Effects of statin therapy on progression of mild noncalcified coronary plaque assessed by serial coronary computed tomography angiography: A multicenter prospective study.


BACKGROUND:There are limited data assessing statin therapy in patients with nonobstructive coronary plaque on coronary computed tomography angiography (CCTA). METHODS:Two hundred six consecutive patients with mild noncalcified plaque on CCTA were enrolled in this multicenter prospective observational study. Subjects were divided into 3 groups according to subsequent statin therapy: intensive statin therapy (n = 55), moderate statins (n = 85), and no statin (n = 66). Serial scans were performed after a median interval of 18 months. Low-attenuation plaque (LAP) volume, total plaque volume, and percent plaque volume were measured. RESULTS:The LAP volume, total plaque volume, and percent plaque volume showed significant regression among intensive-statin compared with no-statin group (annualized changes: -7.1 ± 13.1 vs 0.9 ± 12.7 mm(3), P< .001; -16.4 ± 35.0 vs 12.3 ± 32.4 mm(3), P< .001; and -6.2% ± 11.8% vs 3.5% ± 12.1%, P< .001, respectively). Progression of LAP volume, total plaque volume, and percent plaque volume was retarded among moderate-statin compared with no-statin group (annualized changes: -2.8 ± 7.6 vs 0.9 ± 12.7 mm(3), P= .041; -0.1 ± 25.6 vs 12.3 ± 32.4 mm(3), P= .014; and -1.8% ± 11.2% vs 3.5% ± 12.1%, P= .006, respectively). On multivariable model predicting change in total plaque volume, higher baseline LAP volume, moderate statin therapy, and intensive statin therapy were each independent predictors of plaque regression (standardized coefficients: baseline LAP volume -0.36, P< .001; moderate statin -0.21, P= .004; intensive statin -0.36, P< .001, respectively). CONCLUSIONS:This study suggests that statin treatment can retard progression and even induce regression of mild noncalcified coronary plaque. Patients with greater baseline LAP volume are more likely to benefit from statin therapy.


Am Heart J


American heart journal


Li Z,Hou Z,Yin W,Liu K,Gao Y,Xu H,Yu F,Ma Z,Yu W,Yang L,Lu B




Has Abstract


2016-10-01 00:00:00












  • Interactions of wine drinking with omega-3 fatty acids in patients with coronary heart disease: a fish-like effect of moderate wine drinking.

    abstract:BACKGROUND:Moderate alcohol drinking and marine omega-3 fatty acids (omega3) have both been associated with low mortality from coronary heart disease (CHD). However, there is little data evaluating the interactions of wine ethanol drinking with omega3 in CHD patients. METHODS:The relationships between wine drinking an...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验


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    abstract:BACKGROUND:Sexuality is an important factor influencing quality of life that may be altered for patients with coronary disease. Little is known about the extent to which patients want their cardiologists to counsel them about sexuality. PURPOSE:Our study evaluated the extent to which patients with known coronary disea...

    journal_title:American heart journal

    pub_type: 杂志文章


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    更新日期:2002-08-01 00:00:00

  • Comparison of the hemodynamic responses to molsidomine and isosorbide dinitrate in congestive heart failure.

    abstract::To evaluate the mechanisms involved in nitrate tolerance, we randomized 23 patients with congestive heart failure resulting from coronary artery disease to an isosorbide dinitrate or a molsidomine infusion. The drugs were titrated to decrease pulmonary capillary wedge pressure by > or = 30% or > or = 10 mm Hg. Then is...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


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    journal_title:American heart journal

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    journal_title:American heart journal

    pub_type: 杂志文章,评审


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    journal_title:American heart journal

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    journal_title:American heart journal

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    journal_title:American heart journal

    pub_type: 杂志文章,评审


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    journal_title:American heart journal

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    journal_title:American heart journal

    pub_type: 杂志文章,评审


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    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Burch GE

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    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


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    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究


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    journal_title:American heart journal

    pub_type: 杂志文章


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    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究


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    更新日期:2008-11-01 00:00:00

  • Selection of thrombolytic therapy for individual patients: development of a clinical model. GUSTO-I Investigators.

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    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


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    journal_title:American heart journal

    pub_type: 杂志文章


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    journal_title:American heart journal

    pub_type: 杂志文章


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    journal_title:American heart journal

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    更新日期:1998-08-01 00:00:00

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    journal_title:American heart journal

    pub_type: 杂志文章


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    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Kauf TL,Velazquez EJ,Crosslin DR,Weaver WD,Diaz R,Granger CB,McMurray JJ,Rouleau JL,Aylward PE,White HD,Califf RM,Schulman KA

    更新日期:2006-01-01 00:00:00

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    abstract::In older patients (70 ± 7 years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6 months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exercise oxygen consumption (14.9 ± 0.2 mL kg-1 min-1 versus 14.4 ...

    journal_title:American heart journal

    pub_type: 信件


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    更新日期:2018-07-01 00:00:00

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    journal_title:American heart journal

    pub_type: 杂志文章


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    journal_title:American heart journal

    pub_type: 杂志文章


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    更新日期:1988-09-01 00:00:00

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    journal_title:American heart journal

    pub_type: 杂志文章


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  • Can the optimal type of stent be predicted based on clinical risk factors? A subgroup analysis of the randomized BASKET-PROVE trial.

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    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


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    更新日期:2016-03-01 00:00:00

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    journal_title:American heart journal

    pub_type: 杂志文章


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    更新日期:1978-08-01 00:00:00