Beta-adrenergic blockade by nadolol in control of ventricular tachyarrhythmias.

Abstract:

:The antiarrhythmic effect of nadolol, a long-acting, nonselective beta antagonist without intrinsic sympathomimetic or membrane-stabilizing properties, was evaluated in 36 patients with ventricular dysrhythmias as determined by three baseline 24-hour Holter recordings at a time when subjects were receiving placebo. Nadolol was administered once daily at a dose of 40 to 80 mg and increased at weekly intervals to a maximum daily dose of 640 mg. Thereafter the drug was stopped gradually and placebo was given again for a period of 2 weeks. Nadolol was effective in reducing premature ventricular contractions (PVCs) in 17 of 36 patients (48%), in reducing ventricular couplets in 24 of 27 patients (89%), and in reducing nonsustained runs of ventricular tachycardia in all 13 subjects. Serum nadolol levels obtained at dosages resulting in a 75% reduction in PVCs varied from 58 to 853 ng/ml. In the majority of the subjects studied, a nadolol dosage of 160 mg/day or less was effective for arrhythmia suppression.

journal_name

Am Heart J

journal_title

American heart journal

authors

Nademanee K,Schleman MM,Singh BN,Morganroth J,Reid PR,Stritar JA

doi

10.1016/0002-8703(84)90590-8

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

1109-15

issue

4 Pt 2

eissn

0002-8703

issn

1097-6744

pii

0002-8703(84)90590-8

journal_volume

108

pub_type

临床试验,杂志文章
  • Postinfarction ventricular arrhythmias in children.

    abstract::Because limited information is available on significant arrhythmias after myocardial infarction in pediatric patients, this study was performed to determine the incidence and impact of ventricular tachycardia or fibrillation on the postinfarction course in patients aged 1 day to 16 years. Review of 96 such children sh...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(95)90400-x

    authors: Johnsrude CL,Towbin JA,Cecchin F,Perry JC

    更新日期:1995-06-01 00:00:00

  • Superiority of biphasic shocks in the defibrillation of dogs by epicardial patches and catheter electrodes.

    abstract::Currently available internal cardiac defibrillators use a uniphasic, truncated exponential waveform morphology of about 6 msec in duration at an energy level of 23 to 33 joules. To determine if improved defibrillation could be achieved with a different waveform morphology, we implanted 4.5 cm2 titanium patches to the ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(89)90187-7

    authors: Flaker GC,Schuder JC,McDaniel WC,Stoeckle H,Dbeis M

    更新日期:1989-08-01 00:00:00

  • Intermittent inotropic therapy in an outpatient setting: a cost-effective therapeutic modality in patients with refractory heart failure.

    abstract::Patients with intractable heart failure (New York Heart Association [NYHA] class III and IV) who were receiving maximal conventional treatment were enrolled in an outpatient program that included inotropic infusions, intensive patient education, and close follow-up. The effects of this approach to therapy were evaluat...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(96)90315-4

    authors: Marius-Nunez AL,Heaney L,Fernandez RN,Clark WA,Ranganini A,Silber E,Denes P

    更新日期:1996-10-01 00:00:00

  • Worldwide evaluation of a defibrillation lead with a small geometric electrode surface for high-impedance pacing.

    abstract:BACKGROUND:Pacing leads with a small electrode surface for high-impedance stimulation have been shown to prolong pacemaker longevity, but no sufficient data is available on the safety and feasibility of a defibrillation lead with this novel design. METHODS:We evaluated the clinical performance of a tined, steroid-elut...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/S0002-8703(03)00411-3

    authors: Vollmann D,Ahern T,Gerritse B,Canby RC,Zenker D,Binner L,Kimber SK,Unterberg C,Worldwide Medtronic Model 6944 Investigators.

