Tezosentan in patients with acute heart failure: design of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Study (VERITAS).

Abstract:

BACKGROUND:Endothelin 1 is a potent endogenous vasoconstrictor neurohormone, and endothelin 1 plasma concentrations predict adverse outcomes in patients with acute heart failure (AHF). Tezosentan, an intravenous endothelin receptor antagonist, improved hemodynamics in patients with AHF; however, its effects on morbidity and mortality have not been evaluated. METHODS:The VERITAS program consists of 2 identical, double-blind, randomized, placebo-controlled, concurrently conducted trials (VERITAS-1 and VERITAS-2), performed in 150 centers in Europe, Israel, Australia, and North America. The program is designed to enroll at least 1760 patients hospitalized with dyspnea at rest because of AHF requiring intravenous therapy. In addition to conventional therapy, patients are randomized to receive tezosentan (5 mg/h for 30 minutes, then 1 mg/h for 24-72 hours) or matching placebo. The 2 prespecified primary end points are the incidence of death or worsening heart failure at 7 days in the combined studies and the change from baseline in dyspnea over the first 24 hours of treatment, measured using a visual analog scale in VERITAS-1 and VERITAS-2, individually. RESULTS:Enrollment started in April 2003, and the program was discontinued in November 2005 because of the low probability of achieving a significant treatment effect. CONCLUSIONS:No currently available agents have been shown in a prospective, randomized, clinical trial to improve outcomes in patients with AHF. Thus, the VERITAS program will provide valuable insights into the effect of tezosentan on clinical outcomes in patients with AHF, as well as hemodynamics and clinical symptoms.

journal_name

Am Heart J

journal_title

American heart journal

authors

Teerlink JR,McMurray JJ,Bourge RC,Cleland JG,Cotter G,Jondeau G,Krum H,Metra M,O'Connor CM,Parker JD,Torre-Amione G,Van Veldhuisen DJ,Frey A,Rainisio M,Kobrin I,VERITAS Investigators.

doi

10.1016/j.ahj.2005.04.035

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

46-53

issue

1

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(05)00519-3

journal_volume

150

pub_type

杂志文章
  • Association of left ventricular dilatation and hypertrophy with chronotropic incompetence in the Framingham Heart Study.

    abstract:BACKGROUND:Chronotropic incompetence and left ventricular (LV) dilatation have both been shown to be markers of an adverse cardiovascular prognosis. Chronotropic incompetence has been described in patients with symptomatic LV dilatation and dysfunction, but the effect of asymptomatic LV dilatation and hypertrophy on ex...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(99)70415-1

    authors: Lauer MS,Larson MG,Evans JC,Levy D

    更新日期:1999-05-01 00:00:00

  • Predictors of surgical mortality and long-term results of endocardial resection for drug-refractory ventricular tachycardia.

    abstract::The results of surgical therapy performed in 51 consecutive patients with ventricular tachycardia were reviewed to determine short- and long-term predictors of success of such therapy in preventing recurrences of life-threatening ventricular arrhythmias. Of 41 patients (80%) who survived surgery, 40 had postoperative ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(92)90404-j

    authors: Mittleman RS,Candinas R,Dahlberg S,Vander Salm T,Moran JM,Huang SK

    更新日期:1992-11-01 00:00:00

  • Pathophysiologic mechanisms underlying dobutamine- and exercise-induced wall motion abnormalities.

    abstract:BACKGROUND:Dobutamine and exercise echocardiography are accepted as tests of comparable efficacy for the diagnosis of coronary artery disease. Although dobutamine has been classified as "exercise simulating," the mechanisms of ischemia with dobutamine and exercise have not been well studied. This study sought to compar...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(98)70183-8

    authors: Mairesse GH,Vanoverschelde JL,Robert A,Climov D,Detry JM,Marwick TH

    更新日期:1998-07-01 00:00:00

  • The role of the central nervous system in chronic congestive heart failure.

