Abstract:
:Antiplatelet therapy has been shown to significantly reduce the risk of serious vascular events in high-risk patients, including those with a prior acute ischemic event. The long-term use of antiplatelet agents is a key component of secondary prevention measures following acute coronary syndromes, including ST-segment elevation myocardial infarction. While minimizing ischemic recurrences, an intensified antiplatelet regimen also invariably leads to an increased risk for bleeding, which can in turn lead to treatment discontinuation and worse overall cardiovascular outcomes. Thus, a critical balance between efficacy and safety must be pursued in clinical practice. Selection of agents and their combination, dose optimization, and a customized approach based on genotype or assessment of on-treatment phenotype are discussed in the context of available evidence.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Valgimigli M,Minarelli Mdoi
10.1016/j.ahj.2010.10.014subject
Has Abstractpub_date
2010-12-01 00:00:00pages
S36-41issue
6 Suppleissn
0002-8703issn
1097-6744pii
S0002-8703(10)00914-2journal_volume
160pub_type
杂志文章abstract:BACKGROUND:Three landmark trials involving 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) were published between 1994 and 1996 (the Scandinavian Simvastatin Survival Study [4S], the West of Scotland Coronary Prevention Study, and the Cholesterol and Recurrent Events trial). These trials provided e...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2001.115587
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Pulmonary vein antrum isolation (PVI) as a treatment of paroxysmal atrial fibrillation (AF) is associated with a high rate of success; however, outcomes for treating persistent and long-standing persistent AF with PVI alone are substantially lower and often require multiple procedures to maintain long-term f...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2015.09.019
更新日期:2015-12-01 00:00:00
abstract::Traditionally, assessment of therapy has been judged by the ability of treatment to alleviate symptoms with tolerable side effects or toxicity. In recent years, it has become obvious that more subtle and patient-oriented approaches are urgently needed to evaluate progression of cardiovascular disease and to monitor th...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(87)90963-x
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:The outpatient prognostic assessment of coronary artery disease (CAD) by exercise electrocardiography has limitations, including the feasibility of the test and its low positive predictive value in several clinical conditions. In the current study we investigated the safety, feasibility, and prognostic value...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2001.113997
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Recently revised American College of Cardiology/American Heart Association guidelines for exercise electrocardiography (ExECG) have suggested that ExECG scores be used to assist in management decisions in patients with suspected coronary artery disease (CAD). METHODS:We used 442 women who underwent both ExE...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2002.125835
更新日期:2002-11-01 00:00:00
abstract::We investigated the incidence and mechanism of pulmonary artery hypertension (PAH) in a consecutive series of patients with aortic stenosis who were undergoing diagnostic cardiac catheterization. Forty-five patients with severe aortic stenosis were divided into two groups: group 1 comprised 13 patients (29%) with PAH ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(93)90067-j
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:New percutaneous coronary intervention (PCI) device technologies are often rapidly adopted into clinical practice, yet few studies have examined the overall impact of these new technologies on patient outcomes in community practice. METHODS:In hopes of determining temporal trends in PCI outcomes, we used da...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2013.05.006
更新日期:2013-08-01 00:00:00
abstract::Four children with cor triatriatum underwent intraoperative transesophageal echocardiography. Two patients had cor triatriatum alone and two had associated complex congenital heart disease. Transesophageal echocardiography provided optimal imaging of these defects and provided unique information that facilitated surgi...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(95)90277-5
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:The same electrocardiographic (ECG) criteria that have been used for detection of left ventricular hypertrophy (LVH) have recently been recognized as predictors of adverse clinical outcomes, but this predictive ability is inadequately explored and understood. METHODS:A total of 14,984 participants from the ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2015.04.004
更新日期:2015-07-01 00:00:00
abstract::Thiazides produce an average loss of 2 L of extracellular fluid volume, of which about 300 ml is plasma volume, during the first 48 hours of administration, and this reduction is maintained without further loss for as long as the drug is given. Do thiazides lower blood pressure by volume depletion or by direct vasodil...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(83)90116-3
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:The pectoral approach to implantation of cardioverter defibrillators (ICDs) has become a standard in defibrillator therapy because of reduced generator size, weight, and volume. But the size of these devices is still comparable to the size of the early conventional antibradycardia pacemakers that were associ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(98)70270-4
更新日期:1998-04-01 00:00:00
abstract::Endocarditis is a rare manifestation of disseminated Histoplasma capsulatum infection. A 22-year-old man presented with a seven month history of fever, weight loss, and progressive aortic insufficiency. The diagnosis of H. capsulatum was suggested by a diagnostic rise in complement fixation titers and positive echocar...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(80)90630-4
更新日期:1980-06-01 00:00:00
abstract::This study uses echocardiography to characterize the pattern of left ventricular hypertrophy in a new hypertensive heart failure-prone rat strain designated SHHF/Mcc-cp (SHHF). M-mode echocardiograms of the left ventricle in nine 10- to 12-month old SHHF rats and nine age-matched spontaneously hypertensive rats (SHR) ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(95)90081-0
更新日期:1995-10-01 00:00:00
abstract::Tolerance to prolonged nitroglycerin (NTG) may be due to drug-induced intravascular expansion. To test the hypothesis that concomitant diuretics may reduce volume expansions and thus prevent NTG tolerance, we studied 23 healthy volunteers randomized to hydrochlorthiazide or placebo before and during 74-hour continuous...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0002-8703(95)90361-5
更新日期:1995-09-01 00:00:00
abstract::During the last few decades, acute ST-elevation on an electrocardiogram (ECG) in the proper clinical context has been a reliable surrogate marker of acute coronary occlusion requiring primary percutaneous coronary intervention (PPCI). In 2004, the American College of Cardiology/American Heart Association ST-elevation ...
