Mild dehydration induces echocardiographic signs of mitral valve prolapse in healthy females with prior normal cardiac findings.

Abstract:

:This study was designed to investigate the hypothesis that mitral valve prolapse (MVP) can be induced after diuresis in women without the abnormality who have characteristic body habitus. Fifteen tall, slim, healthy female volunteers with a normal cardiac findings, echocardiogram, and history were investigated after mild diuresis with furosemide and after placebo. All subjects lost weight after furosemide and placebo administration; but mean weight loss was significantly greater after furosemide administration than after placebo administration. Echocardiography showed MVP in none of the 15 patients before treatment, in seven after administration of placebo, and in seven after administration of furosemide. Coaptation point prolapsed superior to the anulus in seven subjects with echocardiographically determined MVP. Left ventricular end-diastolic dimensions decreased significantly after placebo or furosemide administration in subjects in whom MVP developed compared with the measurement in those in whom MVP did not develop. Murmurs characteristic of MVP disappeared in all four rehydrated subjects and echocardiographic changes resolved in two of the five rehydrated subjects. Thus echocardiographically determined MVP can be induced by mild dehydration in women with phenotypic body habitus of MVP; changes may resolve with rehydration. Results suggest an explanation for variable physical examination findings in persons with MVP.

journal_name

Am Heart J

journal_title

American heart journal

authors

Lax D,Eicher M,Goldberg SJ

doi

10.1016/0002-8703(92)90068-7

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

1533-40

issue

6

eissn

0002-8703

issn

1097-6744

pii

0002-8703(92)90068-7

journal_volume

124

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.1016/0002-8703(89)90405-5

    authors: Batchelor AJ,Kruyer WB,Hickman JR Jr

    更新日期:1989-06-01 00:00:00

  • Cardiologists' discussions about sexuality with patients with chronic coronary artery disease.

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    journal_title:American heart journal

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    doi:10.1067/mhj.2002.124053

    authors: Bedell SE,Duperval M,Goldberg R

    更新日期:2002-08-01 00:00:00

  • Amiodarone pharmacokinetics.

    abstract::The single-dose pharmacokinetics of amiodarone have been studied in volunteer subjects given 400 mg doses by the intravenous and oral routes. The data show the compound to have a very large volume of distribution, a low total clearance, and a long and variable terminal elimination half-life. In patients the terminal e...

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    doi:10.1016/0002-8703(83)90006-6

    authors: Holt DW,Tucker GT,Jackson PR,Storey GC

    更新日期:1983-10-01 00:00:00

  • Erythropoietin as a treatment of anemia in heart failure: systematic review of randomized trials.

    abstract:BACKGROUND:Anemia in heart failure is both common and associated with worse symptoms and increased mortality. Several small randomized controlled trials (RCTs) have assessed erythropoiesis-stimulating agents (ESAs), but definitive evaluation and clinical guidance are required. We sought to systematically review the eff...

    journal_title:American heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ahj.2011.02.013

    authors: Kotecha D,Ngo K,Walters JA,Manzano L,Palazzuoli A,Flather MD

    更新日期:2011-05-01 00:00:00

  • Factors for modifying the termination of resuscitation rule in out-of-hospital cardiac arrest.

    abstract:BACKGROUND:False positive rate (FPR) of the current basic life support (BLS) termination of resuscitation (TOR) rule in out-of-hospital cardiac arrest (OHCA) patients (not witnessed; no return of spontaneous circulation prior to transport; and no shocks were delivered) has been ethically challenging. We validated the c...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2019.04.003

    authors: Yoon JC,Kim YJ,Ahn S,Jin YH,Lee SW,Song KJ,Shin SD,Hwang SO,Kim WY,Korean Cardiac Arrest Research Consortium KoCARC.

    更新日期:2019-07-01 00:00:00

  • Pathobiology of atherosclerosis and plaque complications.

    abstract::To understand the process of atherosclerosis, the homeostatic and protective functions of the endothelium must be considered. The endothelium serves as the interface between blood flow and the vascular tissues. It normally regulates vascular tone and structure through the release of vasoactive substances and maintenan...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(94)90251-8

    authors: Dzau VJ

    更新日期:1994-12-01 00:00:00

  • Comparison of a new 3-item self-reported measure of adherence to medication with pharmacy claims data in patients with cardiometabolic disease.

