abstract：:Viral encephalitis is a devastating disease with high mortality, and survivors often suffer from severe neurological complications. Microglia are innate immune cells of the central nervous system (CNS) parenchyma whose turnover is reliant on local proliferation. Microglia express a diverse range of proteins, which all...

journal_title：Cellular & molecular immunology

authors： Chhatbar C,Prinz M

更新日期：2021-02-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the r...

journal_title：Cellular & molecular immunology

authors： Barroso A,Mahler JV,Fonseca-Castro PH,Quintana FJ

更新日期：2021-02-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations. Plaque psoriasis, which is the most common manifestation of psoriasis, is located on one end of the spectrum, dominated by adaptive immune responses, whereas the rarer pustular psoriasis lies on the opposite end,...

journal_title：Cellular & molecular immunology

authors： Uppala R,Tsoi LC,Harms PW,Wang B,Billi AC,Maverakis E,Michelle Kahlenberg J,Ward NL,Gudjonsson JE

更新日期：2021-02-01 00:00:00

abstract：:The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...

journal_title：Cellular & molecular immunology

authors： Horst AK,Kumashie KG,Neumann K,Diehl L,Tiegs G

更新日期：2021-01-01 00:00:00

abstract：:Activation of the TAK1 signalosome is crucial for mediating the innate immune response to pathogen invasion and is regulated by multiple layers of posttranslational modifications, including ubiquitination, SUMOylation, and phosphorylation; however, the underlying molecular mechanism is not fully understood. In this st...

journal_title：Cellular & molecular immunology

authors： Gu Z,Chen X,Yang W,Qi Y,Yu H,Wang X,Gong Y,Chen Q,Zhong B,Dai L,Qi S,Zhang Z,Zhang H,Hu H

更新日期：2020-11-12 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data a...

journal_title：Cellular & molecular immunology

authors： Hu F,Chen F,Ou Z,Fan Q,Tan X,Wang Y,Pan Y,Ke B,Li L,Guan Y,Mo X,Wang J,Wang J,Luo C,Wen X,Li M,Ren P,Ke C,Li J,Lei C,Tang X,Li F

更新日期：2020-11-01 00:00:00

abstract：:The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host immunity is poorly understood. We performed an extensive analysis of immune responses in 32 patients with severe COVID-19, some of whom succumbed. A control population of healthy subjects was included. Patients with COVID-19...

journal_title：Cellular & molecular immunology

authors： Varchetta S,Mele D,Oliviero B,Mantovani S,Ludovisi S,Cerino A,Bruno R,Castelli A,Mosconi M,Vecchia M,Roda S,Sachs M,Klersy C,Mondelli MU

更新日期：2020-10-15 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cellular & molecular immunology

authors： Alim MA,Grujic M,Ackermann PW,Kristiansson P,Blomgran P,Eliasson P,Peterson M,Pejler G

更新日期：2020-10-01 00:00:00

abstract：:Epigenetic regulation of gene expression in cancer cells has been extensively studied in recent decades, resulting in the FDA approval of multiple epigenetic agents for treating different cancer types. Recent studies have revealed novel roles of epigenetic dysregulation in altering the phenotypes of immune cells and t...

journal_title：Cellular & molecular immunology

authors： Pan X,Zheng L

更新日期：2020-09-01 00:00:00

abstract：:The interactions of CD4+ T cells and B cells are fundamental for the generation of protective antibody responses, as well as for the development of harmful autoimmune diseases. Recent studies of human tissues and blood samples have established a new subset of CD4+ B helper T cells named peripheral helper T (Tph) cells...

journal_title：Cellular & molecular immunology

authors： Yoshitomi H,Ueno H

更新日期：2020-08-31 00:00:00

abstract：:In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB (glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with tumor cells. Here, using mouse tumor models, we show that macrophage-derived soluble GPNMB increases tumor growth and metastasis in Gpnmb-mu...

journal_title：Cellular & molecular immunology

authors： Liguori M,Digifico E,Vacchini A,Avigni R,Colombo FS,Borroni EM,Farina FM,Milanesi S,Castagna A,Mannarino L,Craparotta I,Marchini S,Erba E,Panini N,Tamborini M,Rimoldi V,Allavena P,Belgiovine C

更新日期：2020-07-29 00:00:00

abstract：:Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltrat...

journal_title：Cellular & molecular immunology

authors： Shen Z,Kuang S,Zhang M,Huang X,Chen J,Guan M,Qin W,Xu HHK,Lin Z

更新日期：2020-07-16 00:00:00

abstract：:Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to the induction of downstream antiviral effectors and the innate antiviral immune response. Here, we identified the zinc-finger FYVE domain-containing protein ZFYVE1, a guanylate-binding protein (GBP), as a positive regulator of TLR3-mediated signaling. ...

journal_title：Cellular & molecular immunology

authors： Zhong X,Feng L,Xu WH,Wu X,Ding YD,Zhou Y,Lei CQ,Shu HB

更新日期：2020-07-01 00:00:00

abstract：:Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules for naive T cell activation and expansion, dendritic cells are thought to also provide signals for the differentiation of CD4+ T ce...

