Novel antiplatelet therapies for treatment of patients with ischemic heart disease: inhibitors of the platelet glycoprotein IIb/IIIa integrin receptor.

abstract：BACKGROUND:The independent prognostic value of blood pressure (BP) variability in essential hypertension and particularly in uncomplicated mild hypertension is not yet completely clear. We investigated the relationship between BP variability, evaluated by noninvasive monitoring, and cardiovascular outcome in uncomplica...

journal_title：American heart journal

authors： Pierdomenico SD,Lapenna D,Bucci A,Manente BM,Mancini M,Cuccurullo F,Mezzetti A

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Half of patients with hypertension have poor blood pressure (BP) control. Recent models for treating hypertension have integrated disease monitoring and telephone-based interventions delivered in patients' homes. This study evaluated the costs of the Hypertension Intervention Nurse Telemedicine Study (HINTS)...

journal_title：American heart journal

authors： Wang V,Smith VA,Bosworth HB,Oddone EZ,Olsen MK,McCant F,Powers BJ,Van Houtven CH

更新日期：2012-06-01 00:00:00

abstract：:Combination therapy with mexiletine (MEX) and quinidine (Q) may be more efficacious than monotherapy with either drug in suppressing ventricular arrhythmias, but its effects on ventricular performance are not known. Thus, right ventricular ejection fraction (RVEF) and left ventricular ejection fraction (LVEF) and wall...

journal_title：American heart journal

authors： Sheldon RS,Duff HJ,Mitchell LB,Wyse DG,Manyari DE

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Infants born to cocaine-using mothers have a 3- to 8-fold increase in sudden infant death syndrome. Its underlying cause, in part, may be attributed to abnormal autonomic function. We proposed to study heart rate variability, reflecting autonomic control of the heart, in cocaine-exposed infants. METHODS:Fro...

journal_title：American heart journal

authors： Mehta SK,Super DM,Salvator A,Singer L,Connuck D,Fradley LG,Harcar-Sevcik RA,Kaufman ES

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) is the most common cause of left ventricular systolic dysfunction (LVSD). Patients with ischemia as the cause of LVSD may warrant revascularization. Angiography is the most accurate method of CAD diagnosis but is invasive, expensive, and associated with some risk. Noninvasive im...

journal_title：American heart journal

authors： Reynolds HR,Steckman DA,Tunick PA,Kronzon I,Lobach I,Rosenzweig BP

更新日期：2010-06-01 00:00:00

abstract：:Coronary atherosclerosis may cause acute and chronic ischemic syndromes; the former are caused by "acute plaque events," mostly thrombosis complicating vulnerable ruptured plaques, namely severe lesions with large core, thin cap, and weak shoulder infiltrated by activated inflammatory cells. Plaque rupture may also oc...

journal_title：American heart journal

authors： Arbustini E,Morbini P,Bello BD,Prati F,Specchia G

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:The major structural characteristic of congestive heart failure is myocardial cell death. The aim of our study was to determine whether the level of cardiac troponin T, a protein specific for cardiac necrosis, was increased in patients with congestive heart failure. METHODS AND RESULTS:Plasma samples were o...

journal_title：American heart journal

authors： Missov E,Mair J

更新日期：1999-07-01 00:00:00

abstract：:To evaluate whether the identification of the different types of relations between premature ventricular contractions (PVCs) and the preceding sinus cycle length is capable of predicting the effect of beta-blockers on the PVCs themselves, 55 patients (43 men, 12 women, mean age 52.6 +/- 15.6 years) with different card...

journal_title：American heart journal

authors： Pitzalis MV,Mastropasqua F,Massari F,Totaro P,Di Maggio M,Rizzon P

更新日期：1996-03-01 00:00:00

abstract：:Antiplatelet therapy is the current criterion standard for the treatment of patients undergoing percutaneous coronary intervention and patients who have acute coronary syndromes. Clopidogrel in combination with aspirin is the current standard of care for reducing cardiovascular events in these patients. However, patie...

journal_title：American heart journal

authors： Angiolillo DJ,Guzman LA,Bass TA

更新日期：2008-08-01 00:00:00

abstract：:Automatic external defibrillators (AEDs) represent an important technologic innovation in the management of out-of-hospital cardiac arrest. We propose the following concept: AEDs are machines with the limited task of ventricular fibrillation (VF) identification, countershock delivery, and defibrillation. They cannot b...

journal_title：American heart journal

authors： Cummins RO,Eisenberg MS,Hallstrom AP,Hearne TR,Graves JR,Litwin PE

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:The Total Occlusion Study of Canada (TOSCA) is a multicenter, randomized trial evaluating the effect of stenting with > =1 heparin-coated stent on long-term patency after percutaneous coronary intervention by balloon angioplasty of occluded coronary arteries. The purpose of the current study was to compare t...

journal_title：American heart journal

authors： Dzavik V,Carere RG,Mancini GB,Cohen EA,Catellier D,Anderson TE,Barbeau G,Lazzam C,Title LM,Berger PB,Labinaz M,Teo KK,Buller CE,Total Occlusion Study of Canada Investigators.