    abstract::Even though congestive heart failure is extremely common, the mechanisms responsible for the clinical manifestations remain a puzzle. The central and autonomic (sympathetic) nervous systems are responsible for a large part of the clinical manifestations. The role of the nervous system in CHF is discussed briefly. It i...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(78)90471-4

    authors: Burch GE

    更新日期:1978-02-01 00:00:00

  • Recurrent cerebrovascular events in patients with patent foramen ovale, atrial septal aneurysm, or both and cryptogenic stroke or transient ischemic attack. French Study Group on Patent Foramen Ovale and Atrial Septal Aneurysm.

    abstract::Patent foramen ovale (PFO) and atrial septal aneurysm (ASA) have been identified as potential risk factors for stroke, but information about the risk of recurrent cerebral ischemia is scarce. The aim of this retrospective study was to assess the absolute risk of recurrent cerebrovascular events in 132 patients under 6...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(95)90212-0

    authors: Mas JL,Zuber M

    更新日期:1995-11-01 00:00:00

  • Evaluation of systolic time intervals in patients with angina pectoris.

    abstract::We have explored the systolic time intervals of 52 patients with angina pectoris at the time of their hospitalization in our wards. Our results are in close agreement with published data, essentially indicating prolongation of the preejection time and shortening of the ejection time. These alterations of systolic time...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(83)90237-5

    authors: Randazzo A,Sardella F,Martinotti R,Daffara G,Parziale M,Cremonesi G

    更新日期:1983-05-01 00:00:00

  • T wave abnormalities in top-ranking athletes: effects of isoproterenol, atropine, and physical exercise.

    abstract::Eight cases of top-ranking athletes with "repolarization disorders" are reported. All subjects were asymptomatic and were otherwise suited for excellent cardiovascular performances. Seven athletes did not show any evidence of heart disease. Seven had MVP (mitral valve prolapse). Umprompted variability of ECG tracings ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(80)90117-9

    authors: Zeppilli P,Pirrami MM,Sassara M,Fenici R

    更新日期:1980-08-01 00:00:00

  • Prevalence of ideal cardiovascular health in young adults: A birth cohort from southern Brazil.

    abstract:BACKGROUND:Ideal cardiovascular health (ICH) aims at primordial prevention of cardiovascular diseases in the population. However, there is a lack of research describing ICH in youth from middle-income countries. The aims of this study were to describe the prevalence of ICH at 18 and 22-years old and to investigate the ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2021.01.014

    authors: Oliveira RS,Schneider BC,Callo-Quinte G,Oliveira IO,Gonçalves H,Wehrmeister F,Menezes AMB

    更新日期:2021-01-25 00:00:00

  • Wall motion abnormalities and electrocardiographic changes in acute transmural myocardial infarction: implications of reciprocal ST segment depression.

    abstract::Left ventricular ejection fraction and regional wall motion were assessed by multigated equilibrium radionuclide ventriculography within 24 hours of onset of first acute transmural myocardial infarction (MI) in 32 patients. Abnormal left ventricular wall motion was noted in all 16 patients with anterior infarction and...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(83)90644-0

    authors: Pichler M,Shah PK,Peter T,Singh B,Berman D,Shellock F,Swan HJ

    更新日期:1983-11-01 00:00:00

  • beta-Blocker use following myocardial infarction: low prevalence of evidence-based dosing.

    abstract:BACKGROUND:Quality improvement programs have shown increased use of beta-blockers post-myocardial infarction (MI), but there are no data on whether appropriate doses are administered. METHODS:In a prospective registry that enrolled consecutive patients with MI, we evaluated beta-blocker dosing at discharge after MI an...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2010.06.023

    authors: Goldberger JJ,Bonow RO,Cuffe M,Dyer A,Rosenberg Y,O'Rourke R,Shah PK,Smith SC Jr,PACE-MI Investigators.

