Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: a systematic review and meta-analysis.

Abstract:

BACKGROUND:Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is associated with better outcomes in these patients. METHODS:MEDLINE, ISI Web of Science, Cochrane Database and ClinicalTrials.gov were searched from inception to 25 May 2020. All clinical studies investigating the effects of antiviral therapy on the outcome of mechanically ventilated ICU patients in whom HSV was detected in the respiratory tract were eligible for inclusion, regardless of study design, publication status or language. Titles and abstracts were reviewed independently by two authors. If the articles seemed eligible, full-text articles were reviewed and data extracted. We performed a random-effects meta-analysis to estimate relative risks (RRs) with corresponding 95% confidence intervals (CIs). The primary endpoint was hospital all-cause mortality. RESULTS:Nine studies were included in the meta-analysis (one randomized controlled trial, eight cohort studies). Antiviral treatment was associated with lower hospital mortality (with antiviral treatment, 40.6% (189 out of 465 patients); without, 52.7% (193 out of 366 patients); RR 0.74 [0.64, 0.85]; eight studies, low quality of evidence). Furthermore, antiviral treatment was associated with lower 30-day mortality (RR 0.75 [0.59, 0.94]; three studies, very low quality of evidence). We did not observe evidence for differences in ICU mortality (RR 0.73 [0.51, 1.05]; three studies, very low quality of evidence). CONCLUSIONS:This meta-analysis of the available data shows that antiviral therapy might result in lower hospital and 30-day all-cause mortality in mechanically ventilated ICU patients who are positive for HSV in the respiratory tract. However, this result must be interpreted with great caution due to the high risk of bias and limited number of patients. Large, well-designed randomized controlled clinical trials are urgently needed. TRIAL REGISTRATION:The study was registered in advance on International Prospective Register of Systematic Reviews (CRD42020180053) .

journal_name

Crit Care

authors

Hagel S,Scherag A,Schuierer L,Hoffmann R,Luyt CE,Pletz MW,Kesselmeier M,Weis S

doi

10.1186/s13054-020-03296-5

subject

Has Abstract

pub_date

2020-09-29 00:00:00

pages

584

issue

1

eissn

1364-8535

issn

1466-609X

pii

10.1186/s13054-020-03296-5

journal_volume

24

pub_type

杂志文章
  • Pulse high-volume haemofiltration for treatment of severe sepsis: effects on hemodynamics and survival.

    abstract:INTRODUCTION:Severe sepsis is the leading cause of mortality in critically ill patients. Abnormal concentrations of inflammatory mediators appear to be involved in the pathogenesis of sepsis. Based on the humoral theory of sepsis, a potential therapeutic approach involves high-volume haemofiltration (HVHF), which has e...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章

    doi:10.1186/cc3529

    authors: Ratanarat R,Brendolan A,Piccinni P,Dan M,Salvatori G,Ricci Z,Ronco C

    更新日期:2005-08-01 00:00:00

  • Choice of hospital after out-of-hospital cardiac arrest--a decision with far-reaching consequences: a study in a large German city.

    abstract:INTRODUCTION:Between 1 and 31% of patients suffering out-of-hospital cardiac arrest (OHCA) survive to discharge from hospital. International studies have shown that the level of care provided by the admitting hospital determines survival for patients suffering from OHCA. These data may only be partially transferable to...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc11516

    authors: Wnent J,Seewald S,Heringlake M,Lemke H,Brauer K,Lefering R,Fischer M,Jantzen T,Bein B,Messelken M,Gräsner JT

    更新日期:2012-09-12 00:00:00

  • Diagnostic value of neutrophil gelatinase-associated lipocalin, cystatin C, and soluble triggering receptor expressed on myeloid cells-1 in critically ill patients with sepsis-associated acute kidney injury.

    abstract:INTRODUCTION:Neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (Cys-C), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) are novel diagnostic biomarkers of acute kidney injury (AKI). We aimed to determine the diagnostic properties of these biomarkers for detecting AKI in critically ill...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-015-0941-6

    authors: Dai X,Zeng Z,Fu C,Zhang S,Cai Y,Chen Z

    更新日期:2015-05-06 00:00:00

  • Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock.

    abstract:INTRODUCTION:During septic shock, resistance to the haemodynamic effects of catecholamine vasopressors and inotropes is a well-recognised marker of mortality risk. However, the specific cardiovascular or metabolic response elements that are most closely associated with outcome have not been well defined. The objective ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc6814

    authors: Kumar A,Schupp E,Bunnell E,Ali A,Milcarek B,Parrillo JE

    更新日期:2008-01-01 00:00:00

  • Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?