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Recently revised American College of Cardiology/American Heart Association guidelines for exercise electrocardiography (ExECG) have suggested that ExECG scores be used to assist in management decisions in patients with suspected coronary artery disease (CAD). METHODS:We used 442 women who underwent both ExE...

journal_title：American heart journal

authors： Morise AP,Lauer MS,Froelicher VF

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:African-American ancestry, hypokalemia, and QT interval prolongation on the electrocardiogram are all risk factors for sudden cardiac death (SCD), but their interactions remain to be characterized. SCN5A-1103Y is a common missense variant, of African ancestry, of the cardiac sodium channel gene. SCN5A-1103Y ...

journal_title：American heart journal

authors： Akylbekova EL,Payne JP,Newton-Cheh C,May WL,Fox ER,Wilson JG,Sarpong DF,Taylor HA,Maher JF

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Appropriate thromboprophylaxis for patients with atrial fibrillation or atrial flutter (AF) remains a national challenge. METHODS:We hypothesized that a shared decision-making interaction facilitated by an Atrial Fibrillation Shared Decision Making Tool (AFSDM) would improve patient knowledge about atrial f...

journal_title：American heart journal

authors： Eckman MH,Costea A,Attari M,Munjal J,Wise RE,Knochelmann C,Flaherty ML,Baker P,Ireton R,Harnett BM,Leonard AC,Steen D,Rose A,Kues J

更新日期：2018-05-01 00:00:00

abstract：:It has been suggested that the myocardium is able to recruit endogenous protective mechanisms in response to repeated ischemia and reperfusion. We set out to study whether this is manifested in patients with coronary artery disease in the form of fewer signs of myocardial ischemia during the second of two successive e...

journal_title：American heart journal

authors： Ylitalo K,Jama L,Raatikainen P,Peuhkurinen K

更新日期：1996-04-01 00:00:00

abstract：:The aim of this study was to assess the relative value of exercise echocardiography and perfusion single-photon emission computed tomography (SPECT) in identifying the presence and severity of coronary artery stenosis. Accordingly, 44 consecutive patients with stenosis in one vessel performed simultaneous postexercise...

journal_title：American heart journal

authors： Salustri A,Pozzoli MM,Hermans W,Ilmer B,Cornel JH,Reijs AE,Roelandt JR,Fioretti PM

更新日期：1992-07-01 00:00:00

abstract：:CHD remains the leading cause of death in most developed countries; therefore, elucidation of risk factors and associated mechanisms for atherosclerosis and development of CHD has been a high priority. Data from the Framingham Heart Study and other large-scale epidemiologic studies have identified major risk factors a...

journal_title：American heart journal

authors： Basha BJ,Sowers JR

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Little data exist to assist to help those organizing and managing heart failure (HF) disease management (DM) programs. We aimed to describe the intensity of outpatient HF care (clinic visits and telephone calls) and medical and nonpharmacological interventions in the outpatient setting. METHODS:This was a p...

journal_title：American heart journal

authors： Shah MR,Whellan DJ,Peterson ED,Nohria A,Hasselblad V,Xue Z,Bowers MT,O'Connor CM,Califf RM,Stevenson LW

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Renal function significantly impacts morbidity and mortality after a percutaneous coronary intervention. Platelet glycoprotein (GP) IIb/IIIa inhibitors reduce ischemic complications during percutaneous coronary intervention; little is known of whether their safety and efficacy are influenced by renal functio...

journal_title：American heart journal

authors： Berger PB,Best PJ,Topol EJ,White J,DiBattiste PM,Chan AW,Kristensen SD,Herrmann HC,Moliterno DJ

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Platelets play an important role in the natural history of coronary artery disease. Enhanced platelet aggregation and receptor expression unquestionably occur after coronary stent implantation; however, the functional characteristics of platelets before stenting have not been fully elucidated. METHODS:Plate...