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    pub_type: 杂志文章

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    更新日期:2020-10-01 00:00:00

  • Hospital patterns of medical management strategy use for patients with non-ST-elevation myocardial infarction and 3-vessel or left main coronary artery disease.

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    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2013.12.004

    authors: Harskamp RE,Wang TY,Bhatt DL,Wiviott SD,Amsterdam EA,Li S,Thomas L,de Winter RJ,Roe MT

    更新日期:2014-03-01 00:00:00

  • Hemodynamic effects of molsidomine in patients with acute myocardial infarction.

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    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-8703(85)90688-x

    authors: Reifart N,Neidl K,Kaltenbach M,Bussmann WD

    更新日期:1985-03-01 00:00:00

  • Effects of hyperoxia on myocardial injury following cardioversion-A randomized clinical trial.

    abstract::Oxygen has long been assumed beneficial for all ill and injured patients. However, hyperoxia may be harmful and aggravate myocardial injury such as that caused by myocardial infarction. We aimed to investigate if hyperoxia increases myocardial injury following direct current cardioversion compared with room air. METH...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2017.10.006

    authors: Lauridsen KG,Schmidt AS,Adelborg K,Bach L,Hornung N,Jepsen SM,Deakin CD,Rickers H,Løfgren B

    更新日期:2018-02-01 00:00:00

  • Ancrod decreases the frequency of cyclic flow variations and causes thrombolysis following acute coronary thrombosis.

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    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90050-0

    authors: Apprill PG,Ashton J,Guerrero J,Glas-Greenwalt P,Buja LM,Willerson JT

    更新日期:1987-04-01 00:00:00

  • The role of the central nervous system in chronic congestive heart failure.

    abstract::Even though congestive heart failure is extremely common, the mechanisms responsible for the clinical manifestations remain a puzzle. The central and autonomic (sympathetic) nervous systems are responsible for a large part of the clinical manifestations. The role of the nervous system in CHF is discussed briefly. It i...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(78)90471-4

    authors: Burch GE

    更新日期:1978-02-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1016/0002-8703(92)90507-r

    authors: Brignole M,Oddone D,Cogorno S,Menozzi C,Gianfranchi L,Bertulla A

    更新日期:1992-03-01 00:00:00

  • Prognostic value of C-reactive protein and cardiac troponin I in primary percutaneous interventions for ST-elevation myocardial infarction.

    abstract:BACKGROUND:The rise in cardiac troponin I after ST-elevation myocardial infarction treated by primary percutaneous coronary interventions (PCIs) is predictive of infarct size and left ventricular ejection fraction (LVEF). However, the comparative value of C-reactive protein (CRP) and troponin I for infarct size evaluat...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2006.07.016

    authors: Ohlmann P,Jaquemin L,Morel O,El Behlgiti R,Faure A,Michotey MO,Beranger N,Roul G,Schneider F,Bareiss P,Monassier JP

    更新日期:2006-12-01 00:00:00

  • Endothelin-1 release in acute myocardial infarction as a predictor of long-term prognosis and no-reflow assessed by contrast-enhanced magnetic resonance imaging.

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    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2010.02.019

    authors: Eitel I,Nowak M,Stehl C,Adams V,Fuernau G,Hildebrand L,Desch S,Schuler G,Thiele H

    更新日期:2010-05-01 00:00:00

  • Endothelin and von Willebrand factor as parameters of endothelial function in idiopathic dilated cardiomyopathy: different stimuli for release before and after heart transplantation?

    abstract:BACKGROUND:Congestive heart failure (CHF) and heart transplantation (HTX) are characterized by endothelial dysfunction as indicated by elevation of markers of endothelial function, including endothelin and von Willebrand factor (vWF). However, previous studies included both patients with idiopathic dilated cardiomyopat...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(99)70505-3

    authors: Galatius S,Wroblewski H,Sørensen VB,Bie P,Parving HH,Kastrup J

    更新日期:1999-03-01 00:00:00

  • The value of stress single photon emission computed tomography in patients without known coronary artery disease presenting with dyspnea.