    abstract::Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known a...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc12700

    authors: Souza-Fonseca-Guimaraes F,Cavaillon JM,Adib-Conquy M

    更新日期:2013-08-27 00:00:00

  • Bench-to-bedside review: High-mobility group box 1 and critical illness.

    abstract::High-mobility group box 1 (HMGB1) is a DNA-binding protein that also exhibits proinflammatory cytokine-like activity. HMGB1 is passively released by necrotic cells and also is actively secreted by immunostimulated macrophages, dendritic cells, and enterocytes. Although circulating HMGB1 levels are increased relative t...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc6088

    authors: Fink MP

    更新日期:2007-01-01 00:00:00

  • Plasma colloid osmotic pressure in healthy infants.

    abstract:BACKGROUND:The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This ...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章

    doi:10.1186/cc1043

    authors: Sussmane JB,de Soto M,Torbati D

    更新日期:2001-10-01 00:00:00

  • "Awake" extracorporeal membrane oxygenation (ECMO): pathophysiology, technical considerations, and clinical pioneering.

    abstract::Venovenous extracorporeal membrane oxygenation (vv-ECMO) has been classically employed as a rescue therapy for patients with respiratory failure not treatable with conventional mechanical ventilation alone. In recent years, however, the timing of ECMO initiation has been readdressed and ECMO is often started earlier i...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/s13054-016-1329-y

    authors: Langer T,Santini A,Bottino N,Crotti S,Batchinsky AI,Pesenti A,Gattinoni L

    更新日期:2016-06-30 00:00:00

  • Eubaric hyperoxia: controversies in the management of acute traumatic brain injury.

    abstract::Controversy exists on the role of hyperoxia in major trauma with brain injury. Hyperoxia on arterial blood gas has been associated with acute lung injury and pulmonary complications, impacting clinical outcome. The hyperoxia could be reflective of the physiological interventions following major systemic trauma. Despit...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章

    doi:10.1186/cc13065

    authors: Narotam PK

    更新日期:2013-10-16 00:00:00

  • Diagnostic value of real-time polymerase chain reaction to detect viruses in young children admitted to the paediatric intensive care unit with lower respiratory tract infection.

    abstract:INTRODUCTION:The aetiology of lower respiratory tract infections in young children admitted to the paediatric intensive care unit (PICU) is often difficult to establish. However, most infections are believed to be caused by respiratory viruses. A diagnostic study was performed to compare conventional viral tests with t...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc4895

    authors: van de Pol AC,Wolfs TF,Jansen NJ,van Loon AM,Rossen JW

    更新日期:2006-01-01 00:00:00

  • Antiarrhythmic drugs for out-of-hospital cardiac arrest with refractory ventricular fibrillation.

    abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/s13054-017-1639-8

    authors: Tagami T,Yasunaga H,Yokota H

    更新日期:2017-03-21 00:00:00

  • Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and meta-analysis.

    abstract:INTRODUCTION:Making a differential diagnosis between bacterial meningitis and aseptic meningitis is a critical clinical problem. The utility of a cerebrospinal fluid (CSF) lactate assay for this purpose has been debated and is not yet routinely clinically performed. To adequately evaluate this assay, a systematic revie...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/cc9395

    authors: Huy NT,Thao NT,Diep DT,Kikuchi M,Zamora J,Hirayama K

    更新日期:2010-01-01 00:00:00

  • Development and validation of a risk factor-based system to predict short-term survival in adult hospitalized patients with COVID-19: a multicenter, retrospective, cohort study.

    abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors of 14-day and 28-day mortality and develop a model for predicting 14-day and 28-day survival probability among adult hospitalized patients with COVID-19. METHODS:In this multicent...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s13054-020-03123-x

    authors: Zhang S,Guo M,Duan L,Wu F,Hu G,Wang Z,Huang Q,Liao T,Xu J,Ma Y,Lv Z,Xiao W,Zhao Z,Tan X,Meng D,Zhang S,Zhou E,Yin Z,Geng W,Wang X,Zhang J,Chen J,Zhang Y,Jin Y

    更新日期:2020-07-16 00:00:00

  • Delirium prediction in the intensive care unit: comparison of two delirium prediction models.

    abstract:BACKGROUND:Accurate prediction of delirium in the intensive care unit (ICU) may facilitate efficient use of early preventive strategies and stratification of ICU patients by delirium risk in clinical research, but the optimal delirium prediction model to use is unclear. We compared the predictive performance and user c...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1186/s13054-018-2037-6

    authors: Wassenaar A,Schoonhoven L,Devlin JW,van Haren FMP,Slooter AJC,Jorens PG,van der Jagt M,Simons KS,Egerod I,Burry LD,Beishuizen A,Matos J,Donders ART,Pickkers P,van den Boogaard M