journal_title:American heart journal
pub_type: 杂志文章,评审
doi:10.1016/j.ahj.2010.08.011
更新日期:2010-12-01 00:00:00
abstract::To examine the recovery time of left atrial mechanical function after electrical cardioversion of atrial fibrillation, we recorded transmitral flow, pulmonary venous flow velocities, and interatrial septal motion during atrial systole within 24 hours (16 +/- 5 hours) and 10 days after cardioversion in 25 patients with...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(96)90353-1
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Biolimus-eluting stents (BESs) with a biodegradable polymer in abluminal coating achieve more complete coverage at 9 months compared with sirolimus-eluting stents (SESs) with a durable polymer, as assessed by optical coherence tomography (OCT). Whether this advantage persists or augments after complete resor...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2011.09.005
更新日期:2011-11-01 00:00:00
abstract::Little is known about the impact of accountable care organizations (ACO) on hospitalized heart failure (HF) patients, a high-cost and high-risk population. OBJECTIVE:We linked Medicare fee-for-service claims from 2013 to 2015 with data from American Heart Association Get With The Guidelines-HF registry to compare HF ...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2020.04.028
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:In chronic heart failure the cause of exercise limitation is still unclear: ergoreceptors, muscle afferents sensitive to exercise metabolites, are proposed as a neural link between muscular abnormalities and the limited exercise responses in this syndrome. METHODS:In 92 stable patients with heart failure (3...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(99)70361-3
更新日期:1999-06-01 00:00:00
abstract::Clinically available automatic implantable defibrillators use a monophasic truncated exponential waveform shock; after delivery the charge remaining on the device's capacitors is "dumped" internally and wasted. The efficacy of a monophasic and biphasic truncated exponential defibrillation waveform produced by a single...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(89)90779-5
更新日期:1989-02-01 00:00:00
abstract::Patients experiencing out-of-hospital cardiac arrest (OHCA) without ST-segment elevation are a heterogenic group with a variety of underlying causes. Up to one-third of patients display a significant coronary lesion compatible with myocardial infarction as OHCA trigger. There are no randomized data on patient selectio...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ahj.2018.12.005
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:There is interest in measuring and comparing outcomes of percutaneous transluminal coronary angioplasty (PTCA) other than death, but there are no accepted methods for adjusting these outcomes for preprocedure differences in populations. We sought to identify independent predictors of functional outcome after...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/s0002-8703(99)70142-0
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Knowledge of pressure gradients across valves, arteries, and ventricular septal defects (VSD) is important in patient management. It was determined how well such gradients can be estimated by auscultation of a murmur's frequencies. METHODS:In 151 patients with pulmonary stenosis (PS) (n = 77), aortic stenos...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2001.113222
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Recent work has demonstrated a link between retinopathy, a marker of microvascular disease, and the development of heart failure, a finding particularly relevant in individuals with diabetes. Our objective was to assess the relationship between retinopathy and cardiac structure and function in a cohort of in...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2008.10.019
更新日期:2009-03-01 00:00:00
abstract::The associations between socioeconomic status, ethnic origin, and risk factors for CHD were studied in 2,591 white and black children from two socioeconomically dissimilar populations in the New York City area. The study subjects were selected from all fourth graders in 44 elementary schools. Blood pressure, plasma li...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/0002-8703(87)90724-1
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:Enhanced external counterpulsation (EECP) reduces angina and extends time to exercise-induced ischemia in patients with symptomatic coronary disease. One- and two-center studies and a retrospective case series reported that EECP improves myocardial perfusion in stable angina pectoris. We sought to critically...
journal_title:American heart journal
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ahj.2005.01.054
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Patients with non-ST-elevation myocardial infarction (NSTEMI) and three-vessel or left main coronary disease (3VD/LMD) have a high risk of long-term mortality when treated with a medical management strategy (MMS) compared with revascularization. METHODS:We evaluated patterns of use and patient features acro...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1016/j.ahj.2013.12.004
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Despite the common practice of clopidogrel loading for coronary stenting, the time dependence and degree of platelet inhibition after this therapy are not well defined. We sought to establish an optimal clopidogrel dosing regimen for sustained platelet inhibition in stented patients. METHODS AND RESULTS:Pla...
journal_title:American heart journal
pub_type: 杂志文章
doi:10.1067/mhj.2003.109
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of stroke, heart failure, and death. Data on contemporary treatment patterns and outcomes associated with AF in clinical practice are limited. METHODS/DESIGN:The Outcomes Registry for Better Inf...
journal_title:American heart journal
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.ahj.2011.07.001
更新日期:2011-10-01 00:00:00
abstract::The efficacy and safety of once-daily administration of the new angiotensin-converting enzyme inhibitor quinapril or quinapril plus hydrochlorothiazide (HCTZ) were assessed in 64 older (greater than 65 years) patients with mild to moderate hypertension in an uncontrolled, open-label study. Treatment was initiated with...
journal_title:American heart journal
pub_type: 临床试验,杂志文章
doi:10.1016/0002-8703(92)91065-9
更新日期:1992-05-01 00:00:00