    abstract:BACKGROUND:Dyspnea is a complex system with multiple etiologies, including myocardial ischemia ("anginal equivalent"). Few studies have examined the utility of stress testing to detect coronary artery disease in this setting. The purpose of this study was to examine the prevalence, severity, and prognostic value of per...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2006.03.002

    authors: Balaravi B,Miller TD,Hodge DO,Gibbons RJ

    更新日期:2006-09-01 00:00:00

  • Extent of ischemic stimulus and plasma beta-endorphin levels in silent myocardial ischemia.

    abstract:BACKGROUND:Beta-endorphin has been reported to play a role in the mechanism of silent myocardial ischemia. OBJECTIVES:Plasma beta-endorphin levels during coronary angioplasty-induced silent and symptomatic myocardial ischemia were compared with those during exercise-induced silent ischemia. METHODS AND RESULTS:The st...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(98)70039-0

    authors: Hikita H,Etsuda H,Takase B,Satomura K,Kurita A,Nakamura H

    更新日期:1998-05-01 00:00:00

  • Revival of transcatheter PFO closure: A meta-analysis of randomized controlled trials - impact of shunt size and age.

    abstract:BACKGROUND:Transcatheter foramen ovale closure (TPC) has emerged as a potential treatment option for patients with cryptogenic strokes and persistent foramen ovale (PFO). However, previous randomized controlled trials could hardly demonstrate any benefit compared to medical treatment (Med-Tx). Recently new data have be...

    journal_title:American heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ahj.2018.03.025

    authors: Reinthaler M,Ozga AK,Sinning D,Curio J,Al-Hindwan HS,Bäckemo Johansson J,Jung F,Lendlein A,Rauch G,Landmesser U

    更新日期:2018-07-01 00:00:00

  • Impact of computerized dosing on eptifibatide-associated bleeding and mortality.

    abstract:OBJECTIVE:The study aimed to determine the impact on eptifibatide-associated bleeding by implementing a computerized dosing algorithm in the cardiac catheterization suite. BACKGROUND:Excessive dosing of eptifibatide is associated with increased bleeding rates and hospital mortality. Although dosing adjustments based o...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2009.10.006

    authors: Putney DR,Kleiman NS,Fromm RE Jr,Buergler JM

    更新日期:2009-12-01 00:00:00

  • Acute coronary occlusion following blunt injury to the chest in the absence of coronary atherosclerosis.

    abstract::A 35-year-old man suffered transmural diaphragmatic wall infarction immediately after receiving a nonpenetrating trauma to his chest. During subsequent months crippling angina pectoris developed and coronary arteriography was performed. A complete obstruction of the left circumflex coronary artery was demonstrated 2 c...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(76)80051-8

    authors: Oren A,Bar-Shlomo B,Stern S

    更新日期:1976-10-01 00:00:00

  • Findings of coronary angioscopy in angiographically normal coronary segments of patients with coronary artery disease.

    abstract::Compared with pathologic studies coronary angiography is a relatively insensitive technique to detect early atherosclerosis. Coronary angioscopy is a new technique providing direct information on luminal vessel surface. To determine whether coronary angioscopy may detect the presence of atherosclerotic disease on angi...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(95)90198-1

    authors: Alfonso F,Goicolea J,Hernandez R,Segovia J,Silva JC,Perez-Vizcayno MJ,Rollan MJ,Bañuelos C,Macaya C

    更新日期:1995-11-01 00:00:00

  • Serial thallium-201 imaging after dipyridamole for coronary disease detection: quantitative analysis using myocardial clearance.

