Provision of ECPR during COVID-19: evidence, equity, and ethical dilemmas.

abstract：INTRODUCTION:Due to resource limitations, few critical care interventions have been rigorously evaluated with adequately powered randomized clinical trials (RCTs). There is a need to improve the efficiency of RCTs in critical care so that more definitive high quality RCTs can be completed with the available resources. ...

journal_title：Critical care (London, England)

authors： Heyland DK,Muscedere J,Drover J,Jiang X,Day AG,Canadian Critical Care Trials Group.

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Procalcitonin (PCT) and C-reactive protein (CRP) are established markers of infection in the general population. In contrast, several studies reported falsely increased PCT levels in patients receiving T-cell antibodies. We evaluated the validity of these markers in patients scheduled for hemopoietic stem ...

journal_title：Critical care (London, England)

authors： Brodska H,Drabek T,Malickova K,Kazda A,Vitek A,Zima T,Markova M

更新日期：2009-01-01 00:00:00

abstract：:The use of controlled mechanical ventilation (CMV) in patients who experience weaning failure after a spontaneous breathing trial or after extubation is a strategy based on the premise that respiratory muscle fatigue (requiring rest to recover) is the cause of weaning failure. Recent evidence, however, does not suppor...

journal_title：Critical care (London, England)

authors： Vassilakopoulos T,Zakynthinos S,Roussos C

更新日期：2006-02-01 00:00:00

abstract：:Two international multicentre randomised controlled trials of drotrecogin alfa (activated) (DrotAA), the Recombinant Human Activated Protein C Worldwide Evaluation of Severe Sepsis (PROWESS) and Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) trials, have produced inconsistent res...

journal_title：Critical care (London, England)

authors： Friedrich JO,Adhikari NK,Meade MO

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:As a result of drug sequestration and increased volume of distribution, the extracorporeal membrane oxygenation (ECMO) procedure might lead to a decrease in drug concentrations during a patient's treatment. The aim of this study was to evaluate sedative, antibiotic and immunosuppressive drug loss in ECMO c...

journal_title：Critical care (London, England)

authors： Lemaitre F,Hasni N,Leprince P,Corvol E,Belhabib G,Fillâtre P,Luyt CE,Leven C,Farinotti R,Fernandez C,Combes A

更新日期：2015-02-12 00:00:00

abstract：INTRODUCTION:Recent data have suggested that patient admission during intensive care unit (ICU) morning bedside rounds is associated with less favorable outcome. We undertook the present study to explore the association between morning round-time ICU admissions and hospital mortality in a large Canadian health region. ...

journal_title：Critical care (London, England)

authors： de Souza IA,Karvellas CJ,Gibney RT,Bagshaw SM

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. METHODS:A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal...

journal_title：Critical care (London, England)

authors： Bassetti M,Giacobbe DR,Vena A,Trucchi C,Ansaldi F,Antonelli M,Adamkova V,Alicino C,Almyroudi MP,Atchade E,Azzini AM,Carannante N,Carnelutti A,Corcione S,Cortegiani A,Dimopoulos G,Dubler S,García-Garmendia JL,Girardis

更新日期：2019-06-14 00:00:00

abstract：:Five to 10% of the coronavirus SARS-CoV-2-infected patients, i.e., with new coronavirus disease 2019 (COVID-19), are presenting with an acute respiratory distress syndrome (ARDS) requiring urgent respiratory and hemodynamic support in the intensive care unit (ICU). However, nutrition is an important element of care. T...

journal_title：Critical care (London, England)

authors： Thibault R,Seguin P,Tamion F,Pichard C,Singer P

更新日期：2020-07-19 00:00:00

abstract：INTRODUCTION:The ventilator and the endotracheal tube impose additional workload in mechanically ventilated patients breathing spontaneously. The total work of breathing (WOB) includes elastic and resistive work. In a bench test we assessed the imposed WOB using 3100 A/3100 B SensorMedics high-frequency oscillatory ven...

journal_title：Critical care (London, England)

authors： van Heerde M,van Genderingen HR,Leenhoven T,Roubik K,Plötz FB,Markhorst DG

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:In the past two decades, healthcare adopted industrial strategies for process measurement and control. In the industry model, care is taken to avoid minimal deviations from a standard. In healthcare there is scarce data to support that a similar strategy can lead to better outcomes. Briefly, when complianc...

