Abstract：
:Follicular helper T (Tfh) cells select mutated B cells in germinal centres, which can then differentiate into long-lived high affinity memory B cells and plasma cells. Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6. This transcription factor turns down expression of multiple genes, including transcriptional regulators of other T helper lineages and a vast amount of microRNAs. This enables Tfh cells to express a suite of chemokine receptors, stimulatory ligands and cytokines that enable migration into B-cell follicles, and provision of effective help to B cells. Not surprisingly, dysregulation of this powerful helper subset can lead to a range of autoantibody-mediated diseases; indeed, aberrant accumulation of Tfh cells has been linked with systemic lupus erythematosus, Sjogren's disease and autoimmune arthritis. Here we dissect multiple checkpoints that operate throughout Tfh cell development and maturation to maintain immunological tolerance while mounting robust and long-lasting antibody responses.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Yu D,Vinuesa CGdoi
10.1038/cmi.2010.18subject
Has Abstractpub_date
2010-05-01 00:00:00pages
198-203issue
3eissn
1672-7681issn
2042-0226pii
cmi201018journal_volume
7pub_type
杂志文章,评审abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Cellular & molecular immunology
pub_type： 已发布勘误
doi：10.1038/s41423-020-00543-1
更新日期：2020-10-01 00:00:00
abstract：:The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK) cells. Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they c...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2014.53
更新日期：2014-09-01 00:00:00
abstract：:The outcome of hepatitis B viral (HBV) infection is determined by the complex interactions between replicating HBV and the immune system. While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively, the contribution of innate immune mechanisms remains to be defined. Her...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2017.43
更新日期：2017-12-01 00:00:00
abstract：:The type 2 immune response is critical for host defense against large parasites such as helminths. On the other hand, dysregulation of the type 2 immune response may cause immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis. Thus, a balanced type 2 immune response must be achi...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-019-0210-8
更新日期：2019-03-01 00:00:00
abstract：:Cytomegaloviruses (CMVs), members of the herpesvirus family, have evolved a variety of mechanisms to evade the immune response to survive in infected hosts and to establish latent infection. They effectively hide infected cells from the effector mechanisms of adaptive immunity by eliminating cellular proteins (major h...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2014.85
更新日期：2015-03-01 00:00:00
abstract：:Natural killer (NK) cells are bone marrow-derived lymphocytes. They produce cytokines that regulate the development of acquired immunity. In view of their accumulation at the maternal-fetal interface, uterine natural killer (uNK) cells are also thought to play essential roles during pregnancy. Our results compared the...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：:In human adipose tissue and obesity, miR-99a expression is negatively correlated with inflammation. Therefore, the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation. M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-018-0038-7
更新日期：2019-05-01 00:00:00
abstract：:The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance. Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver m...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-020-00568-6
更新日期：2021-01-01 00:00:00
abstract：:Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2015.11
更新日期：2016-05-01 00:00:00
abstract：:Transplantable experimental tumor models were constructed to study the activities of recombinant human interleukin-15 (rhIL-15) against tumor recurrence and metastasis. The results showed that tumor nodule formation was retarded and tumor growth was inhibited in the subcutaneous tumor model of LA795 lung adenocarcinom...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2008.23
更新日期：2008-06-01 00:00:00
abstract：:pR(ST98) is a large and conjugative resistant plasmid (R plasmid) of 98.6 mega-dalton from multi-drug resistant Salmonella typhi (S. typhi), which was classified to incompatibility group C (Inc C). It has been found that pRST98 made its host bacteria not only antibiotic resistant but also more virulent. In this study ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2005-04-01 00:00:00
abstract：:The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In par...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-018-0007-1
更新日期：2018-12-01 00:00:00
abstract：:Kupffer cells (KCs), the liver resident macrophages accounting for 80-90% of the total population of fixed tissue macrophages in the body, not only play a key role in host defense via removing particulate materials from the portal circulation, but may also contribute to the pathogenesis of various liver diseases. We h...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.56
更新日期：2009-12-01 00:00:00
