当前位置： SCI文献检索 > Cellular & Molecular Immunology期刊下所有文献 > The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.

The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.

Abstract：

:In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB (glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with tumor cells. Here, using mouse tumor models, we show that macrophage-derived soluble GPNMB increases tumor growth and metastasis in Gpnmb-mutant mice (DBA/2J). GPNMB triggers in the cancer cells the formation of self-renewing spheroids, which are characterized by the expression of cancer stem cell markers, prolonged cell survival and increased tumor-forming ability. Through the CD44 receptor, GPNMB mechanistically activates tumor cells to express the cytokine IL-33 and its receptor IL-1R1L. We also determined that recombinant IL-33 binding to IL-1R1L is sufficient to induce tumor spheroid formation with features of cancer stem cells. Overall, our results reveal a new paracrine axis, GPNMB and IL-33, which is activated during the cross talk of macrophages with tumor cells and eventually promotes cancer cell survival, the expansion of cancer stem cells and the acquisition of a metastatic phenotype.

journal_name

Cell Mol Immunol

journal_title

Cellular & molecular immunology

authors

Liguori M,Digifico E,Vacchini A,Avigni R,Colombo FS,Borroni EM,Farina FM,Milanesi S,Castagna A,Mannarino L,Craparotta I,Marchini S,Erba E,Panini N,Tamborini M,Rimoldi V,Allavena P,Belgiovine C

doi

10.1038/s41423-020-0501-0

subject

Has Abstract

pub_date

2020-07-29 00:00:00

eissn

1672-7681

issn

2042-0226

pii

10.1038/s41423-020-0501-0

pub_type

杂志文章

相关文献

Cellular & Molecular Immunology文献大全
  • Chemoattractants and cytokines in primary ciliary dyskinesia and cystic fibrosis: key players in chronic respiratory diseases.

    abstract：:Patients with primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), two inherited disorders, suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable inflammation. Although present in high counts, neutrophils fail to clear infection in the airways. High levels ...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/cmi.2017.118

    authors： Cockx M,Gouwy M,Van Damme J,Struyf S

    更新日期：2018-04-01 00:00:00

  • Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis.

    abstract：:We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN. The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic candidiasis. We dis...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-018-0161-5

    authors： Chen WY,Wu SY,Lin TC,Lin SL,Wu-Hsieh BA

    更新日期：2019-03-01 00:00:00

  • TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells.

    abstract：:The combination of immunotherapy and chemotherapy is regarded as a promising approach for the treatment of certain types of cancer. However, the underlying mechanisms need to be fully investigated to guide the design of more efficient protocols for cancer chemoimmunotherapy. It is well known that danger-associated mol...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2013.59

    authors： Fang H,Ang B,Xu X,Huang X,Wu Y,Sun Y,Wang W,Li N,Cao X,Wan T

    更新日期：2014-03-01 00:00:00

  • A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract.

    abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data a...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-020-00550-2

    authors： Hu F,Chen F,Ou Z,Fan Q,Tan X,Wang Y,Pan Y,Ke B,Li L,Guan Y,Mo X,Wang J,Wang J,Luo C,Wen X,Li M,Ren P,Ke C,Li J,Lei C,Tang X,Li F

    更新日期：2020-11-01 00:00:00

  • The complement system in liver diseases.

    abstract：:The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver (mainly hepatocytes) is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：

    authors： Qin X,Gao B

    更新日期：2006-10-01 00:00:00

  • Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters.

    abstract：:Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We aimed to assess the effects of simulated weightlessness (Second Berlin BedRest Study; BBR2-2) on immunologica...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/cmi.2014.106

    authors： Hoff P,Belavý DL,Huscher D,Lang A,Hahne M,Kuhlmey AK,Maschmeyer P,Armbrecht G,Fitzner R,Perschel FH,Gaber T,Burmester GR,Straub RH,Felsenberg D,Buttgereit F

    更新日期：2015-07-01 00:00:00

  • The roles of microglia in viral encephalitis: from sensome to therapeutic targeting.

    abstract：:Viral encephalitis is a devastating disease with high mortality, and survivors often suffer from severe neurological complications. Microglia are innate immune cells of the central nervous system (CNS) parenchyma whose turnover is reliant on local proliferation. Microglia express a diverse range of proteins, which all...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/s41423-020-00620-5

    authors： Chhatbar C,Prinz M

    更新日期：2021-02-01 00:00:00

  • Construction and identification of a human liver specific microRNA eukaryotic expression vector.

    abstract：:MiR-122 is one of the non-coding RNAs which showed its effects on the lipo-metablism, virus infection and HCC forming through regulation of liver gene expression. Its eukaryotic expression vector was constructed by using pSuper which was widely applied in the siRNA expression. The precursor of human miR-122 gene was a...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：

    authors： Chen S,Ni M,Yu B,Lv T,Lu M,Gong F

    更新日期：2007-12-01 00:00:00

  • HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction.

    abstract：:The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK) cells. Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they c...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/cmi.2014.53

    authors： Rajagopalan S

    更新日期：2014-09-01 00:00:00

  • Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy.