    更新日期:2018-05-05 00:00:00

  • Dosing adjuvant vitamin C in critically ill patients undergoing continuous renal replacement therapy: We are not there yet!

    abstract:: ...

    journal_title:Critical care (London, England)

    pub_type: 评论,信件

    doi:10.1186/s13054-018-2297-1

    authors: Honore PM,De Bels D,Kugener L,Redant S,Attou R,Gallerani A,Spapen HD

    更新日期:2019-01-09 00:00:00

  • Serial increase of IL-12 response and human leukocyte antigen-DR expression in severe sepsis survivors.

    abstract:INTRODUCTION:Sepsis-induced immunosuppression may result in death. The mechanisms of immune suppression include loss of macrophage and monocyte expression of the major histocompatibility complex, increased anti-inflammatory cytokine expression and decreased expression of proinflammatory cytokines. In this study, we sou...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc10464

    authors: Wu HP,Shih CC,Lin CY,Hua CC,Chuang DY

    更新日期:2011-01-01 00:00:00

  • Plasma thioredoxin levels during post-cardiac arrest syndrome: relationship with severity and outcome.

    abstract:INTRODUCTION:Despite experimental evidence, clinical demonstration of acute state of oxidative stress and inflammation during post-cardiac arrest syndrome is lacking. Plasma level of thioredoxin (TRX), a redox-active protein induced under conditions of oxidative stress and inflammation, is increased in various critical...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc12492

    authors: Mongardon N,Lemiale V,Borderie D,Burke-Gaffney A,Perbet S,Marin N,Charpentier J,Pène F,Chiche JD,Mira JP,Cariou A

    更新日期:2013-01-29 00:00:00

  • Copeptin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and short-term survival.

    abstract:BACKGROUND:Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failure, and high short-term mortality rates. Hemodynamic dysfunction and activation of endogenous vasoconstrictor systems are thought to contribute to the pathogenesis of ACLF. We explored...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-017-1894-8

    authors: Kerbert AJC,Verspaget HW,Navarro ÀA,Jalan R,Solà E,Benten D,Durand F,Ginès P,van der Reijden JJ,van Hoek B,Coenraad MJ,CANONIC Study Investigators of the EASL-CLIF Consortium.

    更新日期:2017-12-21 00:00:00

  • Clinical manifestations of disordered microcirculatory perfusion in severe sepsis.

    abstract::Microcirculatory dysfunction plays a pivotal role in the development of the clinical manifestations of severe sepsis. Prior to the advent of new imaging technologies, clinicians had been limited in their ability to assess the microcirculation at the bedside. Clinical evidence of microcirculatory perfusion has historic...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc3744

    authors: Trzeciak S,Rivers EP

    更新日期:2005-01-01 00:00:00

  • Contrast-enhanced ultrasound to evaluate changes in renal cortical perfusion around cardiac surgery: a pilot study.

    abstract:INTRODUCTION:Contrast-enhanced ultrasound (CEUS) is a new technique that might enable portable and non-invasive organ perfusion quantification at the bedside. However, it has not yet been tested in critically ill patients. We sought to establish CEUS's feasibility, safety, reproducibility and potential diagnostic value...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc12817

    authors: Schneider AG,Goodwin MD,Schelleman A,Bailey M,Johnson L,Bellomo R

    更新日期:2013-07-12 00:00:00

  • Bench-to-bedside review: Beta-adrenergic modulation in sepsis.

    abstract::Sepsis, despite recent therapeutic progress, still carries unacceptably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta-adrenergic regulation of the immune function in sepsis is complex ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc8026

    authors: de Montmollin E,Aboab J,Mansart A,Annane D

    更新日期:2009-01-01 00:00:00

  • Left ventricular function: time-varying elastance and left ventricular aortic coupling.

    abstract::Many aspects of left ventricular function are explained by considering ventricular pressure-volume characteristics. Contractility is best measured by the slope, Emax, of the end-systolic pressure-volume relationship. Ventricular systole is usefully characterized by a time-varying elastance (ΔP/ΔV). An extended area, t...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/s13054-016-1439-6

    authors: Walley KR

    更新日期:2016-09-10 00:00:00

  • Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis.