abstract：:Previous study showed that aerosolized signal transducer and activator of transcription-1 (STAT1) antisense oligodeoxynucleotide (ASON) inhibited the expression of STAT1 and ICAM-1 mRNA and protein in alveolar macrophages (AMs) and decreased the concentrations of TGF-beta, PDGF and TNF-alpha in bronchioalveolar lavage...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.7
更新日期：2009-02-01 00:00:00
abstract：:B cells are generally considered to be positive regulators of the immune response because of their capability to produce antibodies, including autoantibodies. The production of antibodies facilitates optimal CD4(+) T-cell activation because B cells serve as antigen-presenting cells and exert other modulatory functions...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2012.60
更新日期：2013-03-01 00:00:00
abstract：:In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB (glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with tumor cells. Here, using mouse tumor models, we show that macrophage-derived soluble GPNMB increases tumor growth and metastasis in Gpnmb-mu...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-020-0501-0
更新日期：2020-07-29 00:00:00
abstract：:Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltrat...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-020-0500-1
更新日期：2020-07-16 00:00:00
abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data a...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-020-00550-2
更新日期：2020-11-01 00:00:00
abstract：:Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of he...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.15
更新日期：2009-04-01 00:00:00
abstract：:Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8+ memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of non...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-018-0192-y
更新日期：2019-03-01 00:00:00
abstract：:We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive regulatory protein (rLrp) inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α), interleukin-6, and interleukin-12 production and blocks the nuclear translocation of subunits of the nuclear-receptor transcription fact...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2015.58
更新日期：2016-11-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the r...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/s41423-020-00585-5
更新日期：2021-02-01 00:00:00
abstract：:Some pathogens can use host suppressor of cytokine signaling 1 (SOCS-1), an important negative-feedback molecule, as the main mode of immune evasion. Here we found that group A Streptococcus (GAS) is capable of inducing SOCS-1 expression in RAW264.7 and BMDM macrophages. IFN-β plays a role in GAS-induced SOCS-1 expres...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2014.107
更新日期：2015-05-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Cellular & molecular immunology
pub_type： 已发布勘误
doi：10.1038/s41423-019-0332-z
更新日期：2020-03-01 00:00:00
abstract：:Interleukin-22 (IL-22) is a recently identified T cell-derived cytokine whose biological significance remains obscure. Previously, we have shown that IL-22 plays a protective role in T cell-mediated hepatitis induced by Concanavalin A (Con A), acting as a survival factor for hepatocytes. In the present paper, we demon...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
abstract：:Many monoclonal antibodies (mAbs) have been extensively used in the clinic, such as rituximab to treat lymphoma. However, resistance and non-responsiveness to mAb treatment have been challenging for this line of therapy. Complement is one of the main mediators of antibody-based cancer therapy via the complement-depend...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2010.35
更新日期：2011-03-01 00:00:00
abstract：:We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN. The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic candidiasis. We dis...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/s41423-018-0161-5
更新日期：2019-03-01 00:00:00
abstract：:Transplantation of mesenchymal stem cells (MSCs) has been recently studied in animal models, and in clinical trials of patients with fulminant hepatic failure, end-stage liver diseases and inherited metabolic disorders. Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liv...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章,评审
doi：10.1038/cmi.2010.57
更新日期：2011-01-01 00:00:00
abstract：:Immunoglobulins (Igs) are known to be synthesized and secreted only by B lymphocytes. Class switch recombination (CSR) is a key event that enables B cells to express Igs, and one of the crucial steps for CSR initiation is the germline transcription of Ig genes. Surprisingly, recent studies have demonstrated that the I...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2013.52
更新日期：2014-03-01 00:00:00
abstract：:The unmethylated CpG DNA can prevent spontaneous apoptosis of B cells. However, the precise mechanisms by which CpG DNA blocks apoptosis remain unclear. In this study, we showed B cell apoptosis was significantly inhibited by addition of CpG DNA. Treatment of CpG DNA could reduce the expression of caspase 3, increase ...
journal_title：Cellular & molecular immunology
pub_type： 杂志文章
doi：10.1038/cmi.2009.24
更新日期：2009-06-01 00:00:00
