Abstract:
:Transplantation of mesenchymal stem cells (MSCs) has been recently studied in animal models, and in clinical trials of patients with fulminant hepatic failure, end-stage liver diseases and inherited metabolic disorders. Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liver, thereby attenuating inflammatory injury and reducing hepatocyte apoptosis. In addition, MSCs play an important role in regressing liver fibrosis and in supporting the function, proliferation and differentiation of endogenous hepatocytes under appropriate conditions. Although remarkable progress has been achieved in basic and clinical MSC studies, optimal therapeutic regimens for the clinical application of MSCs, such as optimal doses, transplantation routine and interval period for transplantation, need to be elucidated in detail. Furthermore, the long-term safety and therapeutic efficacy of MSC transplantation should be evaluated in future clinical trials. This review summarizes our current understanding of the immunomodulatory effects of MSC therapies on human liver diseases.
journal_name
Cell Mol Immunoljournal_title
Cellular & molecular immunologyauthors
Lin H,Xu R,Zhang Z,Chen L,Shi M,Wang FSdoi
10.1038/cmi.2010.57subject
Has Abstractpub_date
2011-01-01 00:00:00pages
19-22issue
1eissn
1672-7681issn
2042-0226pii
cmi201057journal_volume
8pub_type
杂志文章,评审abstract::4-1BB (CD137) is a strong enhancer of the proliferation of CD8+ T cells. Since these cells require increased production of energy and biomass to support their proliferation, we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism. We found that treatment with agonistic anti-4-1BB mAb promoted ...
journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
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abstract::Neutrophil infiltration is a hallmark of alcoholic steatohepatitis; however, the underlying mechanisms remain unclear. We previously reported that chronic-plus-binge ethanol feeding synergistically induces hepatic recruitment of neutrophils, which contributes to liver injury. In this paper, we investigated the roles o...
journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
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更新日期:2005-10-01 00:00:00
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journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
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journal_title:Cellular & molecular immunology
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更新日期:2007-06-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
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journal_title:Cellular & molecular immunology
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更新日期:2004-10-01 00:00:00
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journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:
更新日期:2006-10-01 00:00:00
abstract::Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltrat...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-020-0500-1
更新日期:2020-07-16 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2004-06-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
abstract::Interleukin-22 (IL-22) is a recently identified T cell-derived cytokine whose biological significance remains obscure. Previously, we have shown that IL-22 plays a protective role in T cell-mediated hepatitis induced by Concanavalin A (Con A), acting as a survival factor for hepatocytes. In the present paper, we demon...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:10.1038/s41423-020-00620-5
更新日期:2021-02-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-019-0260-y
更新日期:2020-03-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:
更新日期:2004-04-01 00:00:00
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journal_title:Cellular & molecular immunology
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doi:
更新日期:2004-08-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
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journal_title:Cellular & molecular immunology
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章,评审
doi:
更新日期:2006-06-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Cellular & molecular immunology
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
abstract::Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of he...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/cmi.2009.15
更新日期:2009-04-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding domain (RBD), and thus is believed to be a major target to block...
journal_title:Cellular & molecular immunology
pub_type: 杂志文章
doi:10.1038/s41423-020-0458-z
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Plasma phospholipid transfer protein (PLTP) is a key determinant of lipoprotein metabolism, and both animal and human studies converge to indicate that PLTP promotes atherogenesis and its thromboembolic complications. Moreover, it has recently been reported that PLTP modulates inflammation and immune response...
journal_title:Cellular & molecular immunology
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abstract::Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NL...
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pub_type: 杂志文章,评审
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更新日期:2016-03-01 00:00:00