journal_title：American heart journal

authors： Serebruany VL,Cummings CC,Malinin AI,Steinhubl SR,Gurbel PA

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is an increasingly prevalent condition among heart failure (HF) patients. The long-term morbidity and mortality among patients with and without diabetes with HF with reduced (HFrEF), borderline (HFbEF), and preserved ejection fraction (HFpEF) are not well described. METHODS:Using the Get W...

journal_title：American heart journal

authors： Ziaeian B,Hernandez AF,DeVore AD,Wu J,Xu H,Heidenreich PA,Matsouaka RA,Bhatt DL,Yancy CW,Fonarow GC

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Coronary calcium detected noninvasively is an attractive way to diagnose atherosclerosis before the development of symptoms. This study examines the prognostic value of coronary calcium in asymptomatic subjects with usual cardiovascular risk. METHODS AND RESULTS:In 425 asymptomatic subjects, 229 men (aged 4...

journal_title：American heart journal

authors： Alexopoulos D,Toulgaridis T,Davlouros P,Christodoulou J,Sitafidis G,Hahalis G,Vagenakis AG

更新日期：2003-03-01 00:00:00

abstract：:Our hypothesis was that the postoperative abnormalities in septal motion observed by M-mode echocardiography (MME) are due to changes of either ventricular shape or of total cardiac motion within the thorax. We obtained preoperative and early and late postoperative MME and two-dimensional echocardiograms on 25 patient...

journal_title：American heart journal

authors： Kerber RE,Litchfield R

更新日期：1982-08-01 00:00:00

abstract：:The development of a group of calcium channel blockers that prolong the QT interval has raised interest in their possible proarrhythmic potential. In animal experiments lidoflazine has no observed arrhythmogenic potential and no antiarrhythmic potential in a model sensitive to the antiarrhythmic properties of both con...

journal_title：American heart journal

authors： Somberg JC

更新日期：1985-02-01 00:00:00

abstract：:A double-blind multicenter study compared oral acebutolol (n = 182) with hydrochlorothiazide (n = 178) in the treatment of mild to moderate essential hypertension (diastolic blood pressure 95 to 114 mm Hg). Both agents produced significant and comparable reductions in systolic, diastolic, and mean arterial blood press...

journal_title：American heart journal

authors： Wahl J,Singh BN,Thoden WR

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Recently revised American College of Cardiology/American Heart Association guidelines have suggested that exercise test scores be used in decisions concerning patients with suspected coronary artery disease (CAD). Pretest and exercise test scores derived for use in women without known CAD have not been teste...

journal_title：American heart journal

authors： Morise AP,Olson MB,Merz CN,Mankad S,Rogers WJ,Pepine CJ,Reis SE,Sharaf BL,Sopko G,Smith K,Pohost GM,Shaw L

更新日期：2004-06-01 00:00:00

abstract：:Atherosclerosis and its vascular sequela are responsible for considerable morbidity and mortality rates. Several risk factors have been implicated in the pathogenesis of atherosclerosis, and the search for other risk factors continues on the medical horizon. Renin-angiotensin system (RAS), a multienzyme, multilocale a...

journal_title：American heart journal

authors： Malik FS,Lavie CJ,Mehra MR,Milani RV,Re RN

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:The oxygen uptake efficiency slope (OUES) is a new submaximal parameter which objectively predicts the maximal exercise capacity in children and healthy subjects. However, the usefulness of OUES in adult patients with and without advanced heart failure remains undetermined. The present study investigates the...

journal_title：American heart journal

authors： Van Laethem C,Bartunek J,Goethals M,Nellens P,Andries E,Vanderheyden M

更新日期：2005-01-01 00:00:00

abstract：:Traditionally, assessment of therapy has been judged by the ability of treatment to alleviate symptoms with tolerable side effects or toxicity. In recent years, it has become obvious that more subtle and patient-oriented approaches are urgently needed to evaluate progression of cardiovascular disease and to monitor th...

journal_title：American heart journal

authors： Storstein L

更新日期：1987-07-01 00:00:00

abstract：:Angina pectoris before and after MI was evaluated in a sample of 729 men and women from a general population in whom MI developed during a 36-year period of follow-up. Relations of AP to subsequent CHD events and mortality after initial MI were analyzed by proportional hazards regression models and were adjusted for c...

journal_title：American heart journal

authors： Brand FN,Larson M,Friedman LM,Kannel WB,Castelli WP

更新日期：1996-07-01 00:00:00