听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Cellular & Molecular Immunology期刊下所有文献
  • "Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis.

    abstract::Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations. Plaque psoriasis, which is the most common manifestation of psoriasis, is located on one end of the spectrum, dominated by adaptive immune responses, whereas the rarer pustular psoriasis lies on the opposite end,...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-0519-3

    authors: Uppala R,Tsoi LC,Harms PW,Wang B,Billi AC,Maverakis E,Michelle Kahlenberg J,Ward NL,Gudjonsson JE

    更新日期:2021-02-01 00:00:00

  • The aryl hydrocarbon receptor and the gut-brain axis.

    abstract::The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the r...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-00585-5

    authors: Barroso A,Mahler JV,Fonseca-Castro PH,Quintana FJ

    更新日期:2021-02-01 00:00:00

  • The roles of microglia in viral encephalitis: from sensome to therapeutic targeting.

    abstract::Viral encephalitis is a devastating disease with high mortality, and survivors often suffer from severe neurological complications. Microglia are innate immune cells of the central nervous system (CNS) parenchyma whose turnover is reliant on local proliferation. Microglia express a diverse range of proteins, which all...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-00620-5

    authors: Chhatbar C,Prinz M

    更新日期:2021-02-01 00:00:00

  • Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease.

    abstract::The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-00568-6

    authors: Horst AK,Kumashie KG,Neumann K,Diehl L,Tiegs G

    更新日期:2021-01-01 00:00:00

  • The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response.

    abstract::Activation of the TAK1 signalosome is crucial for mediating the innate immune response to pathogen invasion and is regulated by multiple layers of posttranslational modifications, including ubiquitination, SUMOylation, and phosphorylation; however, the underlying molecular mechanism is not fully understood. In this st...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-020-00564-w

    authors: Gu Z,Chen X,Yang W,Qi Y,Yu H,Wang X,Gong Y,Chen Q,Zhong B,Dai L,Qi S,Zhang Z,Zhang H,Hu H

    更新日期:2020-11-12 00:00:00

  • A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract.

    abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data a...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-020-00550-2

    authors: Hu F,Chen F,Ou Z,Fan Q,Tan X,Wang Y,Pan Y,Ke B,Li L,Guan Y,Mo X,Wang J,Wang J,Luo C,Wen X,Li M,Ren P,Ke C,Li J,Lei C,Tang X,Li F

    更新日期:2020-11-01 00:00:00

  • Unique immunological profile in patients with COVID-19.

    abstract::The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host immunity is poorly understood. We performed an extensive analysis of immune responses in 32 patients with severe COVID-19, some of whom succumbed. A control population of healthy subjects was included. Patients with COVID-19...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-020-00557-9

    authors: Varchetta S,Mele D,Oliviero B,Mantovani S,Ludovisi S,Cerino A,Bruno R,Castelli A,Mosconi M,Vecchia M,Roda S,Sachs M,Klersy C,Mondelli MU

    更新日期:2020-10-15 00:00:00

  • Correction to: Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Cellular & molecular immunology

    pub_type: 已发布勘误

    doi:10.1038/s41423-020-00543-1

    authors: Alim MA,Grujic M,Ackermann PW,Kristiansson P,Blomgran P,Eliasson P,Peterson M,Pejler G

    更新日期:2020-10-01 00:00:00

  • Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment.

    abstract::Epigenetic regulation of gene expression in cancer cells has been extensively studied in recent decades, resulting in the FDA approval of multiple epigenetic agents for treating different cancer types. Recent studies have revealed novel roles of epigenetic dysregulation in altering the phenotypes of immune cells and t...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-0505-9

    authors: Pan X,Zheng L

    更新日期:2020-09-01 00:00:00

  • Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases.

    abstract::The interactions of CD4+ T cells and B cells are fundamental for the generation of protective antibody responses, as well as for the development of harmful autoimmune diseases. Recent studies of human tissues and blood samples have established a new subset of CD4+ B helper T cells named peripheral helper T (Tph) cells...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-00529-z

    authors: Yoshitomi H,Ueno H

    更新日期:2020-08-31 00:00:00

  • The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.

