Imbalance of interleukin 18 and interleukin 18 binding protein in patients with lupus nephritis.

abstract：:Dendritic cells (DCs) are the most potent professional antigen-presenting cells, and capable of stimulating naïve T cells and driving primary immune responses. DCs are poised to capture antigen, migrate to draining lymphoid organs, and after a process of maturation, select antigen-specific lymphocytes to which they pr...

journal_title：Cellular & molecular immunology

authors： Sun K,Wang L,Zhang Y

更新日期：2006-06-01 00:00:00

abstract：:The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia (PE), in which an imbalance between the inflammation-limiting regulatory T cells (Tregs) and the inflammation-mediating Th17 cells plays an essential role. Previously, we reported that the...

journal_title：Cellular & molecular immunology

authors： Ding H,Dai Y,Lei Y,Wang Z,Liu D,Li R,Shen L,Gu N,Zheng M,Zhu X,Zhao G,Hu Y

更新日期：2019-01-01 00:00:00

abstract：:Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for mol...

journal_title：Cellular & molecular immunology

authors： Wei Y,Zhang F,Zhang Y,Wang X,Xing C,Guo J,Zhang H,Suo Z,Li Y,Wang J,Wang R,Cai Z

更新日期：2019-06-01 00:00:00

abstract：:Epigenetic modifications to histones dictate the differentiation of naïve CD4+ T cells into different subsets of effector T helper (TH) cells. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been implicated in the mechanism regulating the differentiation of TH1, TH2 and regulatory T (Treg) cells. ...

journal_title：Cellular & molecular immunology

authors： Chen X,Cao G,Wu J,Wang X,Pan Z,Gao J,Tian Q,Xu L,Li Z,Hao Y,Huang Q,Wang P,Xiao M,Xie L,Tang S,Liu Z,Hu L,Tang J,He R,Wang L,Zhou X,Wu Y,Chen M,Sun B,Zhu B,Huang J,Ye L

更新日期：2020-03-01 00:00:00

abstract：:Epstein-Barr virus (EBV), a potential oncogenic herpesvirus, has been found to be associated with several malignancies. It's critical to elicit cellular immunity of the body to fight against EBV-associated tumor development. Using dendritic cells (DCs) loaded with latent membrane protein 2A (LMP2A) to elicit T cell re...

journal_title：Cellular & molecular immunology

authors： Chen Y,Yao K,Wang B,Qing J,Liu G

更新日期：2008-10-01 00:00:00

abstract：:Interleukin-22 (IL-22) is a recently identified T cell-derived cytokine whose biological significance remains obscure. Previously, we have shown that IL-22 plays a protective role in T cell-mediated hepatitis induced by Concanavalin A (Con A), acting as a survival factor for hepatocytes. In the present paper, we demon...

journal_title：Cellular & molecular immunology

authors： Pan H,Hong F,Radaeva S,Gao B

更新日期：2004-02-01 00:00:00

abstract：:Previous study showed that aerosolized signal transducer and activator of transcription-1 (STAT1) antisense oligodeoxynucleotide (ASON) inhibited the expression of STAT1 and ICAM-1 mRNA and protein in alveolar macrophages (AMs) and decreased the concentrations of TGF-beta, PDGF and TNF-alpha in bronchioalveolar lavage...

journal_title：Cellular & molecular immunology

authors： Wang WJ,Liao B,Zeng M,Zhu C,Fan XM

更新日期：2009-02-01 00:00:00

abstract：:Recent studies suggest differential roles for CD103+ and CD11bhi lung dendritic cells (LDCs) in host defense against viral and bacterial infections. In this study, we examined the contribution of these LDC subsets in protective immunity to chlamydial lung infection using a Chlamydia muridarum mouse infection model. We...

journal_title：Cellular & molecular immunology

authors： Shekhar S,Peng Y,Wang S,Yang X

更新日期：2018-04-01 00:00:00

abstract：:Low-dose total body irradiation (LTBI) is used in the treatment of some cancers mainly for immune enhancement rather than cell killing. However, the mechanism underlying LTBI remains unknown. In this study, by analyzing the immune patterns of lymphocytes, we found that the percentage and absolute number of CD4(+)CD25(...

