Abstract：
BACKGROUND:Low-molecular weight heparins have different pharmacokinetic and pharmacodynamic characteristics and may vary in efficacy. We compared the efficacy of enoxaparin with that of tinzaparin in the management of non-ST-segment elevation acute coronary syndromes (NSTACS). METHODS:A total of 438 patients with NSTACS were randomized to receive subcutaneous treatment with enoxaparin, 100 IU/kg twice daily (equivalent to 1 mg/kg twice daily; n = 220), or tinzaparin, 175 IU/kg once daily, (n = 218) for as long as 7 days. The primary composite end point was recurrent angina, myocardial infarction (or reinfarction), or death at day 7. Secondary end points were the primary end point at day 30 and the occurrence of individual events at days 7 and 30. RESULTS:The incidence of the primary end point was 12.3% in the enoxaparin group and 21.1% in the tinzaparin group (P =.015). At day 7, the rate of recurrent angina was lower with enoxaparin than with tinzaparin (11.8% vs 19.3%). At day 30, the incidences of the composite end point, recurrent angina, and myocardial infarction were also lower with enoxaparin, 17.7% vs 28.0% (P =.012), 17.3% vs 26.1% and 0.5% vs 2.8%, respectively. The rate of revascularization was lower in the enoxaparin group, 8.6% vs 17.9% (P =.010) at day 7 and 16.4% vs 26.1% (P =.019) at day 30. Rates of bleeding complications were similar in the 2 treatment groups. CONCLUSIONS:This study indicates a benefit of enoxaparin (100 IU/kg twice daily) as compared with tinzaparin (175 IU/kg once daily) in the treatment of patients with NSTACS, which is sustained for at least 30 days.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Michalis LK,Katsouras CS,Papamichael N,Adamides K,Naka KK,Goudevenos J,Sideris DAdoi
10.1016/S0002-8703(03)00179-0subject
Has Abstractpub_date
2003-08-01 00:00:00pages
304-10issue
2eissn
0002-8703issn
1097-6744pii
S0002870303001790journal_volume
146pub_type
临床试验,杂志文章,随机对照试验abstract：:Ambulatory ECG recordings were obtained from 313 consecutive, totally symptom-free male subjects on whom cardiac catheterization was subsequently performed for occupational reasons. These recordings were examined for ventricular ectopy and the results were studied in relation to the findings on selective coronary angi...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(89)90405-5
更新日期：1989-06-01 00:00:00
abstract：BACKGROUND:Platelets play an important role in the natural history of coronary artery disease. Enhanced platelet aggregation and receptor expression unquestionably occur after coronary stent implantation; however, the functional characteristics of platelets before stenting have not been fully elucidated. METHODS:Plate...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1067/mhj.2001.116478
更新日期：2001-10-01 00:00:00
abstract：:Sodium-glucose cotransporter 2 inhibitor (SGLT2i) use is associated with improved cardiovascular and kidney outcomes. However, the magnitude and potential heterogeneity of effect across patients with varying types of cardiometabolic and kidney disease is unclear. To examine the effect of SGLT2i on cardiovascular and k...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/j.ahj.2020.10.064
更新日期：2021-02-01 00:00:00
abstract：:Sixty-nine patients receiving atrioventricular sequential (DVI) pacemakers are compared to 67 patients receiving ventricular demand (VVI) pacemakers for control of the symptoms of sinus node dysfunction. The populations were similar with comparable preparing incidences of each assayed symptom and number of symptoms pe...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(82)90162-4
更新日期：1982-12-01 00:00:00
abstract：:The QRS complex and ST segment in the ECGs of 80 patients who died of an acute myocardial infarction (MI) were studied in relation to the extent of the MI (subendocardial vs. transmural). Changes in the QRS complex developed in nine out of the 15 cases with an acute subendocardial MI. Five of these cases fulfilled the...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(79)90219-9
更新日期：1979-08-01 00:00:00
abstract：:The results of valve replacement in 150 patients with Lillehei-Kaster aortic and mitral prostheses followed for 20 to 40 months are reviewed. Actuarial analysis showed 78 per cent cummulative thromboembolic-free rate three years following mitral valve replacement and 89 per cent following aortic valve replacement. Fiv...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(77)80469-9
更新日期：1977-09-01 00:00:00
abstract：BACKGROUND:Standard gray-scale imaging (GSI), three-dimensional (3D) echocardiography has been shown to be superior to two-dimensional echocardiography in measuring left ventricular volume. However, the often relatively poor quality of transthoracic gray-scale data can limit the potential application of this technique....