    更新日期:2003-12-01 00:00:00

  • Clinical, angiographic, and procedural determinants of major and minor coronary dissection during angioplasty.

    abstract::Angiographic evidence of coronary dissection after angioplasty is found in 25% to 30% of cases. Although patients are usually asymptomatic, in a small percentage angioplasty-induced coronary dissection results in luminal impairment and ischemic complications. The present study was undertaken to identify factors respon...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(07)80008-1

    authors: Sharma SK,Israel DH,Kamean JL,Bodian CA,Ambrose JA

    更新日期:1993-07-01 00:00:00

  • Gender differences among patients with acute coronary syndromes undergoing percutaneous coronary intervention in the American College of Cardiology-National Cardiovascular Data Registry (ACC-NCDR).

    abstract:BACKGROUND:Although prior studies have demonstrated disparities in the management and outcomes of women with acute coronary syndrome (ACS), there are limited large-scale contemporary data on gender differences in post-intervention outcomes in this population. METHODS:We analyzed patients according to 2 ACS categories,...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2008.08.012

    authors: Akhter N,Milford-Beland S,Roe MT,Piana RN,Kao J,Shroff A

    更新日期:2009-01-01 00:00:00

  • CardioSEAL/STARflex versus Amplatzer devices for percutaneous closure of small to moderate (up to 18 mm) atrial septal defects.

    abstract:BACKGROUND:The Amplatzer septal occluder (ASO) allows the percutaneous closure of small to very large atrial septal defects (ASDs). The CardioSEAL/STARflex (CS/SF) can be used only for closure of small to moderate ASDs (stretch size up to 18 mm). These 2 devices are widely used in clinical practice. Therefore, a compar...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2004.03.013

    authors: Butera G,Carminati M,Chessa M,Delogu A,Drago M,Piazza L,Giamberti A,Frigiola A

    更新日期:2004-09-01 00:00:00

  • Temporal trends in pharmacotherapy for congestive heart failure at an academic medical center: 1990-1995.

    abstract::The objectives of this study were to assess current practice patterns in pharmacotherapy for congestive heart failure at an academic medical center and to analyze temporal trends in management of congestive heart failure from 1990 to 1995. Records of all patients discharged from the hospital in 1990 or 1995 with a pri...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(98)70309-6

    authors: Rich MW,Brooks K,Luther P

    更新日期:1998-03-01 00:00:00

  • Temporal trends and hospital-level variation of inhospital cardiac arrest incidence and outcomes in the Veterans Health Administration.

    abstract:BACKGROUND:Despite significant attention to resuscitation care by hospitals, national data on trends in the incidence and survival of patients with inhospital cardiac arrest (IHCA) are limited. OBJECTIVE:To determine trends and hospital-level variation in the incidence and outcomes associated with IHCA. In exploratory...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2017.05.018

    authors: Bradley SM,Kaboli P,Kamphuis LA,Chan PS,Iwashyna TJ,Nallamothu BK

    更新日期:2017-11-01 00:00:00

  • Prenatal diagnosis of atrioventricular canal malformations with up-to-date echocardiographic technology: report of 14 cases.

    abstract::Fourteen fetuses with atrioventricular canal malformations were examined by two-dimensional echocardiography, pulsed-wave Doppler echocardiography, and color Doppler flow mapping. Eleven fetuses had complete and three fetuses had partial atrioventricular canal malformations. Nonimmune hydrops fetalis was associated wi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90156-c

    authors: Gembruch U,Knöpfle G,Chatterjee M,Bald R,Redel DA,Födisch HJ,Hansmann M

    更新日期:1991-05-01 00:00:00

  • Induction of neointimal hyperplasia by coronary angioplasty balloon overinflation: comparison of feeder pigs to Yucatan minipigs.

    abstract::We evaluated the use of simple balloon overinflation to induce neointimal hyperplasia in a porcine model of coronary artery restenosis. By using standard percutaneous transluminal coronary angioplasty techniques, left anterior descending (LAD) and/or left circumflex (LCX) coronary arteries of either juvenile feeder pi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90505-3

    authors: Humphrey WR,Simmons CA,Toombs CF,Shebuski RJ

    更新日期:1994-01-01 00:00:00

  • Different expressivity of a ventricular essential myosin light chain gene Ala57Gly mutation in familial hypertrophic cardiomyopathy.