journal_title：Critical care (London, England)

authors： Amaral AC,Kure L,Jeffs A

更新日期：2012-05-08 00:00:00

abstract：INTRODUCTION:To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU). METHODS:Medline, EMBASE and other databases were searched for English-language articles with the major objective of ...

journal_title：Critical care (London, England)

authors： Minne L,Abu-Hanna A,de Jonge E

更新日期：2008-01-01 00:00:00

abstract：:This review presents key publications from the research field of sepsis published in Critical Care and other relevant journals during 2013. The results of these experimental studies and clinical trials are discussed in the context of current scientific and clinical background. The discussion highlights and summarises ...

journal_title：Critical care (London, England)

authors： de Montmollin E,Annane D

更新日期：2014-10-15 00:00:00

abstract：:Investigations on the relationship between sepsis, brain dysfunction, and cerebral perfusion are methodologically very difficult to perform. It is important to interpret the results of such studies in view of our limited ability to diagnose and quantify brain dysfunction and to consider our limited understanding of th...

journal_title：Critical care (London, England)

authors： Steiner LA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failure, and high short-term mortality rates. Hemodynamic dysfunction and activation of endogenous vasoconstrictor systems are thought to contribute to the pathogenesis of ACLF. We explored...

journal_title：Critical care (London, England)

authors： Kerbert AJC,Verspaget HW,Navarro ÀA,Jalan R,Solà E,Benten D,Durand F,Ginès P,van der Reijden JJ,van Hoek B,Coenraad MJ,CANONIC Study Investigators of the EASL-CLIF Consortium.

更新日期：2017-12-21 00:00:00

abstract：INTRODUCTION:Patients after out-of-hospital cardiac arrest (OHCA) benefit from therapeutic hypothermia for 24 hours. The time needed to reach hypothermia (target temperature of 32 degrees C to 34 degrees C) varies widely. In this study, we explore the relation between measures of body composition and the time needed to...

journal_title：Critical care (London, England)

authors： Jimmink JJ,Binnekade JM,Paulus F,Mathus-Vliegen EM,Schultz MJ,Vroom MB

更新日期：2008-01-01 00:00:00

abstract：:Relatively simple measures of echocardiography and Doppler, as left ventricular end-systolic area and volume, should be taken in consideration when performing a Doppler echocardiographic examination, as they could have both clinical and prognostic value. ...

journal_title：Critical care (London, England)

authors： Poelaert J,Roosens C

更新日期：2007-01-01 00:00:00

abstract：:The optimal length of antimicrobial therapy has not been extensively studied for a great majority of infections and, in critically ill patients affected by ventilator-associated pneumonia, is a persisting and unsolved issue confronting clinicians. The integration of biomarkers, clinical judgment, and microbiologic era...

journal_title：Critical care (London, England)

authors： Martin-Loeches I,Torres A

更新日期：2013-01-21 00:00:00

abstract：:Considerable progress has been made in the past few years in the development of therapeutic interventions that can reduce mortality in sepsis. However, encouraging physicians to put the results of new studies into practice is not always simple. A roundtable was thus convened to provide guidance for clinicians on the i...

journal_title：Critical care (London, England)

authors： Vincent JL,Abraham E,Annane D,Bernard G,Rivers E,Van den Berghe G

更新日期：2002-12-01 00:00:00

abstract：INTRODUCTION:A paucity of literature exists regarding delays in transfer out of the intensive care unit. We sought to analyze the incidence, causes, and costs of delayed transfer from a surgical intensive care unit (SICU). METHODS:An IRB-approved prospective observational study was conducted from January 24, 2010, to ...

journal_title：Critical care (London, England)

authors： Johnson DW,Schmidt UH,Bittner EA,Christensen B,Levi R,Pino RM

更新日期：2013-07-04 00:00:00

abstract：:Climate change and environmental stewardship are phrases that have been defining the past few decades and promoting change in our societies. The sensitivities of intensive care as a specialty make the process of greening an intensive care unit a challenge, but not one that is insurmountable. This paper discusses oppor...

