Antiplatelet and antithrombotic treatment after primary percutaneous coronary intervention: balancing safety and efficacy.

Abstract:

:Antiplatelet therapy has been shown to significantly reduce the risk of serious vascular events in high-risk patients, including those with a prior acute ischemic event. The long-term use of antiplatelet agents is a key component of secondary prevention measures following acute coronary syndromes, including ST-segment elevation myocardial infarction. While minimizing ischemic recurrences, an intensified antiplatelet regimen also invariably leads to an increased risk for bleeding, which can in turn lead to treatment discontinuation and worse overall cardiovascular outcomes. Thus, a critical balance between efficacy and safety must be pursued in clinical practice. Selection of agents and their combination, dose optimization, and a customized approach based on genotype or assessment of on-treatment phenotype are discussed in the context of available evidence.

journal_name

Am Heart J

journal_title

American heart journal

authors

Valgimigli M,Minarelli M

doi

10.1016/j.ahj.2010.10.014

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

S36-41

issue

6 Suppl

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(10)00914-2

journal_volume

160

pub_type

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