    abstract:BACKGROUND:Familial hypertrophic cardiomyopathy (HCM) is a clinically and genetically heterogeneous disease of the sarcomere. Molecular genetic studies have shown that familial HCM involves mutations in 8 different genes that encode proteins of the myofibrillar apparatus. METHODS:We thoroughly searched these genes to ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2001.112487

    authors: Lee W,Hwang TH,Kimura A,Park SW,Satoh M,Nishi H,Harada H,Toyama J,Park JE

    更新日期:2001-02-01 00:00:00

  • Assessment of patent foramen ovale in carcinoid heart disease.

    abstract:BACKGROUND AND OBJECTIVE:Carcinoid syndrome may involve right carcinoid heart disease (CHD), secondary to the release of vasoactive substances. Left CHD is rare, as the inactivation of serotonin by the lung protects the left heart. We attempted to evaluate the prevalence of CHD and patent foramen ovale (PFO) with seria...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2006.02.019

    authors: Mansencal N,Mitry E,Forissier JF,Martin F,Redheuil A,Lepère C,Farcot JC,Joseph T,Lacombe P,Rougier P,Dubourg O

    更新日期:2006-05-01 00:00:00

  • Increased uptake of transdermal glyceryl trinitrate during physical exercise and during high ambient temperature.

    abstract::In a study of GTN absorption during exercise and high ambient temperature, 12 healthy volunteers carried 10 mg glyceryl trinitrate (GTN, nitroglycerin) transdermal patches for 6 hours during each of 3 days. During a control day the mean plasma GTN concentration ranged from 1.0 nmol/L (SD +/- 0.8 nmol/L) to 1.5 nmol/L ...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-8703(86)90518-1

    authors: Barkve TF,Langseth-Manrique K,Bredesen JE,Gjesdal K

    更新日期:1986-09-01 00:00:00

  • Abnormal postoperative interventricular motion: new intraoperative transesophageal echocardiographic evidence supports a novel hypothesis.

    abstract::Abnormal interventricular septal motion is a frequent finding after cardiac surgery. However, the time course and underlying mechanisms are not well understood. Nineteen patients, mean age 54 years (range 20 to 82 years), were studied with intraoperative transesophageal echocardiography at five specific times: with th...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(07)80024-x

    authors: Wranne B,Pinto FJ,Siegel LC,Miller DC,Schnittger I

    更新日期:1993-07-01 00:00:00

  • Treatment of long dissections by use of a single long or multiple short stents: clinical and angiographic follow-up.

    abstract:BACKGROUND:Recently, long (> or =20 mm) coronary stents were introduced for clinical use. They are intended as an alternative to multiple conventional stents to treat extensive dissections or suboptimal results of long lesions after balloon angioplasty. METHODS:In a total of 113 such consecutive vessels in 107 patient...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1053/hj.1998.v136.89578

    authors: De Scheerder IK,Wang K,Kostopoulos K,Dens J,Desmet W,Piessens JH

    更新日期:1998-08-01 00:00:00

  • Adaptation to myocardial ischemia during repeated dynamic exercise in relation to findings at cardiac catheterization.

    abstract::It has been suggested that the myocardium is able to recruit endogenous protective mechanisms in response to repeated ischemia and reperfusion. We set out to study whether this is manifested in patients with coronary artery disease in the form of fewer signs of myocardial ischemia during the second of two successive e...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(96)90272-0

    authors: Ylitalo K,Jama L,Raatikainen P,Peuhkurinen K

    更新日期:1996-04-01 00:00:00

  • Successful left ventricular opacification following peripheral venous injection of sonicated contrast agent: an experimental evaluation.