journal_title：Cellular & molecular immunology

authors： Hilligan KL,Ronchese F

更新日期：2020-06-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding domain (RBD), and thus is believed to be a major target to block...

journal_title：Cellular & molecular immunology

authors： Yi C,Sun X,Ye J,Ding L,Liu M,Yang Z,Lu X,Zhang Y,Ma L,Gu W,Qu A,Xu J,Shi Z,Ling Z,Sun B

更新日期：2020-06-01 00:00:00

abstract：:In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...

journal_title：Cellular & molecular immunology

authors： Lee S,Ko Y,Kim TJ

更新日期：2020-06-01 00:00:00

abstract：:Bispecific antibodies (bsAbs) refer to a large family of molecules that recognize two different epitopes or antigens. Although a series of challenges, especially immunogenicity and chain mispairing issues, once hindered the development of bsAbs, they have been gradually overcome with the help of rapidly developing tec...

journal_title：Cellular & molecular immunology

authors： Li H,Er Saw P,Song E

更新日期：2020-05-01 00:00:00

abstract：:Innate lymphoid cells (ILCs), as an important component of the innate immune system, arise from a common lymphoid progenitor and are located in mucosal barriers and various tissues, including the intestine, skin, lung, and adipose tissue. ILCs are heterogeneous subsets of lymphocytes that have emerging roles in orches...

journal_title：Cellular & molecular immunology

authors： Zhou S,Li Q,Wu H,Lu Q

更新日期：2020-04-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cellular & molecular immunology

authors： Romanets-Korbut O,Kovalevska LM,Seya T,Sidorenko SP,Horvat B

更新日期：2020-03-01 00:00:00

abstract：:Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to investigate PD-1-inde...

journal_title：Cellular & molecular immunology

authors： Cai D,Li J,Liu D,Hong S,Qiao Q,Sun Q,Li P,Lyu N,Sun T,Xie S,Guo L,Ni L,Jin L,Dong C

更新日期：2020-03-01 00:00:00

abstract：:The human immunodeficiency virus-1 (HIV-1) envelope protein gp120 is the major contributor to the pathogenesis of HIV-associated neurocognitive disorder (HAND). Neuroinflammation plays a pivotal role in gp120-induced neuropathology, but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remai...

journal_title：Cellular & molecular immunology

authors： He X,Yang W,Zeng Z,Wei Y,Gao J,Zhang B,Li L,Liu L,Wan Y,Zeng Q,Gong Z,Liu L,Zhang H,Li Y,Yang S,Hu T,Wu L,Masliah E,Huang S,Cao H

更新日期：2020-03-01 00:00:00

abstract：:Epigenetic modifications to histones dictate the differentiation of naïve CD4+ T cells into different subsets of effector T helper (TH) cells. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been implicated in the mechanism regulating the differentiation of TH1, TH2 and regulatory T (Treg) cells. ...

journal_title：Cellular & molecular immunology

authors： Chen X,Cao G,Wu J,Wang X,Pan Z,Gao J,Tian Q,Xu L,Li Z,Hao Y,Huang Q,Wang P,Xiao M,Xie L,Tang S,Liu Z,Hu L,Tang J,He R,Wang L,Zhou X,Wu Y,Chen M,Sun B,Zhu B,Huang J,Ye L

更新日期：2020-03-01 00:00:00

abstract：:Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells (MSCs). However, the biological function of chaperone-mediated autophagy (CMA) in MSCs remains elusive. Here, we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ (IFN-γ) ...

journal_title：Cellular & molecular immunology

authors： Zhang J,Huang J,Gu Y,Xue M,Qian F,Wang B,Yang W,Yu H,Wang Q,Guo X,Ding X,Wang J,Jin M,Zhang Y

更新日期：2020-01-03 00:00:00

abstract：:The failure of a massive influx of tumor-infiltrating T lymphocytes to eradicate tumor cells in the tumor microenvironment is mainly due to the dysfunction of T cells hyporesponsive to tumors. T-cell exhaustion and senescence induced by malignant tumors are two important dysfunctional states that coexist in cancer pat...

journal_title：Cellular & molecular immunology

authors： Zhao Y,Shao Q,Peng G

更新日期：2020-01-01 00:00:00

abstract：:Radiofrequency ablation (RFA) is the most common approach to thermal ablation for cancer therapy. Unfortunately, its efficacy is limited by incomplete ablation, and further optimization of RFA is required. Here, we demonstrate that incubation at 65 °C triggers more EG7 tumor cell death by necrosis than treatment at 45...

journal_title：Cellular & molecular immunology

authors： Xu A,Zhang L,Yuan J,Babikr F,Freywald A,Chibbar R,Moser M,Zhang W,Zhang B,Fu Z,Xiang J

更新日期：2019-10-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (GM-CSF), produced by CD4+ T cells, has recently been implicated in the pathogenesis of inflammatory diseases, such as multiple sclerosis and juvenile arthritis. However, the role of GM-CSF-producing CD4+ T cells in sepsis remains unknown. This study reports peripheral changes in ...

