Abstract:
:The medical records of 254 patients with atrial fibrillation were reviewed to determine the incidence of embolic events in relation to type of cardiovascular disease, duration of atrial fibrillation, and use of anticoagulants. During a total follow-up of 833 patient-years in atrial fibrillation, there were 32 instances of systemic embolism: 21 involved the cerebral circulation and 11 were extracerebral. Thirty of these events occurred during 549 patient-years of follow-up without anticoagulation therapy (5.46 of 100 patient-years), while only two embolic events occurred during 284 patient-years on anticoagulants (0.7 of 100 patient-years). Thus, the incidence of embolism was eight times more frequent during the unanticoagulated period of observation in atrial fibrillation (p less than 0.002). The incidence of embolism during follow-up without anticoagulants was the same regardless of the presence or absence of mitral valve disease and regardless of whether atrial fibrillation was chronic or paroxysmal. The rate of serious hemorrhagic complications on anticoagulants was acceptably low (2.11 of 100 patient-years). We conclude that in this study population anticoagulant therapy reduced the risk of embolic complications of atrial fibrillation. The results also indicate that the use of anticoagulants should not be limited to patients with atrial fibrillation due to mitral valve disease.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Roy D,Marchand E,Gagné P,Chabot M,Cartier Rdoi
10.1016/0002-8703(86)90318-2subject
Has Abstractpub_date
1986-11-01 00:00:00pages
1039-43issue
5eissn
0002-8703issn
1097-6744pii
0002-8703(86)90318-2journal_volume
112pub_type
杂志文章abstract:BACKGROUND:The study evaluates whether Optison used during dobutamine stress echocardiography (DSE) will improve endocardial border definition and whether this will translate to an improvement in sensitivity and specificity of the test in patients with poor echocardiographic windows. DSE is extremely valuable in the wo...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2001.117608
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Pregnancy is increasingly common in women with congenital heart disease (CHD), but little is known about long-term cardiovascular outcome after pregnancy in these patients. We studied the incidence of cardiovascular events 1-year postpartum and compared cardiac function prepregnancy and 1-year postpartum in ...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2014.11.010
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Recent data indicate that cardiac antibodies play an active role in the pathogenesis of dilated cardiomyopathy (DCM) and may contribute to cardiac dysfunction in patients with DCM. The present study investigated the influence of immunoadsorption with subsequent immunoglobulin G substitution (IA/IgG) on cardi...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2010.01.012
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:The conventional use of 16-slice multidetector computed tomography (MDCT) remains somewhat limited for evaluating stenoses in vein graft distal anastomotic sites and in coronary arteries. We investigated the diagnostic accuracy of 64-slice MDCT for assessment of both grafts and coronary arteries in patients ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.04.054
更新日期:2007-09-01 00:00:00
abstract::We attempted to predict successful myocardial reperfusion and salvage in acute myocardial infarction (AMI) by using measurements of plasma superoxide dismutase (SOD), a plasma free-radical scavenger, activity. Forty-nine patients with AMI were studied within 6 hours of symptoms onset. In group 1 (n = 26), primary perc...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(96)90163-5
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:The APEX trial assessed the safety and efficacy of extended-duration thromboprophylaxis using betrixaban versus standard dosing of enoxaparin among hospitalized, acutely ill medical patients. The 80-mg betrixaban dose was halved to 40 mg among subjects with severe renal insufficiency and those receiving a co...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2016.12.004
更新日期:2017-03-01 00:00:00
abstract::To assess the relation between myocardial ischemia, ventricular arrhythmias (VA), and left ventricular (LV) dysfunction, we evaluated 74 patients with coronary artery disease (CAD) using radionuclide angiography (to determine the resting ejection fraction [EF]), resting thallium-201 scintigraphy (to ascertain the exte...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(85)90588-5
更新日期:1985-02-01 00:00:00
abstract::Intravascular thrombus often occurs when the rupture or fissure of an atherosclerotic plaque exposes procoagulant elements lying below the plaque surface. This process of plaque rupture is the result both of passive mechanical forces and an active cell-mediated mechanism. Recently a number of investigators have develo...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1053/hj.1998.v135.90300
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Familial dilated cardiomyopathy (FDCM) is attributed to defects in cytoskeletal proteins, and different patterns of inheritance and phenotypic expressions according to assorted-protein modifications have been identified to date. We describe a clinical family study with 24 individuals in 3 generations affecte...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2003.141
更新日期:2003-02-01 00:00:00
abstract::Following pulmonary infarction, three patients developed the classical signs and symptoms of the Dressler syndrome associated with persistent left pleural effusion. Each responded dramatically to corticosteroid therapy. While the pathogenesis of this "Post-Pulmonary Infarction syndrome," like the Dressler syndrome, is...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(79)90477-0
更新日期:1979-12-01 00:00:00
abstract::The purpose of this study was to compare the three most commonly used maximal graded exercise test (GXT) protocols in healthy women. Submaximal and maximal metabolic and hemodynamic responses were determined from two treadmill protocols, Bruce and Balke, and a bicycle protocol, in 49 women. Maximum oxygen uptake (VO2 ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(82)90275-7
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:A simple approach is the predominant strategy for the percutaneous coronary intervention of bifurcation lesions. Performing side branch (SB) predilation in this context is currently a matter of controversy. In this study, we assess the efficacy of SB predilatation before a provisional T-stent strategy for bi...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2014.05.014
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Dilated and hypertrophic cardiomyopathies are primary myocardial diseases that cause considerable morbidity and mortality. Although these cardiomyopathies are clinically heterogeneous, genetic factors play an important role in their etiology and pathogenesis. The defects in the cardiac actin (ACTC) gene can ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2002.122514
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Percutaneous coronary intervention (PCI) of saphenous vein graft (SVG) is associated with frequent postprocedural enzyme elevation and late cardiac events. New strategies are proposed to minimize distal embolization and to improve the outcome of patients treated with stenting for SVG lesions. The objectives ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/S0002-8703(03)00309-0
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Clinical trials have helped clarify the efficacy of clopidogrel for the treatment and prevention of vascular disease. Costs for its use exceeded $5.9 billion in 2005, making it the second greatest source of drug expenditure in the world. However, little is known about the appropriateness of that use. Overuse...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2007.11.039
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Procedural volume has been shown to be associated with outcome in cardiac catheterization and intervention in adults. The impact of center-level factors (such as volume) and their interaction with subject- and procedure-level factors on outcome after cardiac catheterization in children is not well described....