    abstract::A new agent for use in contrast echocardiography that is capable of passing through the pulmonary circulation and opacifying the left ventricular cavity after intravenous injection was evaluated in a canine model. Air-filled albumin microbubbles were produced by sonication. A Coulter counter was used to size and count...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90754-x

    authors: Keller MW,Feinstein SB,Watson DD

    更新日期:1987-09-01 00:00:00

  • Prevalence of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization.

    abstract:BACKGROUND:Heparin is ubiquitously used in cardiac catheterization but predisposes to the development of heparin-induced thrombocytopenia. The objective was to examine prospectively the prevalence of anti-platelet factor 4 (PF4)/heparin antibodies and heparin-induced thrombocytopenia in the population undergoing cardia...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2006.04.028

    authors: Foo SY,Everett BM,Yeh RW,Criss D,Laposata M,Van Cott EM,Jang IK

    更新日期:2006-08-01 00:00:00

  • Heart failure disease management in an indigent population.

    abstract:BACKGROUND:Multidisciplinary disease management programs (MDMP) have demonstrated reduced hospitalizations in motivated pretransplant heart failure populations, but little is known about their effectiveness in largely indigent patients who are not transplant candidates. METHODS AND RESULTS:We studied 35 patients with ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2001.111956

    authors: O'Connell AM,Crawford MH,Abrams J

    更新日期:2001-02-01 00:00:00

  • Myocardial hibernation identified by hyperbaric oxygen treatment and echocardiography in postinfarction patients: comparison with exercise thallium scintigraphy.

    abstract::To evaluate the potential for hyperbaric oxygen (HBO) to produce transient improvement in function in areas of myocardium ischemic at rest (hibernating myocardium), 24 patients were studied within 1 week of acute myocardial infarction. Results were compared with single-photon emission computed tomography (SPECT) thall...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-8703(92)90394-b

    authors: Swift PC,Turner JH,Oxer HF,O'Shea JP,Lane GK,Woollard KV

    更新日期:1992-11-01 00:00:00

  • The relation of renal function to ischemic and bleeding outcomes with 2 different glycoprotein IIb/IIIa inhibitors: the do Tirofiban and ReoPro Give Similar Efficacy Outcome (TARGET) trial.

    abstract:BACKGROUND:Renal function significantly impacts morbidity and mortality after a percutaneous coronary intervention. Platelet glycoprotein (GP) IIb/IIIa inhibitors reduce ischemic complications during percutaneous coronary intervention; little is known of whether their safety and efficacy are influenced by renal functio...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2004.12.002

    authors: Berger PB,Best PJ,Topol EJ,White J,DiBattiste PM,Chan AW,Kristensen SD,Herrmann HC,Moliterno DJ

    更新日期:2005-05-01 00:00:00

  • Rebound phenomena following gradual withdrawal of chronic metoprolol treatment in patients with ischemic heart disease.

    abstract::Metoprolol or placebo was gradually withdrawn during 1 week in 115 patients participating in a 3-year, double-blind, postinfarction study. During the first month after withdrawal mental symptoms and increased cardiac symptoms occurred significantly more frequently in the metoprolol group. Disabling symptoms requiring ...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-8703(84)90408-3

    authors: Olsson G,Hjemdahl P,Rehnqvist N

    更新日期:1984-09-01 00:00:00

  • Does ST resolution achieved via different reperfusion strategies (fibrinolysis vs percutaneous coronary intervention) have different prognostic meaning in ST-elevation myocardial infarction? A systematic review.

    abstract:OBJECTIVE:We perform a systematic review to discern if ST resolution achieved via percutaneous coronary intervention (PCI) has a different meaning to that achieved via fibrinolysis. BACKGROUND:Resolution of ST-segment elevation in acute myocardial infarction has been widely used as a surrogate for treatment success. A...

