higher mortality when compared with no MR (hazard ratio 1.7, 95% CI 1.2-2.4, P = .004). Mild or moderate MR was not independently predictive of outcome, although, in multivariable analyses, a trend toward worse survival was maintained in patients with severe MR. CONCLUSIONS:Mitral regurgitation, identified by echocardiography, early after acute MI predicts poorer survival after acute MI. However, if mild or moderate, it is not an independent prognostic indicator.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Hillis GS,Møller JE,Pellikka PA,Bell MR,Casaclang-Verzosa GC,Oh JKdoi
10.1016/j.ahj.2005.01.020subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1268-75issue
6eissn
0002-8703issn
1097-6744pii
S0002-8703(05)00049-9journal_volume
150pub_type
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journal_title:American heart journal
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更新日期:2009-03-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1999-02-01 00:00:00
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更新日期:2006-05-01 00:00:00
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journal_title:American heart journal
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更新日期:2007-05-01 00:00:00