    abstract::After dipyridamole, canine studies have demonstrated a slower rate of myocardial thallium-201 clearance from zones distal to a coronary artery stenosis compared to normal zones. To determine if criteria based on canine myocardial thallium-201 clearance rates could be applied clinically, 40 patients with and 26 patient...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(84)90088-7

    authors: Okada RD,Dai YH,Boucher CA,Pohost GM

    更新日期:1984-03-01 00:00:00

  • Platelet activation in patients with congestive heart failure: do we have enough evidence to consider clopidogrel?

    abstract::Our understanding of the pathogenesis of congestive heart failure (CHF) has improved remarkably in recent years. However, despite better knowledge and novel pharmaceutical strategies, this disease is still one of the most brutal killers in the Western world. The pathophysiology of CHF is complex, and much of our compr...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1067/mhj.2003.163

    authors: Malinin AI,O'Connor CM,Dzhanashvili AI,Sane DC,Serebruany VL

    更新日期:2003-03-01 00:00:00

  • Effect of delay on racial differences in thrombolysis for acute myocardial infarction.

    abstract:OBJECTIVE:To analyze the effect of delay times on racial differences in thrombolysis for acute myocardial infarction. BACKGROUND:Lower rates of thrombolytic therapy in blacks with acute myocardial infarction have recently been reported, but the reasons for this disparity are unknown. We hypothesized that lower rates o...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2000.109644

    authors: Syed M,Khaja F,Rybicki BA,Wulbrecht N,Alam M,Sabbah HN,Goldstein S,Borzak S

    更新日期:2000-10-01 00:00:00

  • Effects of physiologic load of pregnancy on left ventricular contractility and remodeling.

    abstract::Left ventricular (LV) adaptation to the hemodynamic load of pregnancy has been studied with load-sensitive ejection-phase indexes, but the results of these studies are conflicting. The aim of this study was to examine the effects of the hemodynamic load of pregnancy on the contractile state of the left ventricle by us...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(97)70247-3

    authors: Geva T,Mauer MB,Striker L,Kirshon B,Pivarnik JM

    更新日期:1997-01-01 00:00:00

  • Usefulness of anticoagulant therapy in the prevention of embolic complications of atrial fibrillation.

    abstract::The medical records of 254 patients with atrial fibrillation were reviewed to determine the incidence of embolic events in relation to type of cardiovascular disease, duration of atrial fibrillation, and use of anticoagulants. During a total follow-up of 833 patient-years in atrial fibrillation, there were 32 instance...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90318-2

    authors: Roy D,Marchand E,Gagné P,Chabot M,Cartier R

    更新日期:1986-11-01 00:00:00

  • Design and rationale of the TRI-stent adjudication study (TRIAS) program.

    abstract:BACKGROUND:In the treatment of coronary artery disease, a "pro-healing" approach for prevention of in-stent restenosis and late stent thrombosis is intuitively favored over the use of cytotoxic or cytostatic drugs released from a drug-eluting stent (DES). Promoting accelerated endothelial coverage of the stent surface,...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2009.07.022

    authors: Klomp M,Beijk MA,Verouden NJ,Tijssen JG,de Winter RJ,TRIAS Investigators.

    更新日期:2009-10-01 00:00:00

  • Abnormal postoperative interventricular motion: new intraoperative transesophageal echocardiographic evidence supports a novel hypothesis.

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    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(07)80024-x

    authors: Wranne B,Pinto FJ,Siegel LC,Miller DC,Schnittger I

    更新日期:1993-07-01 00:00:00

  • Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndr

    abstract:BACKGROUND:Experimental studies suggest that metabolic myocardial support by intravenous (IV) glucose, insulin, and potassium (GIK) reduces ischemia-induced arrhythmias, cardiac arrest, mortality, progression from unstable angina pectoris to acute myocardial infarction (AMI), and myocardial infarction size. However, tr...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ahj.2012.02.002

    authors: Selker HP,Beshansky JR,Griffith JL,D'Agostino RB,Massaro JM,Udelson JE,Rashba EJ,Ruthazer R,Sheehan PR,Desvigne-Nickens P,Rosenberg YD,Atkins JM,Sayah AJ,Aufderheide TP,Rackley CE,Opie LH,Lambrew CT,Cobb LA,Macleod BA

    更新日期:2012-03-01 00:00:00