A prognostic comparison of asymptomatic left ventricular hypertrophy and unrecognized myocardial infarction: the Framingham Study.

Abstract:

:In 30 years of follow-up in the Framingham study, routine biennial ECG examinations revealed 315 subjects with ECG-LVH and 164 with unrecognized ECG-MI without previous cardiac explanation. Among subjects initially free of clinically evident coronary heart disease and both ECG abnormalities, the incidence of ECG-LVH was about double that of ECG-MI. Both events exhibited a male predominance and hypertensive subjects were more vulnerable to each. In subjects with asymptomatic ECG-LVH and ECG-MI, the 10-year, age-adjusted incidence of clinical coronary heart disease was greater than the rate experienced by the general Framingham sample. Rates for ECG-LVH were almost as large as those for ECG-MI. Cardiac failure and stroke also occurred more frequently among subjects with either ECG abnormality, and rates for ECG-LVH exceeded those for ECG-MI. Death from coronary heart disease, and sudden death in particular, was also increased two- to fourfold with similar risks for ECG-LVH and ECG-MI. ECG-LVH carried a significantly greater risk than ECG-MI for cardiovascular deaths in women. These findings suggest that ECG-LVH and ECG-MI are similar subclinical events with respect to predisposing characteristics and prognosis for subsequent overt cardiovascular disease including clinical manifestations of coronary heart disease.

journal_name

Am Heart J

journal_title

American heart journal

authors

Kannel WB,Abbott RD

doi

10.1016/0002-8703(86)90156-0

subject

Has Abstract

pub_date

1986-02-01 00:00:00

pages

391-7

issue

2

eissn

0002-8703

issn

1097-6744

pii

0002-8703(86)90156-0

journal_volume

111

pub_type

杂志文章
  • Causes and timing of death during long-term follow-up after transcatheter aortic valve replacement.

    abstract:BACKGROUND:Transcatheter aortic valve replacement (TAVR) is an effective therapeutic option for patients with severe aortic stenosis at high risk for surgery. Identification of causes of death after TAVR may help improve patient selection and outcome. METHODS:We enrolled 874 consecutive patients who underwent TAVR at ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2014.07.023

    authors: Saia F,Latib A,Ciuca C,Gasparetto V,Napodano M,Sticchi A,Anderlucci L,Marrozzini C,Naganuma T,Alfieri O,Facchin M,Hoxha B,Moretti C,Marzocchi A,Colombo A,Tarantini G

    更新日期:2014-11-01 00:00:00

  • Comparison of teaching the basic electrocardiographic concept of frontal plane QRS axis using the classical versus the orderly electrocardiogram limb lead displays.

    abstract::This study compares the effectiveness of teaching the calculation of frontal plane QRS axis with the use of the classical versus the orderly electrocardiographic limb lead display. Eighty-three students from two environments were randomized into two groups and were taught to determine frontal plane axis with one of th...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-8703(97)70020-6

    authors: Pahlm US,O'Brien JE,Pettersson J,Pahlm O,White T,Maynard C,Wagner GS

    更新日期:1997-12-01 00:00:00

  • Cardiac abnormalities and cytosine-thymine-guanine trinucleotide repeats in myotonic dystrophy.

    abstract::This study investigated the correlation between cardiac abnormalities and cytosine-thymine-guanine (CTG) trinucleotide repeat expansion in patients with myotonic dystrophy (MD). We studied 18 patients with the adult form of classical MD and 18 age-matched control subjects. In patients with MD, left ventricular systoli...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(97)70137-6

    authors: Hayashi Y,Ikeda U,Kojo T,Nishinaga M,Miyashita H,Kuroda T,Inoue K,Nishizawa M,Shimada K

    更新日期:1997-08-01 00:00:00

  • A new method of scoring coronary angiograms to reflect extent of coronary atherosclerosis and improve correlation with major risk factors.

    abstract::We developed a new angiographic score of the extent of coronary disease (extent score), which we compared with conventional stenosis and vessel scores that emphasize the severity of stenosis. Scores were determined in 132 patients (29 women, 103 men with a mean age of 55 +/- 10 years) who underwent elective coronary a...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(05)80173-5

    authors: Sullivan DR,Marwick TH,Freedman SB

    更新日期:1990-06-01 00:00:00

  • Exaggerated secretion of atrial natriuretic polypeptide during dynamic exercise in patients with essential hypertension.

    abstract::The plasma concentration of atrial natriuretic polypeptide (ANP) was measured in nine patients with essential hypertension during two grades of exercise tests performed in the supine position on a bicycle ergometer. The plasma ANP concentration significantly increased from 97.0 +/- 19.2 pg/ml to 107.6 +/- 23.7 pg/ml (...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(88)90159-7

    authors: Saito Y,Nakao K,Sugawara A,Nishimura K,Morii N,Yamada T,Itoh H,Shiono S,Mukoyama M,Arai H