    abstract：:Decidual natural killer (dNK) cells express an array of activation receptors to regulate placental immunity and development during early pregnancy. We investigated the functional character of human dNK cells during the first and second trimester of gestation and the interaction between dNK and trophoblast cells. Altho...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2015.66

    authors： Zhang J,Dunk CE,Kwan M,Jones RL,Harris LK,Keating S,Lye SJ

    更新日期：2017-02-01 00:00:00

  • Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression.

    abstract：:MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs, and changes in miRNAs are involved in tumor origin and progression. Studies have shown that miR-20a is overexpressed in human ovarian cancer tissues and that this miRNA enhances long-term cellular proliferation and invasion capabilities. In this study...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2014.30

    authors： Xie J,Liu M,Li Y,Nie Y,Mi Q,Zhao S

    更新日期：2014-09-01 00:00:00

  • Heat shock protein and innate immunity.

    abstract：:In addition to serving as molecular chaperones, heat shock proteins (HSPs) have been implicated in autoimmune diseases, antigen presentation and tumor immunity. Extensive work in the last 10 years has also suggested that HSPs such as Hsp60, Hsp70, Hsp90 and gp96, may be potent activators of the innate immune system ca...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：

    authors： Tsan MF,Gao B

    更新日期：2004-08-01 00:00:00

  • Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy.

    abstract：:Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to investigate PD-1-inde...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-019-0305-2

    authors： Cai D,Li J,Liu D,Hong S,Qiao Q,Sun Q,Li P,Lyu N,Sun T,Xie S,Guo L,Ni L,Jin L,Dong C

    更新日期：2020-03-01 00:00:00

  • Chemokine receptors and transplantation.

    abstract：:A complex process including both the innate and acquired immune responses results in allograft rejection. Some chemokine receptors and their ligands play essential roles not only for leukocyte migration into the graft but also in facilitating dendritic and T cell trafficking between lymph nodes and the transplant in t...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：

    authors： Tan J,Zhou G

    更新日期：2005-10-01 00:00:00

  • Trogocytosis of CD80 and CD86 by induced regulatory T cells.

    abstract：:Trogocytosis is a process which involves the transfer of membrane fragments and cell surface proteins between cells. Various types of T cells have been shown to be able to acquire membrane-bound proteins from antigen-presenting cells and their functions can be modulated following trogocytosis. However, it is not known...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2011.62

    authors： Gu P,Gao JF,D'Souza CA,Kowalczyk A,Chou KY,Zhang L

    更新日期：2012-03-01 00:00:00

  • Multifunctional immune responses of HMBPP-specific Vγ2Vδ2 T cells in M. tuberculosis and other infections.

    abstract：:Vγ2Vδ2 T (also known as Vγ9Vδ2 T) cells exist only in primates, and in humans represent a major γδ T-cell sub-population in the total population of circulating γδ T cells. Results from recent studies suggest that while (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) phosphoantigen from Mycobacterium tuberculos...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/cmi.2012.46

    authors： Chen ZW

    更新日期：2013-01-01 00:00:00

  • The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response.

    abstract：:Activation of the TAK1 signalosome is crucial for mediating the innate immune response to pathogen invasion and is regulated by multiple layers of posttranslational modifications, including ubiquitination, SUMOylation, and phosphorylation; however, the underlying molecular mechanism is not fully understood. In this st...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-020-00564-w

    authors： Gu Z,Chen X,Yang W,Qi Y,Yu H,Wang X,Gong Y,Chen Q,Zhong B,Dai L,Qi S,Zhang Z,Zhang H,Hu H

    更新日期：2020-11-12 00:00:00

  • Molecular mechanisms regulating NLRP3 inflammasome activation.

    abstract：:Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NL...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/cmi.2015.95

    authors： Jo EK,Kim JK,Shin DM,Sasakawa C

    更新日期：2016-03-01 00:00:00

  • Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases.

    abstract：:Transplantation of mesenchymal stem cells (MSCs) has been recently studied in animal models, and in clinical trials of patients with fulminant hepatic failure, end-stage liver diseases and inherited metabolic disorders. Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liv...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/cmi.2010.57

    authors： Lin H,Xu R,Zhang Z,Chen L,Shi M,Wang FS

    更新日期：2011-01-01 00:00:00

  • RGD-FasL induces apoptosis in hepatocellular carcinoma.

    abstract：:Despite impressive results obtained in animal models, the clinical use of Fas ligand (FasL) as an anticancer drug is limited by severe toxicity. Systemic toxicity of death ligands may be prevented by using genes encoding membrane-bound death ligands and by targeted transgene expression through either targeted transduc...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,收录出版

    doi：10.1038/cmi.2009.38

    authors： Liu Z,Wang J,Yin P,Qiu J,Liu R,Li W,Fan X,Cheng X,Chen C,Zhang J,Zhuang G

    更新日期：2009-08-01 00:00:00

  • EBV-induced human CD8(+) NKT cells synergise CD4(+) NKT cells suppressing EBV-associated tumours upon induction of Th1-bias.