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(98)70061-4
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:Recently revised American College of Cardiology/American Heart Association guidelines have suggested that exercise test scores be used in decisions concerning patients with suspected coronary artery disease (CAD). Pretest and exercise test scores derived for use in women without known CAD have not been teste...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.ahj.2003.12.034
更新日期：2004-06-01 00:00:00
abstract：:To investigate the significance and mechanism of dilatation of the left ventricular cavity on dipyridamole thallium-201 imaging, we performed both dipyridamole thallium-201 imaging and dipyridamole radionuclide angiography on 83 patients with known angiograms. The dipyridamole/delayed ratio of the left ventricular dim...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(91)90713-r
更新日期：1991-02-01 00:00:00
abstract：:An exotic strain of Trypanosoma cruzi recovered from Triatoma dimidiata from Tegucigalpa, Honduras, was shown by isoenzyme studies to be closely related to the Miles' zymodeme 1 and laboratory reference strain Tehuantepec. It was injected into Swiss random-bred ICR mice. Clean Triatoma protracta nymphs and adults, whi...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(85)90082-1
更新日期：1985-09-01 00:00:00
abstract：BACKGROUND:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers effectively reduce blood pressure in patients with renovascular disease (RVD); yet, randomized cardiovascular prevention trials of these drugs typically exclude individuals with this condition. PATIENTS AND METHODS:We studied the ass...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2008.05.013
更新日期：2008-09-01 00:00:00
abstract：:The antihypertensive effects of the renin inhibitor enalkiren were compared with those of the angiotensin-converting enzyme inhibitor enalaprilat in 17 hypertensive patients (14 white, 3 black; mean age 57 years), whose renin systems had been stimulated by diuretic pretreatment. Patients were studied on 3 separate in-...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(91)90477-y
更新日期：1991-10-01 00:00:00
abstract：:To investigate the incidence and clinical significance of postoperative pericardial effusion (PE), the presence of PE was evaluated by echocardiography, 1 and 2 weeks postoperatively, in 50 patients after insertion of a valve prosthesis and in 100 patients after coronary bypass surgery (50 patients receiving a combina...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(88)90255-4
更新日期：1988-07-01 00:00:00
abstract：BACKGROUND:Plasma levels of brain natriuretic peptide (BNP) are increased in patients with left heart failure. In patients with severe pulmonary embolism (PE), primary right ventricular (RV) dysfunction is frequent. Little is known about BNP secretion in acute RV failure. METHODS:We prospectively studied 50 consecutiv...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(03)00528-3
更新日期：2004-01-01 00:00:00
abstract：:A case of tricuspid atresia with unusual echocardiographic findings is presented. The echocardiogram was successful in defining great artery interrelationships, ventricular looping, and cavity sizes. An echo pattern resembling the motion of a small tricuspid valve was observed; this was proven to be spurious at cathet...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(78)90508-2
更新日期：1978-06-01 00:00:00
abstract：:To test the hypothesis that elevated plasma levels of natriuretic peptides may serve to identify patients with left ventricular (LV) dysfunction, we assessed the predictive diagnostic value of natriuretic peptide levels, in addition to clinical and electro-cardiographic risk factors, as noninvasive indicators of cardi...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(97)70079-6
更新日期：1997-09-01 00:00:00
abstract：:Following pulmonary infarction, three patients developed the classical signs and symptoms of the Dressler syndrome associated with persistent left pleural effusion. Each responded dramatically to corticosteroid therapy. While the pathogenesis of this "Post-Pulmonary Infarction syndrome," like the Dressler syndrome, is...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(79)90477-0
更新日期：1979-12-01 00:00:00
abstract：BACKGROUND:Chronic total occlusion (CTO) recanalizations remain extremely challenging procedures. With improvements in technology and techniques, success rates for recanalization of CTO continue to improve. However, the clinical benefits of this practice remain unclear. The aim of the study was to determine the effecti...