    更新日期:1988-10-01 00:00:00

  • Mitral valve prolapse in anxiety neurosis (panic disorder).

    abstract::Our purpose was to determine the incidence of mitral valve prolapse in patients with anxiety neurosis or panic disorder, with symptoms including recurrent anxiety attacks, dyspnea, palpitations, chest pain, dizziness, and paresthesias. Twenty-one patients and 20 age- and sex-matched normal controls were studied. Objec...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(80)90142-8

    authors: Venkatesh A,Pauls DL,Crowe R,Noyes R Jr,Van Valkenburg C,Martins JB,Kerber RE

    更新日期:1980-09-01 00:00:00

  • Ultrasound guide wire-directed stent deployment.

    abstract::A new mechanically rotated 20 MHz intravascular ultrasound guide wire (0.032 inch) with a transducer core was placed through the central lumen of a peripheral arterial balloon-expandable stent. Using an anesthetized canine model, 11 stents were then deployed into the iliac or femoral arteries. Eight stents were succes...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:

    authors: Tenaglia AN,Kisslo K,Kelly S,Hamm MA,Crowley R,Davidson CJ

    更新日期:1993-05-01 00:00:00

  • Appropriate cardiac cath lab activation: optimizing electrocardiogram interpretation and clinical decision-making for acute ST-elevation myocardial infarction.

    abstract::During the last few decades, acute ST-elevation on an electrocardiogram (ECG) in the proper clinical context has been a reliable surrogate marker of acute coronary occlusion requiring primary percutaneous coronary intervention (PPCI). In 2004, the American College of Cardiology/American Heart Association ST-elevation ...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.ahj.2010.08.011

    authors: Rokos IC,French WJ,Mattu A,Nichol G,Farkouh ME,Reiffel J,Stone GW

    更新日期:2010-12-01 00:00:00

  • Restrictive hemodynamic patterns after cardiac transplantation: relationship to histologic signs of rejection.

    abstract::Hemodynamic and echocardiographic data from 33 consecutive patients undergoing cardiac transplantation were correlated with endomyocardial biopsy results to determine whether reversible restrictive hemodynamics accompany histologic evidence of transplant rejection. During the study period 251 biopsy specimens were obt...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90475-w

    authors: Wilensky RL,Bourdillon PD,O'Donnell JA,Sharp SM,Armstrong WF,Fineberg NS,Himes V,Waller BF

    更新日期:1991-10-01 00:00:00

  • Patterns of inflammation associated with peripheral arterial disease: the InCHIANTI study.

    abstract:OBJECTIVE:To determine whether peripheral arterial disease is associated with high circulating levels of pro-inflammatory cytokines, independent of confounders. METHODS:Participants were 955 men and women aged 60 years and older representative of the population in 2 Italian communities (107 with peripheral arterial di...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2004.09.032

    authors: McDermott MM,Guralnik JM,Corsi A,Albay M,Macchi C,Bandinelli S,Ferrucci L

    更新日期:2005-08-01 00:00:00

  • Angiotensin II receptor antagonists: a new approach to blockade of the renin-angiotensin system.

    abstract::A-II exerts its activity on various target tissues by binding to its receptors. The discovery of local RASs and A-II receptors within various tissues has generated interest in the clinical usefulness of RAS inhibition by directly blocking the action of A-II at the receptor level. Different A-II receptor subtypes have ...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(94)90061-2

    authors: Kang PM,Landau AJ,Eberhardt RT,Frishman WH

    更新日期:1994-05-01 00:00:00

  • Uncontrolled immune response in acute myocardial infarction: unraveling the thread.

    abstract::Recently, the theory that hyperinflammation is the body's primary response to potent stimulus has been challenged. Indeed, a deregulation of the immune system could be the cause of multiple organ failure. So far, clinicians have focused on the last steps of the inflammatory cascade. However, little attention has been ...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.ahj.2008.07.008

    authors: Bodi V,Sanchis J,Nunez J,Mainar L,Minana G,Benet I,Solano C,Chorro FJ,Llacer A

    更新日期:2008-12-01 00:00:00

  • Morphometric analysis in three-dimensional intracoronary ultrasound: an in vitro and in vivo study performed with a novel system for the contour detection of lumen and plaque.

    abstract::Currently, automated systems for quantitative analysis by intracoronary ultrasound (ICUS) are restricted to the detection of the lumen. The aim of this study was to determine the accuracy and reproducibility of a new semiautomated contour detection method, providing off-line identification of the intimal leading edge ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(96)90233-1

    authors: von Birgelen C,Di Mario C,Li W,Schuurbiers JC,Slager CJ,de Feyter PJ,Roelandt JR,Serruys PW