    abstract::In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB (glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with tumor cells. Here, using mouse tumor models, we show that macrophage-derived soluble GPNMB increases tumor growth and metastasis in Gpnmb-mu...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-020-0501-0

    authors: Liguori M,Digifico E,Vacchini A,Avigni R,Colombo FS,Borroni EM,Farina FM,Milanesi S,Castagna A,Mannarino L,Craparotta I,Marchini S,Erba E,Panini N,Tamborini M,Rimoldi V,Allavena P,Belgiovine C

    更新日期:2020-07-29 00:00:00

  • Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties.

    abstract::Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltrat...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-020-0500-1

    authors: Shen Z,Kuang S,Zhang M,Huang X,Chen J,Guan M,Qin W,Xu HHK,Lin Z

    更新日期:2020-07-16 00:00:00

  • The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.

    abstract::Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to the induction of downstream antiviral effectors and the innate antiviral immune response. Here, we identified the zinc-finger FYVE domain-containing protein ZFYVE1, a guanylate-binding protein (GBP), as a positive regulator of TLR3-mediated signaling. ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-019-0265-6

    authors: Zhong X,Feng L,Xu WH,Wu X,Ding YD,Zhou Y,Lei CQ,Shu HB

    更新日期:2020-07-01 00:00:00

  • Homeostasis and regulation of autoreactive B cells.

    abstract::In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-0445-4

    authors: Lee S,Ko Y,Kim TJ

    更新日期:2020-06-01 00:00:00

  • Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies.

    abstract::Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding domain (RBD), and thus is believed to be a major target to block...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-020-0458-z

    authors: Yi C,Sun X,Ye J,Ding L,Liu M,Yang Z,Lu X,Zhang Y,Ma L,Gu W,Qu A,Xu J,Shi Z,Ling Z,Sun B

    更新日期:2020-06-01 00:00:00

  • Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses.

    abstract::Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules for naive T cell activation and expansion, dendritic cells are thought to also provide signals for the differentiation of CD4+ T ce...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-0465-0

    authors: Hilligan KL,Ronchese F

    更新日期:2020-06-01 00:00:00

  • Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics.

    abstract::Bispecific antibodies (bsAbs) refer to a large family of molecules that recognize two different epitopes or antigens. Although a series of challenges, especially immunogenicity and chain mispairing issues, once hindered the development of bsAbs, they have been gradually overcome with the help of rapidly developing tec...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-020-0417-8

    authors: Li H,Er Saw P,Song E

    更新日期:2020-05-01 00:00:00

  • The pathogenic role of innate lymphoid cells in autoimmune-related and inflammatory skin diseases.

    abstract::Innate lymphoid cells (ILCs), as an important component of the innate immune system, arise from a common lymphoid progenitor and are located in mucosal barriers and various tissues, including the intestine, skin, lung, and adipose tissue. ILCs are heterogeneous subsets of lymphocytes that have emerging roles in orches...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-020-0399-6

    authors: Zhou S,Li Q,Wu H,Lu Q

    更新日期:2020-04-01 00:00:00

  • NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.

    abstract::The human immunodeficiency virus-1 (HIV-1) envelope protein gp120 is the major contributor to the pathogenesis of HIV-associated neurocognitive disorder (HAND). Neuroinflammation plays a pivotal role in gp120-induced neuropathology, but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remai...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-019-0260-y

    authors: He X,Yang W,Zeng Z,Wei Y,Gao J,Zhang B,Li L,Liu L,Wan Y,Zeng Q,Gong Z,Liu L,Zhang H,Li Y,Yang S,Hu T,Wu L,Masliah E,Huang S,Cao H

    更新日期:2020-03-01 00:00:00

  • Correction to: Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Cellular & molecular immunology

    pub_type: 已发布勘误

    doi:10.1038/s41423-019-0332-z

    authors: Romanets-Korbut O,Kovalevska LM,Seya T,Sidorenko SP,Horvat B

    更新日期:2020-03-01 00:00:00

  • Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy.

    abstract::Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to investigate PD-1-inde...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-019-0305-2

    authors: Cai D,Li J,Liu D,Hong S,Qiao Q,Sun Q,Li P,Lyu N,Sun T,Xie S,Guo L,Ni L,Jin L,Dong C