journal_title：American heart journal
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ahj.2010.04.015
更新日期：2010-07-01 00:00:00
abstract：:We developed a new angiographic score of the extent of coronary disease (extent score), which we compared with conventional stenosis and vessel scores that emphasize the severity of stenosis. Scores were determined in 132 patients (29 women, 103 men with a mean age of 55 +/- 10 years) who underwent elective coronary a...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(05)80173-5
更新日期：1990-06-01 00:00:00
abstract：:The efficacy of chronic ambulatory captopril (CPT) therapy was evaluated over an 18-month period in 36 patients with refractory chronic congestive heart failure (CHF) by cardiac catheterization, treadmill exercise, nuclear scintigraphy, echocardiography, and symptomatology. Clinical improvement to New York Heart Assoc...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(82)90043-6
更新日期：1982-11-01 00:00:00
abstract：:Twelve cirrhotic patients with portal hypertension and esophageal varices were treated with nadolol for 1 month, and the effects on renal and hepatic hemodynamics and function were studied. A significant decrease in cardiac output, portohepatic gradient, and effective hepatic blood flow was found, whereas mean arteria...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(84)90602-1
更新日期：1984-10-01 00:00:00
abstract：:Twenty-six patients with Ebstein's anomaly were classified into three types according to their clinical features, heart catheterization data, angiocardiographic and anatomical findings which were obtained on surgery or autopsy. The hemodynamics in each type were discussed. 1. Tricuspid Stenosis Dominant Type. Eight pa...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(78)90458-1
更新日期：1978-02-01 00:00:00
abstract：BACKGROUND:Although there is evidence linking smoking and heart failure (HF), the association between lifetime smoking exposure and HF in older adults and the strength of this association among current and past smokers is not well known. METHODS:We examined the association between smoking status, pack-years of exposur...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/j.ahj.2012.05.013
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Patients with atrial fibrillation (AF) are at increased risk for ischemic stroke. In patients who have suffered a stroke, screening for AF is routinely performed only for a short period after the stroke as part of the evaluation for possible causes. If AF is detected after an ischemic stroke, oral anticoagul...
journal_title：American heart journal
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ahj.2010.03.032
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of stroke, heart failure, and death. Data on contemporary treatment patterns and outcomes associated with AF in clinical practice are limited. METHODS/DESIGN:The Outcomes Registry for Better Inf...
journal_title：American heart journal
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.ahj.2011.07.001
更新日期：2011-10-01 00:00:00
abstract：:The present study refers to six patients in whom an A-V reciprocal rhythm could be documented; in four cases it took the form of sustained tachycardia. None of the patients showed any ECG feature of ventricular pre-excitation (PR interval of more than 0.12 sec. and normal QRS configuration). The extrastimulus method s...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(76)80427-9
更新日期：1976-01-01 00:00:00
abstract：BACKGROUND:As stenting practice has evolved to include greater numbers of stents and adjunctive balloon catheters per case, concern has focused on the increasing costs of equipment for the delivery of stents. METHODS AND RESULTS:To evaluate temporal changes in costs of intracoronary stenting, we examined total costs, ...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/s0002-8703(98)70193-0
更新日期：1998-07-01 00:00:00
abstract：:Atrial fibrillation is a common disease of the elderly, conferring considerable morbidity and mortality related to cardiovascular effects and thromboembolic risks. Anticoagulation, antiarrhythmic medications, and rate control are the cornerstone of contemporary management, whereas ablation and evolving surgical techni...
journal_title：American heart journal
pub_type： 杂志文章,评审
doi：10.1016/j.ahj.2014.12.015
更新日期：2015-04-01 00:00:00
abstract：:A 17-year-old man with staphylococcal endocarditis of the mitral valve developed an infective aneurysm of the posterior left ventricular wall. Echocardiography revealed an echo-free space posterior to the posterior left ventricular wall. This echo-free space undoubtedly represented the aneurysmal sac, because it could...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(78)90051-0
更新日期：1978-09-01 00:00:00
abstract：:Inhibition of the enzyme that synthesizes thromboxanes may protect against the development of ventricular fibrillation (VF) during acute myocardial ischemia. This study was carried out to test this hypothesis with a new thromboxane synthetase inhibitor, and to extend the studies to alternative animal models of myocard...
journal_title：American heart journal
pub_type： 杂志文章
doi：10.1016/0002-8703(89)90622-4
更新日期：1989-04-01 00:00:00