journal_title：Critical care (London, England)

authors： Chapman M,Chapman A

更新日期：2011-01-01 00:00:00

abstract：:Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance. The pathophysiology is complex and includes dysregulation of vasodilatory and vasoconstrictive properties of smooth vascular muscle cells. Specific bypas...

journal_title：Critical care (London, England)

authors： Busse LW,Barker N,Petersen C

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Several choices of inotropic therapy are available and used in relation to cardiac surgery. Comparisons are necessary to select optimal therapy. In Denmark, dobutamine and milrinone are the two inotropic agents most commonly used to treat post-bypass low cardiac output syndrome. This study compares all-cause...

journal_title：Critical care (London, England)

authors： Nielsen DV,Torp-Pedersen C,Skals RK,Gerds TA,Karaliunaite Z,Jakobsen CJ

更新日期：2018-02-26 00:00:00

abstract：:Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequ...

journal_title：Critical care (London, England)

authors： Rudd KE,Kissoon N,Limmathurotsakul D,Bory S,Mutahunga B,Seymour CW,Angus DC,West TE

更新日期：2018-09-23 00:00:00

abstract：BACKGROUND:Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio (PLR), a novel systemic inflammation marker, among patients with AKI is scarce. In this study, we investigated the value o...

journal_title：Critical care (London, England)

authors： Zheng CF,Liu WY,Zeng FF,Zheng MH,Shi HY,Zhou Y,Pan JY

更新日期：2017-09-08 00:00:00

abstract：INTRODUCTION:In severely neutropenic septic acute respiratory distress syndrome (ARDS) patients, macrophages and monocytes are the last potentially remaining innate immune cells. We have previously shown, however, a deactivation of the alveolar macrophage in neutropenic septic ARDS patients. In the present study, we tr...

journal_title：Critical care (London, England)

authors： Mokart D,Kipnis E,Guerre-Berthelot P,Vey N,Capo C,Sannini A,Brun JP,Blache JL,Mege JL,Blaise D,Guery BP

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Abdominal compartment syndrome has been described in patients with severe acute pancreatitis, but its clinical impact remains unclear. We therefore studied patient factors associated with the development of intra-abdominal hypertension (IAH), the incidence of organ failure associated with IAH, and the effe...

journal_title：Critical care (London, England)

authors： De Waele JJ,Hoste E,Blot SI,Decruyenaere J,Colardyn F

更新日期：2005-08-01 00:00:00

abstract：:Venovenous extracorporeal membrane oxygenation (vv-ECMO) has been classically employed as a rescue therapy for patients with respiratory failure not treatable with conventional mechanical ventilation alone. In recent years, however, the timing of ECMO initiation has been readdressed and ECMO is often started earlier i...

journal_title：Critical care (London, England)

authors： Langer T,Santini A,Bottino N,Crotti S,Batchinsky AI,Pesenti A,Gattinoni L

更新日期：2016-06-30 00:00:00

abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors of 14-day and 28-day mortality and develop a model for predicting 14-day and 28-day survival probability among adult hospitalized patients with COVID-19. METHODS:In this multicent...

journal_title：Critical care (London, England)

authors： Zhang S,Guo M,Duan L,Wu F,Hu G,Wang Z,Huang Q,Liao T,Xu J,Ma Y,Lv Z,Xiao W,Zhao Z,Tan X,Meng D,Zhang S,Zhou E,Yin Z,Geng W,Wang X,Zhang J,Chen J,Zhang Y,Jin Y

更新日期：2020-07-16 00:00:00

abstract：INTRODUCTION:The appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates. METHODS:This retrospective analysis included trauma patients who received >or= 5 units of red blood cell concentrate within 24 hours. C...

journal_title：Critical care (London, England)

authors： Schöchl H,Nienaber U,Hofer G,Voelckel W,Jambor C,Scharbert G,Kozek-Langenecker S,Solomon C

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Cardiac surgery using cardiopulmonary bypass in newborns, infants and small children often requires intraoperative red blood cell transfusions to prime the circuit and oxygenator and to replace blood lost during surgery. The purpose of this study was to investigate the influence of red blood cell storage t...

journal_title：Critical care (London, England)

authors： Ranucci M,Carlucci C,Isgrò G,Boncilli A,De Benedetti D,De la Torre T,Brozzi S,Frigiola A

更新日期：2009-01-01 00:00:00