解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The properties of semi-elemental enteral nutrition might theoretically improve gastrointestinal tolerance in brain-injured patients, known to suffer gastroparesis. The purpose of this study was to compare the efficacy and tolerance of a semi-elemental versus a polymeric formula for enteral nutrition (EN) in ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03456-7
更新日期:2021-01-20 00:00:00
abstract:BACKGROUND:In patients intubated for mechanical ventilation, prolonged diaphragm inactivity could lead to weakness and poor outcome. Time to resume a minimal diaphragm activity may be related to sedation practice and patient severity. METHODS:Prospective observational study in critically ill patients. Diaphragm electr...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03435-y
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis (LONS) diagnosis. The aim of this study was to evaluate the association of interleukin-6(IL-6), pro...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03423-2
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Burnout has gained increasing attention worldwide; however, there is a lack of relevant research in China. This study investigated the prevalence and factors associated with burnout in physicians of the intensive care unit (ICU) in mainland China. METHODS:This cross-sectional multicenter study included crit...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03439-8
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:Patients with COVID-19 (COVID) may develop acute respiratory distress syndrome with or without sepsis, coagulopathy and visceral damage. While chest CT scans are routinely performed in the initial assessment of patients with severe pulmonary forms, thymus involvement and reactivation have not been investigat...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03440-1
更新日期:2021-01-04 00:00:00
abstract::COVID-19 has caused great devastation in the past year. Multi-organ point-of-care ultrasound (PoCUS) including lung ultrasound (LUS) and focused cardiac ultrasound (FoCUS) as a clinical adjunct has played a significant role in triaging, diagnosis and medical management of COVID-19 patients. The expert panel from 27 co...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-03369-5
更新日期:2020-12-24 00:00:00
abstract:BACKGROUND:Crystalloids and different component colloids, used for volume resuscitation, are sometimes associated with various adverse effects. Clinical trial findings for such fluid types in different patients' conditions are conflicting. Whether the mortality benefit of balanced crystalloid than saline can be inferre...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03419-y
更新日期:2020-12-14 00:00:00
abstract:BACKGROUND:The short-term and long-term consequences of the most frequent painful procedures performed in the ICU are unclear. This study aimed to identify the risk factors associated with pain-related discomfort perceived by critically ill patients during the whole ICU stay as self-reported by patients at the end of t...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03396-2
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:Effective antimicrobial treatment is key to reduce mortality associated with bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often necessary to account for pathophysiological changes or renal replacement therapy. Extracorporeal membrane oxygenation (ECMO) is increasingly bei...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03397-1
更新日期:2020-11-25 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) affects a large proportion of the critically ill and is associated with worse patient outcomes. Early identification of AKI can lead to earlier initiation of supportive therapy and better management. In this study, we evaluate the impact of computerized AKI decision support tool int...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03343-1
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The primary aim of this study was to investigate the association of circulating bioactive adrenomedullin ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03351-1
更新日期:2020-11-04 00:00:00
abstract:BACKGROUND:Omega-3 (ω-3) fatty acid (FA)-containing parenteral nutrition (PN) is associated with significant improvements in patient outcomes compared with standard PN regimens without ω-3 FA lipid emulsions. Here, we evaluate the impact of ω-3 FA-containing PN versus standard PN on clinical outcomes and costs in adult...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03356-w
更新日期:2020-11-03 00:00:00
abstract::Sepsis is characterized by a dysregulated immune response to infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful independent predictor of mortality in the intensive care unit. During systemic infections, the liver regulates immune defenses via bacterial clea...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-03327-1
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:Recurrent delivery of tidal mechanical energy (ME) inflicts ventilator-induced lung injury (VILI) when stress and strain exceed the limits of tissue tolerance. Mechanical power (MP) is the mathematical description of the ME delivered to the respiratory system over time. It is unknown how ME relates to underl...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03313-7
更新日期:2020-10-07 00:00:00
abstract:BACKGROUND:Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is associated with better outcomes in these patients. METHODS:MEDLINE, ISI Web of Science, Cochrane Data...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03296-5
更新日期:2020-09-29 00:00:00
abstract::Coronavirus disease (COVID-19) is an emerging viral infection that is rapidly spreading across the globe. SARS-CoV-2 belongs to the same coronavirus class that caused respiratory illnesses such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). During the SARS and MERS outbreaks, ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-03231-8
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:(1,3)-β-D-Glucan has been widely used in clinical practice for the diagnosis of invasive Candida infections. However, such serum biomarker showed potential to guide antimicrobial therapy in order to reduce the duration of empirical antifungal treatment in critically ill septic patients with suspected invasiv...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03265-y
更新日期:2020-09-05 00:00:00
abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-19 remains to be elucidated. We aimed to clarify correlation of systemic inflammation with disease s...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03255-0
更新日期:2020-08-27 00:00:00
abstract:OBJECTIVES:To evaluate the incidence and mortality of acute respiratory distress syndrome (ARDS) in medical/respiratory intensive care units (MICUs/RICUs) to assess ventilation management and the use of adjunct therapy in routine clinical practice for patients fulfilling the Berlin definition of ARDS in mainland China....