journal_title：Cellular & molecular immunology

authors： Liu R,Xiong S,Zhang L,Chu Y

更新日期：2010-03-01 00:00:00

abstract：:The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver (mainly hepatocytes) is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety...

journal_title：Cellular & molecular immunology

authors： Qin X,Gao B

更新日期：2006-10-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data a...

journal_title：Cellular & molecular immunology

authors： Hu F,Chen F,Ou Z,Fan Q,Tan X,Wang Y,Pan Y,Ke B,Li L,Guan Y,Mo X,Wang J,Wang J,Luo C,Wen X,Li M,Ren P,Ke C,Li J,Lei C,Tang X,Li F

更新日期：2020-11-01 00:00:00

abstract：:Kupffer cells (KCs), the liver resident macrophages accounting for 80-90% of the total population of fixed tissue macrophages in the body, not only play a key role in host defense via removing particulate materials from the portal circulation, but may also contribute to the pathogenesis of various liver diseases. We h...

journal_title：Cellular & molecular immunology

authors： Miller AM,Zhang JX

更新日期：2009-12-01 00:00:00

abstract：:In addition to serving as molecular chaperones, heat shock proteins (HSPs) have been implicated in autoimmune diseases, antigen presentation and tumor immunity. Extensive work in the last 10 years has also suggested that HSPs such as Hsp60, Hsp70, Hsp90 and gp96, may be potent activators of the innate immune system ca...

journal_title：Cellular & molecular immunology

authors： Tsan MF,Gao B

更新日期：2004-08-01 00:00:00

abstract：:The major limitation for the maturation of dendritic cells (DCs) using Toll-like receptor (TLR) agonists is their decreased ability to migrate into lymph nodes compared with conventional DCs. CD38 can be used as a multifunctional marker to modulate migration, survival and Th1 responses of DCs. CD74 has been shown to n...

journal_title：Cellular & molecular immunology

authors： Nguyen-Pham TN,Lim MS,Nguyen TA,Lee YK,Jin CJ,Lee HJ,Hong CY,Ahn JS,Yang DH,Kim YK,Chung IJ,Park BC,Kim HJ,Lee JJ

更新日期：2011-07-01 00:00:00

abstract：:A complex process including both the innate and acquired immune responses results in allograft rejection. Some chemokine receptors and their ligands play essential roles not only for leukocyte migration into the graft but also in facilitating dendritic and T cell trafficking between lymph nodes and the transplant in t...

journal_title：Cellular & molecular immunology

authors： Tan J,Zhou G

更新日期：2005-10-01 00:00:00

abstract：:Viral encephalitis is a devastating disease with high mortality, and survivors often suffer from severe neurological complications. Microglia are innate immune cells of the central nervous system (CNS) parenchyma whose turnover is reliant on local proliferation. Microglia express a diverse range of proteins, which all...

journal_title：Cellular & molecular immunology

authors： Chhatbar C,Prinz M

更新日期：2021-02-01 00:00:00

abstract：:Complications arising from abnormal immune responses are the major causes of mortality and morbidity in diabetic patients. CD4+CD25+T regulatory cells (Tregs) play pivotal roles in controlling immune homeostasis, immunity and tolerance. The effect of hyperglycemia on CD4+CD25+Tregs has not yet been addressed. Here we ...

journal_title：Cellular & molecular immunology

authors： Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y

更新日期：2012-01-01 00:00:00

abstract：:In order to investigate immunogenicity in the induction of humoral and cellular immune responses, severe acute respiratory syndrome associated coronavirus (SARS-CoV)-N gene recombinant replication-defective adenoviral vector, rAd-N, was generated and immunized BALB/c mice in a pcDNA3.1-N prime-rAd-N boost regimen. Aft...

journal_title：Cellular & molecular immunology

authors： Ma C,Yao K,Zhou F,Zhu M

更新日期：2006-12-01 00:00:00

abstract：:The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, 'how compatible these cells are immunologically?' Indeed, the ...