    更新日期:1996-09-01 00:00:00

  • Validation of a specific activity questionnaire to estimate exercise tolerance in patients referred for exercise testing.

    abstract:BACKGROUND:Physical activity and symptom questionnaires have been used as surrogates for exercise testing to estimate a patient's functional capacity and to individualize an exercise testing protocol in accordance with exercise testing guidelines. To validate these approaches, they must be compared with measured oxygen...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2001.118740

    authors: Myers J,Bader D,Madhavan R,Froelicher V

    更新日期:2001-12-01 00:00:00

  • Efficacy of prolonged infusion of urodilatin [ANP-(95-126)] in patients with congestive heart failure.

    abstract::Urodilatin [ANP-95-126] is a new natriuretic peptide of renal origin not subjected to tolerance in experimental congestive heart failure (CHF). To evaluate its therapeutic potentials in CHF, we investigated the efficacy of a prolonged infusion of urodilatin (15 ng/kg/min for 10 hours) in 12 patients with CHF (New York...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-8703(95)90328-3

    authors: Elsner D,Muders F,Müntze A,Kromer EP,Forssmann WG,Riegger GA

    更新日期:1995-04-01 00:00:00

  • HLA-DR typing and lymphocyte subset evaluation in rheumatic heart disease: a search for immune response factors.

    abstract::Several autoimmune diseases have been associated with increased frequencies of specific histocompatibility (HLA) antigens, particularly for the D (DR) locus, that may be linked to immune response genes. Rheumatic valvular heart disease (RHD) has been postulated to have autoimmune features, but HLA associations have no...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90311-x

    authors: Anastasiou-Nana MI,Anderson JL,Carlquist JF,Nanas JN

    更新日期:1986-11-01 00:00:00

  • Drinking and coronary heart disease: the Albany Study.

    abstract::The relation of alcohol consumption to coronary heart disease (CHD) was examined in a cohort of 1910 employed men aged 38 to 55 years enrolled in the Albany Study, a prospective investigation of factors related to cardiovascular disease. Two follow-up periods were examined, one between 1953-54 and 1971-72, the other a...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(85)90152-8

    authors: Gordon T,Doyle JT

    更新日期:1985-08-01 00:00:00

  • Relation between cardiac troponin I and mortality in acute decompensated heart failure.

    abstract:BACKGROUND:Troponin level elevations are common in patients with acute decompensated heart failure (ADHF), yet their prognostic value above and beyond traditional predictors of outcomes in heart failure is uncertain. METHODS:In the EFFECT study, we determined the association between cardiac troponin I and all-cause mo...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2007.01.027

    authors: You JJ,Austin PC,Alter DA,Ko DT,Tu JV

    更新日期:2007-04-01 00:00:00

  • Coronary vascular reactivity is abnormal in patients with Chagas' heart disease.

    abstract::Symptoms of myocardial ischemia, such as chest pain (sometimes with anginal features), acute myocardial infarction, and segmental wall motion abnormalities (including left ventricular apical aneurysm), frequently occur in patients with Chagas' heart disease. Because these clinical findings occur in the presence of nor...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(95)90122-1

    authors: Torres FW,Acquatella H,Condado JA,Dinsmore R,Palacios IF

    更新日期:1995-05-01 00:00:00

  • Diet and incident venous thromboembolism: the Iowa Women's Health Study.

    abstract:BACKGROUND:Little is known about the role of diet in the development of venous thromboembolism (VTE). We explored the prospective relation of dietary patterns, food groups, and nutrients to incident VTE in older women. METHODS:In 1986, Iowa women aged 55 to 69 years completed a mailed survey, including a 127-item food...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2009.04.003

    authors: Lutsey PL,Steffen LM,Virnig BA,Folsom AR

    更新日期:2009-06-01 00:00:00

  • Appropriate test selection for single-photon emission computed tomography imaging: association with clinical risk, posttest management, and outcomes.

    abstract:BACKGROUND:Appropriate use criteria (AUC) for stress single-photon emission computed tomography (SPECT) are only one step in appropriate use of imaging. Other steps include pretest clinical risk evaluation and optimal management responses. We sought to understand the link between AUC, risk evaluation, management, and o...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2013.06.003

    authors: Aldweib N,Negishi K,Seicean S,Jaber WA,Hachamovitch R,Cerqueira M,Marwick TH

    更新日期:2013-09-01 00:00:00

  • Rupture of interventricular septum in acute myocardial infarction.

    abstract::Three cases of rupture of the interventricular septum occurring coincident with acute inferior myocardial infarction are reported and the relevant literature is reviewed. One patient under-went successful surgical repair and, in addition, had an aneurysmectomy. Clues and pitfalls in diagnosis as well as the possible c...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(76)80407-3

    authors: Longo EA,Cohen LS

    更新日期:1976-07-01 00:00:00

  • Outcomes of cardiac pacing in adult patients after a Fontan operation.

