当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations.

The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations.

Abstract：

:Recent developments have highlighted the challenges facing cardiovascular clinical research in global contemporary practice, particularly in North America, including shifting priorities for drug development targets, increasing regulatory requirements, and expensive operational approaches for conducting randomized clinical trials. Nonetheless, emerging trends such as the consolidation of practices and hospitals into integrated health systems, the integration of electronic health records from thousands of practices into large data repositories to support prospective research studies, and streamlined operational approaches such as registry-based trials and risk-based monitoring have created numerous opportunities to disrupt the clinical research paradigm. Within this context, academic research organizations around the globe, particularly a strengthened collaboration of 3 established academic research organizations in North America, are uniquely positioned to promote and develop grassroots collaborations across all types of clinical practices, to delineate successful solutions to obstacles that limit clinical research initiatives, and to guide the future of cardiovascular research in the global research environment.

journal_name

Am Heart J

journal_title

American heart journal

authors

Roe MT,Mahaffey KW,Ezekowitz JA,Alexander JH,Goodman SG,Hernandez A,Temple T,Berdan L,Califf RM,Harrington RA,Peterson ED,Armstrong PW

doi

10.1016/j.ahj.2015.03.002

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

743-50

issue

6

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(15)00124-6

journal_volume

169

pub_type

杂志文章,评审

相关文献

AMERICAN HEART JOURNAL文献大全
  • The long-term prognosis of patients with out-of-hospital cardiac arrest but no inducible ventricular tachycardia.

    abstract：:The long-term prognosis of patients successfully resuscitated from cardiac arrest who do not have acute precipitating factors and in whom ventricular arrhythmias cannot be induced during baseline electrophysiologic testing is controversial. The purpose of this investigation was to evaluate the long-term risk of recurr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(90)90245-s

    authors： Sager PT,Choudhary R,Leon C,Rahimtoola SH,Bhandari AK

    更新日期：1990-12-01 00:00:00

  • Hemodynamic effects of molsidomine in patients with acute myocardial infarction.

    abstract：:The hemodynamic effects of molsidomine were studied in 48 patients with acute myocardial infarction and compared with hemodynamic properties in a control group of 24 patients. The most pronounced decrease in pulmonary artery diastolic pressure occurs between 30 and 60 minutes after oral administration of 8 to 12 mg (n...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(85)90688-x

    authors： Reifart N,Neidl K,Kaltenbach M,Bussmann WD

    更新日期：1985-03-01 00:00:00

  • Drinking and coronary heart disease: the Albany Study.

    abstract：:The relation of alcohol consumption to coronary heart disease (CHD) was examined in a cohort of 1910 employed men aged 38 to 55 years enrolled in the Albany Study, a prospective investigation of factors related to cardiovascular disease. Two follow-up periods were examined, one between 1953-54 and 1971-72, the other a...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(85)90152-8

    authors： Gordon T,Doyle JT

    更新日期：1985-08-01 00:00:00

  • Uniform platelet activation exists before coronary stent implantation despite aspirin therapy.

    abstract：BACKGROUND:Platelets play an important role in the natural history of coronary artery disease. Enhanced platelet aggregation and receptor expression unquestionably occur after coronary stent implantation; however, the functional characteristics of platelets before stenting have not been fully elucidated. METHODS:Plate...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2001.116478

    authors： Serebruany VL,Cummings CC,Malinin AI,Steinhubl SR,Gurbel PA

    更新日期：2001-10-01 00:00:00

  • Monitoring clinical changes in patients with heart failure: a comparison of methods.

    abstract：BACKGROUND:Although monitoring the clinical status of patients with heart failure rests at the core of clinical medicine, the ability of different techniques to reflect clinical change has not been evaluated. This study sought to describe changes in various measures of disease status associated with gradations of clini...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2004.12.010

    authors： Spertus J,Peterson E,Conard MW,Heidenreich PA,Krumholz HM,Jones P,McCullough PA,Pina I,Tooley J,Weintraub WS,Rumsfeld JS,Cardiovascular Outcomes Research Consortium.