    更新日期:2020-03-01 00:00:00

  • The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection.

    abstract::Epigenetic modifications to histones dictate the differentiation of naïve CD4+ T cells into different subsets of effector T helper (TH) cells. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been implicated in the mechanism regulating the differentiation of TH1, TH2 and regulatory T (Treg) cells. ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-019-0219-z

    authors: Chen X,Cao G,Wu J,Wang X,Pan Z,Gao J,Tian Q,Xu L,Li Z,Hao Y,Huang Q,Wang P,Xiao M,Xie L,Tang S,Liu Z,Hu L,Tang J,He R,Wang L,Zhou X,Wu Y,Chen M,Sun B,Zhu B,Huang J,Ye L

    更新日期:2020-03-01 00:00:00

  • Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells.

    abstract::Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells (MSCs). However, the biological function of chaperone-mediated autophagy (CMA) in MSCs remains elusive. Here, we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ (IFN-γ) ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-019-0345-7

    authors: Zhang J,Huang J,Gu Y,Xue M,Qian F,Wang B,Yang W,Yu H,Wang Q,Guo X,Ding X,Wang J,Jin M,Zhang Y

    更新日期:2020-01-03 00:00:00

  • Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment.

    abstract::The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to tumors. T-cell exhaustion and senescence induced by malignant tumors are two important dysfunctional states that coexist in cancer pat...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-019-0344-8

    authors: Zhao Y,Shao Q,Peng G

    更新日期:2020-01-01 00:00:00

  • TLR9 agonist enhances radiofrequency ablation-induced CTL responses, leading to the potent inhibition of primary tumor growth and lung metastasis.

    abstract::Radiofrequency ablation (RFA) is the most common approach to thermal ablation for cancer therapy. Unfortunately, its efficacy is limited by incomplete ablation, and further optimization of RFA is required. Here, we demonstrate that incubation at 65 °C triggers more EG7 tumor cell death by necrosis than treatment at 45...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-018-0184-y

    authors: Xu A,Zhang L,Yuan J,Babikr F,Freywald A,Chibbar R,Moser M,Zhang W,Zhang B,Fu Z,Xiang J

    更新日期:2019-10-01 00:00:00

  • Delayed allogeneic skin graft rejection in CD26-deficient mice.

    abstract::Organ transplantation is an effective therapeutic tool for treating many terminal diseases. However, one of the biggest challenges of transplantation is determining how to achieve the long-term survival of the allogeneic or xenogeneic transplant by, for example, preventing transplant rejection. In the current study, C...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-018-0009-z

    authors: Zhao X,Zhang K,Daniel P,Wisbrun N,Fuchs H,Fan H

    更新日期:2019-06-01 00:00:00

  • Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells.

    abstract::Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for mol...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-018-0041-z

    authors: Wei Y,Zhang F,Zhang Y,Wang X,Xing C,Guo J,Zhang H,Suo Z,Li Y,Wang J,Wang R,Cai Z

    更新日期:2019-06-01 00:00:00

  • High levels of circulating GM-CSF+CD4+ T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study.

    abstract::Granulocyte colony-stimulating factor (GM-CSF), produced by CD4+ T cells, has recently been implicated in the pathogenesis of inflammatory diseases, such as multiple sclerosis and juvenile arthritis. However, the role of GM-CSF-producing CD4+ T cells in sepsis remains unknown. This study reports peripheral changes in ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-018-0164-2

    authors: Huang H,Wang S,Jiang T,Fan R,Zhang Z,Mu J,Li K,Wang Y,Jin L,Lin F,Xia J,Sun L,Xu B,Ji C,Chen J,Chang J,Tu B,Song B,Zhang C,Wang FS,Xu R

    更新日期:2019-06-01 00:00:00

  • MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα.

    abstract::In human adipose tissue and obesity, miR-99a expression is negatively correlated with inflammation. Therefore, the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation. M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-018-0038-7

    authors: Jaiswal A,Reddy SS,Maurya M,Maurya P,Barthwal MK

    更新日期:2019-05-01 00:00:00

  • Innate lymphoid cell memory.