journal_title：Cellular & molecular immunology

authors： Sujata L,Chaudhuri S

更新日期：2008-04-01 00:00:00

abstract：:In contrast to the previous belief that autoreactive B cells are eliminated from the normal repertoire of B cells, many autoreactive B cells actually escape clonal deletion and develop into mature B cells. These autoreactive B cells in healthy individuals perform some beneficial functions in the host and are homeostat...

journal_title：Cellular & molecular immunology

authors： Lee S,Ko Y,Kim TJ

更新日期：2020-06-01 00:00:00

abstract：:Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of he...

journal_title：Cellular & molecular immunology

authors： Mojadadi S,Jamali A,Khansarinejad B,Soleimanjahi H,Bamdad T

更新日期：2009-04-01 00:00:00

abstract：:The type 2 immune response is critical for host defense against large parasites such as helminths. On the other hand, dysregulation of the type 2 immune response may cause immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis. Thus, a balanced type 2 immune response must be achi...

journal_title：Cellular & molecular immunology

authors： Gurram RK,Zhu J

更新日期：2019-03-01 00:00:00

abstract：:While there is mounting evidence that interleukin (IL)-23-IL-17 axis plays a critical role in the pathogenesis of various autoimmune diseases, much remains to be elucidated on how IL-23 is induced in the pathological processes. IL-23 is a heterodimer composed of p19 and p40, the latter being shared with IL-12. We prev...

journal_title：Cellular & molecular immunology

authors： Ma X,Aoki T,Narumiya S

更新日期：2016-03-01 00:00:00

abstract：:Allergen-specific immunotherapy (allergen-SIT) is a highly effective treatment for children with allergic asthma (AA), an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens. T helper cells and secreted cytokines play important roles in the p...

journal_title：Cellular & molecular immunology

authors： Wang CM,Chang CB,Chan MW,Wen ZH,Wu SF

更新日期：2018-11-01 00:00:00

abstract：:Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltrat...

journal_title：Cellular & molecular immunology

authors： Shen Z,Kuang S,Zhang M,Huang X,Chen J,Guan M,Qin W,Xu HHK,Lin Z

更新日期：2020-07-16 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) has been recognized as an activator of nuclear factor kappaB (NF-kappaB), a factor implicated in the protection of many cell types from apoptosis. We and others have presented evidence to suggest that Fas-induced apoptosis may be an important aspect of the resolution of inflamma...

journal_title：Cellular & molecular immunology

authors： Qin Y,Auh S,Blokh L,Long C,Gagnon I,Hamann KJ

更新日期：2007-02-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations. Plaque psoriasis, which is the most common manifestation of psoriasis, is located on one end of the spectrum, dominated by adaptive immune responses, whereas the rarer pustular psoriasis lies on the opposite end,...

journal_title：Cellular & molecular immunology

authors： Uppala R,Tsoi LC,Harms PW,Wang B,Billi AC,Maverakis E,Michelle Kahlenberg J,Ward NL,Gudjonsson JE

更新日期：2021-02-01 00:00:00

abstract：:Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NL...

journal_title：Cellular & molecular immunology

authors： Jo EK,Kim JK,Shin DM,Sasakawa C

更新日期：2016-03-01 00:00:00

abstract：:Recent study has suggested that innate immune system might play an important role in pregnancy progression. In this study, to investigate whether NK cells and NKT cells, instead of T cells, are the dominant populations of peripheral blood in early pregnancy, flow cytometry was used to detect the percentage and intrace...

journal_title：Cellular & molecular immunology

authors： Shi Y,Ling B,Zhou Y,Gao T,Feng D,Xiao M,Feng L

更新日期：2007-10-01 00:00:00

abstract：:Follicular helper T (Tfh) cells select mutated B cells in germinal centres, which can then differentiate into long-lived high affinity memory B cells and plasma cells. Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6. This transcription factor turns down expres...

journal_title：Cellular & molecular immunology

authors： Yu D,Vinuesa CG

更新日期：2010-05-01 00:00:00