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Effect of vesnarinone on cardiac function in patients with severe congestive heart failure.

Abstract：

BACKGROUND:Vesnarinone has yielded controversial results on morbidity in patients with congestive heart failure. We tested the hypothesis that vesnarinone may have a beneficial effect on cardiac remodeling and function. METHODS:Thirty-four patients with left ventricular ejection fraction (LVEF) <30% (17 treated with vesnarinone) underwent an echocardiography at baseline and at 12+/-5 months. Left ventricular end-diastolic and end-systolic volume, mitral regurgitation, diastolic filling, and right ventricular area change were quantified and compared. RESULTS:When the vesnarinone group was considered as a whole, there was no significant effect of vesnarinone on cardiac systolic and diastolic function or remodeling. However, an increase in LVEF >7% was observed in six of the vesnarinone patients and none of the control group. Vesnarinone improved right and left ventricular systolic function significantly in patients with initial LVEF <25%. CONCLUSIONS:In severe congestive heart failure, vesnarinone induces variable responses but improves biventricular performance in patients with the most impaired initial function.

journal_name

Am Heart J

journal_title

American heart journal

authors

Scherrer-Crosbie M,Cocca-Spofford D,DiSalvo TG,Semigran MJ,Dec GW,Picard MH

doi

10.1016/s0002-8703(98)70120-6

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

769-77

issue

5

eissn

0002-8703

issn

1097-6744

pii

S0002870398000374

journal_volume

136

pub_type

临床试验,杂志文章

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