    abstract::Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-019-0212-6

    authors: Wang X,Peng H,Tian Z

    更新日期:2019-05-01 00:00:00

  • Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin.

    abstract::Induction of osteopontin (OPN), a well-known pro-inflammatory molecule, has been observed in acetaminophen (APAP)-induced hepatotoxicity. However, the precise cell source for OPN induction and its role during APAP-induced hepatotoxicity has not been fully explored. By employing a hepatotoxic mouse model induced by APA...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-018-0033-z

    authors: Wen Y,Wang C,Gu J,Yu C,Wang K,Sun X,Sun Y,Wu H,Tong Y,Xia Q,Kong X

    更新日期:2019-05-01 00:00:00

  • Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis.

    abstract::We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN. The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic candidiasis. We dis...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-018-0161-5

    authors: Chen WY,Wu SY,Lin TC,Lin SL,Wu-Hsieh BA

    更新日期:2019-03-01 00:00:00

  • Orchestration between ILC2s and Th2 cells in shaping type 2 immune responses.

    abstract::The type 2 immune response is critical for host defense against large parasites such as helminths. On the other hand, dysregulation of the type 2 immune response may cause immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis. Thus, a balanced type 2 immune response must be achi...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-019-0210-8

    authors: Gurram RK,Zhu J

    更新日期:2019-03-01 00:00:00

  • Tissue-resident lymphocytes: from adaptive to innate immunity.

    abstract::Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8+ memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of non...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-018-0192-y

    authors: Sun H,Sun C,Xiao W,Sun R

    更新日期:2019-03-01 00:00:00

  • Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia.

    abstract::The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia (PE), in which an imbalance between the inflammation-limiting regulatory T cells (Tregs) and the inflammation-mediating Th17 cells plays an essential role. Previously, we reported that the...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/s41423-018-0186-9

    authors: Ding H,Dai Y,Lei Y,Wang Z,Liu D,Li R,Shen L,Gu N,Zheng M,Zhu X,Zhao G,Hu Y

    更新日期:2019-01-01 00:00:00

  • Role of Hippo signaling in regulating immunity.

    abstract::The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In par...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41423-018-0007-1

    authors: Hong L,Li X,Zhou D,Geng J,Chen L

    更新日期:2018-12-01 00:00:00

  • Dust mite allergen-specific immunotherapy increases IL4 DNA methylation and induces Der p-specific T cell tolerance in children with allergic asthma.

    abstract::Allergen-specific immunotherapy (allergen-SIT) is a highly effective treatment for children with allergic asthma (AA), an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens. T helper cells and secreted cytokines play important roles in the p...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2017.26

    authors: Wang CM,Chang CB,Chan MW,Wen ZH,Wu SF

    更新日期:2018-11-01 00:00:00

  • Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis.

    abstract::Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for ...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2017.119

    authors: Consuegra-Fernández M,Julià M,Martínez-Florensa M,Aranda F,Català C,Armiger-Borràs N,Arias MT,Santiago F,Guilabert A,Esteve A,Muñoz C,Ferrándiz C,Carrascosa JM,Pedrosa E,Romaní J,Alsina M,Mascaró-Galy JM,Lozano F

    更新日期:2018-10-01 00:00:00

  • A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma.

    abstract::Programmed death one homolog (PD-1H) is a cell surface molecule of the B7/CD28 immune modulatory gene family. Although PD-1H has been shown to function as a coinhibitory receptor on T cells to limit naive T-cell activation and proliferation, its role in the regulation of the T-cell response to allergens is unknown. We...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章

    doi:10.1038/cmi.2017.16

    authors: Liu H,Li X,Hu L,Zhu M,He B,Luo L,Chen L

    更新日期:2018-09-01 00:00:00

  • The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation.

    abstract::Among various immunoregulatory molecules, the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy. Antibodies targeting two B7 family co-inhibitory receptors, CTLA-4 and PD-1, have elicited long-term clinical outcomes in previously refractory cancer types and are consi...

    journal_title:Cellular & molecular immunology

    pub_type: 杂志文章,评审

    doi:10.1038/cmi.2017.148

    authors: Xu W,Hiếu T,Malarkannan S,Wang L

    更新日期:2018-05-01 00:00:00

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