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03112-0
更新日期:2020-08-20 00:00:00
abstract:BACKGROUND:Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. This study aimed to investigate the safety and efficacy of Auxora, a novel, intraven...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13054-020-03220-x
更新日期:2020-08-14 00:00:00
abstract::The use of extracorporeal cardiopulmonary resuscitation (ECPR) to restore circulation during cardiac arrest is a time-critical, resource-intensive intervention of unproven efficacy. The current COVID-19 pandemic has brought additional complexity and significant barriers to the ongoing provision and implementation of E...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03172-2
更新日期:2020-07-27 00:00:00
abstract:BACKGROUND:Hypoxia is common during daily nursing procedures (DNPs) routinely performed on mechanically ventilated patients. The impact of automated ventilation on the incidence and severity of blood oxygen desaturation during DNPs remains unknown. METHODS:A prospective randomized controlled crossover trial was carrie...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03155-3
更新日期:2020-07-22 00:00:00
abstract::Five to 10% of the coronavirus SARS-CoV-2-infected patients, i.e., with new coronavirus disease 2019 (COVID-19), are presenting with an acute respiratory distress syndrome (ARDS) requiring urgent respiratory and hemodynamic support in the intensive care unit (ICU). However, nutrition is an important element of care. T...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-03159-z
更新日期:2020-07-19 00:00:00
abstract::COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infe...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-03166-0
更新日期:2020-07-18 00:00:00
abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors of 14-day and 28-day mortality and develop a model for predicting 14-day and 28-day survival probability among adult hospitalized patients with COVID-19. METHODS:In this multicent...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-020-03123-x
更新日期:2020-07-16 00:00:00
abstract:PURPOSE:Measurement of central venous pressure (CVP) can be a useful clinical tool. However, the formal utility of CVP measurement in preventing mortality in septic patients has never been proven. METHODS:The Medical Information Mart for Intensive Care III (MIMIC-III) database was searched to identify septic patients ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03109-9
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:Improving timeliness of pathogen identification is crucial to allow early adaptation of antibiotic therapy and improve prognosis in patients with pneumonia. We evaluated the relevance of a new syndromic rapid multiplex PCR test (rm-PCR) on respiratory samples to guide empirical antimicrobial therapy in adult...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03114-y
更新日期:2020-07-14 00:00:00
abstract:INTRODUCTION:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03121-z
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Dysregulation of the host immune response is a pathognomonic feature of sepsis. Abnormal physiological conditions are understood to shift efficient linear splicing of protein-coding RNA towards non-canonical splicing, characterized by the accumulation of non-coding circularized (circ)RNA. CircRNAs remain une...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03146-4
更新日期:2020-07-13 00:00:00
abstract::An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various human organ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-03120-0
更新日期:2020-07-13 00:00:00
abstract::Those involved in the airway management of COVID-19 patients are particularly at risk. Here, we describe a practical, stepwise protocol for safe in-hospital airway management in patients with suspected or confirmed COVID-19 infection. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-03018-x
更新日期:2020-06-05 00:00:00
abstract:INTRODUCTION:Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis. In the present review, we evaluate the progress in the research of sepsis biomarkers. METHODS:Using the same ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-02993-5
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:The intestinal microbiota plays a crucial role in human health, which could affect host immunity and the susceptibility to infectious diseases. However, the role of intestinal microbiota in the immunopathology of invasive candidiasis remains unknown. METHODS:In this work, an antibiotic cocktail was used to ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-02977-5
更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:Heterogeneity of acute respiratory distress syndrome (ARDS) could be reduced by identification of biomarker-based phenotypes. The set of ARDS biomarkers to prospectively define these phenotypes remains to be established. OBJECTIVE:To provide an overview of the biomarkers that were multivariately associated ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-02913-7
更新日期:2020-05-24 00:00:00
abstract:BACKGROUND:Hemophagocytic lymphohistiocytosis (HLH) is a rare though often fatal hyperinflammatory syndrome mimicking sepsis in the critically ill. Diagnosis relies on the HLH-2004 criteria and HScore, both of which have been developed in pediatric or adult non-critically ill patients, respectively. Therefore, we aimed...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-02941-3
更新日期:2020-05-24 00:00:00
abstract:BACKGROUND:Microcirculatory perfusion disturbances are associated with increased morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Technological advancements made it possible to monitor sublingual microcirculatory perfusion over time. The goal of this review is to provide...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-02948-w
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND:In December 2019, coronavirus disease 2019 (COVID-19) outbreak was reported from Wuhan, China. Information on the clinical course and prognosis of COVID-19 was not thoroughly described. We described the clinical courses and prognosis in COVID-19 patients. METHODS:Retrospective case series of COVID-19 patien...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-02895-6
更新日期:2020-04-30 00:00:00
abstract:BACKGROUND:Clinical team composition for prehospital paediatric intubation may affect success and complication rates. We performed a systematic review and meta-analysis to determine the success and complication rates by type of clinical team. METHODS:We searched MEDLINE, EMBASE, and CINAHL for interventional and obser...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析
doi:10.1186/s13054-020-02865-y
更新日期:2020-04-15 00:00:00
abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-2776-z
更新日期:2020-03-24 00:00:00
abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-2780-3
更新日期:2020-03-24 00:00:00