    更新日期:2010-09-01 00:00:00

  • Depression and ischemic heart disease.

    abstract::Major depression is a common comorbidity associated with ischemic heart disease (IHD). There is growing evidence that psychological stress in general and depression in particular predispose to cardiovascular disease. Persons who have mental stress during daily life are at twice the risk of myocardial ischemia, and pat...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1067/mhj.2000.109979

    authors: O'connor CM,Gurbel PA,Serebruany VL

    更新日期:2000-10-01 00:00:00

  • Comparison of the dose-response relationships of 2 lipid-lowering agents: a Bayesian meta-analysis.

    abstract:BACKGROUND:Comparing the dose-response of a new drug to that of a previously studied drug can aid in understanding their relative potencies. Two dose-finding studies addressed the effect of a new drug, rosuvastatin, on its ability to decrease low-density lipoprotein cholesterol (LDL-C) levels. One of these studies incl...

    journal_title:American heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/S0002-8703(03)00106-6

    authors: Berry DA,Berry SM,McKellar J,Pearson TA

    更新日期:2003-06-01 00:00:00

  • Immediate and 6-month follow-up results of coronary angioplasty for restenosis: analysis of factors predicting recurrent clinical restenosis.

    abstract::To determine the results of coronary angioplasty for a first restenosis, the clinical, anatomic, and procedural data of 400 consecutive patients were compared with the data of 507 consecutive patients undergoing a first angioplasty. After angioplasty for restenosis, emergency redilatation had to be performed in only 0...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(93)90405-x

    authors: Piessens JH,Stammen F,Desmet W,De Scheerder IK,Willems JL

    更新日期:1993-09-01 00:00:00

  • Effect of concealed anterograde impulse penetration on retrograde atrioventricular nodal conduction in man.

    abstract::The manner in which concealed anterograde impulse penetration may affect retrograde atrioventricular nodal conduction was studied systematically in 12 patients with intact ventriculoatrial (VA) conduction. After the last beat of a basic atrial drive (A1), an extrastimulus (A2) was introduced 20 msec inside the effecti...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90539-4

    authors: Lehmann MH,Mahmud R,Denker ST,Tchou PJ,Dongas J,Akhtar M

    更新日期:1987-12-01 00:00:00

  • Automatic adjustment of pacing output in the clinical setting.

    abstract:BACKGROUND:AutoCapture (AC) is a programmable feature that enables the pacemaker to both track the capture threshold and automatically adjust the output on a beat-by-beat basis. Although AC safely and significantly reduces the current drainage, some authors have argued that the longevity benefit of such a system is ove...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(03)00529-5

    authors: Ribeiro AL,Rincón LG,Oliveira BG,Vinha CR,Melatto D,Torres AA,Barros VC,Levine PA

    更新日期:2004-01-01 00:00:00

  • Transcatheter closure of patent ductus arteriosus with the use of Rashkind occluders and/or Gianturco coils: long-term follow-up in 123 patients and special reference to comparison, residual shunts, complications, and technique.

    abstract:BACKGROUND:This report describes the long-term follow-up of transcatheter closure of patent ductus arteriosus (PDA) with 2 different modalities in 123 patients of diverse ages. METHODS AND RESULTS:Between October 1990 and August 1997, 123 patients underwent transcatheter PDA (1.9 to 7.5 mm) closure at a mean age of 6....

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0002-8703(99)70085-2

    authors: Janorkar S,Goh T,Wilkinson J

    更新日期:1999-12-01 00:00:00

  • Randomized coronary patency trial of double-bolus recombinant staphylokinase versus front-loaded alteplase in acute myocardial infarction.

    abstract::One hundred two patients with evolving myocardial infarction of 6 hours' duration were given aspirin and intravenous heparin and randomly allocated to intravenous front-loaded, weight-adjusted rTPA administration over a 90-minute period (52 patients) or to two 15 mg doses of recombinant staphylokinase, 30 minutes apar...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0002-8703(97)70127-3

    authors: Vanderschueren S,Dens J,Kerdsinchai P,Desmet W,Vrolix M,De Man F,Van den Heuvel P,Hermans L,Collen D,Van de Werf F