    更新日期：2005-10-01 00:00:00

  • Correlation of "critical" left coronary artery lesions with positive submaximal exercise tests in patients with chest pain.

    abstract：:This study correlates the anatomic pathologic coronary anatomy found by arteriography in each of three groups of symptomatic patients, all with coronary artery disease, divided according to the magnitude of ST-segment depression after an adequate submaximal treadmill exercise test. Group I consists of 45 patients with...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(75)90080-0

    authors： Cheitlin MD,Davia JE,de Castro CM,Barrow EA,Anderson WT

    更新日期：1975-03-01 00:00:00

  • R-wave amplitude responses to rapid atrial pacing: a marker for myocardial ischemia.

    abstract：:Atrial pacing-induced changes in the sum of R-wave amplitude were measured in leads V5, X, Y, and Z at rates of 100 bpm (phase I), 150 bpm (phase II), and immediately after pacing (phase III) in 33 patients undergoing cardiac catheterization for evaluation of chest pain. Seventeen (51%) patients showed evidence of isc...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(84)90133-9

    authors： David D,Kitchen JG 3rd,Michelson EL,Naito M,Sawin HS,Chen CC

    更新日期：1984-01-01 00:00:00

  • The natural history of benign and potentially malignant ventricular arrhythmias with special reference to nonsustained ventricular tachycardia.

    abstract：:Ambulatory ECG recordings are routinely used to identify patients at increased risk of sudden cardiac death and to monitor changes in ventricular arrhythmias during antiarrhythmic drug therapy. The arrhythmia frequency established during the initial baseline has previously been reported to change during a second place...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(88)90139-1

    authors： Pratt CM,Francis M,Mahler S,Aogaichi K,Keus P,Young JB

    更新日期：1988-10-01 00:00:00

  • Adaptation to myocardial ischemia during coronary angioplasty demonstrated by clinical, electrocardiographic, echocardiographic, and metabolic parameters.

    abstract：:It has been shown that brief episodes of myocardial ischemia can render the heart more resistant to a prolonged subsequent ischemic episode. This phenomenon, called "preconditioning," has been described in human beings during coronary angioplasty with the use of clinical, electrocardiographic (ECG), or metabolic param...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(97)70200-x

    authors： Eltchaninoff H,Cribier A,Tron C,Derumeaux G,Koning R,Hecketsweiller B,Letac B

    更新日期：1997-04-01 00:00:00

  • Editorial: Observations on the diagnosis of isolated rheumatic carditis.

    abstract：:There are many similarities between the clinical features of viral heart disease and of rheumatic carditis, as defined in the revised Jones criteria for the diagnosis of rheumatic fever. Because of this, it is likely that viral heart disease has been, and still is, diagnosed as rheumatic. This situation can be avoided...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(76)80137-8

    authors： Ward C

    更新日期：1976-05-01 00:00:00

  • Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes.

    abstract：BACKGROUND:Coronary artery disease (CAD) and, increasingly, diabetes are recognized as having an inflammatory basis. Membrane toll-like receptors (TLRs) activate signaling pathways that up-regulate inflammation. We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is a...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2004.05.049

    authors： Kolek MJ,Carlquist JF,Muhlestein JB,Whiting BM,Horne BD,Bair TL,Anderson JL

    更新日期：2004-12-01 00:00:00

  • Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes.

    abstract：BACKGROUND:Bleeding and blood transfusion are associated with increased morbidity and mortality among patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS); however, the economic consequences of these complications are not well defined. We sought to determine the relationship between bleeding, bloo...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2007.10.014

    authors： Rao SV,Kaul PR,Liao L,Armstrong PW,Ohman EM,Granger CB,Califf RM,Harrington RA,Eisenstein EL,Mark DB

    更新日期：2008-02-01 00:00:00

  • "Non-Q wave," alias "nontransmural," myocardial infarction: a specific entity.

    abstract：:Although Q wave and non-Q wave MI are often referred to as "transmural" and "nontransmural," there is no anatomic evidence to justify this distinction. Nevertheless, a distinction is important, because the two entities have a different prognosis. At the present time, between 25% and 35% of MIs are non-Q wave. They are...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(89)90629-7

    authors： André-Fouet X,Pillot M,Leizorovicz A,Finet G,Gayet C,Milon H

    更新日期：1989-04-01 00:00:00

  • Regional metabolism during coronary occlusion, reperfusion, and reocclusion using phosphorus31 nuclear magnetic resonance spectroscopy in the intact rabbit.

    abstract：:Few studies have examined metabolic consequences of coronary occlusion and reperfusion using phosphorus31 nuclear magnetic resonance (31P-NMR) in an intact animal model. Accordingly, we developed a model to study serial changes in myocardial metabolism in the intact open-chest rabbit. Ten animals underwent 20 +/- 2 mi...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(89)90656-x

    authors： Kavanaugh KM,Aisen AM,Fechner KP,Chenevert TL,Dunham WR,Buda AJ

    更新日期：1989-01-01 00:00:00

  • A new method for automated detection of the R-on-T phenomenon.