journal_title：Cellular & molecular immunology

authors： Huang H,Wang S,Jiang T,Fan R,Zhang Z,Mu J,Li K,Wang Y,Jin L,Lin F,Xia J,Sun L,Xu B,Ji C,Chen J,Chang J,Tu B,Song B,Zhang C,Wang FS,Xu R

更新日期：2019-06-01 00:00:00

abstract：:Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for mol...

journal_title：Cellular & molecular immunology

authors： Wei Y,Zhang F,Zhang Y,Wang X,Xing C,Guo J,Zhang H,Suo Z,Li Y,Wang J,Wang R,Cai Z

更新日期：2019-06-01 00:00:00

abstract：:Organ transplantation is an effective therapeutic tool for treating many terminal diseases. However, one of the biggest challenges of transplantation is determining how to achieve the long-term survival of the allogeneic or xenogeneic transplant by, for example, preventing transplant rejection. In the current study, C...

journal_title：Cellular & molecular immunology

authors： Zhao X,Zhang K,Daniel P,Wisbrun N,Fuchs H,Fan H

更新日期：2019-06-01 00:00:00

abstract：:Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, ...

journal_title：Cellular & molecular immunology

authors： Wang X,Peng H,Tian Z

更新日期：2019-05-01 00:00:00

abstract：:In human adipose tissue and obesity, miR-99a expression is negatively correlated with inflammation. Therefore, the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation. M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and ...

journal_title：Cellular & molecular immunology

authors： Jaiswal A,Reddy SS,Maurya M,Maurya P,Barthwal MK

更新日期：2019-05-01 00:00:00

abstract：:Induction of osteopontin (OPN), a well-known pro-inflammatory molecule, has been observed in acetaminophen (APAP)-induced hepatotoxicity. However, the precise cell source for OPN induction and its role during APAP-induced hepatotoxicity has not been fully explored. By employing a hepatotoxic mouse model induced by APA...

journal_title：Cellular & molecular immunology

authors： Wen Y,Wang C,Gu J,Yu C,Wang K,Sun X,Sun Y,Wu H,Tong Y,Xia Q,Kong X

更新日期：2019-05-01 00:00:00

abstract：:The type 2 immune response is critical for host defense against large parasites such as helminths. On the other hand, dysregulation of the type 2 immune response may cause immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis. Thus, a balanced type 2 immune response must be achi...

journal_title：Cellular & molecular immunology

authors： Gurram RK,Zhu J

更新日期：2019-03-01 00:00:00

abstract：:Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8+ memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of non...

journal_title：Cellular & molecular immunology

authors： Sun H,Sun C,Xiao W,Sun R

更新日期：2019-03-01 00:00:00

abstract：:We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN. The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic candidiasis. We dis...

journal_title：Cellular & molecular immunology

authors： Chen WY,Wu SY,Lin TC,Lin SL,Wu-Hsieh BA

更新日期：2019-03-01 00:00:00

abstract：:The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia (PE), in which an imbalance between the inflammation-limiting regulatory T cells (Tregs) and the inflammation-mediating Th17 cells plays an essential role. Previously, we reported that the...

journal_title：Cellular & molecular immunology

authors： Ding H,Dai Y,Lei Y,Wang Z,Liu D,Li R,Shen L,Gu N,Zheng M,Zhu X,Zhao G,Hu Y

更新日期：2019-01-01 00:00:00

abstract：:The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In par...

journal_title：Cellular & molecular immunology

authors： Hong L,Li X,Zhou D,Geng J,Chen L

更新日期：2018-12-01 00:00:00

abstract：:Allergen-specific immunotherapy (allergen-SIT) is a highly effective treatment for children with allergic asthma (AA), an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens. T helper cells and secreted cytokines play important roles in the p...

journal_title：Cellular & molecular immunology

authors： Wang CM,Chang CB,Chan MW,Wen ZH,Wu SF

更新日期：2018-11-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for ...

journal_title：Cellular & molecular immunology

authors： Consuegra-Fernández M,Julià M,Martínez-Florensa M,Aranda F,Català C,Armiger-Borràs N,Arias MT,Santiago F,Guilabert A,Esteve A,Muñoz C,Ferrándiz C,Carrascosa JM,Pedrosa E,Romaní J,Alsina M,Mascaró-Galy JM,Lozano F

更新日期：2018-10-01 00:00:00

abstract：:Programmed death one homolog (PD-1H) is a cell surface molecule of the B7/CD28 immune modulatory gene family. Although PD-1H has been shown to function as a coinhibitory receptor on T cells to limit naive T-cell activation and proliferation, its role in the regulation of the T-cell response to allergens is unknown. We...

journal_title：Cellular & molecular immunology

authors： Liu H,Li X,Hu L,Zhu M,He B,Luo L,Chen L

更新日期：2018-09-01 00:00:00

abstract：:Among various immunoregulatory molecules, the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy. Antibodies targeting two B7 family co-inhibitory receptors, CTLA-4 and PD-1, have elicited long-term clinical outcomes in previously refractory cancer types and are consi...

journal_title：Cellular & molecular immunology

authors： Xu W,Hiếu T,Malarkannan S,Wang L

更新日期：2018-05-01 00:00:00