    更新日期:1997-08-01 00:00:00

  • Histoplasma capsulatum endocarditis.

    abstract::Endocarditis is a rare manifestation of disseminated Histoplasma capsulatum infection. A 22-year-old man presented with a seven month history of fever, weight loss, and progressive aortic insufficiency. The diagnosis of H. capsulatum was suggested by a diagnostic rise in complement fixation titers and positive echocar...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(80)90630-4

    authors: Blair TP,Waugh RA,Pollack M,Ashworth HE,Young NA,Anderson SE,Bem TP

    更新日期:1980-06-01 00:00:00

  • Three-year clinical outcome of patients with bifurcation treatment with second-generation Resolute and Xience V stents in the randomized TWENTE trial.

    abstract:BACKGROUND:Only limited data from large randomized clinical trials have been published on the long-term performance of second-generation drug-eluting stents in bifurcation lesions. METHODS:We investigated in patients in the randomized TWENTE trial the long-term safety and efficacy of treating bifurcation lesions with ...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2014.10.011

    authors: Lam MK,Sen H,van Houwelingen KG,Löwik MM,van der Heijden LC,Kok MM,de Man FH,Linssen GC,Tandjung K,Doggen CJ,von Birgelen C

    更新日期:2015-01-01 00:00:00

  • Race-ethnic differences in subclinical left ventricular systolic dysfunction by global longitudinal strain: A community-based cohort study.

    abstract:BACKGROUND:Race-ethnic differences exist in the epidemiology of heart failure, with blacks experiencing higher incidence and worse prognosis. Left ventricular (LV) systolic dysfunction (LVSD) detected by speckle-tracking global longitudinal strain (GLS) is a predictor of cardiovascular events including heart failure. I...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2015.02.011

    authors: Russo C,Jin Z,Homma S,Rundek T,Elkind MS,Sacco RL,Di Tullio MR

    更新日期:2015-05-01 00:00:00

  • Systolic anterior motion of the mitral chordae tendineae: prevalence and clinical and Doppler-echocardiographic features.

    abstract::The objective of this investigation was to determine the prevalence and clinical associations of systolic anterior motion (SAM) of the mitral chordae (chordal SAM) in patients without evidence of hypertrophic cardiomyopathy. Although SAM of the mitral valve is thought to be a specific marker of hypertrophic obstructiv...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(96)90282-3

    authors: Pearson AC,Pasierski TJ,Orsinelli DA,Gray P,Huschart K

    更新日期:1996-04-01 00:00:00

  • Transdermal clonidine as an adjunct to nifedipine-GITS therapy in patients with mild-to-moderate hypertension.

    abstract::Calcium channel blockers and central alpha-agonists are among the classes of antihypertensive drugs that yield the most favorable overall effects on risk factors for hypertension-related end-organ damage. An open-label prospective trial in 42 patients with a mean baseline blood pressure of 144/102 mm Hg sought to asse...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-8703(93)90707-g

    authors: Houston MC,Hays L

    更新日期:1993-10-01 00:00:00

  • Neighborhood socioeconomic disparities and 1-year case fatality after incident myocardial infarction: the Atherosclerosis Risk in Communities (ARIC) Community Surveillance (1992-2002).

    abstract:BACKGROUND:Declines in case fatality post-myocardial infarction (MI) have been observed over the past 3 decades. Few studies report socioeconomic disparities in survival post-MI. METHODS:We assessed 1-year case fatality among 9,116 incident MI patients included in the Atherosclerosis Risk in Communities community surv...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2012.10.022

    authors: Foraker RE,Patel MD,Whitsel EA,Suchindran CM,Heiss G,Rose KM

    更新日期:2013-01-01 00:00:00

  • Knowledge to action: Rationale and design of the Patient-Centered Care Transitions in Heart Failure (PACT-HF) stepped wedge cluster randomized trial.

