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The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation.

Abstract：

:Among various immunoregulatory molecules, the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy. Antibodies targeting two B7 family co-inhibitory receptors, CTLA-4 and PD-1, have elicited long-term clinical outcomes in previously refractory cancer types and are considered a breakthrough in cancer therapy. Despite the success, the relatively low response rate (20-30%) warrants efforts to identify and overcome additional immune-suppressive pathways. Among the expanding list of T cell inhibitory regulators, V domain immunoglobulin suppressor of T cell activation (VISTA) is a unique B7 family checkpoint that regulates a broad spectrum of immune responses. Here, we summarize recent advances that highlight the structure, expression, and multi-faceted immunomodulatory mechanisms of VISTA in the context of autoimmunity, inflammation, and anti-tumor immunity.

journal_name

Cell Mol Immunol

journal_title

Cellular & molecular immunology

authors

Xu W,Hiếu T,Malarkannan S,Wang L

doi

10.1038/cmi.2017.148

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

438-446

issue

5

eissn

1672-7681

issn

2042-0226

pii

10.1038/cmi.2017.148

journal_volume

15

pub_type

杂志文章,评审

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