    journal_title:American heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ahj.2010.06.050

    authors: Wong CK,de la Barra SL,Herbison P

    更新日期:2010-11-01 00:00:00

  • Evaluation of the dual peroxisome proliferator-activated receptor α/γ agonist aleglitazar to reduce cardiovascular events in patients with acute coronary syndrome and type 2 diabetes mellitus: rationale and design of the AleCardio trial.

    abstract:BACKGROUND:Peroxisome proliferator-activated receptors (PPARs) regulate transcription of genes involved in glucose uptake, lipid metabolism, and inflammation. Aleglitazar is a potent dual PPAR agonist with insulin-sensitizing and glucose-lowering actions and favorable effects on lipid profiles and biomarkers of cardiov...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2013.05.013

    authors: Lincoff AM,Tardif JC,Neal B,Nicholls SJ,Rydén L,Schwartz GG,Malmberg K,Buse JB,Henry RR,Wedel H,Weichert A,Cannata R,Grobbee DE

    更新日期:2013-09-01 00:00:00

  • Role of intracellular calcium in the antiarrhythmic effect of procainamide during ventricular fibrillation in rat hearts.

    abstract::Increased intracellular calcium (calcium overload) is considered one of the factors that can initiate ventricular fibrillation. In addition, ventricular fibrillation itself can cause and possibly maintain calcium overload. The goal of this study was to determine whether the class IA antiarrhythmic agent procainamide c...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(95)90453-0

    authors: Zaugg CE,Wu ST,Kojima S,Wikman-Coffelt J,Parmley WW,Buser PT

    更新日期:1995-08-01 00:00:00

  • Telemedicine in myocarditis: Evolution of a mutidisciplinary "disease unit" at the time of COVID-19 pandemic.

    abstract::Myocarditis Disease Unit (MDU) is a functional multidisciplinary network designed to offer multidisciplinary assistance to patients with myocarditis. More than 300 patients coming from the whole Country are currently followed up at a specialized multidisciplinary outpatient clinic. Following the pandemic outbreak of t...

    journal_title:American heart journal

    pub_type: 信件

    doi:10.1016/j.ahj.2020.07.015

    authors: Peretto G,De Luca G,Campochiaro C,Palmisano A,Busnardo E,Sartorelli S,Barzaghi F,Cicalese MP,Esposito A,Sala S

    更新日期:2020-11-01 00:00:00

  • The use of the systolic time interval for predicting left ventricular ejection fraction ischemic heart disease.

    abstract::A large series of 306 patients with ischemic heart disease was studied with automated systolic time intervals and left ventricular ejection fraction as determined by the angiocardiographic method. It was found the pre-ejection period, left ventricular ejection time, delta values, and PEP/LVET ratio all were related to...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(77)80407-9

    authors: Swatzell RH Jr,Bancroft WH Jr,Baldone JC Jr,Tucker MS

    更新日期:1977-04-01 00:00:00

  • Dilatation of the left ventricular cavity on dipyridamole thallium-201 imaging: a new marker of triple-vessel disease.

    abstract::To investigate the significance and mechanism of dilatation of the left ventricular cavity on dipyridamole thallium-201 imaging, we performed both dipyridamole thallium-201 imaging and dipyridamole radionuclide angiography on 83 patients with known angiograms. The dipyridamole/delayed ratio of the left ventricular dim...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90713-r

    authors: Takeishi Y,Tono-oka I,Ikeda K,Komatani A,Tsuiki K,Yasui S

    更新日期:1991-02-01 00:00:00

  • The evolving pattern of digoxin intoxication: observations at a large urban hospital from 1980 to 1988.

    abstract::Digoxin intoxication has been reported to be a common adverse drug reaction with an in-hospital incidence of 6% to 23% and an associated mortality rate as high as 41%. A retrospective review was conducted to assess the accuracy of diagnosis, the morbidity and mortality of digoxin intoxication, and its incidence in hos...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(90)90135-k

    authors: Mahdyoon H,Battilana G,Rosman H,Goldstein S,Gheorghiade M

    更新日期:1990-11-01 00:00:00