    abstract：:The detection of premature ectopic beats coinciding with the T-wave of the antecedent beat is important for patient monitoring. In the method described here, the difficulties of direct measurement of QT time are avoided by evaluating the changes of QT time according to heart rate by use of a diode function generator. ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(75)90191-x

    authors： Breithardt G,Loogen F,Schmiel FK,Seipel L

    更新日期：1975-06-01 00:00:00

  • Lifestyle changes and 14-year change in high-density lipoprotein cholesterol in a cohort of male physicians.

    abstract：BACKGROUND:Although cross-sectional studies have identified lifestyle factors associated with high-density lipoprotein cholesterol (HDL-C), no studies have examined the association between changes in lifestyle factors and long-term changes in HDL-C. METHODS:We examined the association between changes in lifestyle fact...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2010.12.015

    authors： Rahilly-Tierney C,Sesso HD,Djoussé L,Gaziano JM

    更新日期：2011-04-01 00:00:00

  • High-dose, brief intravenous streptokinase early in acute myocardial infarction.

    abstract：:An acute thrombus at the proximal border of a high-grade atherosclerotic obstruction is the usual cause of myocardial infarction. Although intracoronary thrombolysis is potentially an exciting new therapy for reducing the extent of myocardial infarction by lysing coronary clot, a number of major difficulties limit its...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-8703(82)90267-8

    authors： Spann JF,Sherry S,Carabello BA,Mann RH,McCann WD,Gault JH,Gentzler RD,Rosenberg KM,Maurer AH,Denenberg BS,Warner HF,Rubin RN,Malmud LS,Comerota A

    更新日期：1982-10-01 00:00:00

  • Long-term outcome of unsuccessful percutaneous transluminal coronary angioplasty.

    abstract：:We analyzed the long-term outcome of 198 patients after unsuccessful percutaneous transluminal coronary angioplasty. Forty-nine percent underwent emergency coronary artery bypass grafting surgery, 17% had elective bypass surgery, and 34% were treated medically. The in-hospital mortality rate was 4%, and myocardial inf...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/s0002-8703(05)80313-8

    authors： Tuzcu M,Simpfendorfer C,Dorosti K,Franco I,Golding L,Hollman J,Whitlow P

    更新日期：1990-04-01 00:00:00

  • Isolated T wave alternans.

    abstract：:Two patients with isolated T wave alternans are reported, with their vectocardiograms, their response to carotid sinus stimulation, and the response to calcium infusion in one of them with documented severe hypocalcemia. Eleven cases of the literature are briefly reviewed. The alternans of the T wave appears with seve...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(78)90369-1

    authors： Navarro-Lopez F,Cinca J,Sanz G,Periz A,Magriña J,Betriu A

    更新日期：1978-03-01 00:00:00

  • Contrast bidimensional echocardiography in the morphologic and functional postoperative evaluation of the Senning technique for complete transposition of the great vessels.

    abstract：:Contrast bidimensional echocardiographic (2DE) studies were performed in eight patients with d-transposition of the great vessels in the postoperative period of the Senning technique. Contrast was injected into a peripheral vein of all patients, and into the arterial atrium in five in the postoperative period. The 2DE...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(84)90552-0

    authors： Pasalodos J,González V,Suárez de Lezo J,Concha M,Vallés F

    更新日期：1984-07-01 00:00:00

  • Duration of red cell storage before transfusion and in-hospital mortality.

    abstract：BACKGROUND:Red cell transfusions are lifesaving in severely anemic or acutely bleeding patients but may be associated with an increased risk of cardiovascular events in critically ill patients. The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospi...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2009.12.045

    authors： Eikelboom JW,Cook RJ,Liu Y,Heddle NM

    更新日期：2010-05-01 00:00:00

  • Borderline left ventricles in prenatally diagnosed atrioventricular septal defect or double outlet right ventricle: echocardiographic predictors of biventricular repair.

    abstract：BACKGROUND:Atrioventricular septal defect (AVSD) and double outlet right ventricle (DORV) with normally related great arteries and normal ventricular sizes are associated with a good long-term prognosis after biventricular (BV) repair. The outcome of cases with a borderline small left ventricle (bLV) is unclear. The pu...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2006.04.018

    authors： Pitkänen OM,Hornberger LK,Miner SE,Mondal T,Smallhorn JF,Jaeggi E,Nield LE

    更新日期：2006-07-01 00:00:00

  • Effects of exercise training on left ventricular volumes and function in patients with nonischemic cardiomyopathy: application of magnetic resonance myocardial tagging.