    abstract:BACKGROUND:Cardiac pacing can be challenging after a Fontan operation, and limited data exist regarding pacing in adult Fontan patients. The objectives of our study were to determine risk factors for pacing and occurrence of device-related complications (DRCs) and pacemaker reinterventions. METHODS:We performed a retr...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2017.08.019

    authors: Egbe AC,Huntley GD,Connolly HM,Ammash NM,Deshmukh AJ,Khan AR,Said SM,Akintoye E,Warnes CA,Kapa S

    更新日期:2017-12-01 00:00:00

  • Outpatient dobutamine and dopamine infusions in the management of chronic heart failure: clinical experience in 21 patients.

    abstract::Dobutamine (and dopamine) are potent positive inotropic drugs which are frequently given to treat decompensated congestive heart failure. This study reports on the use of ambulatory dobutamine (and dopamine) infusions in 21 outpatients with advanced congestive heart failure. Each patient was initially hospitalized, an...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90757-5

    authors: Applefeld MM,Newman KA,Sutton FJ,Reed WP,Roffman DS,Talesnick BS,Grove WR

    更新日期:1987-09-01 00:00:00

  • Ventricular ectopy in totally symptom-free subjects with defined coronary artery anatomy.

    abstract::Ambulatory ECG recordings were obtained from 313 consecutive, totally symptom-free male subjects on whom cardiac catheterization was subsequently performed for occupational reasons. These recordings were examined for ventricular ectopy and the results were studied in relation to the findings on selective coronary angi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(89)90405-5

    authors: Batchelor AJ,Kruyer WB,Hickman JR Jr

    更新日期:1989-06-01 00:00:00

  • Apixaban compared with parenteral heparin and/or vitamin K antagonist in patients with nonvalvular atrial fibrillation undergoing cardioversion: Rationale and design of the EMANATE trial.

    abstract:BACKGROUND:Stroke prevention in anticoagulation-naïve patients with atrial fibrillation undergoing cardioversion has not been systematically studied. OBJECTIVE:To determine outcomes in anticoagulation-naïve patients (defined as those receiving an anticoagulant for <48 hours during the index episode of atrial fibrillat...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2016.06.008

    authors: Ezekowitz MD,Pollack CV,Sanders P,Halperin JL,Spahr J,Cater N,Petkun W,Breazna A,Kirchhof P,Oldgren J

    更新日期:2016-09-01 00:00:00

  • Long-term intraindividual cholesterol variability: natural course and adverse impact on morbidity and mortality--the Framingham Study.

    abstract::We examined intraindividual variability in serum TC in 2912 men and women having TC measured at each of biennial examinations 2 through 7 of the FHS. RMSE described variability around the linear slope of an individual's TC during the baseline decade. Average biennial difference +/- SD was +3.7 +/- 6.7 mg/dl in men, +6...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90393-x

    authors: Kreger BE,Odell PM,D'Agostino RB,Wilson PF

    更新日期:1994-06-01 00:00:00

  • A comparison of the acute hypotensive effects of two different doses of nifedipine.

    abstract::To determine whether a dose of 5 mg of nifedipine would be useful in the treatment of hypertensive emergencies, we compared the acute hypotensive effects of two different doses of nifedipine, 5 mg and 10 mg, in patients with severe hypertension. In this prospective, randomized, double-blind study, 30 consecutive black...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-8703(92)90283-2

    authors: Maharaj B,van der Byl K

    更新日期:1992-09-01 00:00:00

  • Hemodynamic correlates of late diastolic posterior motion of the aortic root.

    abstract::Motion of the posterior aortic root on echocardiography is related to left atrial volume changes. Early diastolic posterior motion of the aortic root reflects both LA emptying and filling and has been measured as the atrial emptying index. To study late diastolic motion of the aortic root, we measured the slope of pos...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(80)90654-7

    authors: Ambrose JA,Martinez EE,Meller J,Gorlin R,Pichard AD,Herman MV,Teichlolz LE

    更新日期:1980-10-01 00:00:00

  • Evaluation of coronary artery bypass grafts and native coronary arteries using 64-slice multidetector computed tomography.

    abstract:BACKGROUND:The conventional use of 16-slice multidetector computed tomography (MDCT) remains somewhat limited for evaluating stenoses in vein graft distal anastomotic sites and in coronary arteries. We investigated the diagnostic accuracy of 64-slice MDCT for assessment of both grafts and coronary arteries in patients ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2007.04.054

    authors: Onuma Y,Tanabe K,Chihara R,Yamamoto H,Miura Y,Kigawa I,Fukuda S,Miyairi T,Nakajima H,Hara K

    更新日期:2007-09-01 00:00:00