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2015.02.018
更新日期:2015-06-01 00:00:00
abstract::Percutaneous transluminal balloon angioplasty for stenosis of the aorta was performed in 36 patients with Takayasu's arteritis (age range, 8 to 36 years; mean, 19.1 +/- 7.7 years). Balloon dilatation was successful in 34 patients and resulted in a decrease in the mean peak systolic pressure gradient (PSG) from 75.2 +/...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(92)90967-z
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Although cross-sectional studies have identified lifestyle factors associated with high-density lipoprotein cholesterol (HDL-C), no studies have examined the association between changes in lifestyle factors and long-term changes in HDL-C. METHODS:We examined the association between changes in lifestyle fact...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2010.12.015
更新日期:2011-04-01 00:00:00
abstract::Congestive heart failure with dilated left ventricle developed in two patients with symptomatic hypertrophic obstructive cardiomyopathy. Both patients previously underwent cardiac surgery for relief of their outflow obstruction. Alterations in structure and function of the left ventricle during their episode of cardia...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(79)90012-7
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:Although monitoring the clinical status of patients with heart failure rests at the core of clinical medicine, the ability of different techniques to reflect clinical change has not been evaluated. This study sought to describe changes in various measures of disease status associated with gradations of clini...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2004.12.010
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess one-year outcomes of invasive and non-invasive strategies in ST-elevation myocardial infarction (STEMI) among multimorbid older people with complex health needs. METHODS:We included patients, registered between 2006 and 2013 in the SWEDEHEART registry, who were 70 years o...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2019.01.008
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Previous studies have generated inconsistent results when attempting to define predictors of stroke and death in patients with endocarditis. We sought to examine the relationship between vegetation 2-dimensional size and stroke in those with infective endocarditis (IE) and to identify differences between aor...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2001.115790
更新日期:2001-07-01 00:00:00
abstract::In 10 treated and 2 control dogs, the short-term effects of intravenous propafenone (2 mg/kg/10 minutes, followed by 1 mg/min [n = 2] or 25 micrograms/kg/min [n = 8]) on the internal ventricular defibrillation energy requirements (DER) were investigated. Multiple stored energy levels were randomly tested and the perce...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(91)90577-5
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Appropriate thromboprophylaxis for patients with atrial fibrillation or atrial flutter (AF) remains a national challenge. METHODS:We hypothesized that a shared decision-making interaction facilitated by an Atrial Fibrillation Shared Decision Making Tool (AFSDM) would improve patient knowledge about atrial f...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2018.01.003
更新日期:2018-05-01 00:00:00
abstract::Calcium channel blockers and central alpha-agonists are among the classes of antihypertensive drugs that yield the most favorable overall effects on risk factors for hypertension-related end-organ damage. An open-label prospective trial in 42 patients with a mean baseline blood pressure of 144/102 mm Hg sought to asse...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/0002-8703(93)90707-g
更新日期:1993-10-01 00:00:00
abstract::To determine the frequency and significance of left ventricular wall motion abnormalities in patients without clinical evidence of myocardial infarction, we reviewed the two-dimensional echocardiograms of 252 patients who had no history or electrocardiographic evidence of myocardial infarction and who subsequently und...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(91)90666-6
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Prior studies regarding the effect of racial status on post-myocardial infarction (MI) in subjects with diabetes have yielded conflicting results. We evaluated the effect of diabetes status on racial differences in post-MI mortality and morbidity for a 7-year period, from 1990 through 1997. METHODS:All pati...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2005.02.042
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Dual antiplatelet therapy with aspirin and clopidogrel is currently recommended in off-pump coronary artery bypass (OPCAB). However, no data exist concerning platelet reactivity on clopidogrel after OPCAB. The aim of this study was to assess the relationship between platelet reactivity and late major adverse...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2014.01.016
更新日期:2014-06-01 00:00:00
abstract::Probucol, a new cholesterol-lowering agent, was administered to ambulatory outpatients representing several classes of hyperlipoproteinemia (HL) for two years without dietary restriction. In 32 patients with Type II HL and 12 with Type IIB HL, statistically significant reduction in mean serum cholesterol levels occurr...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/0002-8703(78)90088-1
更新日期:1978-08-01 00:00:00
abstract::To investigate the influence of intrinsic limb vasodilator capacity on exercise performance, limb reactive hyperemic flows and their relations to exercise capacity during upright bicycle exercise were examined in 52 patients with recent myocardial infarction. Reactive hyperemic flow was measured in the forearm and the...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(96)90243-4
更新日期:1996-09-01 00:00:00