    abstract:INTRODUCTION:Deregulated apoptosis and overshooting neutrophil functions contribute to immune and organ dysfunction in sepsis and multiple organ failure (MOF). In the present study, we determined the role of soluble Fas (sFas) in the regulation of posttraumatic neutrophil extrinsic apoptosis and the development of seps...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc9965

    authors: Paunel-Görgülü A,Flohé S,Scholz M,Windolf J,Lögters T

    更新日期:2011-01-01 00:00:00

  • In-vivo validation of a new non-invasive continuous ventricular stroke volume monitoring system in an animal model.

    abstract:INTRODUCTION:Recently, a non-invasive, continuous ventricular stroke volume monitoring system using skin electrodes has been developed. In contrast to impedance-based methods, the new technique (ventricular field recognition) enables measurement of changes in ventricular volume. A prototype using this new method was bu...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc10306

    authors: Konings MK,Grundeman PF,Goovaerts HG,Roosendaal MR,Hoefer IE,Doevendans PA,Rademakers FE,Buhre WF

    更新日期:2011-07-11 00:00:00

  • Retrospective cohort study of hospital variation in airway management during in-hospital cardiac arrest and the association with patient survival: insights from Get With The Guidelines-Resuscitation.

    abstract:IMPORTANCE:The optimal approach to airway management during in-hospital cardiac arrest is unknown. OBJECTIVE:To describe hospital-level variation in endotracheal intubation during cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest and the association between hospital use of endotracheal intubation and ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-019-2426-5

    authors: Bradley SM,Zhou Y,Ramachandran SK,Engoren M,Donnino M,Girotra S

    更新日期:2019-05-06 00:00:00

  • Evidence-based review of the use of the pulmonary artery catheter: impact data and complications.

    abstract::The pulmonary artery catheter (PAC) was introduced in 1971 for the assessment of heart function at the bedside. Since then it has generated much enthusiasm and controversy regarding the benefits and potential harms caused by this invasive form of hemodynamic monitoring. This review discusses all clinical studies condu...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审

    doi:10.1186/cc4834

    authors: Hadian M,Pinsky MR

    更新日期:2006-01-01 00:00:00

  • Renal haemodynamic, microcirculatory, metabolic and histopathological responses to peritonitis-induced septic shock in pigs.

    abstract:INTRODUCTION:Our understanding of septic acute kidney injury (AKI) remains incomplete. A fundamental step is the use of animal models designed to meet the criteria of human sepsis. Therefore, we dynamically assessed renal haemodynamic, microvascular and metabolic responses to, and ultrastructural sequelae of, sepsis in...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc7164

    authors: Chvojka J,Sykora R,Krouzecky A,Radej J,Varnerova V,Karvunidis T,Hes O,Novak I,Radermacher P,Matejovic M

    更新日期:2008-01-01 00:00:00

  • Respiratory variations of inferior vena cava diameter to predict fluid responsiveness in spontaneously breathing patients with acute circulatory failure: need for a cautious use.

    abstract:INTRODUCTION:To investigate whether respiratory variation of inferior vena cava diameter (cIVC) predict fluid responsiveness in spontaneously breathing patients with acute circulatory failure (ACF). METHODS:Forty patients with ACF and spontaneous breathing were included. Response to fluid challenge was defined as a 15...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc11672

    authors: Muller L,Bobbia X,Toumi M,Louart G,Molinari N,Ragonnet B,Quintard H,Leone M,Zoric L,Lefrant JY,AzuRea group.

    更新日期:2012-10-08 00:00:00

  • Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study.

    abstract:INTRODUCTION:The objective of the study was to describe the pharmacokinetics (PK) of fluconazole, anidulafungin, and caspofungin in critically ill patients and to compare with previously published data. We also sought to determine whether contemporary fluconazole doses achieved PK/pharmacodynamic (PD; PK/PD) targets in...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/s13054-015-0758-3

    authors: Sinnollareddy MG,Roberts JA,Lipman J,Akova M,Bassetti M,De Waele JJ,Kaukonen KM,Koulenti D,Martin C,Montravers P,Rello J,Rhodes A,Starr T,Wallis SC,Dimopoulos G,DALI Study authors.

    更新日期:2015-02-04 00:00:00

  • High serum cortisol level is associated with increased risk of delirium after coronary artery bypass graft surgery: a prospective cohort study.

    abstract:INTRODUCTION:The pathophysiology of postoperative delirium remains poorly understood. The purpose of this study was to examine the relationship between serum cortisol level and occurrence of early postoperative delirium in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS:A total of 243 patients...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章

    doi:10.1186/cc9393

    authors: Mu DL,Wang DX,Li LH,Shan GJ,Li J,Yu QJ,Shi CX

    更新日期:2010-01-01 00:00:00