    abstract:INTRODUCTION:Heart Failure (HF) is a common cause of hospitalization in older adults. The transition from hospital to home is high-risk, and gaps in transitional care can increase the risk of re-hospitalization and death. Combining health care services supported by meta-analyses, we designed the PACT-HF transitional ca...

    journal_title:American heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ahj.2017.12.013

    authors: Van Spall HGC,Lee SF,Xie F,Ko DT,Thabane L,Ibrahim Q,Mitoff PR,Heffernan M,Maingi M,Tjandrawidjaja MC,Zia MI,Panju M,Perez R,Simek KD,Porepa L,Graham ID,Haynes RB,Haughton D,Connolly SJ

    更新日期:2018-05-01 00:00:00

  • Successful left ventricular opacification following peripheral venous injection of sonicated contrast agent: an experimental evaluation.

    abstract::A new agent for use in contrast echocardiography that is capable of passing through the pulmonary circulation and opacifying the left ventricular cavity after intravenous injection was evaluated in a canine model. Air-filled albumin microbubbles were produced by sonication. A Coulter counter was used to size and count...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90754-x

    authors: Keller MW,Feinstein SB,Watson DD

    更新日期:1987-09-01 00:00:00

  • Relationship between changes in ST segment elevation and patency of the infarct-related coronary artery in acute myocardial infarction.

    abstract::Forty-one patients with acute myocardial infarction and ST segment elevation were studied to determine the relationship between early changes in ST segment elevation, time to peak serum creatine kinase (CK), peak serum CK, left ventricular function, and patency of the infarct-related artery. ST segment elevation decre...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90262-0

    authors: Hackworthy RA,Vogel MB,Harris PJ

    更新日期:1986-08-01 00:00:00

  • Clinical setting and prognostic significance of high degree atrioventricular block in acute inferior myocardial infarction: a study of 144 patients.

    abstract::High degree AV block occurred in 144 of 843 patients consecutively admitted because of acute inferior myocardial infarction and was associated with more extensive myocardial damage and a higher mortality rate, as compared to those without AV block. Patients with power failure at the time of appearance of high degree A...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(80)90308-7

    authors: Tans AC,Lie KI,Durrer D

    更新日期:1980-01-01 00:00:00

  • Association between depression and worse disease-specific functional status in outpatients with coronary artery disease.

    abstract:BACKGROUND:The objective of this study was to determine if depression is associated with worse disease-specific functional status in patients with coronary artery disease. The study was designed as a cross-sectional survey and 3-month longitudinal cohort. METHODS AND RESULTS:The study took place in outpatient clinics ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2000.106600

    authors: Spertus JA,McDonell M,Woodman CL,Fihn SD

    更新日期:2000-07-01 00:00:00

  • Response of the left ventricle in idiopathic dilated cardiomyopathy to postextrasystolic potentiation.

    abstract::The effectiveness of postextrasystolic potentiation (PESP) was assessed to detect residual function of the left ventricle in seven patients with idiopathic dilated cardiomyopathy (IDC). The postextrasystolic changes in the aortic pressure pulse, global left ventricular function, and quantitative regional left ventricu...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90661-2

    authors: Yamazoe M

    更新日期:1987-06-01 00:00:00

  • Vasodilatation with felodipine in chronic asymptomatic aortic regurgitation.

    abstract:BACKGROUND:Afterload reduction decreases volume overload on the left ventricle and may thereby delay the need for valve replacement in chronic asymptomatic aortic regurgitation. The aims of this randomized double-blind, placebo-controlled trial were to examine short- and long-term hemodynamic effects of felodipine in c...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-8703(00)90046-2

    authors: Søndergaard L,Aldershvile J,Hildebrandt P,Kelbaek H,Ståhlberg F,Thomsen C

    更新日期:2000-04-01 00:00:00