    abstract：:CD8(+) natural killer T (NKT) cells from EBV-associated tumour patients are quantitatively and functionally impaired. EBV-induced CD8(+) NKT cells drive syngeneic T cells into a Th1-bias response to suppress EBV-associated malignancies. IL-4-biased CD4(+) NKT cells do not affect either syngeneic T cell cytotoxicity or...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2009.48

    authors： Xiao W,Li L,Zhou R,Xiao R,Wang Y,Ji X,Wu M,Wang L,Huang W,Zheng X,Tan X,Chen L,Xiong T,Xiong J,Jin Y,Tan J,He Y

    更新日期：2009-10-01 00:00:00

  • Unique immunological profile in patients with COVID-19.

    abstract：:The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host immunity is poorly understood. We performed an extensive analysis of immune responses in 32 patients with severe COVID-19, some of whom succumbed. A control population of healthy subjects was included. Patients with COVID-19...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-020-00557-9

    authors： Varchetta S,Mele D,Oliviero B,Mantovani S,Ludovisi S,Cerino A,Bruno R,Castelli A,Mosconi M,Vecchia M,Roda S,Sachs M,Klersy C,Mondelli MU

    更新日期：2020-10-15 00:00:00

  • Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment.

    abstract：:Epigenetic regulation of gene expression in cancer cells has been extensively studied in recent decades, resulting in the FDA approval of multiple epigenetic agents for treating different cancer types. Recent studies have revealed novel roles of epigenetic dysregulation in altering the phenotypes of immune cells and t...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/s41423-020-0505-9

    authors： Pan X,Zheng L

    更新日期：2020-09-01 00:00:00

  • Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B-cell hyperreactivity. The Toll-like receptor 7 (TLR7) signaling pathway is abnormally activated in SLE B cells. CyclinD3 (CCND3) plays an important role in B-cell proliferation, development, and differentiation. Although previous studies fo...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2015.48

    authors： Ren D,Liu F,Dong G,You M,Ji J,Huang Y,Hou Y,Fan H

    更新日期：2016-11-01 00:00:00

  • The effects of aerosolized STAT1 antisense oligodeoxynucleotides on rat pulmonary fibrosis.

    abstract：:Previous study showed that aerosolized signal transducer and activator of transcription-1 (STAT1) antisense oligodeoxynucleotide (ASON) inhibited the expression of STAT1 and ICAM-1 mRNA and protein in alveolar macrophages (AMs) and decreased the concentrations of TGF-beta, PDGF and TNF-alpha in bronchioalveolar lavage...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2009.7

    authors： Wang WJ,Liao B,Zeng M,Zhu C,Fan XM

    更新日期：2009-02-01 00:00:00

  • Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases.

    abstract：:The interactions of CD4+ T cells and B cells are fundamental for the generation of protective antibody responses, as well as for the development of harmful autoimmune diseases. Recent studies of human tissues and blood samples have established a new subset of CD4+ B helper T cells named peripheral helper T (Tph) cells...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/s41423-020-00529-z

    authors： Yoshitomi H,Ueno H

    更新日期：2020-08-31 00:00:00

  • TLR9 agonist enhances radiofrequency ablation-induced CTL responses, leading to the potent inhibition of primary tumor growth and lung metastasis.

    abstract：:Radiofrequency ablation (RFA) is the most common approach to thermal ablation for cancer therapy. Unfortunately, its efficacy is limited by incomplete ablation, and further optimization of RFA is required. Here, we demonstrate that incubation at 65 °C triggers more EG7 tumor cell death by necrosis than treatment at 45...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/s41423-018-0184-y

    authors： Xu A,Zhang L,Yuan J,Babikr F,Freywald A,Chibbar R,Moser M,Zhang W,Zhang B,Fu Z,Xiang J

    更新日期：2019-10-01 00:00:00

  • Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity.

    abstract：:Follicular helper T (Tfh) cells select mutated B cells in germinal centres, which can then differentiate into long-lived high affinity memory B cells and plasma cells. Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6. This transcription factor turns down expres...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章,评审

    doi：10.1038/cmi.2010.18

    authors： Yu D,Vinuesa CG

    更新日期：2010-05-01 00:00:00

  • Altered endothelin-1 signaling in production of thromboxane A2 in kupffer cells from bile duct ligated rats.

    abstract：:Kupffer cells (KCs), the liver resident macrophages accounting for 80-90% of the total population of fixed tissue macrophages in the body, not only play a key role in host defense via removing particulate materials from the portal circulation, but may also contribute to the pathogenesis of various liver diseases. We h...

    journal_title：Cellular & molecular immunology

    pub_type： 杂志文章

    doi：10.1038/cmi.2009.56

    authors： Miller AM,Zhang JX

    更新日期：2009-12-01 00:00:00

  • Correction to: Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Cellular & molecular immunology

    pub_type： 已发布勘误

    doi：10.1038/s41423-019-0332-z

    authors： Romanets-Korbut O,Kovalevska LM,Seya T,Sidorenko SP,Horvat B

    更新日期：2020-03-01 00:00:00