    abstract：BACKGROUND:Exercise training is now an accepted component of the therapeutic regimen in patients with heart failure and underlying ischemia, but few data are available on the effects of training in patients with nonischemic dilated cardiomyopathy. METHODS:Twenty-four patients (mean age 55 +/- 9 years, mean ejection fr...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1067/mhj.2002.124401

    authors： Myers J,Wagner D,Schertler T,Beer M,Luchinger R,Klein M,Rickli H,Muller P,Mayer K,Schwitter J,Dubach P

    更新日期：2002-10-01 00:00:00

  • Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardi

    abstract：:Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol efflux, mediated by apolipoprotein A-I, removes excess cholesterol from atherosclerotic plaque and transports it to the liver for excretion. Impaired cholesterol efflux is associated with higher cardiovascular (CV) event ra...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2020.10.052

    authors： Gibson CM,Kastelein JJP,Phillips AT,Aylward PE,Yee MK,Tendera M,Nicholls SJ,Pocock S,Goodman SG,Alexander JH,Lincoff AM,Bode C,Duffy D,Heise M,Berman G,Mears SJ,Tricoci P,Deckelbaum LI,Steg PG,Ridker P,Mehran R

    更新日期：2021-01-01 00:00:00

  • The effect of drug-eluting stents on intermediate angiographic and clinical outcomes in diabetic patients: insights from randomized clinical trials.

    abstract：OBJECTIVE:Implantation of drug-eluting stents has emerged as the predominant percutaneous revascularization strategy in diabetic patients, despite limited outcomes data. Accordingly, our aim was to conduct a meta-analysis to assess the benefit and safety profile of drug-eluting stents in diabetic patients. METHODS:We ...

    journal_title：American heart journal

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ahj.2007.11.017

    authors： Kumbhani DJ,Bavry AA,Kamdar AR,Helton TJ,Bhatt DL

    更新日期：2008-04-01 00:00:00

  • Impact of computerized dosing on eptifibatide-associated bleeding and mortality.

    abstract：OBJECTIVE:The study aimed to determine the impact on eptifibatide-associated bleeding by implementing a computerized dosing algorithm in the cardiac catheterization suite. BACKGROUND:Excessive dosing of eptifibatide is associated with increased bleeding rates and hospital mortality. Although dosing adjustments based o...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2009.10.006

    authors： Putney DR,Kleiman NS,Fromm RE Jr,Buergler JM

    更新日期：2009-12-01 00:00:00

  • Effects of heart rate on phasic coronary blood flow pattern and flow reserve in patients with normal coronary arteries: a study with an intravascular Doppler catheter and spectral analysis.

    abstract：:To assess the effects of pacing-induced tachycardia on phasic coronary blood flow pattern and flow reserve of left anterior descending artery, we examined 16 patients with chest pain and angiographically normal coronary arteries by using an intravascular Doppler catheter with spectral analysis of the velocity signal. ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(94)90661-0

    authors： Hongo M,Nakatsuka T,Watanabe N,Takenaka H,Tanaka M,Kinoshita O,Okubo S,Sekiguchi M

    更新日期：1994-03-01 00:00:00

  • Shortcomings of the Lown grading system for observational or experimental studies in ischemic heart disease.

    abstract：:The Lown grading system uses three levels of frequency and four complex features to grade ventricular arrhythmias. The seven Lown grades are mutually exclusive (a patient can be in only one grade) and hierarchical (higher grades indicate increased likelihood of death). We evaluated the ability of the Lown arrhythmia g...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(80)90217-3

    authors： Bigger JT Jr,Weld FM

    更新日期：1980-12-01 00:00:00

  • Effect of intravenous adenosine on myocardial reperfusion injury in a model with low myocardial collateral blood flow.

    abstract：:The purpose of this study was to investigate the effects of various doses of adenosine administered intravenously on myocardial reperfusion injury in a model with poor collateral blood flow. New Zealand White rabbits were subjected to 30 minutes of occlusion of the obtuse marginal branch of the left circumflex artery ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(91)90567-2

    authors： Norton ED,Jackson EK,Virmani R,Forman MB

    更新日期：1991-11-01 00:00:00

  • Predictors of intra-aortic balloon pump hemodynamic failure in non-acute myocardial infarction cardiogenic shock.

    abstract：OBJECTIVES:To characterize patient profile and hemodynamic profile of those undergoing intra-aortic balloon pump (IABP) for cardiogenic shock and define predictors of hemodynamic failure of IABP support. BACKGROUND:Clinical characteristics of IABP support in cardiogenic shock not related to acute myocardial infarction...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2017.11.016

    authors： Hsu S,Kambhampati S,Sciortino CM,Russell SD,Schulman SP

    更新日期：2018-05-01 00:00:00